CN1452650A - 具有最佳粘合性能的亲水性压敏性粘合剂的制备方法 - Google Patents
具有最佳粘合性能的亲水性压敏性粘合剂的制备方法 Download PDFInfo
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- CN1452650A CN1452650A CN01815221A CN01815221A CN1452650A CN 1452650 A CN1452650 A CN 1452650A CN 01815221 A CN01815221 A CN 01815221A CN 01815221 A CN01815221 A CN 01815221A CN 1452650 A CN1452650 A CN 1452650A
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- MEYZYGMYMLNUHJ-UHFFFAOYSA-N tunicamycin Natural products CC(C)CCCCCCCCCC=CC(=O)NC1C(O)C(O)C(CC(O)C2OC(C(O)C2O)N3C=CC(=O)NC3=O)OC1OC4OC(CO)C(O)C(O)C4NC(=O)C MEYZYGMYMLNUHJ-UHFFFAOYSA-N 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 229920001567 vinyl ester resin Polymers 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000004636 vulcanized rubber Substances 0.000 description 1
- 230000010148 water-pollination Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
聚合物 | Tg,K | ΔCp,J/gK | ΔCpTg,J/g |
聚二甲基硅氧烷 | 150 | 0.30 | 45.0 |
聚异丁烯 | 200 | 0.40 | 79.6 |
天然橡胶 | 200 | 0.46 | 92.0 |
聚乙烯 | 237 | 0.39 | 92.5 |
PEG-400 | 200 | 0.51 | 101.4 |
双酚聚碳酸酯 | 415 | 0.25 | 103.9 |
聚甲基丙烯酸甲酯 | 385 | 0.29 | 112.8 |
聚(N-乙烯基吡咯烷酮) | 449 | 0.27 | 121.2 |
聚丙烯 | 253 | 0.55 | 139.2 |
聚苯乙烯 | 375 | 0.38 | 141.0 |
聚乙酸乙烯酯 | 305 | 0.50 | 153.4 |
聚对苯二甲酸乙二醇酯 | 340 | 0.49 | 165.7 |
聚氯乙烯 | 355 | 0.63 | 229.9 |
编号 | PVPMw | 组分,重量% | RH.% | 厚度(微米) | -ΔTg,K | ΔCpTg,J/g | 剥离力,N/m | 分离方式 | |
PVP | PEG-400 | ||||||||
1 | 1,000,000 | 64 | 36 | 50 | 130 | 71 | 46.2 | 370 | 混杂 |
2 | 73 | 27 | 39 | 119.0 | 83 | 粘合 | |||
3 | 54 | 46 | 65.2 | 92.6 | 95 | 粘结 | |||
4 | 47 | 53 | 37.2 | 77.2 | 64 | 粘结 | |||
5 | 64 | 36 | 20 | 130 | 69 | 30 | 粘合 | ||
6 | 40 | 73 | 90 | 粘合 | |||||
7 | 65 | 70.5 | 59.1 | 330 | 粘结 | ||||
8 | 80 | 66.2 | 42 | 粘结 | |||||
9 | 90 | 77 | 96.0 | 粘结 | |||||
10 | 150,000 | 64 | 36 | 50 | 130 | 82.0 | 15 | 粘结 | |
11 | 8000 | 87.5 | 0 | 粘结 | |||||
12 | 1,000,000 | 64 | 36 | 50 | 250 | 390 | 混杂 | ||
13 | 175 | 390 | 混杂 | ||||||
14 | 119 | 330 | 粘合 | ||||||
15 | 70 | 210 | 粘合 | ||||||
16 | 50 | 185 | 粘合 |
编号 | 增塑剂 | Tg,℃ | Tm,℃ | 组分,重量% | -ΔTg,K | ΔCpTg,J/g | 剥离力,N/m | 分离方式 | |
增塑剂 | PVP | ||||||||
17 | 乙二醇 | -112 | 25 | 75 | n/d | n/d | 123 | 粘合 | |
18 | 36 | 64 | 60 | 62.0 | 142 | 粘合 | |||
19 | 45 | 55 | n/d | n/d | 127±15 | 粘合 | |||
20 | PEG-200 | -70 | n/a | 36 | 64 | 82 | 195 | 粘结 | |
21 | PEG-300 | -70 | n/a | 75 | 110 | 粘合 | |||
22 | PEG-600 | -70 | 16 | 68 | 75.3 | 15 | 粘合 | ||
23 | PEG-1000 | -70 | 39 | 60 | 22.71 | 0 | - | ||
24 | 1,3-丙二醇 | -116 | n/a | 35 | 65 | 55 | 47.9 | 116±10 | 粘合 |
25 | 1,2-丙二醇 | -95 | n/a | 35 | 65 | 42 | 56.5 | 180±20 | 粘合 |
26 | PPG-425 | -68 | n/a | 34 | 66 | 75 | 68.3 | 0 | - |
27 | 1,5-PD | -104 | -12.5 | 43 | 57 | 0 | 47.1 | 0 | - |
28 | 50 | 50 | 55 | 72.6 | 30 | 粘结 | |||
29 | 66.5 | 33.5 | 32.5 | 105.0 | 10 | 粘结 | |||
30 | 2,4-PD | -59 | n/a | 32 | 68 | 02 | 59.7 | 0 | 粘合 |
31 | 49 | 51 | 65.4 | 89.0 | 190 | 粘合 | |||
32 | 65.5 | 34.5 | 39.5 | 140.1 | 0 | 粘结 | |||
33 | 1.6-HD | -99 | 49.1 | 33 | 67 | 27.4 | 29.32 | 0 | - |
34 | 37.6 | 62.4 | 83.1 | 59.6 | 11 | 粘结 | |||
35 | 45 | 55 | 64.6 | 粘结 | |||||
36 | 50 | 50 | 55.6 | 58.6 | 19 | 粘结 | |||
37 | 66.6 | 33.4 | 38.5 | 101.0 | 0 | 粘结 | |||
38 | 2,5-HD | -62 | n/a | 49 | 51 | 65.32 | 76.4 | 26 | 粘合 |
39 | 66 | 34 | 40.1 | 122.2 | 10 | 粘结 | |||
40 | 甘油 | -74 | n/a | 23.4 | 76.6 | 138.1 | 45.92 | 粘合 | |
41 | 38 | 62 | 70.5 | 85.7 | 850 | 混杂 | |||
42 | 羧基末端的PEG-600 | -49 | 12 | 36 | 64 | 752 | 55.9 | 8.5 | 粘合 |
43 | 50 | 50 | 55 | 112 | 346.5±15 | 粘结 | |||
44 | 丁二酸(SA) | n/d | 188 | 50 | 50 | n/d | 26.1/75.03 | 0/62 | 粘合 |
45 | 丙二酸(MA) | n/d | 135 | 50 | 50 | n/d | 52.5/80.13 | 7.6/71 | 粘合 |
46 | 戊二酸(GA) | n/d | 96 | 50 | 50 | n/d | 129/853 | 0/94 | 粘合 |
47 | 己二酸(AA) | n/d | 152 | TBD | TBD | n/d | 58.1/893 | TBD | 粘合 |
编号 | 聚合物/增塑剂 | 聚合物 | 组分,重量% | RH,% | -ΔTg,K | ΔCpTg,J/g | 剥离力,N/m | 分离方式 | ||
Mw | Tg,℃ | 聚合物 | 增塑剂 | |||||||
48 | PVCap/PEG-400 | 100000 | 165 | 64 | 36 | 40 | 71 | 88.3 | 533 | 混杂(misc.) |
49 | 50 | 363 | 粘结 | |||||||
50 | 60 | 300 | 粘结 | |||||||
51 | 80 | 23 | 粘结 | |||||||
52 | PVCap/PEG-400 | 1000000 | 197 | 64 | 36 | 50 | 81 | 98.0 | 150 | 粘合 |
53 | PVAA/PEG-400 | 1000000 | 64 | 36 | 50 | 397 | 粘合 | |||
54 | PNIPM/PEG400 | 250000 | 157 | 64 | 36 | 50 | 66 | 89.0- | 230 | 混杂 |
55 | PMAA*/PEG400 | 150000 | 36 | 64 | 50 | - | - | 0 | - | |
56 | 47 | 53 | - | - | 27.5±5 | 粘合 | ||||
57 | 63 | 37 | - | - | 72 | 粘结 | ||||
58 | PAA/PEG400 | 150000 | 47 | 53 | 50 | - | - | 51 | 粘合 | |
59 | PMAA*/1,5PD | 150000 | 36 | 64 | 50 | - | - | 0 | - | |
60 | 50 | 50 | - | - | 22.3 | 粘合 | ||||
61 | Luvisco173/PEG400 | 100000 | 57.5 | 30 | 70 | 50 | 37.1 | 65.9 | 高** | 粘结 |
62 | 36 | 64 | 34.0 | 79.4 | 高** | 粘结 | ||||
63 | Luvisco137/PEG400 | 100000 | 29 | 17 | 83 | 50 | 9.3 | 138.7 | 高** | 粘结 |
64 | 36 | 64 | 24.4 | 180.1 | 高** | 粘结 |
药物 | 基材组分 | 基材内的药物含量(%) | 体外释放速率,μg/cm2 h | Pm(104)cm/h | Ps(104)cm/h | |
碳化硅 | 人皮肤 | |||||
65新烟碱 | PVP-PEG | 1.6 | 150±20 | 106.3±12.0 | ||
66消心痛 | PVP-PEG | 9.6 | 384±48 | 13.0±4.3 | 44±5 | 1.5±0.5 |
67消心痛 | PVCap-PEG | 9.6 | 411±49 | 47.1±5 | ||
68氨基柱头素 | PVP-PEG | 14.3 | 625±20 | 33.7±12.0 | ||
7.6 | 263±10 | |||||
4.0 | 65±5 | |||||
69三硝酸甘油 | PVP-PEG | 7.3 | 160±40 | 12.4±4.0 | 25.6±1.4 | 1.9±0.5 |
1.9 | 45±12 | |||||
70异搏定 | PVP-PEG | 39.1 | 110±20 | 6±2 | 21.4±1.5 | 0.4±0.1 |
24.3 | 110±16 | |||||
13.8 | 95±19 | |||||
3.9 | 78±6 |
药物 | 基材组分 | 基材内的药物含量(%) | 体外释放速率,μg/cm2 h | Pm(104)cm/h | Ps(104)cm/h | |
碳化硅 | 人皮肤 | |||||
71心得安 | PVP-PEG | 13.8 | 118±25 | 26.0±15.0 | 10.6±1.1 | 2.1±0.2 |
7.4 | 79±6 | |||||
72心得安 | PVCap-PEG | 13.8 | 145±30 | 13.0±1.9 | ||
73 Silabolin | PVP-PEG | 13.9 | 131±30 | 10.3±0.5 | ||
10.8 | 107±21 | |||||
7.2 | 65±14 | |||||
74 Foridone | PVP-PEG | 13.8 | 37.3±4.5 | 4.2±1.5 | ||
10.8 | 34.1±4.0 | |||||
7.4 | 24.8±3.0 | |||||
3.1 | 20.6±1.9 |
药物 | 基材组分 | 基材内的药物含量(%) | 体外释放速率,μg/cm2 h | Pm(104)cm/h | Ps(104)cm/h | |
碳化硅 | 人皮肤 | |||||
75氯压定 | PVP-PEG | 7.7 | 26.8±0.8 | 0.75±0.04 | 4.0±1.1 | 0.6±0.2 |
1.4 | 5±2 | 0.78±0.1 | ||||
76金雀花碱 | PVP-PEG | 7.4 | 21±3 | 9.0±4.0 | 3.0±0.5 | 1.3±0.5 |
77Phenazepam | PVP-PEG | 7.4 | 11±2 | 1.4±0.3 | ||
6.8 | 7±2 | |||||
78硝苯吡啶 | PVP-PEG | 15.4 | 19±3 | 1.3±0.2 | ||
79Fluacizin | PVP-PEG | 13.8 | 5±1 | 6±2 | 0.4±0.1 | 0.4±0.1 |
80舒喘宁 | PVP-PEG | 13.8 | 0.10±0.04 | 0.003 | ||
81舒喘宁 | PVCap-PEG | 13.8 | 4.9±1 | 0.4±0.1 | ||
82奎诺溶 | PVP-PEG | 3.0 | n/a | n/a | n/a | n/a |
药物 | 从亲水性基材通过碳化硅输送药物的速率 | 从憎水性基材输送药物的速率 | 憎水性基材的成分 |
氨基柱头素 | 625±20 | 8±1 | 苯乙烯丁二烯橡胶 |
硝酸甘油 | 160±40 | 80±10 | PDMS(NitrodermTTS) |
Silabolin | 131±30 | 16±7 | 苯乙烯丁二烯橡胶 |
心得安 | 118±25 | 56±4 | 苯乙烯丁二烯橡胶 |
氯压定 | 5±2 | 1.6±0.2 | PIB(CatapressTTS) |
Claims (58)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21638600P | 2000-07-07 | 2000-07-07 | |
US60/216,386 | 2000-07-07 | ||
US60/216386 | 2000-07-07 | ||
US84753201A | 2001-05-01 | 2001-05-01 | |
US09/847532 | 2001-05-01 | ||
US09/847,532 | 2001-05-01 |
Publications (2)
Publication Number | Publication Date |
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CN1452650A true CN1452650A (zh) | 2003-10-29 |
CN1182219C CN1182219C (zh) | 2004-12-29 |
Family
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Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB01815221XA Expired - Lifetime CN1182219C (zh) | 2000-07-07 | 2001-07-06 | 具有最佳粘合性能的亲水性压敏性粘合剂的制备方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US6576712B2 (zh) |
EP (1) | EP1299494B1 (zh) |
JP (1) | JP4323797B2 (zh) |
CN (1) | CN1182219C (zh) |
AT (1) | ATE478932T1 (zh) |
AU (2) | AU7323001A (zh) |
CA (1) | CA2415076C (zh) |
DE (1) | DE60142900D1 (zh) |
WO (1) | WO2002004570A2 (zh) |
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2001
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- 2001-07-06 AU AU7323001A patent/AU7323001A/xx active Pending
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- 2001-07-06 WO PCT/US2001/021417 patent/WO2002004570A2/en active IP Right Grant
- 2001-07-06 CN CNB01815221XA patent/CN1182219C/zh not_active Expired - Lifetime
- 2001-07-06 EP EP01952486A patent/EP1299494B1/en not_active Expired - Lifetime
- 2001-07-06 US US09/900,697 patent/US6576712B2/en not_active Ceased
- 2001-07-06 JP JP2002509427A patent/JP4323797B2/ja not_active Expired - Lifetime
- 2001-07-06 CA CA2415076A patent/CA2415076C/en not_active Expired - Lifetime
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2007
- 2007-02-22 AU AU2007200799A patent/AU2007200799B2/en not_active Expired
Cited By (5)
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CN102414286A (zh) * | 2009-04-28 | 2012-04-11 | 3M创新有限公司 | 水溶性压敏粘合剂 |
CN107629735A (zh) * | 2016-07-19 | 2018-01-26 | 上海暖友实业有限公司 | 医用贴专用热熔压敏胶及其制备方法 |
CN110964466A (zh) * | 2019-11-25 | 2020-04-07 | 深圳市佳鑫一帆科技有限公司 | 一种胶水制作方法 |
CN114773562A (zh) * | 2022-04-27 | 2022-07-22 | 广东粤港澳大湾区黄埔材料研究院 | 生物功能型单组分医用胶粘剂及其制备方法、应用 |
CN114773562B (zh) * | 2022-04-27 | 2023-07-25 | 广东粤港澳大湾区黄埔材料研究院 | 生物功能型单组分医用胶粘剂及其制备方法、应用 |
Also Published As
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DE60142900D1 (de) | 2010-10-07 |
EP1299494A2 (en) | 2003-04-09 |
US6576712B2 (en) | 2003-06-10 |
WO2002004570A3 (en) | 2002-04-18 |
WO2002004570A2 (en) | 2002-01-17 |
AU7323001A (en) | 2002-01-21 |
US20020037977A1 (en) | 2002-03-28 |
EP1299494B1 (en) | 2010-08-25 |
JP4323797B2 (ja) | 2009-09-02 |
CA2415076C (en) | 2010-04-13 |
CA2415076A1 (en) | 2002-01-17 |
ATE478932T1 (de) | 2010-09-15 |
AU2007200799B2 (en) | 2011-02-03 |
CN1182219C (zh) | 2004-12-29 |
JP2004502857A (ja) | 2004-01-29 |
AU2007200799A1 (en) | 2007-03-22 |
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Correction item: Third priority Correct: delete False: [32]2001.05.01[33]US[31]09/847,532 Number: 52 Page: 496 Volume: 20 Correction item: Third inventor Correct: Ann, Tory E., Charlie Kiel False: Ann is Tuoliji E. Charlie Kiel Number: 52 Page: 496 Volume: 20 |
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Correction item: Third priority Correct: delete False: [32]2001.05.01[33]US[31]09/847,532 Number: 52 Page: The title page Volume: 20 Correction item: Third inventor Correct: Ann, Tory E., Charlie Kiel False: Ann is Tuoliji E. Charlie Kiel Number: 52 Page: The title page Volume: 20 |
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