JP2004500801A5 - - Google Patents
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- JP2004500801A5 JP2004500801A5 JP2000547235A JP2000547235A JP2004500801A5 JP 2004500801 A5 JP2004500801 A5 JP 2004500801A5 JP 2000547235 A JP2000547235 A JP 2000547235A JP 2000547235 A JP2000547235 A JP 2000547235A JP 2004500801 A5 JP2004500801 A5 JP 2004500801A5
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- 125000003275 alpha amino acid group Chemical group 0.000 description 1910
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1574
- 238000004458 analytical method Methods 0.000 description 419
- 150000001413 amino acids Chemical class 0.000 description 378
- 241000588652 Neisseria gonorrhoeae Species 0.000 description 287
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 161
- 108090000623 proteins and genes Proteins 0.000 description 54
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- 241000588724 Escherichia coli Species 0.000 description 20
- 239000000047 product Substances 0.000 description 19
- 150000007523 nucleic acids Chemical class 0.000 description 18
- 241000588650 Neisseria meningitidis Species 0.000 description 17
- 239000013598 vector Substances 0.000 description 15
- 108700026244 Open Reading Frames Proteins 0.000 description 14
- 101150095079 menB gene Proteins 0.000 description 14
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- 239000000284 extract Substances 0.000 description 10
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- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 10
- 241001430294 unidentified retrovirus Species 0.000 description 10
- 101000748765 Chlorella vulgaris Uncharacterized 16.5 kDa protein in psaC-atpA intergenic region Proteins 0.000 description 9
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- 241000699666 Mus <mouse, genus> Species 0.000 description 8
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- 101000748771 Cuscuta reflexa Uncharacterized 6.8 kDa protein in trnL 3'region Proteins 0.000 description 7
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- 101000956763 Arabidopsis thaliana Uncharacterized mitochondrial protein AtMg01010 Proteins 0.000 description 5
- 101100214862 Autographa californica nuclear polyhedrosis virus AC152 gene Proteins 0.000 description 5
- 101100214860 Autographa californica nuclear polyhedrosis virus Ac132 gene Proteins 0.000 description 5
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- 101000756436 Autographa californica nuclear polyhedrosis virus Uncharacterized 23.6 kDa protein in LEF2-PH intergenic region Proteins 0.000 description 5
- 101000748754 Chlorella vulgaris Uncharacterized 27.9 kDa protein in trnR-minE intergenic region Proteins 0.000 description 5
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- 101000792454 Euglena gracilis Uncharacterized 32.3 kDa protein in rbcL-atpE intergenic region Proteins 0.000 description 5
- 101000748758 Euglena gracilis Uncharacterized 46.2 kDa protein in 16S rRNA 5'region Proteins 0.000 description 5
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- 101000748785 Guillardia theta Uncharacterized 15.1 kDa protein Proteins 0.000 description 5
- 101000820218 Lactococcus phage LL-H Uncharacterized protein ORF5 Proteins 0.000 description 5
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- 101100495846 Autographa californica nuclear polyhedrosis virus CHIA gene Proteins 0.000 description 4
- 101000764215 Cyanophora paradoxa Probable ABC transporter ATP-binding protein in ycf23-apcF intergenic region Proteins 0.000 description 4
- 101000791598 Enterobacteria phage 82 Uncharacterized protein in rusA 5'region Proteins 0.000 description 4
- 101000818350 Escherichia coli Uncharacterized 27.6 kDa protein Proteins 0.000 description 4
- 101100066648 Escherichia phage T5 D17 gene Proteins 0.000 description 4
- 101000792455 Euglena longa Uncharacterized 13.3 kDa protein in rpl23-rpl2 intergenic region Proteins 0.000 description 4
- 101000748757 Euglena longa Uncharacterized 15.0 kDa protein in rpl12-rps7 intergenic region Proteins 0.000 description 4
- 101000787090 Lactobacillus delbrueckii subsp. bulgaricus Uncharacterized 33.9 kDa protein in glnA 5'region Proteins 0.000 description 4
- 101000747947 Marchantia polymorpha Uncharacterized mitochondrial protein ymf33 Proteins 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 101000751492 Mycoplasma hominis (strain ATCC 23114 / NBRC 14850 / NCTC 10111 / PG21) Uncharacterized protein MHO_3790 Proteins 0.000 description 4
- 101150018310 ORF150 gene Proteins 0.000 description 4
- 101100281854 Orgyia pseudotsugata multicapsid polyhedrosis virus GP64 gene Proteins 0.000 description 4
- 101100429594 Orgyia pseudotsugata multicapsid polyhedrosis virus ORF130 gene Proteins 0.000 description 4
- 101000828225 Porphyra purpurea Putative single-stranded DNA-binding protein ycf41 Proteins 0.000 description 4
- 101000828201 Porphyra purpurea Uncharacterized protein ycf54 Proteins 0.000 description 4
- 101000768322 Synechococcus sp. (strain WH8020) Uncharacterized 16.1 kDa protein in cpeY 3'region Proteins 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 101000616308 Arabidopsis thaliana Uncharacterized mitochondrial protein AtMg00120 Proteins 0.000 description 3
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- 101000979020 Arabidopsis thaliana Uncharacterized mitochondrial protein AtMg00550 Proteins 0.000 description 3
- 101000979025 Arabidopsis thaliana Uncharacterized mitochondrial protein AtMg00610 Proteins 0.000 description 3
- 101000958408 Arabidopsis thaliana Uncharacterized mitochondrial protein AtMg00860 Proteins 0.000 description 3
- 101000956760 Arabidopsis thaliana Uncharacterized mitochondrial protein AtMg01000 Proteins 0.000 description 3
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- 101000615717 Arabidopsis thaliana Uncharacterized mitochondrial protein AtMg01250 Proteins 0.000 description 3
- 101100171547 Autographa californica nuclear polyhedrosis virus E27 gene Proteins 0.000 description 3
- 101000792452 Chlamydomonas reinhardtii Uncharacterized 12.3 kDa protein in petA-petD intergenic region Proteins 0.000 description 3
- 101000764196 Cyanophora paradoxa Uncharacterized membrane protein in ycf23-apcF intergenic region Proteins 0.000 description 3
- 101000768085 Cyanophora paradoxa Uncharacterized protein ycf49 Proteins 0.000 description 3
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- 101000626901 Euglena longa Uncharacterized 20.0 kDa protein in rps12-trnP intergenic region Proteins 0.000 description 3
- 101000626917 Euglena longa Uncharacterized 34.5 kDa protein in rps12-trnP intergenic region Proteins 0.000 description 3
- 101000708517 Marchantia polymorpha Uncharacterized mitochondrial protein ymf13 Proteins 0.000 description 3
- 101000747952 Marchantia polymorpha Uncharacterized mitochondrial protein ymf40 Proteins 0.000 description 3
- 101000953973 Methanothermus fervidus Uncharacterized 28.5 kDa protein in 7S RNA 5'region Proteins 0.000 description 3
- 101150089976 ORF144 gene Proteins 0.000 description 3
- 101150024472 ORF146 gene Proteins 0.000 description 3
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- 101100295700 Orgyia pseudotsugata multicapsid polyhedrosis virus ODVP6E gene Proteins 0.000 description 3
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- 240000000220 Panda oleosa Species 0.000 description 3
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- 101000827797 Rhodobacter capsulatus Uncharacterized 23.7 kDa protein in puhA 5'region Proteins 0.000 description 3
- 101000585887 Streptomyces ambofaciens MutT-like protein Proteins 0.000 description 3
- 101000916381 Streptomyces pristinaespiralis Putative transposase in snaA-snaB intergenic region Proteins 0.000 description 3
- 101100166027 Trichoplusia ni ascovirus 2c MCP-2 gene Proteins 0.000 description 3
- 101000792500 Trieres chinensis Uncharacterized protein ycf88 Proteins 0.000 description 3
- 101000788530 Triticum aestivum Putative ATP synthase protein YMF19 Proteins 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 101000626969 Euglena gracilis Uncharacterized 59.8 kDa protein in psbD intron 8 Proteins 0.000 description 2
- 238000003491 array Methods 0.000 description 2
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- 101100542119 Acidianus filamentous virus 1 (isolate United States/Yellowstone) ORF223 gene Proteins 0.000 description 1
- 101000958403 Arabidopsis thaliana Uncharacterized mitochondrial protein AtMg00970 Proteins 0.000 description 1
- 101000626904 Chlorella vulgaris Uncharacterized 27.2 kDa protein in rrn23-psbC intergenic region Proteins 0.000 description 1
- 101000748770 Cyanophora paradoxa Uncharacterized 24.3 kDa protein in hemA-psbN intergenic region Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
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- 101000963888 Dictyostelium citrinum Uncharacterized mitochondrial protein Mp36 Proteins 0.000 description 1
- 101710204837 Envelope small membrane protein Proteins 0.000 description 1
- 101000788492 Marchantia polymorpha Uncharacterized mitochondrial protein ymf28 Proteins 0.000 description 1
- 101000708534 Marchantia polymorpha Uncharacterized tatC-like protein ymf16 Proteins 0.000 description 1
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- 101000626911 Porphyra purpurea Putative cytochrome c-type biogenesis protein DbsD-like Proteins 0.000 description 1
- 101710130262 Probable Vpr-like protein Proteins 0.000 description 1
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- 101000764086 Pseudomonas stutzeri UPF0339 protein in ptx operon 5'region Proteins 0.000 description 1
- 101710088839 Replication initiation protein Proteins 0.000 description 1
- 101000905762 Staphylococcus aureus Potential ATP-binding protein Proteins 0.000 description 1
- 101000814062 Streptomyces lividans Uncharacterized 6.0 kDa protein Proteins 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
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Images
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8375898P | 1998-05-01 | 1998-05-01 | |
| US60/083,758 | 1998-05-01 | ||
| US9486998P | 1998-07-31 | 1998-07-31 | |
| US60/094,869 | 1998-07-31 | ||
| US9899498P | 1998-09-02 | 1998-09-02 | |
| US9906298P | 1998-09-02 | 1998-09-02 | |
| US60/099,062 | 1998-09-02 | ||
| US60/098,994 | 1998-09-02 | ||
| US10379498P | 1998-10-09 | 1998-10-09 | |
| US10374998P | 1998-10-09 | 1998-10-09 | |
| US10379698P | 1998-10-09 | 1998-10-09 | |
| US60/103,796 | 1998-10-09 | ||
| US60/103,749 | 1998-10-09 | ||
| US60/103,794 | 1998-10-09 | ||
| US12152899P | 1999-02-25 | 1999-02-25 | |
| US60/121,528 | 1999-02-25 | ||
| PCT/US1999/009346 WO1999057280A2 (en) | 1998-05-01 | 1999-04-30 | Neisseria meningitidis antigens and compositions |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009125889A Division JP2009183306A (ja) | 1998-05-01 | 2009-05-25 | 髄膜炎菌抗原および組成物 |
| JP2010031866A Division JP2010166916A (ja) | 1998-05-01 | 2010-02-16 | 髄膜炎菌抗原および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004500801A JP2004500801A (ja) | 2004-01-15 |
| JP2004500801A5 true JP2004500801A5 (enExample) | 2010-04-08 |
| JP5102414B2 JP5102414B2 (ja) | 2012-12-19 |
Family
ID=27574612
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000547235A Expired - Fee Related JP5102414B2 (ja) | 1998-05-01 | 1999-04-30 | 髄膜炎菌抗原および組成物 |
| JP2009125889A Withdrawn JP2009183306A (ja) | 1998-05-01 | 2009-05-25 | 髄膜炎菌抗原および組成物 |
| JP2010031866A Withdrawn JP2010166916A (ja) | 1998-05-01 | 2010-02-16 | 髄膜炎菌抗原および組成物 |
| JP2012140207A Pending JP2012191945A (ja) | 1998-05-01 | 2012-06-21 | 髄膜炎菌抗原および組成物 |
| JP2012140208A Withdrawn JP2012191946A (ja) | 1998-05-01 | 2012-06-21 | 髄膜炎菌抗原および組成物 |
| JP2013157835A Expired - Lifetime JP6025675B2 (ja) | 1998-05-01 | 2013-07-30 | 髄膜炎菌抗原および組成物 |
| JP2013157834A Expired - Lifetime JP6025674B2 (ja) | 1998-05-01 | 2013-07-30 | 髄膜炎菌抗原および組成物 |
| JP2016154472A Withdrawn JP2016222709A (ja) | 1998-05-01 | 2016-08-05 | 髄膜炎菌抗原および組成物 |
| JP2016192774A Withdrawn JP2017012195A (ja) | 1998-05-01 | 2016-09-30 | 髄膜炎菌抗原および組成物 |
Family Applications After (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009125889A Withdrawn JP2009183306A (ja) | 1998-05-01 | 2009-05-25 | 髄膜炎菌抗原および組成物 |
| JP2010031866A Withdrawn JP2010166916A (ja) | 1998-05-01 | 2010-02-16 | 髄膜炎菌抗原および組成物 |
| JP2012140207A Pending JP2012191945A (ja) | 1998-05-01 | 2012-06-21 | 髄膜炎菌抗原および組成物 |
| JP2012140208A Withdrawn JP2012191946A (ja) | 1998-05-01 | 2012-06-21 | 髄膜炎菌抗原および組成物 |
| JP2013157835A Expired - Lifetime JP6025675B2 (ja) | 1998-05-01 | 2013-07-30 | 髄膜炎菌抗原および組成物 |
| JP2013157834A Expired - Lifetime JP6025674B2 (ja) | 1998-05-01 | 2013-07-30 | 髄膜炎菌抗原および組成物 |
| JP2016154472A Withdrawn JP2016222709A (ja) | 1998-05-01 | 2016-08-05 | 髄膜炎菌抗原および組成物 |
| JP2016192774A Withdrawn JP2017012195A (ja) | 1998-05-01 | 2016-09-30 | 髄膜炎菌抗原および組成物 |
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2011
- 2011-03-23 US US13/070,448 patent/US9139621B2/en not_active Expired - Fee Related
-
2012
- 2012-01-26 US US13/359,459 patent/US20120156236A1/en not_active Abandoned
- 2012-01-26 US US13/359,471 patent/US8524251B2/en not_active Expired - Fee Related
- 2012-01-26 US US13/359,442 patent/US9249196B2/en not_active Expired - Fee Related
- 2012-06-21 JP JP2012140207A patent/JP2012191945A/ja active Pending
- 2012-06-21 JP JP2012140208A patent/JP2012191946A/ja not_active Withdrawn
-
2013
- 2013-07-30 JP JP2013157835A patent/JP6025675B2/ja not_active Expired - Lifetime
- 2013-07-30 JP JP2013157834A patent/JP6025674B2/ja not_active Expired - Lifetime
-
2014
- 2014-08-01 US US14/450,075 patent/US9266929B2/en not_active Expired - Fee Related
- 2014-08-01 US US14/450,082 patent/US9249198B2/en not_active Expired - Fee Related
-
2015
- 2015-07-21 US US14/804,756 patent/US20160030545A1/en not_active Abandoned
-
2016
- 2016-08-05 JP JP2016154472A patent/JP2016222709A/ja not_active Withdrawn
- 2016-09-30 JP JP2016192774A patent/JP2017012195A/ja not_active Withdrawn
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