JP2003520248A5 - - Google Patents
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- JP2003520248A5 JP2003520248A5 JP2001552932A JP2001552932A JP2003520248A5 JP 2003520248 A5 JP2003520248 A5 JP 2003520248A5 JP 2001552932 A JP2001552932 A JP 2001552932A JP 2001552932 A JP2001552932 A JP 2001552932A JP 2003520248 A5 JP2003520248 A5 JP 2003520248A5
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- protein
- neisseria meningitidis
- seq
- composition according
- protective antigen
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- 108090000623 proteins and genes Proteins 0.000 description 17
- 102000004169 proteins and genes Human genes 0.000 description 17
- 101710194807 Protective antigen Proteins 0.000 description 12
- 241000588650 Neisseria meningitidis Species 0.000 description 11
- 239000012528 membrane Substances 0.000 description 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 6
- 230000002163 immunogen Effects 0.000 description 6
- 239000012634 fragment Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 241000588653 Neisseria Species 0.000 description 4
- 101150075249 ORF40 gene Proteins 0.000 description 4
- 101100156835 Paenarthrobacter nicotinovorans xdh gene Proteins 0.000 description 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000588677 Neisseria meningitidis serogroup B Species 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 241000588807 Bordetella Species 0.000 description 1
- 101000874355 Escherichia coli (strain K12) Outer membrane protein assembly factor BamA Proteins 0.000 description 1
- 241000606768 Haemophilus influenzae Species 0.000 description 1
- 241000589989 Helicobacter Species 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 241000588654 Neisseria cinerea Species 0.000 description 1
- 241000588649 Neisseria lactamica Species 0.000 description 1
- 241000921898 Neisseria meningitidis serogroup A Species 0.000 description 1
- 241000947238 Neisseria meningitidis serogroup C Species 0.000 description 1
- 201000005702 Pertussis Diseases 0.000 description 1
- -1 PilC Proteins 0.000 description 1
- 208000000474 Poliomyelitis Diseases 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000607768 Shigella Species 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- 108010031133 Transferrin-Binding Protein A Proteins 0.000 description 1
- 108010031127 Transferrin-Binding Protein B Proteins 0.000 description 1
- 241000607734 Yersinia <bacteria> Species 0.000 description 1
- 229940009976 deoxycholate Drugs 0.000 description 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940047650 haemophilus influenzae Drugs 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Description
【特許請求の範囲】
【請求項１】 （ａ）Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｂ外膜調製物、および
（ｂ）Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓタンパク質ＯＲＦ４０
を含む、組成物。
【請求項２】 請求項１に記載の組成物であって、前記成分（ｂ）が、
・ＷＯ９９／３６５４４の配列番号１〜６から選択されるアミノ酸配列を含むタンパク質、または該配列番号１〜６のうちの１つ以上のうちの免疫原性フラグメントを含むタンパク質、または該配列番号１〜６のうちの１つ以上に対して５０％よりも高い配列同一性を有する配列を含むタンパク質；
・ＷＯ００／６６７４１の図１において開示されるタンパク質、またはその免疫原性フラグメント；
・ＷＯ９９／３１１３２の配列番号２からなる群より選択されるアミノ酸配列を含むタンパク質、または該配列番号２の免疫原性フラグメントを含むタンパク質、または該配列番号２に対して５０％よりも高い配列同一性を有する配列を含むタンパク質；および／あるいは
・ＷＯ９９／５８６８３の配列番号２もしくは配列番号４からなる群より選択されるアミノ酸配列を含むタンパク質、または該配列番号２もしくは配列番号４の免疫原性フラグメントを含むタンパク質、または該配列番号２もしくは配列番号４に対して５０％よりも高い配列同一性を有する配列を含むタンパク質；
のうちの１つ以上から選択される、組成物。
【請求項３】 請求項２に記載の組成物であって、前記成分（ｂ）が、
・ＷＯ９９／３６５４４の配列番号１〜６から選択されるアミノ酸配列を含むタンパク質、または該配列番号１〜６のうちの１つ以上のうちの免疫原性フラグメントを含むタンパク質、または該配列番号１〜６のうちの１つ以上に対して５０％よりも高い配列同一性を有する配列を含むタンパク質;
である、組成物。
【請求項４】 請求項１〜３のうちのいずれか１項に記載の組成物であって、前記成分（ｂ）が、Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｂの株に由来するタンパク質を含む、組成物。
【請求項５】 請求項１〜４のうちのいずれか１項に記載の組成物であって、前記成分（ｂ）が、前記成分（ａ）が由来するＮｍＢ株とは異なる株に由来するタンパク質を含む、組成物。
【請求項６】 請求項１〜５のうちのいずれか１項に記載の組成物であって、前記成分のうちの１つ以上が水酸化アルミニウムアジュバントに吸着されている、組成物。
【請求項７】 請求項１〜６のうちのいずれか１項に記載の組成物であって、前記成分（ａ）が外膜小胞（ＯＭＶ）を含む、組成物。
【請求項８】 請求項７に記載の組成物であって、前記ＯＭＶが、Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｂ由来のデオキシコレート抽出物である、組成物。
【請求項９】 請求項７または請求項８に記載の組成物であって、前記ＯＭＶが、Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓの４４／７６株に由来する、組成物。
【請求項１０】 請求項７〜請求項９のうちのいずれか１項に記載の組成物であって、前記ＯＭＶ成分が水酸化アルミニウムアジュバントに吸着している、組成物。
【請求項１１】 請求項１〜１０のうちのいずれか１項に記載の組成物であって、
Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓタンパク質ＮｓｐＡ、ＰｏｒＡ、ＴｂｐＡ、ＴｂｐＢ、ＰｉｌＣ、ＯｐＡ、またはＯｍｐ８５から選択される免疫原性成分；
をさらに含む、組成物。
【請求項１２】 請求項１〜１１のうちのいずれか１項に記載の組成物であって、
・Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ａに対する防御抗原；
・Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｃに対する防御抗原；
・Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｙに対する防御抗原；
・Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｗに対する防御抗原；
・Ｈａｅｍｏｐｈｉｌｕｓ ｉｎｆｌｕｅｎｚａｅに対する防御抗原；
・肺炎球菌（ｐｎｅｕｍｏｃｏｃｃｕｓ）に対する防御抗原；
・ジフテリアに対する防御抗原；
・破傷風に対する防御抗原；
・百日咳に対する防御抗原；
・Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉに対する防御抗原；
・ポリオに対する防御抗原；および／または
・Ｂ型肝炎ウイルスに対する防御抗原；
のうちの１つ以上の成分をさらに含む、組成物。
【請求項１３】 前記組成物がワクチンである、請求項１〜１２のうちのいずれか１項に記載の組成物。
【請求項１４】 医薬品として使用するための、請求項１〜１３のうちのいずれか１項に記載の組成物。
【請求項１５】 （ｉ）Ｎｅｉｓｓｅｒｉａ細菌に起因する感染を処置もしくは予防するための医薬品；（ｉｉ）Ｎｅｉｓｓｅｒｉａ細菌の存在もしくはＮｅｉｓｓｅｒｉａ細菌に対して惹起された抗体の存在を検出するための診断試薬；および／または（ｉｉｉ）Ｎｅｉｓｓｅｒｉａ細菌に対する抗体を惹起し得る試薬；の製造における、請求項２または請求項３において規定される（ａ）Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｂ外膜調製物および（ｂ）Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓタンパク質ＯＲＦ４０の使用。
【請求項１６】 Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓタンパク質ＯＲＦ４０を含む、細菌外膜調製物。
【請求項１７】 請求項１６に記載の細菌外膜調製物であって、前記細菌がその外膜中に成分（ｂ）を過剰生成するように操作されている、細菌外膜調製物。
【請求項１８】 外膜中にＮｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓタンパク質ＯＲＦ４０を過剰生成する、細菌。
【請求項１９】 Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ、Ｎｅｉｓｓｅｒｉａ ｌａｃｔａｍｉｃａ、Ｎｅｉｓｓｅｒｉａ ｃｉｎｅｒｅａ、Ｅ．ｃｏｌｉ、Ｓａｌｍｏｎｅｌｌａ、Ｓｈｉｇｅｌｌａ、Ｂｏｒｄｅｔｅｌｌａ、Ｙｅｒｓｉｎｉａ、Ｈｅｌｉｃｏｂａｃｔｅｒからなる群より選択される、請求項１８に記載の細菌。
【請求項１】 （ａ）Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｂ外膜調製物、および
（ｂ）Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓタンパク質ＯＲＦ４０
を含む、組成物。
【請求項２】 請求項１に記載の組成物であって、前記成分（ｂ）が、
・ＷＯ９９／３６５４４の配列番号１〜６から選択されるアミノ酸配列を含むタンパク質、または該配列番号１〜６のうちの１つ以上のうちの免疫原性フラグメントを含むタンパク質、または該配列番号１〜６のうちの１つ以上に対して５０％よりも高い配列同一性を有する配列を含むタンパク質；
・ＷＯ００／６６７４１の図１において開示されるタンパク質、またはその免疫原性フラグメント；
・ＷＯ９９／３１１３２の配列番号２からなる群より選択されるアミノ酸配列を含むタンパク質、または該配列番号２の免疫原性フラグメントを含むタンパク質、または該配列番号２に対して５０％よりも高い配列同一性を有する配列を含むタンパク質；および／あるいは
・ＷＯ９９／５８６８３の配列番号２もしくは配列番号４からなる群より選択されるアミノ酸配列を含むタンパク質、または該配列番号２もしくは配列番号４の免疫原性フラグメントを含むタンパク質、または該配列番号２もしくは配列番号４に対して５０％よりも高い配列同一性を有する配列を含むタンパク質；
のうちの１つ以上から選択される、組成物。
【請求項３】 請求項２に記載の組成物であって、前記成分（ｂ）が、
・ＷＯ９９／３６５４４の配列番号１〜６から選択されるアミノ酸配列を含むタンパク質、または該配列番号１〜６のうちの１つ以上のうちの免疫原性フラグメントを含むタンパク質、または該配列番号１〜６のうちの１つ以上に対して５０％よりも高い配列同一性を有する配列を含むタンパク質;
である、組成物。
【請求項４】 請求項１〜３のうちのいずれか１項に記載の組成物であって、前記成分（ｂ）が、Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｂの株に由来するタンパク質を含む、組成物。
【請求項５】 請求項１〜４のうちのいずれか１項に記載の組成物であって、前記成分（ｂ）が、前記成分（ａ）が由来するＮｍＢ株とは異なる株に由来するタンパク質を含む、組成物。
【請求項６】 請求項１〜５のうちのいずれか１項に記載の組成物であって、前記成分のうちの１つ以上が水酸化アルミニウムアジュバントに吸着されている、組成物。
【請求項７】 請求項１〜６のうちのいずれか１項に記載の組成物であって、前記成分（ａ）が外膜小胞（ＯＭＶ）を含む、組成物。
【請求項８】 請求項７に記載の組成物であって、前記ＯＭＶが、Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｂ由来のデオキシコレート抽出物である、組成物。
【請求項９】 請求項７または請求項８に記載の組成物であって、前記ＯＭＶが、Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓの４４／７６株に由来する、組成物。
【請求項１０】 請求項７〜請求項９のうちのいずれか１項に記載の組成物であって、前記ＯＭＶ成分が水酸化アルミニウムアジュバントに吸着している、組成物。
【請求項１１】 請求項１〜１０のうちのいずれか１項に記載の組成物であって、
Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓタンパク質ＮｓｐＡ、ＰｏｒＡ、ＴｂｐＡ、ＴｂｐＢ、ＰｉｌＣ、ＯｐＡ、またはＯｍｐ８５から選択される免疫原性成分；
をさらに含む、組成物。
【請求項１２】 請求項１〜１１のうちのいずれか１項に記載の組成物であって、
・Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ａに対する防御抗原；
・Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｃに対する防御抗原；
・Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｙに対する防御抗原；
・Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｗに対する防御抗原；
・Ｈａｅｍｏｐｈｉｌｕｓ ｉｎｆｌｕｅｎｚａｅに対する防御抗原；
・肺炎球菌（ｐｎｅｕｍｏｃｏｃｃｕｓ）に対する防御抗原；
・ジフテリアに対する防御抗原；
・破傷風に対する防御抗原；
・百日咳に対する防御抗原；
・Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉに対する防御抗原；
・ポリオに対する防御抗原；および／または
・Ｂ型肝炎ウイルスに対する防御抗原；
のうちの１つ以上の成分をさらに含む、組成物。
【請求項１３】 前記組成物がワクチンである、請求項１〜１２のうちのいずれか１項に記載の組成物。
【請求項１４】 医薬品として使用するための、請求項１〜１３のうちのいずれか１項に記載の組成物。
【請求項１５】 （ｉ）Ｎｅｉｓｓｅｒｉａ細菌に起因する感染を処置もしくは予防するための医薬品；（ｉｉ）Ｎｅｉｓｓｅｒｉａ細菌の存在もしくはＮｅｉｓｓｅｒｉａ細菌に対して惹起された抗体の存在を検出するための診断試薬；および／または（ｉｉｉ）Ｎｅｉｓｓｅｒｉａ細菌に対する抗体を惹起し得る試薬；の製造における、請求項２または請求項３において規定される（ａ）Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｂ外膜調製物および（ｂ）Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓタンパク質ＯＲＦ４０の使用。
【請求項１６】 Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓタンパク質ＯＲＦ４０を含む、細菌外膜調製物。
【請求項１７】 請求項１６に記載の細菌外膜調製物であって、前記細菌がその外膜中に成分（ｂ）を過剰生成するように操作されている、細菌外膜調製物。
【請求項１８】 外膜中にＮｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓタンパク質ＯＲＦ４０を過剰生成する、細菌。
【請求項１９】 Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ、Ｎｅｉｓｓｅｒｉａ ｌａｃｔａｍｉｃａ、Ｎｅｉｓｓｅｒｉａ ｃｉｎｅｒｅａ、Ｅ．ｃｏｌｉ、Ｓａｌｍｏｎｅｌｌａ、Ｓｈｉｇｅｌｌａ、Ｂｏｒｄｅｔｅｌｌａ、Ｙｅｒｓｉｎｉａ、Ｈｅｌｉｃｏｂａｃｔｅｒからなる群より選択される、請求項１８に記載の細菌。
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| JP2013124556A Pending JP2013181037A (ja) | 2000-01-17 | 2013-06-13 | Ｎ．ｍｅｎｉｎｇｉｔｉｄｉｓ血清型ｂ外膜タンパク質を含む外膜小胞（ｏｍｖ）ワクチン |
| JP2013124554A Expired - Fee Related JP5823446B2 (ja) | 2000-01-17 | 2013-06-13 | Ｎ．ｍｅｎｉｎｇｉｔｉｄｉｓ血清型ｂ外膜タンパク質を含む外膜小胞（ｏｍｖ）ワクチン |
| JP2013124555A Pending JP2013181036A (ja) | 2000-01-17 | 2013-06-13 | Ｎ．ｍｅｎｉｎｇｉｔｉｄｉｓ血清型ｂ外膜タンパク質を含む外膜小胞（ｏｍｖ）ワクチン |
| JP2015145631A Pending JP2015193652A (ja) | 2000-01-17 | 2015-07-23 | Ｎ．ｍｅｎｉｎｇｉｔｉｄｉｓ血清型ｂ外膜タンパク質を含む外膜小胞（ｏｍｖ）ワクチン |
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| GB9810276D0 (en) * | 1998-05-13 | 1998-07-15 | Smithkline Beecham Biolog | Novel compounds |
| JP5074644B2 (ja) * | 1998-05-29 | 2012-11-14 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 組合わせの髄膜炎菌ｂ／ｃワクチン |
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| DK1897555T3 (da) * | 2000-01-17 | 2014-10-13 | Novartis Vaccines & Diagnostic | Kompletteret OMV-vaccine mod meningococcus |
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2001
- 2001-01-17 DK DK07013453.1T patent/DK1897555T3/da active
- 2001-01-17 WO PCT/IB2001/000166 patent/WO2001052885A1/en active IP Right Grant
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