JP2001508445A - 溶解性に劣る薬物のためのエマルジョンビヒクル - Google Patents

溶解性に劣る薬物のためのエマルジョンビヒクル

Info

Publication number
JP2001508445A
JP2001508445A JP53100698A JP53100698A JP2001508445A JP 2001508445 A JP2001508445 A JP 2001508445A JP 53100698 A JP53100698 A JP 53100698A JP 53100698 A JP53100698 A JP 53100698A JP 2001508445 A JP2001508445 A JP 2001508445A
Authority
JP
Japan
Prior art keywords
tocopherol
emulsion
composition
paclitaxel
tpgs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP53100698A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001508445A5 (enExample
Inventor
ランバート，カエル，ジェイ．
コンスタンチニデス，パナイオティス，ピー．
クアイ，スティーヴン，シー．
Original Assignee
ソーナス ファーマシューティカルズ，インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ソーナス ファーマシューティカルズ，インコーポレーテッド filed Critical ソーナス ファーマシューティカルズ，インコーポレーテッド
Publication of JP2001508445A publication Critical patent/JP2001508445A/ja
Publication of JP2001508445A5 publication Critical patent/JP2001508445A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/797—Lipid particle
    • Y10S977/798—Lipid particle having internalized material
    • Y10S977/799—Containing biological material
    • Y10S977/801—Drug
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y10S977/907—Liposome
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP53100698A 1997-01-07 1998-01-06 溶解性に劣る薬物のためのエマルジョンビヒクル Withdrawn JP2001508445A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US3418897P 1997-01-07 1997-01-07
US60/034,188 1997-01-07
US4884097P 1997-06-06 1997-06-06
US60/048,840 1997-06-06
US09/003,173 1998-01-05
US09/003,173 US6458373B1 (en) 1997-01-07 1998-01-05 Emulsion vehicle for poorly soluble drugs
PCT/US1998/000103 WO1998030205A1 (en) 1997-01-07 1998-01-06 Emulsion vehicle for poorly soluble drugs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007219025A Division JP2007332157A (ja) 1997-01-07 2007-08-24 溶解性に劣る薬物のためのエマルジョンビヒクル

Publications (2)

Publication Number Publication Date
JP2001508445A true JP2001508445A (ja) 2001-06-26
JP2001508445A5 JP2001508445A5 (enExample) 2004-09-02

Family

ID=27357338

Family Applications (2)

Application Number Title Priority Date Filing Date
JP53100698A Withdrawn JP2001508445A (ja) 1997-01-07 1998-01-06 溶解性に劣る薬物のためのエマルジョンビヒクル
JP2007219025A Pending JP2007332157A (ja) 1997-01-07 2007-08-24 溶解性に劣る薬物のためのエマルジョンビヒクル

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2007219025A Pending JP2007332157A (ja) 1997-01-07 2007-08-24 溶解性に劣る薬物のためのエマルジョンビヒクル

Country Status (15)

Country Link
US (10) US6458373B1 (enExample)
EP (1) EP0981328B1 (enExample)
JP (2) JP2001508445A (enExample)
KR (1) KR100612528B1 (enExample)
AR (1) AR011518A1 (enExample)
AT (1) ATE356611T1 (enExample)
CA (1) CA2276730C (enExample)
DE (1) DE69837328T2 (enExample)
DK (1) DK0981328T3 (enExample)
ES (1) ES2285753T3 (enExample)
IL (1) IL130737A0 (enExample)
IN (1) IN183539B (enExample)
PT (1) PT981328E (enExample)
TW (2) TW579297B (enExample)
WO (1) WO1998030205A1 (enExample)

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JP2005523295A (ja) * 2002-03-01 2005-08-04 ノバガリ、ファルマ、エスアー 難溶性薬剤の自己乳化型薬物送達システム
JP2005531652A (ja) * 2002-06-07 2005-10-20 フラメル・テクノロジー α−トコフェロールを用いて機能化されたポリアミノ酸、およびその使用、特に治療学的使用
JP2005537285A (ja) * 2002-07-30 2005-12-08 ワイス ラパマイシンヒドロキシエステルを含有する非経口製剤
JP2005343897A (ja) * 2004-06-02 2005-12-15 Cordis Corp Ｃａｄ治療のためのタキサンの注入可能な配合物
JP2006206455A (ja) * 2005-01-25 2006-08-10 Univ Kinki 薬物徐放出性微粒子及びその製造方法
JP2007504124A (ja) * 2003-08-29 2007-03-01 ノバガリ、ファルマ、エスアー 難水溶性薬剤の投与のための自己ナノ乳化油性製剤
JP2007508296A (ja) * 2003-05-22 2007-04-05 リポシン・インコーポレーテッド 疎水性薬物投与のための医薬組成物及び剤形
JP2007332157A (ja) * 1997-01-07 2007-12-27 Sonus Pharmaceuticals Inc 溶解性に劣る薬物のためのエマルジョンビヒクル
JP2008520606A (ja) * 2004-11-19 2008-06-19 ノバルティス アクチエンゲゼルシャフト カンプトテシン誘導体を含む医薬組成物
WO2008088037A1 (ja) * 2007-01-18 2008-07-24 National University Corporation Chiba University 微粒子製剤
JP2009513558A (ja) * 2003-07-18 2009-04-02 アベンティス・ファーマ・ソシエテ・アノニム タキソイドの経口投与用半固体製剤
JP2009531305A (ja) * 2006-03-10 2009-09-03 ラボスイス アーゲー 物質を可溶化、分散、および安定化させる方法とその方法により製造される生成物とその使用
JP2010540159A (ja) * 2007-10-19 2010-12-24 ルトニックス・インコーポレ−テッド 医療装置のための薬物放出コーティング
JP2013523649A (ja) * 2010-03-26 2013-06-17 オンコノバ・セラピューティックス・インコーポレーテッド （ｅ）−４−カルボキシスチリル−４−クロロベンジルスルホンの改善された安定な水性製剤
US9205057B2 (en) 2010-11-30 2015-12-08 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9757389B2 (en) 2014-08-28 2017-09-12 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
US10561615B2 (en) 2010-12-10 2020-02-18 Lipocine Inc. Testosterone undecanoate compositions
US11052096B2 (en) 2009-01-08 2021-07-06 Lipocine Inc. Steroidal compositions
US11433083B2 (en) 2010-11-30 2022-09-06 Lipocine Inc. High-strength testosterone undecanoate compositions
US11559530B2 (en) 2016-11-28 2023-01-24 Lipocine Inc. Oral testosterone undecanoate therapy
US11707467B2 (en) 2014-08-28 2023-07-25 Lipocine Inc. (17-ß)-3-oxoandrost-4-en-17YL tridecanoate compositions and methods of their preparation and use
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ATE356611T1 (de) 2007-04-15
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US6458373B1 (en) 2002-10-01
KR20000069893A (ko) 2000-11-25
DE69837328T2 (de) 2007-12-20
AR011518A1 (es) 2000-08-30
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US20050142189A1 (en) 2005-06-30
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US20030109575A1 (en) 2003-06-12
US20030104015A1 (en) 2003-06-05
US20030170279A1 (en) 2003-09-11
DK0981328T3 (da) 2007-07-02
KR100612528B1 (ko) 2006-08-11
US20030147959A1 (en) 2003-08-07
US6667048B1 (en) 2003-12-23
WO1998030205A1 (en) 1998-07-16
DE69837328D1 (de) 2007-04-26
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EP0981328B1 (en) 2007-03-14
JP2007332157A (ja) 2007-12-27
IL130737A0 (en) 2000-06-01
US6982282B2 (en) 2006-01-03
US6660286B1 (en) 2003-12-09
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CA2276730A1 (en) 1998-07-16
US20040202712A1 (en) 2004-10-14
CA2276730C (en) 2004-10-26
TW200425913A (en) 2004-12-01

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