WO2008088037A1 - 微粒子製剤 - Google Patents

微粒子製剤 Download PDF

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Publication number
WO2008088037A1
WO2008088037A1 PCT/JP2008/050600 JP2008050600W WO2008088037A1 WO 2008088037 A1 WO2008088037 A1 WO 2008088037A1 JP 2008050600 W JP2008050600 W JP 2008050600W WO 2008088037 A1 WO2008088037 A1 WO 2008088037A1
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Prior art keywords
medicinal preparation
finely particulate
fine particles
particulate medicinal
drug
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PCT/JP2008/050600
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English (en)
French (fr)
Inventor
Kunikazu Moribe
Yutaka Inoue
Keiji Yamamoto
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National University Corporation Chiba University
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Publication date
Application filed by National University Corporation Chiba University filed Critical National University Corporation Chiba University
Priority to JP2008554089A priority Critical patent/JP5515075B2/ja
Publication of WO2008088037A1 publication Critical patent/WO2008088037A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

本発明の目的は、薬剤をより安定にミセル型微粒子として存在させることのできる微粒子製剤、及び微粒子又は微粒子製剤の安定化法を提供することである。 本発明は、静脈への注射用薬等としての応用が可能な、アスコルビン酸誘導体、リン脂質誘導体等の界面活性剤、及び、薬剤を含む微粒子製剤、及び、界面活性剤からなる微粒子又は該微粒子に薬剤を含む微粒子製剤に、更にアスコルビン酸誘導体を含有させることから成る、該微粒子又は該微粒子製剤の安定化法に関する。
PCT/JP2008/050600 2007-01-18 2008-01-18 微粒子製剤 WO2008088037A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008554089A JP5515075B2 (ja) 2007-01-18 2008-01-18 微粒子製剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-008620 2007-01-18
JP2007008620 2007-01-18

Publications (1)

Publication Number Publication Date
WO2008088037A1 true WO2008088037A1 (ja) 2008-07-24

Family

ID=39636037

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/050600 WO2008088037A1 (ja) 2007-01-18 2008-01-18 微粒子製剤

Country Status (2)

Country Link
JP (1) JP5515075B2 (ja)
WO (1) WO2008088037A1 (ja)

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06122628A (ja) * 1992-02-05 1994-05-06 Quadra Logic Technol Inc ポルフィリン光増感剤のリポソーム組成物
JPH07232051A (ja) * 1994-02-21 1995-09-05 Nippon Oil & Fats Co Ltd 乳化組成物
JPH09328419A (ja) * 1996-03-11 1997-12-22 Basf Ag 安定な水中油形エマルジョン及びその製造方法
JPH1077225A (ja) * 1996-07-31 1998-03-24 Basf Ag 光学的に透明な、ベータ−カロチン含有の水性−アルコール性総合ビタミン溶液
JPH11509834A (ja) * 1995-08-02 1999-08-31 キューエルティー フォトセラピューティクス，インコーポレイテッド ヒドロ−モノベンゾポルフィリン光増感剤を含有するリポソームの作成方法
JP2001058945A (ja) * 1999-07-06 2001-03-06 F Hoffmann La Roche Ag 炭水化物マトリックス中に脂溶性物質を含む組成物
JP2001508445A (ja) * 1997-01-07 2001-06-26 ソーナス ファーマシューティカルズ，インコーポレーテッド 溶解性に劣る薬物のためのエマルジョンビヒクル
JP2003500368A (ja) * 1999-05-24 2003-01-07 ソーナス ファーマシューティカルス，インコーポレイテッド 溶解度が不十分な薬剤のためのエマルジョンビヒクル
JP2003300870A (ja) * 2002-02-08 2003-10-21 Kyowa Hai Foods Kk ユビキノン含有水可溶性組成物
JP2004514690A (ja) * 2000-11-29 2004-05-20 リオトロピック　セラピュティックス　アイエヌシー． 薬剤の溶媒系
WO2004089419A1 (ja) * 2003-04-04 2004-10-21 The University Of Tokyo 抗ｍｔ－ｍｍｐモノクローナル抗体含有脂質膜構造体
JP2004532219A (ja) * 2001-04-11 2004-10-21 キューエルティー インコーポレイテッド 疎水性薬物のための薬物送達系
WO2005023220A1 (en) * 2003-08-26 2005-03-17 Ceramoptec Industries, Inc. Non-polar photosensitizer formulations for photodynamic therapy
JP2007160287A (ja) * 2005-12-09 2007-06-28 Ito:Kk 乳化組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60231608A (ja) * 1984-04-28 1985-11-18 Terumo Corp 膜構造が強化されたリポソ−ム
US5707608A (en) * 1995-08-02 1998-01-13 Qlt Phototherapeutics, Inc. Methods of making liposomes containing hydro-monobenzoporphyrin photosensitizer
EP1746976B1 (en) * 2004-05-03 2017-01-11 Merrimack Pharmaceuticals, Inc. Liposomes useful for drug delivery
AU2005253852B2 (en) * 2004-06-18 2008-05-29 Kabushiki Kaisha Yakult Honsha Liposome preparation containing slightly water-soluble camptothecin

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06122628A (ja) * 1992-02-05 1994-05-06 Quadra Logic Technol Inc ポルフィリン光増感剤のリポソーム組成物
JPH07232051A (ja) * 1994-02-21 1995-09-05 Nippon Oil & Fats Co Ltd 乳化組成物
JPH11509834A (ja) * 1995-08-02 1999-08-31 キューエルティー フォトセラピューティクス，インコーポレイテッド ヒドロ−モノベンゾポルフィリン光増感剤を含有するリポソームの作成方法
JPH09328419A (ja) * 1996-03-11 1997-12-22 Basf Ag 安定な水中油形エマルジョン及びその製造方法
JPH1077225A (ja) * 1996-07-31 1998-03-24 Basf Ag 光学的に透明な、ベータ−カロチン含有の水性−アルコール性総合ビタミン溶液
JP2001508445A (ja) * 1997-01-07 2001-06-26 ソーナス ファーマシューティカルズ，インコーポレーテッド 溶解性に劣る薬物のためのエマルジョンビヒクル
JP2003500368A (ja) * 1999-05-24 2003-01-07 ソーナス ファーマシューティカルス，インコーポレイテッド 溶解度が不十分な薬剤のためのエマルジョンビヒクル
JP2001058945A (ja) * 1999-07-06 2001-03-06 F Hoffmann La Roche Ag 炭水化物マトリックス中に脂溶性物質を含む組成物
JP2004514690A (ja) * 2000-11-29 2004-05-20 リオトロピック　セラピュティックス　アイエヌシー． 薬剤の溶媒系
JP2004532219A (ja) * 2001-04-11 2004-10-21 キューエルティー インコーポレイテッド 疎水性薬物のための薬物送達系
JP2003300870A (ja) * 2002-02-08 2003-10-21 Kyowa Hai Foods Kk ユビキノン含有水可溶性組成物
WO2004089419A1 (ja) * 2003-04-04 2004-10-21 The University Of Tokyo 抗ｍｔ－ｍｍｐモノクローナル抗体含有脂質膜構造体
WO2005023220A1 (en) * 2003-08-26 2005-03-17 Ceramoptec Industries, Inc. Non-polar photosensitizer formulations for photodynamic therapy
JP2007160287A (ja) * 2005-12-09 2007-06-28 Ito:Kk 乳化組成物

Also Published As

Publication number Publication date
JP5515075B2 (ja) 2014-06-11
JPWO2008088037A1 (ja) 2010-05-13

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