SG11201901679XA - Inhibition of olig2 activity - Google Patents
Inhibition of olig2 activityInfo
- Publication number
- SG11201901679XA SG11201901679XA SG11201901679XA SG11201901679XA SG11201901679XA SG 11201901679X A SG11201901679X A SG 11201901679XA SG 11201901679X A SG11201901679X A SG 11201901679XA SG 11201901679X A SG11201901679X A SG 11201901679XA SG 11201901679X A SG11201901679X A SG 11201901679XA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- texas
- olig2
- rule
- applicant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/18—Nitrogen atoms not forming part of a nitro radical with hetero atoms attached to said nitrogen atoms, except nitro radicals, e.g. hydrazine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 March 2018 (01.03.2018) W I PO I PCT omit °nolo oui No oimIE (10) International Publication Number WO 2018/039621 Al (51) International Patent Classification: C07D 401/12 (2006.01) (21) International Application Number: PCT/US2017/048716 (22) International Filing Date: 25 August 2017 (25.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/380,281 26 August 2016 (26.08.2016) US (71) Applicant: CURTANA PHARMACEUTICALS, INC. [US/US]; 1624 Headway Circle, Suite 100, Austin, Texas 78754 (US). (72) Inventors: BEATON, Graham; 18858 Bernardo Trails Drive, San Diego, California 92128 (US). MCHARDY, Stanton F.; 31 Bennitt Road, Waring, Texas 78074 (US). LOPEZ, Ambrosio, Jr.; 7803 S New Braunfels, Apt. 2208, San Antonio, Texas 78235 (US). CAMPOS, Bismarck; 7403 Tranquillo Way, San Antonio, Texas 78266 (US). WANG, Hua-Yu Leo; 5511 Pecan Springs Road, Apt. 3103, San Antonio, Texas 78249 (US). (74) Agent: MALECHA, James et al.; WILSON SONSINI GOODRICH & ROSATI, 650 Page Mill Road, Palo Alto, California 94304 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) O (54) Title: INHIBITION OF OLIG2 ACTIVITY cc (57) : Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the ac- O tivity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Olig2 inhibitors may be used to treat glioblastoma. O
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662380281P | 2016-08-26 | 2016-08-26 | |
PCT/US2017/048716 WO2018039621A1 (en) | 2016-08-26 | 2017-08-25 | Inhibition of olig2 activity |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201901679XA true SG11201901679XA (en) | 2019-03-28 |
Family
ID=61245339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201901679XA SG11201901679XA (en) | 2016-08-26 | 2017-08-25 | Inhibition of olig2 activity |
Country Status (14)
Country | Link |
---|---|
US (2) | US11242323B2 (en) |
EP (1) | EP3504195A4 (en) |
JP (2) | JP7028860B2 (en) |
KR (2) | KR102605329B1 (en) |
CN (2) | CN115215807A (en) |
AU (1) | AU2017314842B9 (en) |
BR (1) | BR112019003973A2 (en) |
CA (1) | CA3035123A1 (en) |
EA (1) | EA201990508A1 (en) |
IL (1) | IL265034B2 (en) |
MX (1) | MX2019002259A (en) |
SG (1) | SG11201901679XA (en) |
WO (1) | WO2018039621A1 (en) |
ZA (1) | ZA201901367B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7028860B2 (en) * | 2016-08-26 | 2022-03-02 | カーテナ ファーマシューティカルズ,インク. | Inhibition of OLIG2 activity |
CN110283130B (en) * | 2019-07-05 | 2023-12-19 | 温州医科大学 | 1- (2, 5-dimethoxy phenyl) -3-substituted urea colon cancer inhibitor and preparation and application thereof |
WO2022046650A1 (en) * | 2020-08-24 | 2022-03-03 | Curtana Pharmaceuticals, Inc. | Combination therapies with olig2 inhibitors |
WO2023114245A2 (en) * | 2021-12-14 | 2023-06-22 | Radin Daniel Pierce | Compositions and methods for treating cancers of the central nervous system (cns), including glioblastoma and chemoresistant cns tumors, and related compositions and methods for inhibiting and eliminating cns cancer stem cells |
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-
2017
- 2017-08-25 JP JP2019511439A patent/JP7028860B2/en active Active
- 2017-08-25 MX MX2019002259A patent/MX2019002259A/en unknown
- 2017-08-25 CN CN202210878250.XA patent/CN115215807A/en active Pending
- 2017-08-25 AU AU2017314842A patent/AU2017314842B9/en active Active
- 2017-08-25 EP EP17844525.0A patent/EP3504195A4/en not_active Withdrawn
- 2017-08-25 WO PCT/US2017/048716 patent/WO2018039621A1/en unknown
- 2017-08-25 US US16/328,551 patent/US11242323B2/en active Active
- 2017-08-25 EA EA201990508A patent/EA201990508A1/en unknown
- 2017-08-25 KR KR1020227039915A patent/KR102605329B1/en active IP Right Grant
- 2017-08-25 SG SG11201901679XA patent/SG11201901679XA/en unknown
- 2017-08-25 CA CA3035123A patent/CA3035123A1/en active Pending
- 2017-08-25 CN CN201780064032.XA patent/CN109843868A/en active Pending
- 2017-08-25 KR KR1020197008456A patent/KR102468670B1/en active IP Right Grant
- 2017-08-25 BR BR112019003973A patent/BR112019003973A2/en active Search and Examination
-
2019
- 2019-02-25 IL IL265034A patent/IL265034B2/en unknown
- 2019-03-05 ZA ZA2019/01367A patent/ZA201901367B/en unknown
-
2021
- 2021-04-19 US US17/234,332 patent/US20210253535A1/en active Pending
-
2022
- 2022-02-15 JP JP2022021420A patent/JP2022078094A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20190041509A (en) | 2019-04-22 |
IL265034B2 (en) | 2023-05-01 |
JP2022078094A (en) | 2022-05-24 |
KR102468670B1 (en) | 2022-11-17 |
MX2019002259A (en) | 2019-09-18 |
AU2017314842B9 (en) | 2022-02-10 |
BR112019003973A2 (en) | 2019-10-08 |
KR102605329B1 (en) | 2023-11-22 |
EP3504195A1 (en) | 2019-07-03 |
US20190389812A1 (en) | 2019-12-26 |
CN109843868A (en) | 2019-06-04 |
EA201990508A1 (en) | 2019-09-30 |
IL265034A (en) | 2019-04-30 |
KR20220158852A (en) | 2022-12-01 |
WO2018039621A1 (en) | 2018-03-01 |
US20210253535A1 (en) | 2021-08-19 |
JP7028860B2 (en) | 2022-03-02 |
CN115215807A (en) | 2022-10-21 |
AU2017314842B2 (en) | 2022-01-27 |
AU2017314842A1 (en) | 2019-03-21 |
US11242323B2 (en) | 2022-02-08 |
JP2019526568A (en) | 2019-09-19 |
ZA201901367B (en) | 2023-09-27 |
EP3504195A4 (en) | 2020-01-29 |
IL265034B1 (en) | 2023-01-01 |
CA3035123A1 (en) | 2018-03-01 |
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