JP2000506165A - 細胞インターナリゼーションを増強するための物質および方法 - Google Patents

細胞インターナリゼーションを増強するための物質および方法

Info

Publication number
JP2000506165A
JP2000506165A JP9531869A JP53186997A JP2000506165A JP 2000506165 A JP2000506165 A JP 2000506165A JP 9531869 A JP9531869 A JP 9531869A JP 53186997 A JP53186997 A JP 53186997A JP 2000506165 A JP2000506165 A JP 2000506165A
Authority
JP
Japan
Prior art keywords
composition
apparent viscosity
cytosol
target cell
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9531869A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000506165A5 (enExample
Inventor
エイ． エドワーズ，デイビッド
アール． ディーバー，ダニエル
エス． レインジャー，ロバート
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of JP2000506165A publication Critical patent/JP2000506165A/ja
Publication of JP2000506165A5 publication Critical patent/JP2000506165A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Otolaryngology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP9531869A 1996-03-04 1997-03-03 細胞インターナリゼーションを増強するための物質および方法 Pending JP2000506165A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1272196P 1996-03-04 1996-03-04
US60/012,721 1996-03-04
PCT/US1997/003276 WO1997032572A2 (en) 1996-03-04 1997-03-03 Materials and methods for enhancing cellular internalization

Publications (2)

Publication Number Publication Date
JP2000506165A true JP2000506165A (ja) 2000-05-23
JP2000506165A5 JP2000506165A5 (enExample) 2005-02-10

Family

ID=21756381

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9531869A Pending JP2000506165A (ja) 1996-03-04 1997-03-03 細胞インターナリゼーションを増強するための物質および方法

Country Status (9)

Country Link
US (1) US5985320A (enExample)
EP (1) EP0885002B1 (enExample)
JP (1) JP2000506165A (enExample)
AT (1) ATE508733T1 (enExample)
AU (1) AU2063197A (enExample)
DK (1) DK0885002T3 (enExample)
ES (1) ES2395214T3 (enExample)
PT (1) PT885002E (enExample)
WO (1) WO1997032572A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003534366A (ja) * 2000-05-25 2003-11-18 アルカームズ コントロールド セラピューティクス インコーポレイテッド 改善された注射性を有する注射可能な懸濁物の調製
JPWO2004078213A1 (ja) * 2003-03-06 2006-06-08 千佳子 錦織 対象物質導入用組成物及び対象物質導入方法
JP2007525463A (ja) * 2003-05-12 2007-09-06 ベクトン・ディキンソン・アンド・カンパニー インフルエンザワクチンの真皮送達を向上する分子
JP2007529558A (ja) * 2004-03-19 2007-10-25 レット・ゼア・ビー・ホープ、メディカル、リサーチ、インスティテュート Ｃｔｌ／ｃｔｌｄの細胞炭水化物認識ドメインへターゲティングするための炭水化物誘導体化リポソーム、および治療的に活性な化合物の細胞内送達

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* Cited by examiner, † Cited by third party
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