SG11202102419VA - Herboxidiene splicing modulator antibody-drug conjugates and methods of use - Google Patents

Herboxidiene splicing modulator antibody-drug conjugates and methods of use

Info

Publication number
SG11202102419VA
SG11202102419VA SG11202102419VA SG11202102419VA SG11202102419VA SG 11202102419V A SG11202102419V A SG 11202102419VA SG 11202102419V A SG11202102419V A SG 11202102419VA SG 11202102419V A SG11202102419V A SG 11202102419VA SG 11202102419V A SG11202102419V A SG 11202102419VA
Authority
SG
Singapore
Prior art keywords
herboxidiene
methods
drug conjugates
splicing modulator
modulator antibody
Prior art date
Application number
SG11202102419VA
Inventor
Nathan Fishkin
Thiwanka Samarakoon
James Palacino
Kenzo Arai
Yoshihiko Kotake
Shinya Okubo
Norio Murai
Masayuki Miyano
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of SG11202102419VA publication Critical patent/SG11202102419VA/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
    • A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • A—HUMAN NECESSITIES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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SG11202102419VA 2018-12-13 2019-12-12 Herboxidiene splicing modulator antibody-drug conjugates and methods of use SG11202102419VA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862779400P 2018-12-13 2018-12-13
US201862779406P 2018-12-13 2018-12-13
US201962941220P 2019-11-27 2019-11-27
PCT/US2019/066029 WO2020123836A2 (en) 2018-12-13 2019-12-12 Herboxidiene splicing modulator antibody-drug conjugates and methods of use

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SG11202102419VA true SG11202102419VA (en) 2021-04-29

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US (1) US20220031859A1 (en)
EP (1) EP3893937A2 (en)
JP (1) JP2022512401A (en)
KR (1) KR20210102274A (en)
CN (1) CN113271981A (en)
AU (1) AU2019397062A1 (en)
BR (1) BR112021010936A2 (en)
CA (1) CA3114931A1 (en)
CL (1) CL2021001534A1 (en)
CO (1) CO2021006503A2 (en)
IL (1) IL283787A (en)
JO (1) JOP20210045A1 (en)
MX (1) MX2021005878A (en)
PE (1) PE20211473A1 (en)
SG (1) SG11202102419VA (en)
TW (1) TW202039007A (en)
WO (1) WO2020123836A2 (en)

Families Citing this family (5)

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