|
US6403597B1
(en)
*
|
1997-10-28 |
2002-06-11 |
Vivus, Inc. |
Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
|
|
US20040014761A1
(en)
*
|
1997-10-28 |
2004-01-22 |
Place Virgil A. |
Treatment of female sexual dysfunction with phosphodiesterase inhibitors
|
|
DK1049695T3
(da)
*
|
1997-11-12 |
2002-05-13 |
Bayer Ag |
2-Phenyl-substituerede imidazotriazinoner som phosphodiesterase-inhibitorer
|
|
DE19827640A1
(de)
|
1998-06-20 |
1999-12-23 |
Bayer Ag |
7-Alkyl- und Cycloalkyl-substituierte Imidazotriazinone
|
|
US7235625B2
(en)
|
1999-06-29 |
2007-06-26 |
Palatin Technologies, Inc. |
Multiple agent therapy for sexual dysfunction
|
|
DE19944161A1
(de)
*
|
1999-09-15 |
2001-03-22 |
Bayer Ag |
Neue Kombination zur Behandlung von sexueller Dysfunktion
|
|
US6503908B1
(en)
|
1999-10-11 |
2003-01-07 |
Pfizer Inc |
Pharmaceutically active compounds
|
|
IL139457A0
(en)
*
|
1999-11-08 |
2001-11-25 |
Pfizer |
Compounds for the treatment of female sexual dysfunction
|
|
US20050020547A1
(en)
*
|
1999-11-08 |
2005-01-27 |
Pfizer Inc. |
Compounds for the treatment of female sexual dysfunction
|
|
TR200201638T2
(tr)
|
1999-12-24 |
2002-11-21 |
Bayer Aktiengesellschaft |
Yeni imidazo[1,3,5]triazinonlar ve kullanımları
|
|
CA2395418A1
(en)
|
1999-12-24 |
2001-07-05 |
Bayer Aktiengesellschaft |
Isoxazolo pyrimidinones and the use thereof
|
|
US6683081B2
(en)
|
1999-12-24 |
2004-01-27 |
Bayer Aktiengesellschaft |
Triazolotriazinones and the use thereof
|
|
DE10010067A1
(de)
*
|
2000-03-02 |
2001-09-06 |
Bayer Ag |
Neue Imidazotriazinone und ihre Verwendung
|
|
AU5584901A
(en)
|
2000-04-19 |
2001-10-30 |
Icos Corp |
Use of cyclic gmp-specific phosphodiesterase inhibitors for treatment of parkinson's disease
|
|
US6821978B2
(en)
|
2000-09-19 |
2004-11-23 |
Schering Corporation |
Xanthine phosphodiesterase V inhibitors
|
|
CN1478084A
(zh)
*
|
2000-09-29 |
2004-02-25 |
|
用于治疗炎性疾病的化合物
|
|
US6548508B2
(en)
|
2000-10-20 |
2003-04-15 |
Pfizer, Inc. |
Use of PDE V inhibitors for improved fecundity in mammals
|
|
US20020091129A1
(en)
*
|
2000-11-20 |
2002-07-11 |
Mitradev Boolell |
Treatment of premature ejaculation
|
|
DE10063108A1
(de)
*
|
2000-12-18 |
2002-06-20 |
Bayer Ag |
Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
|
|
DE10063106A1
(de)
*
|
2000-12-18 |
2002-06-20 |
Bayer Ag |
Verfahren zur Herstellung von 2-(2-Ethoxyphenyl)-substituierten Imidazotriazinonen
|
|
DE10064105A1
(de)
*
|
2000-12-21 |
2002-06-27 |
Bayer Ag |
Neue Substituierte Imidazotriazinone
|
|
EP1355651A2
(en)
|
2001-02-02 |
2003-10-29 |
Pfizer Limited |
Treatment of diabetes mellitus using vardenafil
|
|
DE10107639A1
(de)
*
|
2001-02-15 |
2002-08-22 |
Bayer Ag |
2-Alkoxyphenyl-substituierte Imidazotriazinone
|
|
DE10108752A1
(de)
*
|
2001-02-23 |
2002-09-05 |
Bayer Ag |
Neue Substituierte Imidazotriazinone
|
|
GB0107751D0
(en)
*
|
2001-03-28 |
2001-05-16 |
Pfizer Ltd |
Pharmaceutically active compounds
|
|
DE10118306A1
(de)
|
2001-04-12 |
2002-10-17 |
Bayer Ag |
Imidazotriazinonhaltige Zusammensetzungen zur nasalen Applikation
|
|
BR0209541A
(pt)
*
|
2001-05-09 |
2004-04-20 |
Bayer Healthcare Ag |
Uso das imidazotriazinonas 2-fenil-substituìdas
|
|
US7585493B2
(en)
|
2001-05-24 |
2009-09-08 |
Alexza Pharmaceuticals, Inc. |
Thin-film drug delivery article and method of use
|
|
US7458374B2
(en)
|
2002-05-13 |
2008-12-02 |
Alexza Pharmaceuticals, Inc. |
Method and apparatus for vaporizing a compound
|
|
US20070122353A1
(en)
|
2001-05-24 |
2007-05-31 |
Hale Ron L |
Drug condensation aerosols and kits
|
|
US7090830B2
(en)
|
2001-05-24 |
2006-08-15 |
Alexza Pharmaceuticals, Inc. |
Drug condensation aerosols and kits
|
|
US7766013B2
(en)
|
2001-06-05 |
2010-08-03 |
Alexza Pharmaceuticals, Inc. |
Aerosol generating method and device
|
|
GB0113344D0
(en)
*
|
2001-06-01 |
2001-07-25 |
Bayer Ag |
Novel heterocycles 3
|
|
US7087605B2
(en)
|
2001-06-01 |
2006-08-08 |
Bayer Aktiengesellschaft |
5-Ethyl-imidazotriazinones
|
|
DE10130167A1
(de)
|
2001-06-22 |
2003-01-02 |
Bayer Ag |
Imidazotriazine
|
|
DE10135815A1
(de)
*
|
2001-07-23 |
2003-02-06 |
Bayer Ag |
Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen
|
|
CA2457944C
(en)
|
2001-08-28 |
2009-09-29 |
Schering Corporation |
Polycyclic guanine phosphodiesterase v inhibitors
|
|
WO2003042216A1
(en)
*
|
2001-11-09 |
2003-05-22 |
Schering Corporation |
Polycyclic guanine derivative phosphodiesterase v inhibitors
|
|
GB0129274D0
(en)
*
|
2001-12-06 |
2002-01-23 |
Pfizer Ltd |
Novel kit
|
|
DE60222931T2
(de)
*
|
2001-12-13 |
2008-07-10 |
Asubio Pharma Co., Ltd. |
Pyrazolopyrimidinonderivate mit pde7-hemmender wirkung
|
|
GB0130219D0
(en)
*
|
2001-12-18 |
2002-02-06 |
Pfizer Ltd |
Compounds for the treatment of sexual dysfunction
|
|
GB0209988D0
(en)
*
|
2002-05-01 |
2002-06-12 |
Bayer Ag |
Novel Heterocycles
|
|
DE10220570A1
(de)
|
2002-05-08 |
2003-11-20 |
Bayer Ag |
Carbamat-substituierte Pyrazolopyridine
|
|
AU2003265239A1
(en)
|
2002-05-22 |
2003-12-19 |
Virginia Commonwealth University |
Protective effects of pde-5 inhibitors
|
|
RU2004133973A
(ru)
*
|
2002-05-23 |
2005-09-10 |
Пфайзер Инк. (US) |
Новая комбинация
|
|
EP1719772A1
(en)
|
2002-05-31 |
2006-11-08 |
Schering Corporation |
Process for preparing xanthine phosphodiesterase v inhibitors and precursors thereof
|
|
GB0214784D0
(en)
*
|
2002-06-26 |
2002-08-07 |
Pfizer Ltd |
Novel combination
|
|
DE10229778A1
(de)
*
|
2002-07-03 |
2004-01-29 |
Bayer Ag |
Neue Verwendung von Imidazotriazinonen
|
|
DE10230605A1
(de)
|
2002-07-08 |
2004-01-29 |
Bayer Ag |
Substituierte Imidazotriazine
|
|
DE10232113A1
(de)
*
|
2002-07-16 |
2004-01-29 |
Bayer Ag |
Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
|
|
GB0219961D0
(en)
|
2002-08-28 |
2002-10-02 |
Pfizer Ltd |
Oxytocin inhibitors
|
|
US7323462B2
(en)
|
2002-12-10 |
2008-01-29 |
Pfizer Inc. |
Morpholine dopamine agonists
|
|
KR20070091049A
(ko)
|
2002-12-13 |
2007-09-06 |
워너-램버트 캄파니 엘엘씨 |
하부요로증상을 치료하기 위한 알파-2-델타 리간드
|
|
ES2326808T3
(es)
*
|
2003-04-01 |
2009-10-20 |
Smithkline Beecham Corporation |
Compuestos de imidazotriazina para el tratamiento de enfermedades cancerosas.
|
|
OA13050A
(en)
|
2003-04-29 |
2006-11-10 |
Pfizer Ltd |
5,7-diaminopyrazolo [4,3-D] pyrimidines useful in the treatment of hypertension.
|
|
US20040220186A1
(en)
*
|
2003-04-30 |
2004-11-04 |
Pfizer Inc. |
PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
|
|
JP2007516404A
(ja)
|
2003-05-21 |
2007-06-21 |
アレックザ ファーマシューティカルズ, インコーポレイテッド |
光学点火されたかまたは電気点火された内蔵式加熱ユニットおよびそれを使用する薬剤供給ユニット
|
|
EA012279B1
(ru)
|
2003-05-22 |
2009-08-28 |
Никомед Гмбх |
Композиция, включающая ингибитор pde4 и ингибитор pde5
|
|
CN100374441C
(zh)
|
2003-06-06 |
2008-03-12 |
天津倍方科技发展有限公司 |
二氢吡咯[2,3-d]嘧啶-4-酮衍生物,其制备方法及其制药用途
|
|
JP2006219374A
(ja)
|
2003-06-13 |
2006-08-24 |
Daiichi Asubio Pharma Co Ltd |
Pde7阻害作用を有するイミダゾトリアジノン誘導体
|
|
US20050079548A1
(en)
*
|
2003-07-07 |
2005-04-14 |
Plexxikon, Inc. |
Ligand development using PDE4B crystal structures
|
|
US7291640B2
(en)
*
|
2003-09-22 |
2007-11-06 |
Pfizer Inc. |
Substituted triazole derivatives as oxytocin antagonists
|
|
BRPI0416202A
(pt)
*
|
2003-11-21 |
2006-12-26 |
Schering Corp |
formulações inibidoras de fosfodiesterase v
|
|
GB0327323D0
(en)
*
|
2003-11-24 |
2003-12-31 |
Pfizer Ltd |
Novel pharmaceuticals
|
|
US7572799B2
(en)
*
|
2003-11-24 |
2009-08-11 |
Pfizer Inc |
Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
|
|
US7449462B2
(en)
|
2004-01-22 |
2008-11-11 |
Pfizer, Inc. |
Triazole derivatives which inhibit vasopressin antagonistic activity
|
|
CA2562251C
(en)
*
|
2004-04-07 |
2009-04-28 |
Pfizer Inc. |
Pyrazolo'4,3-d pyrimidines
|
|
DE102004023069A1
(de)
|
2004-05-11 |
2005-12-08 |
Bayer Healthcare Ag |
Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil
|
|
US7540286B2
(en)
|
2004-06-03 |
2009-06-02 |
Alexza Pharmaceuticals, Inc. |
Multiple dose condensation aerosol devices and methods of forming condensation aerosols
|
|
JP2008501617A
(ja)
*
|
2004-06-11 |
2008-01-24 |
アスビオファーマ株式会社 |
Pde7阻害作用を有するイミダゾトリアジノン誘導体
|
|
EP2246086A3
(en)
|
2004-08-12 |
2012-11-21 |
Alexza Pharmaceuticals, Inc. |
Aerosol drug delivery device incorporating percussively activated heating unit
|
|
DE102005001989A1
(de)
*
|
2005-01-15 |
2006-07-20 |
Bayer Healthcare Ag |
Intravenöse Formulierungen von PDE-Inhibitoren
|
|
US20110172422A1
(en)
*
|
2005-02-18 |
2011-07-14 |
Surface Logix, Inc. |
Methods of Making Pharmacokinetically Improved Compounds Comprising Functional Residues or Groups and Pharmaceutical Compositions Comprising Said Compounds
|
|
EP1850853A4
(en)
*
|
2005-02-18 |
2011-09-07 |
Surface Logix Inc |
PHARMACOKINETICALLY IMPROVED COMPOUNDS
|
|
DE102005009240A1
(de)
|
2005-03-01 |
2006-09-07 |
Bayer Healthcare Ag |
Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
|
|
DE102005009241A1
(de)
*
|
2005-03-01 |
2006-09-07 |
Bayer Healthcare Ag |
Arzneiformen mit kontrollierter Bioverfügbarkeit
|
|
DE102005016345A1
(de)
*
|
2005-04-09 |
2006-10-12 |
Bayer Healthcare Ag |
Neue Verwendung von 2-Phenyl-substituierten Imidazotriazinon-Derivaten
|
|
EP2366393B1
(en)
|
2005-04-19 |
2013-08-07 |
Takeda GmbH |
Roflumilast for the treatment of pulmonary hypertension
|
|
NZ564187A
(en)
|
2005-05-12 |
2010-03-26 |
Pfizer |
Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide
|
|
US20060264624A1
(en)
*
|
2005-05-20 |
2006-11-23 |
Alexander Heim-Riether |
Methods for synthesizing imidazotriazinones
|
|
US20070010525A1
(en)
*
|
2005-06-27 |
2007-01-11 |
Meyer Jackson |
Method and compositions for modulating neuropeptide hormone secretion
|
|
US20100222365A1
(en)
*
|
2005-08-10 |
2010-09-02 |
Pfizer Inc |
Substituted triazole deriviatives as oxytocin antagonists
|
|
EP2258357A3
(en)
|
2005-08-26 |
2011-04-06 |
Braincells, Inc. |
Neurogenesis with acetylcholinesterase inhibitor
|
|
CA2620333A1
(en)
|
2005-08-26 |
2007-03-01 |
Braincells, Inc. |
Neurogenesis by muscarinic receptor modulation
|
|
RU2435588C2
(ru)
*
|
2005-09-29 |
2011-12-10 |
Байер Шеринг Фарма Акциенгезельшафт |
Ингибиторы фдэ и их комбинации для лечения урологических расстройств
|
|
US20070093493A1
(en)
*
|
2005-10-12 |
2007-04-26 |
Lilly Icos Llc |
Treatment of benign prostatic hypertrophy and lower urinary tract symptoms
|
|
WO2007047978A2
(en)
|
2005-10-21 |
2007-04-26 |
Braincells, Inc. |
Modulation of neurogenesis by pde inhibition
|
|
EP1942879A1
(en)
|
2005-10-31 |
2008-07-16 |
Braincells, Inc. |
Gaba receptor mediated modulation of neurogenesis
|
|
GB0601951D0
(en)
|
2006-01-31 |
2006-03-15 |
Novartis Ag |
Organic compounds
|
|
CA2637615A1
(en)
*
|
2006-02-17 |
2007-08-30 |
Wyeth |
Selective n-sulfonylation of 2-amino trifluoroalkyl substituted alcohols
|
|
WO2007098029A1
(en)
*
|
2006-02-17 |
2007-08-30 |
Wyeth |
Methods for preparing sulfonamide substituted alcohols and intermediates thereof
|
|
US20100216734A1
(en)
|
2006-03-08 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis by nootropic agents
|
|
US7977478B2
(en)
*
|
2006-03-13 |
2011-07-12 |
Dr. Reddy's Laboratories Limited |
Polymorphic forms of vardenafil
|
|
ES2448807T3
(es)
*
|
2006-03-17 |
2014-03-17 |
Johns Hopkins University School Of Medicine |
Derivados de N-hidroxilsulfonamida como nuevos donantes de nitroxilo fisiológicamente útiles
|
|
US20080027072A1
(en)
*
|
2006-04-20 |
2008-01-31 |
Ampla Pharmaceuticals, Inc. |
Potentiation of MC4 receptor activity
|
|
JP2009536669A
(ja)
|
2006-05-09 |
2009-10-15 |
ブレインセルス,インコーポレイティド |
アンジオテンシン調節による神経新生
|
|
WO2007134077A2
(en)
|
2006-05-09 |
2007-11-22 |
Braincells, Inc. |
5 ht receptor mediated neurogenesis
|
|
US20100204470A1
(en)
|
2006-06-27 |
2010-08-12 |
Sandoz Ag |
method for salt preparation
|
|
WO2008008398A2
(en)
*
|
2006-07-14 |
2008-01-17 |
Shionogi & Co., Ltd. |
Oxime compounds and the use thereof
|
|
BRPI0716571A2
(pt)
*
|
2006-08-24 |
2013-11-05 |
Surface Logix Inc |
Compostos farmacocineticamente otimizados
|
|
AR062501A1
(es)
|
2006-08-29 |
2008-11-12 |
Actelion Pharmaceuticals Ltd |
Composiciones terapeuticas
|
|
KR20090064418A
(ko)
|
2006-09-08 |
2009-06-18 |
브레인셀즈 인코퍼레이션 |
4-아실아미노피리딘 유도체 포함 조합물
|
|
DE102006043443A1
(de)
*
|
2006-09-15 |
2008-03-27 |
Bayer Healthcare Ag |
Neue aza-bicyclische Verbindungen und ihre Verwendung
|
|
US20100184806A1
(en)
|
2006-09-19 |
2010-07-22 |
Braincells, Inc. |
Modulation of neurogenesis by ppar agents
|
|
US8314119B2
(en)
*
|
2006-11-06 |
2012-11-20 |
Abbvie Inc. |
Azaadamantane derivatives and methods of use
|
|
EP2952193A1
(en)
|
2006-12-12 |
2015-12-09 |
Gilead Sciences, Inc. |
Composition for treating a pulmonary hypertension
|
|
KR20130122023A
(ko)
|
2007-02-12 |
2013-11-06 |
디엠아이 바이오사이언시스 인코포레이티드 |
트라마돌의 부작용을 감소시키는 방법
|
|
KR20140054312A
(ko)
*
|
2007-02-12 |
2014-05-08 |
디엠아이 바이오사이언시스 인코포레이티드 |
조루 및 발기부전을 동시에 치료하는 방법
|
|
US20080194529A1
(en)
*
|
2007-02-12 |
2008-08-14 |
Auspex Pharmaceuticals, Inc. |
HIGHLY SELECTIVE and LONG-ACTING PDE5 MODULATORS
|
|
EP2121088B1
(en)
|
2007-03-09 |
2016-07-13 |
Alexza Pharmaceuticals, Inc. |
Heating unit for use in a drug delivery device
|
|
DE102007027067A1
(de)
|
2007-06-12 |
2008-12-18 |
Ratiopharm Gmbh |
Verfahren zur Herstellung eines Arzneimittels enthaltend Vardenafil Hydrochlorid Trihydrat
|
|
WO2008151734A1
(en)
*
|
2007-06-13 |
2008-12-18 |
Bayer Schering Pharma Aktiengesellschaft |
Pde inhibitors for the treatment of hearing impairment
|
|
CN101965348B
(zh)
*
|
2007-09-06 |
2013-11-13 |
上海特化医药科技有限公司 |
伐地那非的制备方法及其中间体
|
|
ES2388371T3
(es)
|
2007-12-28 |
2012-10-15 |
Topharman Shanghai Co., Ltd. |
N-{1-[3-(2-etoxi-5-(4-etilpiperazinil)bencenosulfonil)-4,5-dihidro-5-oxo-1,2,4-triazin-6-il]etil}-butiramida, método de preparación y uso
|
|
WO2009091777A1
(en)
*
|
2008-01-15 |
2009-07-23 |
Forest Laboratories Holdings Limited |
Nebivolol in the treatment of sexual dysfunction
|
|
DE102008063992A1
(de)
|
2008-12-19 |
2010-09-02 |
Lerner, Zinoviy, Dipl.-Ing. |
Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung
|
|
EP2379076B1
(en)
|
2008-12-23 |
2014-11-12 |
The Trustees of Columbia University in the City of New York |
Phosphodiesterase inhibitors and uses thereof
|
|
WO2010099217A1
(en)
|
2009-02-25 |
2010-09-02 |
Braincells, Inc. |
Modulation of neurogenesis using d-cycloserine combinations
|
|
GB0903493D0
(en)
|
2009-02-27 |
2009-04-08 |
Vantia Ltd |
New compounds
|
|
DE102009020888A1
(de)
|
2009-05-12 |
2010-11-18 |
Ratiopharm Gmbh |
Schmelztablette, enthaltend ein Vardenafil-Salz
|
|
EP2462127A1
(en)
|
2009-08-07 |
2012-06-13 |
Ranbaxy Laboratories Limited |
Processes for the preparation of vardenafil
|
|
PH12012501023A1
(en)
|
2009-11-27 |
2014-12-19 |
Adverio Pharma Gmbh |
Method for producing methyl - {4, 6-diamino -2-[1- (2-fluorobenzyl) -1h- pyrazolo [3,4-b] pyridino -3-yl] pyrimidino -5-yl} methyl carbamate and its purification for use thereof as pharmaceutical substance
|
|
UY33041A
(es)
|
2009-11-27 |
2011-06-30 |
Bayer Schering Pharma Aktienegesellschaft |
Procedimiento para la preparaciòn de {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}carbamato de metilo y su purificaciòn para el uso como principio activo farmacèutico
|
|
WO2011075801A1
(pt)
|
2009-12-21 |
2011-06-30 |
Acef S.A. |
Cubebina, lignana dibenzilbutirolactólica, seus derivados semi-sintéticos e sintéticos, bem como outras lignanas e neolignanas como agente vasodilatador na terapia da disfunção erétil
|
|
PL390079A1
(pl)
*
|
2009-12-30 |
2011-07-04 |
Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna |
Sposób otrzymywania wardenafilu i jego izolacji jako soli z kwasem cytrynowym oraz krystaliczna postać tej soli
|
|
WO2011126250A2
(ko)
|
2010-04-05 |
2011-10-13 |
에스케이케미칼 주식회사 |
Pde5 억제제를 함유하는 피부 주름 개선용 조성물
|
|
DE102010021637A1
(de)
|
2010-05-26 |
2011-12-01 |
Bayer Schering Pharma Aktiengesellschaft |
Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
|
|
CN102382129B
(zh)
*
|
2010-08-19 |
2014-02-26 |
山东轩竹医药科技有限公司 |
螺环取代的磷酸二酯酶抑制剂
|
|
CN102372730B
(zh)
*
|
2010-08-19 |
2014-03-26 |
山东轩竹医药科技有限公司 |
桥环取代的磷酸二酯酶抑制剂
|
|
TWI541244B
(zh)
|
2010-09-20 |
2016-07-11 |
福倫製藥股份有限公司 |
咪唑三酮化合物
|
|
SG188307A1
(en)
|
2010-09-23 |
2013-04-30 |
Abbvie Inc |
Monohydrate of an azaadamantane derivative
|
|
EP3106163A1
(en)
|
2010-10-15 |
2016-12-21 |
Gilead Sciences, Inc. |
Compositions and methods of treating pulmonary hypertension
|
|
TWI462739B
(zh)
|
2010-11-02 |
2014-12-01 |
Univ Kaohsiung Medical |
Sildenafil-同族物四級銨哌嗪鹽類之製備及醫療用途
|
|
CN102134242B
(zh)
*
|
2011-01-21 |
2013-08-28 |
浙江大德药业集团有限公司 |
一种用于治疗阳痿的快速长效的化合物
|
|
US9643970B2
(en)
|
2011-10-10 |
2017-05-09 |
H. Lundbeck A/S |
Substituted imidazo [1,5-a]pyrazines as PDE9 inhibitors
|
|
AT512084A1
(de)
|
2011-10-20 |
2013-05-15 |
Univ Wien Tech |
Diazabicyclo- und diazaspiro-alkanderivate als phosphodiesterase-5 inhibitoren
|
|
US9402877B2
(en)
|
2011-11-04 |
2016-08-02 |
Xion Pharmaceuticals Corporation |
Methods and compositions for oral administration of melanocortin receptor agonist compounds
|
|
CZ303877B6
(cs)
*
|
2011-11-24 |
2013-06-05 |
Zentiva, K.S. |
Zpusob prípravy a izolace solí vardenafilu s kyselinami
|
|
WO2013106547A1
(en)
|
2012-01-10 |
2013-07-18 |
President And Fellows Of Harvard College |
Beta-cell replication promoting compounds and methods of their use
|
|
WO2013109738A1
(en)
|
2012-01-17 |
2013-07-25 |
The Trustees Of Columbia University In The City Of New York |
Novel phosphodiesterase inhibitors and uses thereof
|
|
HK1199879A1
(en)
|
2012-01-26 |
2015-07-24 |
H.隆德贝克有限公司 |
Pde9 inhibitors with imidazo triazinone backbone
|
|
IN2014MN01706A
(enEXAMPLES)
|
2012-02-28 |
2015-05-29 |
Seoul Pharma Co Ltd |
|
|
HK1206726A1
(en)
|
2012-03-19 |
2016-01-15 |
Ironwood Pharmaceuticals, Inc. |
Imidazotriazinone compounds
|
|
CN103374002B
(zh)
*
|
2012-04-19 |
2015-07-15 |
山东轩竹医药科技有限公司 |
磷酸二酯酶-5抑制剂
|
|
CZ307091B6
(cs)
|
2012-09-14 |
2018-01-10 |
Zentiva, K.S. |
Stabilní farmaceutický přípravek obsahující Vardenafil hydrochlorid
|
|
EP2929886B1
(en)
|
2012-12-04 |
2021-11-24 |
Aribio Inc. |
Composition comprising phosphodiesterase type 5 inhibitor for inhibiting apoptosis of nerve cells
|
|
KR101953735B1
(ko)
|
2012-12-14 |
2019-03-04 |
한미약품 주식회사 |
포스포다이에스터라제-5 억제제를 포함하는 츄정
|
|
CA2901636A1
(en)
|
2013-02-21 |
2014-08-28 |
Adverio Pharma Gmbh |
Forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridino-3-yl]pyrimidino-5-yl}methyl carbamate
|
|
CN104109164B
(zh)
*
|
2013-04-18 |
2016-05-25 |
广州朗圣药业有限公司 |
一种适合工业化的高纯度盐酸伐地那非三水合物的制备方法
|
|
WO2015009930A2
(en)
|
2013-07-17 |
2015-01-22 |
The Trustees Of Columbia University In The City Of New York |
Novel phosphodiesterase inhibitors and uses thereof
|
|
WO2015089105A1
(en)
|
2013-12-09 |
2015-06-18 |
Respira Therapeutics, Inc. |
Pde5 inhibitor powder formulations and methods relating thereto
|
|
PL223869B1
(pl)
*
|
2013-12-16 |
2016-11-30 |
Starogardzkie Zakłady Farm Polpharma Spółka Akcyjna |
Sposób otrzymywania wardenafilu i jego soli
|
|
KR101645652B1
(ko)
|
2014-11-03 |
2016-08-08 |
(주)퓨젠바이오농업회사법인 |
세리포리아 락세라타에 의해 생산되는 세포외다당체를 유효성분으로 함유하는 성기능개선용 조성물
|
|
HRP20210543T1
(hr)
|
2015-07-07 |
2021-05-14 |
H. Lundbeck A/S |
Inhibitori pde9 s imidazo triazinonskom okosnicom i imidazo pirazinonskom okosnicom za liječenje perifernih bolesti
|
|
ES2912648T3
(es)
*
|
2015-11-16 |
2022-05-26 |
Topadur Pharma Ag |
Derivados de 2-fenil-3,4-dihidropirrolo[2,1-f] [1,2,4]triazinona como inhibidores de la fosfodiesterasa y usos de los mismos
|
|
WO2017168174A1
(en)
|
2016-04-02 |
2017-10-05 |
N4 Pharma Uk Limited |
New pharmaceutical forms of sildenafil
|
|
US10912778B2
(en)
|
2016-12-14 |
2021-02-09 |
Respira Therapeutics, Inc. |
Methods for treatment of pulmonary hypertension
|
|
US11155558B2
(en)
|
2017-05-22 |
2021-10-26 |
Topadur Pharma Ag |
Dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
|
|
CN107445964A
(zh)
*
|
2017-07-29 |
2017-12-08 |
合肥创新医药技术有限公司 |
一种盐酸伐地那非杂质的合成方法
|
|
BR112020012239A2
(pt)
|
2017-12-20 |
2020-11-24 |
Klaria Pharma Holding Ab |
método para preparar um filme mucoadesivo, e, filme mucoadesivo
|
|
KR102852740B1
(ko)
|
2018-02-02 |
2025-08-29 |
알렉스자 파마스티칼즈, 인크. |
전기적 응축 에어로졸 디바이스
|
|
EP3801526B1
(en)
|
2018-05-25 |
2023-12-27 |
Imara Inc. |
Monohydrate and crystalline forms of 6-[(3s,4s)-4-methyl-1- (pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl- 7h-imid azo [1,5- a] pyrazin-8-one
|
|
JP2021527875A
(ja)
|
2018-06-14 |
2021-10-14 |
アストラゼネカ・ユーケイ・リミテッドAstraZeneca UK Limited |
Cgmp特異的ホスホジエステラーゼ5阻害剤の薬学的組成物により勃起不全を治療するための方法
|
|
CA3103716A1
(en)
|
2018-06-14 |
2019-12-19 |
Astrazeneca Uk Limited |
Methods for treating erectile dysfunction with a cgmp-specific phosphodiesterase 5 inhibitor pharmaceutical composition
|
|
KR102831968B1
(ko)
|
2018-08-31 |
2025-07-08 |
카듀리온 파마슈티칼스, 인크. |
겸상 세포 질환의 치료를 위한 pde9 억제제
|
|
IL282618B2
(en)
*
|
2018-11-28 |
2025-05-01 |
Topadur Pharma Ag |
Novel dual-action soluble guanylate cyclase activators and phosphodiesterase inhibitors and their uses
|
|
WO2020184670A1
(ja)
|
2019-03-13 |
2020-09-17 |
大塚製薬株式会社 |
二級アミンを含有する化合物のアミン部分に重水素低級アルキルを導入する方法
|
|
US11590209B2
(en)
|
2020-01-21 |
2023-02-28 |
Palatin Technologies, Inc. |
Use of bremelanotide in patients with controlled hypertension
|
|
WO2021245192A1
(en)
|
2020-06-04 |
2021-12-09 |
Topadur Pharma Ag |
Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
|
|
TW202237615A
(zh)
*
|
2020-12-11 |
2022-10-01 |
南韓商日東製藥股份有限公司 |
作為雄激素受體及磷酸二酯酶雙重抑制劑的新穎化合物
|
|
CN117177974A
(zh)
*
|
2021-04-21 |
2023-12-05 |
长春金赛药业有限责任公司 |
含咪唑稠环类衍生物、其制备方法及其在医药上的应用
|
|
CN114085225A
(zh)
*
|
2021-06-04 |
2022-02-25 |
广东西捷药业有限公司 |
一种伐地那非类似物及其合成方法和应用
|
|
KR20240064630A
(ko)
|
2021-09-29 |
2024-05-13 |
토파두르 파마 아게 |
2-페닐-3,4-디히드로피롤로[2,l-f][1,2,4]트리아지논 유도체의 국소 조성물 및 이들의 용도
|
|
WO2023166013A1
(en)
|
2022-03-02 |
2023-09-07 |
Topadur Pharma Ag |
Topical compositions and uses therof
|
|
KR20230129639A
(ko)
|
2022-03-02 |
2023-09-11 |
연세대학교 산학협력단 |
이중작용 pde5 억제제/질산유기에스터의 국소 혈류 증진을 위한 경피 투약 형태
|
|
WO2024173675A1
(en)
|
2023-02-16 |
2024-08-22 |
University Of Rochester |
Improving glymphatic-lymphatic efflux
|