IL148642A0 - Medium for the protein-free and serum-free cultivation of cells - Google Patents
Medium for the protein-free and serum-free cultivation of cellsInfo
- Publication number
- IL148642A0 IL148642A0 IL14864200A IL14864200A IL148642A0 IL 148642 A0 IL148642 A0 IL 148642A0 IL 14864200 A IL14864200 A IL 14864200A IL 14864200 A IL14864200 A IL 14864200A IL 148642 A0 IL148642 A0 IL 148642A0
- Authority
- IL
- Israel
- Prior art keywords
- free
- medium
- cells
- serum
- protein
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0043—Medium free of human- or animal-derived components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/005—Protein-free medium
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/46—Amines, e.g. putrescine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/76—Undefined extracts from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C12N2500/92—Medium free of human- or animal-derived components
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0165999A AT409379B (de) | 1999-06-02 | 1999-09-28 | Medium zur protein- und serumfreien kultivierung von zellen |
PCT/EP2000/009453 WO2001023527A1 (en) | 1999-09-28 | 2000-09-27 | Medium for the protein-free and serum-free cultivation of cells |
Publications (1)
Publication Number | Publication Date |
---|---|
IL148642A0 true IL148642A0 (en) | 2002-09-12 |
Family
ID=3518214
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14864200A IL148642A0 (en) | 1999-09-28 | 2000-09-27 | Medium for the protein-free and serum-free cultivation of cells |
IL148642A IL148642A (en) | 1999-09-28 | 2002-03-12 | Medium for the protein-free and serum-free cultivation of cells |
IL219969A IL219969A (en) | 1999-09-28 | 2012-05-24 | Cell culture containing recombinant cho cells expressing protein factor viii |
IL250619A IL250619B (en) | 1999-09-28 | 2017-02-15 | Substrate without proteins and without serum for cell cultivation |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL148642A IL148642A (en) | 1999-09-28 | 2002-03-12 | Medium for the protein-free and serum-free cultivation of cells |
IL219969A IL219969A (en) | 1999-09-28 | 2012-05-24 | Cell culture containing recombinant cho cells expressing protein factor viii |
IL250619A IL250619B (en) | 1999-09-28 | 2017-02-15 | Substrate without proteins and without serum for cell cultivation |
Country Status (21)
Country | Link |
---|---|
US (6) | US20030203448A1 (xx) |
EP (1) | EP1220893B2 (xx) |
JP (6) | JP5441288B2 (xx) |
CN (2) | CN1318577C (xx) |
AT (2) | AT409379B (xx) |
AU (1) | AU780791B2 (xx) |
CA (1) | CA2385299A1 (xx) |
CY (1) | CY1106135T1 (xx) |
CZ (1) | CZ305307B6 (xx) |
DE (1) | DE60028989T3 (xx) |
DK (1) | DK1220893T4 (xx) |
ES (1) | ES2265991T5 (xx) |
HU (1) | HU228210B1 (xx) |
IL (4) | IL148642A0 (xx) |
PL (1) | PL215234B1 (xx) |
PT (1) | PT1220893E (xx) |
RU (3) | RU2266325C2 (xx) |
SI (1) | SI1220893T1 (xx) |
SK (1) | SK288059B6 (xx) |
TR (1) | TR200200757T2 (xx) |
WO (1) | WO2001023527A1 (xx) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
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US6475725B1 (en) | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
AT409379B (de) | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
CA2466881A1 (en) * | 2001-11-28 | 2003-06-05 | Sandoz Gmbh | Cell culture process |
US7195905B2 (en) | 2001-12-10 | 2007-03-27 | Baxter Healthcare S.A. | Enveloped virus vaccine and method for production |
JP3916516B2 (ja) * | 2002-06-10 | 2007-05-16 | 独立行政法人科学技術振興機構 | 硬組織−軟組織界面再生用足場材料 |
EP1520008B1 (en) | 2002-07-09 | 2012-09-05 | Baxter International Inc. | Animal protein free media for cultivation of cells |
CA2548162C (en) * | 2003-12-19 | 2013-10-29 | Wyeth | Serum-free vero cell banking process |
ME01218B (me) | 2004-03-01 | 2013-06-20 | Ares Trading Sa | Upotreba podloge za ćelijsku strukturu bez sadrzaja seruma za produkciju il-18bp u ćelijama sisara |
US20060094104A1 (en) | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
AU2011221414B2 (en) * | 2004-10-29 | 2012-09-20 | Takeda Pharmaceutical Company Limited | Animal Protein-Free Media for Cultivation of Cells |
CA2585547A1 (en) * | 2004-10-29 | 2006-05-11 | Centocor, Inc. | Chemically defined media compositions |
FR2879214A1 (fr) * | 2004-12-14 | 2006-06-16 | Pierre Fabre Medicament Sa | Fractions peptidiques favorisant la croissance et la synthese de produit(s) d'interet en culture de cellules et/ou de tissus |
WO2006084826A1 (en) | 2005-02-11 | 2006-08-17 | Novo Nordisk Health Care Ag | Production of a polypeptide in a serum-free cell culture liquid containing plant protein hydrolysate |
EP1862537B1 (en) * | 2005-03-10 | 2013-05-08 | Kyoritsu Seiyaku Corporation | Cell line culturable without aminal-derived component, method for establishment thereof, method for production of virus using the cell line and method for production of vaccine |
EP1707634A1 (en) | 2005-03-29 | 2006-10-04 | Octapharma AG | Method for isolation of recombinantly produced proteins |
KR100670105B1 (ko) | 2005-06-29 | 2007-01-17 | 주식회사 셀트리온 | 콩가수분해물의 저분자량 분획을 이용하여 시알산 함량이증가된 에리스로포이에틴을 생산하는 방법 및 그에 의하여생산된 시알산 함량이 증가된 에리스로포이에틴 |
US7375188B2 (en) * | 2005-07-29 | 2008-05-20 | Mallinckrodt Baker, Inc. | Vegetarian protein a preparation and methods thereof |
PL3121266T3 (pl) | 2006-01-04 | 2020-07-13 | Baxalta Incorporated | Wolne od oligopeptydów pożywki do hodowli komórkowej |
CA2644926A1 (en) * | 2006-03-06 | 2007-09-13 | Humagene, Inc. | A method for the preparation of recombinant human thrombin and fibrinogen |
SG174804A1 (xx) | 2006-09-13 | 2011-10-28 | Abbott Lab | |
EP2500415A1 (en) | 2006-09-13 | 2012-09-19 | Abbott Laboratories | Cell culture improvements |
EP2084265A2 (en) * | 2006-11-13 | 2009-08-05 | Schering Corporation | Method for reducing protease activity in plant hydrolysate |
US20090294288A1 (en) | 2006-12-11 | 2009-12-03 | Schering Corporation | High-sensitivity proteolysis assay |
EP1988101A1 (en) * | 2007-05-04 | 2008-11-05 | Novo Nordisk A/S | Improvement of factor VIII polypeptide titers in cell cultures |
KR101190605B1 (ko) | 2007-06-15 | 2012-10-15 | 재단법인 목암생명공학연구소 | 활성형 재조합 혈액응고 9인자의 대량생산 방법 |
WO2009115495A1 (de) * | 2008-03-19 | 2009-09-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Methode zur steigerung der reklonierungseffizienz |
WO2009127098A1 (zh) | 2008-04-18 | 2009-10-22 | 上海中信国健药业有限公司 | 一种浓缩培养液及其使用方法 |
TW201012930A (en) | 2008-06-16 | 2010-04-01 | Intervet Int Bv | Method of replicating viruses in suspension |
JP5458536B2 (ja) * | 2008-09-17 | 2014-04-02 | 不二製油株式会社 | 乳酸の製造方法及び乳酸発酵用添加剤 |
CA2737580A1 (en) * | 2008-09-26 | 2010-04-01 | Schering Corporation | High titer antibody production |
EP2356247B2 (en) * | 2008-11-12 | 2019-05-15 | Baxalta Incorporated | Method of producing serum-free insulin-free factor vii |
KR101737645B1 (ko) | 2008-12-30 | 2017-05-18 | 박스알타 인코퍼레이티드 | 알킬-아민-n-옥시드 (aanox)를 사용하는 세포 성장 증진 방법 |
CN101603026B (zh) * | 2009-06-19 | 2011-01-19 | 华东理工大学 | 适于动物细胞产品生产的无动物来源低蛋白培养基 |
KR101574056B1 (ko) | 2009-07-31 | 2015-12-02 | 백스터 인터내셔널 인코포레이티드 | Adamts 단백질 발현을 위한 세포 배양 배지 |
CN102115728B (zh) * | 2009-12-31 | 2012-09-26 | 北京清大天一科技有限公司 | 无血清动物细胞培养基干粉、液体培养基及其制备方法 |
AU2011246502B2 (en) | 2010-04-26 | 2014-08-28 | Novartis Ag | Improved cell cultivation process |
SG185038A1 (en) * | 2010-04-26 | 2012-11-29 | Novartis Ag | Improved cell culture medium |
TWI670073B (zh) | 2010-07-08 | 2019-09-01 | 美商巴克斯歐塔公司 | 在細胞培養物中生產重組高分子量vWF的方法 |
CN101914485A (zh) * | 2010-08-05 | 2010-12-15 | 乐能生物工程股份有限公司 | 一种无血清大豆蛋白肽动物细胞培养基的配制方法 |
KR20130101034A (ko) | 2010-08-31 | 2013-09-12 | 프리슬랜드 브랜즈 비브이 | 진핵 세포를 위한 배양 배지 |
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WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
CN103160458A (zh) * | 2011-12-15 | 2013-06-19 | 西南民族大学 | 一种适合Vero细胞生长的低血清培养基 |
JP2015509376A (ja) * | 2012-03-08 | 2015-03-30 | フリーズランド ブランズ ビー.ブイ. | 真核細胞のための培養培地 |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
EP2830651A4 (en) | 2013-03-12 | 2015-09-02 | Abbvie Inc | HUMAN ANTIBODIES THAT BIND TNF-ALPHA AND PREPARATION METHODS |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
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US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
CN104593317B (zh) * | 2013-10-31 | 2018-05-04 | 中国食品发酵工业研究院 | 一种用于细胞培养基的大豆活性肽添加剂 |
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TW202340452A (zh) | 2015-08-04 | 2023-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
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JP6258536B1 (ja) | 2017-03-03 | 2018-01-10 | 協和発酵キリン株式会社 | ダルベポエチン組成物の製造方法およびダルべポエチン産生細胞の培養方法 |
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CN113151183A (zh) * | 2021-04-21 | 2021-07-23 | 赵峻岭 | 一种促进蛋白表达的培养基添加物及其应用 |
WO2024024671A1 (ja) * | 2022-07-27 | 2024-02-01 | 不二製油グループ本社株式会社 | 動物細胞増殖促進剤 |
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AT165999B (de) | 1947-06-26 | 1950-05-25 | Delle Atel Const Electr | Einirchtung zum Schutz von Drehstrommotoren gegen Überstrom |
FR2196386A1 (en) | 1972-08-17 | 1974-03-15 | Cudennec Alain | Culture media selection - for identification of unknown bacteria |
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