HRP20170457T1 - Postupak proizvodnje cjepiva - Google Patents

Postupak proizvodnje cjepiva Download PDF

Info

Publication number
HRP20170457T1
HRP20170457T1 HRP20170457TT HRP20170457T HRP20170457T1 HR P20170457 T1 HRP20170457 T1 HR P20170457T1 HR P20170457T T HRP20170457T T HR P20170457TT HR P20170457 T HRP20170457 T HR P20170457T HR P20170457 T1 HRP20170457 T1 HR P20170457T1
Authority
HR
Croatia
Prior art keywords
saccharide
aliquot
protein carrier
period
amino
Prior art date
Application number
HRP20170457TT
Other languages
English (en)
Inventor
Ralph Leon Biemans
Pierre Duvivier
Original Assignee
Glaxosmithkline Biologicals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36716943&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20170457(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB0513071.1A external-priority patent/GB0513071D0/en
Priority claimed from GBGB0513069.5A external-priority patent/GB0513069D0/en
Priority claimed from GB0515556A external-priority patent/GB0515556D0/en
Priority claimed from GB0524204A external-priority patent/GB0524204D0/en
Priority claimed from GB0526041A external-priority patent/GB0526041D0/en
Priority claimed from GB0526040A external-priority patent/GB0526040D0/en
Application filed by Glaxosmithkline Biologicals S.A. filed Critical Glaxosmithkline Biologicals S.A.
Publication of HRP20170457T1 publication Critical patent/HRP20170457T1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0016—Combination vaccines based on diphtheria-tetanus-pertussis
    • A61K39/0017—Combination vaccines based on whole cell diphtheria-tetanus-pertussis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0016—Combination vaccines based on diphtheria-tetanus-pertussis
    • A61K39/0018—Combination vaccines based on acellular diphtheria-tetanus-pertussis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/116—Polyvalent bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16271—Demonstrated in vivo effect
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Surgical Instruments (AREA)

Claims (11)

1. Postupak konjugiranja saharida s proteinskin nosačem karbodiimidnim kondenziranjem, gdje saharid sadrži (primjerice kao dio svoje repetitivne jedinice), ili je tako deriviran da sadrži, amino i/ili karboksilne skupine, te gdje proteinski nosač sadrži, ili je tako deriviran da sadrži, amino i/ili karboksilne skupine, naznačen time što se sastoji u koracima: I) – ako proteinski nosač sadrži i amino i karboksilne skupine i saharid sadrži bilo amino ili karboksilne skupine: a) miješanja saharida s alikvotom karbodiimida potrebnim za provođenje konjugiranja, i b) dodavanja alikvota proteinskog nosača potrebnog u periodu od 5 minuta do 6 sata, gdje se najmanje jednu četvrtinu alikvota dodaje tijekom prve polovine perioda, a najmanje jednu četvrtinu alikvota tijekom druge polovine perioda; II) – ako saharid sadrži i amino i karboksilne skupine i proteinski nosač sadrži bilo amino ili karboksilne skupine: a) miješanja proteinskog nosača s alikvotom karbodiimida potrebnim za provođenje konjugiranja, i b) dodavanja alikvota saharida potrebnog u periodu od 1 minute do 6 sata, gdje se najmanje jednu četvrtinu alikvota dodaje tijekom prve polovine perioda, a najmanje jednu četvrtinu alikvota tijekom druge polovine perioda; III) – ako saharid sadrži i amino i karboksilne skupine i proteinski nosač sadrži i amino i karboksilne skupine: a) miješanja proteinskog nosača sa saharidom, i b) dodavanja alikvota karbodiimida potrebnog za provođenje konjugiranja u periodu od 1 minute do 6 sata, gdje se tijekom prve polovine perioda dodaje najmanje jednu četvrtinu alikvota, a najmanje jednu četvrtinu alikvota tijekom druge polovine perioda; te što: alikvot karbodiimida je 0,01 do 3 mg karbodiimida/mg saharida; saharid je prisutan u konačnoj koncentraciji od 0,5-50 mg/ml u koraku b); proteinski nosač je prisutan u konačnoj koncentraciji od 1-50 mg/ml u koraku b); početni omjer između proteinskog nosača i saharida je 4:1 do 1:1 (tež./tež.); pH reakcije u koraku b) se održava na pH 4,5-6,5, ili pH 4,5-7,5 ako je prisutan u koraku b) spoj koji održava reakcijski međuprodukt stabilnim; temperaturu reakcije u koraku b) se održava na 4-37 °C.
2. Postupak u skladu s patentnim zahtjevom 1, naznačen time što je u koraku b) period 1 minute do 4 sata, 2 minute do 3 sata, 3 minute do 2 sata, 4 do 60 minuta, 5 do 50 minuta, 6 do 40 minuta, 7 do 30 minuta ili 8 do 20 minuta.
3. Postupak u skladu s patentnim zahtjevom 1 ili 2, naznačen time što je karbodiimid EDAC (1-etil-3-(3-dimetilaminopropil)karbodiimid).
4. Postupak u skladu s patentnim zahtjevima 1-3, naznačen time što je saharid i/ili proteinski nosač tako deriviran da sadrži amino ili karboksilne skupine.
5. Postupak u skladu s patentnim zahtjevima 1-4, naznačen time što uključuje naknadni korak c), u kojem se saharidno-proteinski konjugat pročisti na stupcu za kromatografiju s isključivošću na veličinu.
6. Postupak u skladu s patentnim zahtjevima 1-5, naznačen time što uključuje naknadni korak d), u kojem se saharidno-proteinski konjugat sterilno filtrira.
7. Postupak u skladu s patentnim zahtjevima 1-6, naznačen time što je saharid saharid iz bakterijske kapsule, primjerice dobiven iz bakterije koju se bira sa spiska kojeg čine: N. meningitidis seroskupina A, B, C, W135 ili Y, Streptococcus pneumoniae serotipovi 1, 2, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F ili 33F, Group B Streptococcus skupina la, Ib, II, III, IV, V, VI ili VII, Staphilococcus aureus tip 5, Staphilococcus aureus tip 8, Salmonella typhi (saharid Vi), Vibrio cholerae, ili H. influenzae tip b.
8. Postupak u skladu s patentnim zahtjevima 1-6, naznačen time što je saharid bakterijski lipooligosaharid ili lipopolisaharid, primjerice dobiven iz bakterije koju se bira sa spiska kojeg čine: N. meningitidis, H. influenzae, E. coli, Salmonella ili M. catarrhalis.
9. Postupak u skladu s patentnim zahtjevima 1-8, naznačen time što proteinski nosač sadrži jedan ili više epitopa iz pomoćničkih T-stanica.
10. Postupak u skladu s patentnim zahtjevima 1-9, naznačen time što se proteinski nosač bira iz skupine koju čine: TT, DT, CRM197, fragment C od TT, protein D iz bakterije H. influenzae, pneumokokni PhtD, te pneumokokni pneumolizin.
11. Konjugat saharida s proteinskim nosačem, kojeg se može dobiti postupkom u skladu s patentnim zahtjevima 1-10, naznačen time što je saharid saharid iz bakterijske kapsule, primjerice dobiven iz bakterije koju se bira sa spiska kojeg čine: N. meningitidis seroskupina A, B, C, W135 ili Y, Streptococcus pneumoniae serotipovi 1, 2, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F ili 33F, skupine Ia, Ib, II, III, IV, V, VI ili VII iz skupine B streptokoka, Staphilococcus aureus tip 5, Staphilococcus aureus tip 8, Salmonella typhi (saharid Vi), Vibrio cholerae, ili što je saharid bakterijski lipooligosaharid ili lipopolisaharid, primjerice dobiven iz bakterije koju se bira sa spiska kojeg čine: N. meningitidis, H. influenzae, E. coli, Salmonella ili M. catarrhalis.
HRP20170457TT 2005-06-27 2017-03-20 Postupak proizvodnje cjepiva HRP20170457T1 (hr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB0513071.1A GB0513071D0 (en) 2005-06-27 2005-06-27 Immunogenic composition
GBGB0513069.5A GB0513069D0 (en) 2005-06-27 2005-06-27 Immunogenic composition
GB0515556A GB0515556D0 (en) 2005-07-28 2005-07-28 Immunogenic composition
GB0524204A GB0524204D0 (en) 2005-11-28 2005-11-28 Immunogenic composition
GB0526041A GB0526041D0 (en) 2005-12-21 2005-12-21 Immunogenic composition
GB0526040A GB0526040D0 (en) 2005-12-21 2005-12-21 Immunogenic composition
EP10179820.5A EP2351578B1 (en) 2005-06-27 2006-06-23 Process for manufacturing vaccines

Publications (1)

Publication Number Publication Date
HRP20170457T1 true HRP20170457T1 (hr) 2017-05-19

Family

ID=36716943

Family Applications (4)

Application Number Title Priority Date Filing Date
HR20100211T HRP20100211T1 (hr) 2005-06-27 2010-04-14 Imunogeni pripravak
HRP20110567TT HRP20110567T4 (en) 2005-06-27 2011-07-29 Process for manufacturing vaccines
HR20120102T HRP20120102T1 (hr) 2005-06-27 2012-02-01 Imunogeni pripravak
HRP20170457TT HRP20170457T1 (hr) 2005-06-27 2017-03-20 Postupak proizvodnje cjepiva

Family Applications Before (3)

Application Number Title Priority Date Filing Date
HR20100211T HRP20100211T1 (hr) 2005-06-27 2010-04-14 Imunogeni pripravak
HRP20110567TT HRP20110567T4 (en) 2005-06-27 2011-07-29 Process for manufacturing vaccines
HR20120102T HRP20120102T1 (hr) 2005-06-27 2012-02-01 Imunogeni pripravak

Country Status (37)

Country Link
US (13) US9789179B2 (hr)
EP (11) EP1896061B1 (hr)
JP (9) JP2008543907A (hr)
KR (7) KR20130122810A (hr)
CN (3) CN102218138A (hr)
AP (1) AP2436A (hr)
AR (3) AR053935A1 (hr)
AT (3) ATE516816T1 (hr)
AU (7) AU2006263964B2 (hr)
BE (1) BE2012C042I2 (hr)
BR (5) BRPI0612669B8 (hr)
CA (5) CA2612963C (hr)
CY (5) CY1109996T1 (hr)
DE (1) DE602006013313D1 (hr)
DK (7) DK2351578T3 (hr)
EA (4) EA013374B1 (hr)
ES (9) ES2750243T3 (hr)
FR (1) FR22C1008I2 (hr)
HK (4) HK1114011A1 (hr)
HR (4) HRP20100211T1 (hr)
HU (7) HUE031380T2 (hr)
IL (8) IL187924A (hr)
LT (1) LT2351578T (hr)
LU (1) LU92085I2 (hr)
MA (4) MA29602B1 (hr)
MX (5) MX2007016237A (hr)
MY (3) MY147490A (hr)
NL (1) NL300549I2 (hr)
NO (4) NO345422B1 (hr)
NZ (6) NZ564370A (hr)
PE (6) PE20070163A1 (hr)
PL (8) PL1896062T3 (hr)
PT (8) PT2283857T (hr)
SI (8) SI1896061T1 (hr)
TW (5) TWI477283B (hr)
UA (2) UA95237C2 (hr)
WO (6) WO2007000342A2 (hr)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1946769T3 (da) * 2000-06-29 2012-07-16 Smithkline Beecham Biolog Multivalent vaccinesammensætning med nedsat dosis af Haemophilus influenzae type B
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
CA3042073C (en) 2003-01-30 2022-09-13 Novartis Vaccines And Diagnostics S.R.L. Injectable vaccines against multiple meningococcal serogroups
GB0408977D0 (en) * 2004-04-22 2004-05-26 Chiron Srl Immunising against meningococcal serogroup Y using proteins
GB0505518D0 (en) * 2005-03-17 2005-04-27 Chiron Srl Combination vaccines with whole cell pertussis antigen
US7955605B2 (en) * 2005-04-08 2011-06-07 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
PE20070163A1 (es) 2005-06-27 2007-03-01 Glaxosmithkline Biolog Sa Composicion inmunogenica de conjugados de sacaridos de n. meningitidis
JP5135220B2 (ja) * 2005-09-01 2013-02-06 ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー 血清群ｃ髄膜炎菌を含む複数ワクチン接種
AU2012261764B2 (en) * 2005-09-01 2016-09-08 Novartis Vaccines And Diagnostics Gmbh & Co. Kg Multiple vaccination including serogroup C meningococcus
DK3017827T3 (en) 2005-12-22 2019-02-18 Glaxosmithkline Biologicals Sa Pneumococcal polysaccharide conjugate VACCINE
US10543265B2 (en) 2006-03-22 2020-01-28 Glaxosmithkline Biologicals Sa Regimens for immunisation with meningococcal conjugates
US10828361B2 (en) * 2006-03-22 2020-11-10 Glaxosmithkline Biologicals Sa Regimens for immunisation with meningococcal conjugates
GB0612854D0 (en) 2006-06-28 2006-08-09 Novartis Ag Saccharide analysis
MX2009002561A (es) 2006-09-07 2009-03-20 Glaxosmithkline Biolog Sa Vacuna.
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
GB0700135D0 (en) * 2007-01-04 2007-02-14 Glaxosmithkline Biolog Sa Vaccine
GB0700136D0 (en) * 2007-01-04 2007-02-14 Glaxosmithkline Biolog Sa Process for manufacturing vaccines
WO2009000826A1 (en) 2007-06-26 2008-12-31 Glaxosmithkline Biologicals S.A. Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates
GB0713880D0 (en) 2007-07-17 2007-08-29 Novartis Ag Conjugate purification
US20160228500A9 (en) * 2007-07-23 2016-08-11 Martina Ochs Immunogenic Polypeptides and Monoclonal Antibodies
GB0714963D0 (en) 2007-08-01 2007-09-12 Novartis Ag Compositions comprising antigens
CA2702871A1 (en) 2007-10-19 2009-04-23 Novartis Ag Meningococcal vaccine formulations
EP2328613A1 (en) * 2008-08-28 2011-06-08 GlaxoSmithKline Biologicals S.A. Vaccine
DK2349520T3 (en) 2008-10-27 2016-08-15 Glaxosmithkline Biologicals Sa Purification Procedure for Group A Streptococcus Carbohydrate
GB0822633D0 (en) 2008-12-11 2009-01-21 Novartis Ag Formulation
GB0822634D0 (en) 2008-12-11 2009-01-21 Novartis Ag Meningitis vaccines
WO2010070453A2 (en) 2008-12-17 2010-06-24 Novartis Ag Meningococcal vaccines including hemoglobin receptor
NZ595291A (en) 2009-03-24 2013-08-30 Novartis Ag Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates
PL2411048T3 (pl) 2009-03-24 2020-11-16 Glaxosmithkline Biologicals Sa Adjuwantowe meningokokowe białko wiążące czynnik h
JP5593626B2 (ja) * 2009-03-31 2014-09-24 凸版印刷株式会社 計量スプーン
WO2010119343A2 (en) 2009-04-14 2010-10-21 Novartis Ag Compositions for immunising against staphylococcus aureus
KR101450958B1 (ko) * 2009-04-30 2014-10-15 콜레이 파마시티컬 그룹, 인코포레이티드 폐렴구균 백신 및 그의 용도
GB0910046D0 (en) * 2009-06-10 2009-07-22 Glaxosmithkline Biolog Sa Novel compositions
US9125951B2 (en) 2009-06-22 2015-09-08 Wyeth Llc Compositions and methods for preparing Staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions
KR101486122B1 (ko) 2009-06-22 2015-01-23 와이어쓰 엘엘씨 스타필로코커스 아우레우스 항원의 면역원성 조성물
US9950062B2 (en) 2009-09-02 2018-04-24 Glaxosmithkline Biologicals Sa Compounds and compositions as TLR activity modulators
BR112012008338A2 (pt) 2009-09-10 2019-09-24 Novartis Ag combinação de vacinas contra doenças do trato respiratório.
DK2493498T3 (en) 2009-10-30 2017-05-08 Glaxosmithkline Biologicals Sa Purification of Staphylococcus aureus type 5 and type 8 capsule saccharides
GB0919690D0 (en) 2009-11-10 2009-12-23 Guy S And St Thomas S Nhs Foun compositions for immunising against staphylococcus aureus
JP5781542B2 (ja) 2009-12-30 2015-09-24 ノバルティス アーゲー Ｅ．ｃｏｌｉキャリアタンパク質に結合体化した多糖免疫原
TW201136603A (en) * 2010-02-09 2011-11-01 Merck Sharp & Amp Dohme Corp 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition
GB201003333D0 (en) 2010-02-26 2010-04-14 Novartis Ag Immunogenic proteins and compositions
GB201003924D0 (en) * 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Immunogenic composition
GB201003922D0 (en) * 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
GB201005625D0 (en) 2010-04-01 2010-05-19 Novartis Ag Immunogenic proteins and compositions
US10478483B2 (en) 2010-06-25 2019-11-19 Glaxosmithkline Biologicals Sa Combinations of meningococcal factor H binding proteins
EP2608805B1 (en) 2010-08-23 2017-07-05 Wyeth LLC STABLE FORMULATIONS OF NEISSERIA MENINGITIDIS rLP2086 ANTIGENS
US20120177681A1 (en) 2010-09-01 2012-07-12 Manmohan Singh Formulation of immunopotentiators
ES2759484T3 (es) 2010-09-10 2020-05-11 Glaxosmithkline Biologicals Sa Meningococo que sobreexpresa NadA y/o NHBA y vesículas de la membrana externa derivadas del mismo
ES2585328T5 (es) 2010-09-10 2022-12-14 Wyeth Llc Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis
WO2012072769A1 (en) 2010-12-01 2012-06-07 Novartis Ag Pneumococcal rrgb epitopes and clade combinations
RU2013144207A (ru) 2011-03-02 2015-04-10 Новартис Аг Комбинированные вакцины с пониженными дозами антигена и/или адъюванта
GB201114923D0 (en) 2011-08-30 2011-10-12 Novartis Ag Immunogenic proteins and compositions
EP2776069A1 (en) 2011-11-07 2014-09-17 Novartis AG Carrier molecule comprising a spr0096 and a spr2021 antigen
JP2013112653A (ja) * 2011-11-30 2013-06-10 Jnc Corp 新規重合体およびその製造方法
GB201121301D0 (en) 2011-12-12 2012-01-25 Novartis Ag Method
US10596246B2 (en) 2011-12-29 2020-03-24 Glaxosmithkline Biological Sa Adjuvanted combinations of meningococcal factor H binding proteins
TR201900778T4 (tr) * 2012-01-30 2019-02-21 Serum Institute Of India Private Ltd İmmünojenik bileşim.
MX2014008988A (es) 2012-02-02 2014-08-27 Novartis Ag Promotores para aumento de expresion de proteinas en meningococo.
CN102569723A (zh) * 2012-02-13 2012-07-11 华为技术有限公司 锂离子电池正极材料及其制备方法、正极及锂离子电池
US20150132339A1 (en) 2012-03-07 2015-05-14 Novartis Ag Adjuvanted formulations of streptococcus pneumoniae antigens
WO2013132043A1 (en) 2012-03-08 2013-09-12 Novartis Ag Combination vaccines with tlr4 agonists
JP6345603B2 (ja) 2012-03-08 2018-06-20 ノバルティス アーゲー 追加免疫ワクチンのアジュバント化された処方物
JP5925342B2 (ja) 2012-03-09 2016-05-25 ファイザー・インク 髄膜炎菌（Ｎｅｉｓｓｅｒｉａｍｅｎｉｎｇｉｔｉｄｉｓ）組成物およびその方法
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
KR102057217B1 (ko) 2012-06-20 2020-01-22 에스케이바이오사이언스 주식회사 다가 폐렴구균 다당류-단백질 접합체 조성물
AU2013311702A1 (en) 2012-09-06 2015-02-19 Novartis Ag Combination vaccines with serogroup B meningococcus and D/T/P
ITMI20121597A1 (it) * 2012-09-25 2014-03-26 Beta Pharma S A Coniugato tra frammento di parete cellulare batterica ed un veicolo mucopolisaccaridico e suoi usi in ambito medico
CN105307684A (zh) 2012-10-02 2016-02-03 葛兰素史密丝克莱恩生物有限公司 非直链糖缀合物
CN111249455A (zh) 2012-11-30 2020-06-09 葛兰素史密丝克莱恩生物有限公司 假单胞菌抗原和抗原组合
KR20140075196A (ko) 2012-12-11 2014-06-19 에스케이케미칼주식회사 다가 폐렴구균 다당류-단백질 접합체 조성물
US20150320852A1 (en) 2012-12-18 2015-11-12 Glaxosmithkline Biologicals Sa Conjugates for protecting against diphtheria and/or tetanus
CA2899787A1 (en) 2013-02-01 2014-08-07 Glaxosmithkline Biologicals Sa Intradermal delivery of immunological compositions comprising toll-like receptor agonists
JP6446377B2 (ja) 2013-03-08 2018-12-26 ファイザー・インク 免疫原性融合ポリペプチド
KR20150121265A (ko) * 2013-03-18 2015-10-28 글락소스미스클라인 바이오로지칼즈 에스.에이. 치료 방법
KR102199096B1 (ko) 2013-09-08 2021-01-06 화이자 인코포레이티드 나이세리아 메닌지티디스 조성물 및 그의 방법
IN2014DE02450A (hr) 2013-09-25 2015-06-26 Suzuki Motor Corp
RU2535122C1 (ru) * 2013-11-06 2014-12-10 Федеральное казенное учреждение здравоохранения "Российский научно-исследовательский противочумный институт "Микроб" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека ("РосНИПЧИ "Микроб") Способ получения холерогена-анатоксина
US11160855B2 (en) 2014-01-21 2021-11-02 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
CA3206112A1 (en) * 2014-01-21 2015-07-30 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
EP2921856B1 (en) 2014-03-18 2016-09-14 Serum Institute Of India Private Limited A quantitative assay for 4-pyrrolidinopyridine (4-ppy) in polysaccharide-protein conjugate vaccines
WO2015158898A2 (en) * 2014-04-17 2015-10-22 Medizinische Hochschule Hannover Means and methods for producing neisseria meningitidis capsular polysaccharides of low dispersity
WO2016132294A1 (en) 2015-02-19 2016-08-25 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
WO2017013548A1 (en) * 2015-07-21 2017-01-26 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof
US20170333546A1 (en) * 2015-12-08 2017-11-23 Jl Medical Corporation Method for Producing and Vaccine Composition of Neisseria Meningitidis Serogroups A, C, Y, and W-135 Oligosaccharides Conjugated to Glycan-Free Carrier Protein
RU2758090C2 (ru) * 2016-03-15 2021-10-26 Мсд Уэлком Траст Хиллеман Лабораторис Пвт. Лтд. Новые конъюгаты полисахарида с белком и способ их получения
EP3506935B1 (en) * 2016-09-02 2024-01-10 Sanofi Pasteur, Inc. Neisseria meningitidis vaccine
EP3506933A2 (en) 2016-09-02 2019-07-10 GlaxoSmithKline Biologicals SA Vaccines for neisseria gonorrhoeae
IL265109B2 (en) 2016-09-13 2024-05-01 Allergan Inc Stabilized Clostridium toxin preparations without protein
CN109922828A (zh) * 2016-10-20 2019-06-21 Km生物医药股份公司 使用具有降低了的分子量的PRP的Hib结合疫苗的制造方法
BR112019013475A2 (pt) 2016-12-30 2020-02-27 Sutrovax, Inc. Conjugados de polipeptídeo-antígeno com aminoácidos não naturais
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
PE20191107A1 (es) 2017-01-31 2019-08-26 Pfizer Composiciones de neisseria meningitidis y metodos respectivos
EP3678652A4 (en) 2017-09-07 2021-05-19 Merck Sharp & Dohme Corp. ANTIPNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN POLYSACCHARIDE-CARRIER PROTEIN IMMUNOGENIC CONJUGATES
US11524076B2 (en) 2017-09-07 2022-12-13 Merck Sharp & Dohme Llc Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
US20200353064A1 (en) * 2018-01-29 2020-11-12 Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. Novel meningococcal vaccine composition and process thereof
WO2019198096A1 (en) * 2018-04-11 2019-10-17 Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. Tetravalent meningococcal vaccine composition and process to prepare thereof
JOP20200214A1 (ar) 2019-09-03 2021-03-03 Serum Institute Of India Pvt Ltd تركيبات مولدة للمناعة ضد الأمراض المعوية وطرق لتحضيرها
WO2021099982A1 (en) 2019-11-22 2021-05-27 Glaxosmithkline Biologicals Sa Dosage and administration of a bacterial saccharide glycoconjugate vaccine
EP4243862A1 (en) 2020-11-13 2023-09-20 GlaxoSmithKline Biologicals SA Bacterial protein carriers and conjugation methods
RU2770877C1 (ru) * 2021-04-08 2022-04-22 Федеральное бюджетное учреждение науки "Ростовский научно-исследовательский институт микробиологии и паразитологии" Способ получения антигенной конъюгированной субстанции гемофильного типа b микроба для создания вакцинных препаратов
GB202215414D0 (en) 2022-10-18 2022-11-30 Glaxosmithkline Biologicals Sa Vaccine

Family Cites Families (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB513069A (en) 1937-04-24 1939-10-03 Linde Air Prod Co Improvements in method of and apparatus for the treatment of metallic bodies by oxidising gas
GB505518A (en) 1938-02-03 1939-05-12 Daniel Morgan Skeins Improvements in or relating to envelopes
US4057685A (en) 1972-02-02 1977-11-08 Abbott Laboratories Chemically modified endotoxin immunizing agent
US4123520A (en) * 1977-08-01 1978-10-31 Merck & Co., Inc. Method for preparing high molecular weight meningococcal Group C vaccine
DE2748132A1 (de) * 1977-10-27 1979-05-03 Behringwerke Ag Stabilisator fuer polysaccharid
US4235994A (en) * 1978-06-26 1980-11-25 Merck & Co., Inc. High molecular weight meningococcal group C vaccine and method for preparation thereof
US4235877A (en) 1979-06-27 1980-11-25 Merck & Co., Inc. Liposome particle containing viral or bacterial antigenic subunit
EP0027888B1 (en) 1979-09-21 1986-04-16 Hitachi, Ltd. Semiconductor switch
DE3040825A1 (de) * 1980-10-30 1982-09-09 Dr. Karl Thomae Gmbh, 7950 Biberach Neues tridekapeptid, verfahren zu seiner herstellung und verwendung
US4673574A (en) 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
US4459286A (en) * 1983-01-31 1984-07-10 Merck & Co., Inc. Coupled H. influenzae type B vaccine
HU193083B (en) * 1984-02-22 1987-08-28 Sandoz Ag Process for preparing diazepinoindole derivatives further pharmaceutical compositions containing such compounds
US4695624A (en) 1984-05-10 1987-09-22 Merck & Co., Inc. Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
US4808700A (en) 1984-07-09 1989-02-28 Praxis Biologics, Inc. Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
US4709017A (en) 1985-06-07 1987-11-24 President And Fellows Of Harvard College Modified toxic vaccines
IT1187753B (it) 1985-07-05 1987-12-23 Sclavo Spa Coniugati glicoproteici ad attivita' immunogenica trivalente
DE3526940A1 (de) 1985-07-27 1987-02-12 Siegfried Fricker Anker zum einbetonieren in schwere lasten
IL78929A0 (en) 1985-07-29 1986-09-30 Abbott Lab Microemulsion compositions for parenteral administration
US4727136A (en) 1985-10-01 1988-02-23 Canadian Patents And Development Ltd. Modified meningococcal group B polysaccharide for conjugate vaccine
US4950740A (en) 1987-03-17 1990-08-21 Cetus Corporation Recombinant diphtheria vaccines
RU2023448C1 (ru) 1987-07-30 1994-11-30 Сентро Насьональ Де Биопрепарадос Способ получения вакцины против различных патогенных серотипов менингита нейссера группы в
US5180815A (en) * 1988-04-13 1993-01-19 Fuji Photo Film Co., Ltd. Modified protein for carrying hapten
JPH03504564A (ja) 1988-05-31 1991-10-09 ベアトリーセ　ケーニッヒ‐ハウク 棚装置
DE3841091A1 (de) 1988-12-07 1990-06-13 Behringwerke Ag Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung
DE68907045T2 (de) 1989-01-17 1993-12-02 Eniricerche Spa Synthetische Peptide und deren Verwendung als allgemeine Träger für die Herstellung von immunogenischen Konjugaten, die für die Entwicklung von synthetischen Impfstoffen geeignet sind.
AU651949B2 (en) 1989-07-14 1994-08-11 American Cyanamid Company Cytokine and hormone carriers for conjugate vaccines
IT1237764B (it) 1989-11-10 1993-06-17 Eniricerche Spa Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici.
DK0504202T3 (da) 1989-12-14 1995-10-02 Ca Nat Research Council Forbedret meningokok-polysaccharid-konjugat vaccine
SE466259B (sv) 1990-05-31 1992-01-20 Arne Forsgren Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
ATE128628T1 (de) 1990-08-13 1995-10-15 American Cyanamid Co Faser-hemagglutinin von bordetella pertussis als träger für konjugierten impfstoff.
US5153312A (en) 1990-09-28 1992-10-06 American Cyanamid Company Oligosaccharide conjugate vaccines
CA2059693C (en) 1991-01-28 2003-08-19 Peter J. Kniskern Polysaccharide antigens from streptococcus pneumoniae
CA2059692C (en) 1991-01-28 2004-11-16 Peter J. Kniskern Pneumoccoccal polysaccharide conjugate vaccine
GB2264352A (en) 1992-01-31 1993-08-25 Richards Eng Ltd Incineration apparatus
ATE245446T1 (de) 1992-02-11 2003-08-15 Jackson H M Found Military Med Dualer träger für immunogene konstrukte
IT1262896B (it) 1992-03-06 1996-07-22 Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini.
ATE178907T1 (de) * 1992-05-06 1999-04-15 Harvard College Rezeptorbindende region des diphtherietoxius
JP3626996B2 (ja) 1992-05-23 2005-03-09 グラクソスミスクライン・バイオロジカルス・ソシエテ・アノニム Ｂ型肝炎表面抗原および他の抗原からなる複合ワクチン
IL102687A (en) 1992-07-30 1997-06-10 Yeda Res & Dev Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them
EP0594950B1 (en) 1992-10-27 1999-01-27 American Cyanamid Company Combination pediatric vaccine with enhanced immunogenicity of each vaccine component
CA2128895C (en) 1992-12-14 1999-04-13 John M. Crowell Removable piston bore liner for hydraulically actuated seismic vibrator
ATE254475T1 (de) 1993-09-22 2003-12-15 Jackson H M Found Military Med Verfahren zur aktivierung von löslichem kohlenhydraten durch verwendung von neuen cyanylierungsreagenzien, zur herstellung von immunogenischen konstrukten
US5849301A (en) * 1993-09-22 1998-12-15 Henry M. Jackson Foundation For The Advancement Of Military Medicine Producing immunogenic constructs using soluable carbohydrates activated via organic cyanylating reagents
DE4416166C2 (de) * 1994-05-06 1997-11-20 Immuno Ag Stabiles Präparat zur Behandlung von Blutgerinnungsstörungen
US5869058A (en) 1994-05-25 1999-02-09 Yeda Research And Development Co. Ltd. Peptides used as carriers in immunogenic constructs suitable for development of synthetic vaccines
US6455673B1 (en) 1994-06-08 2002-09-24 President And Fellows Of Harvard College Multi-mutant diphtheria toxin vaccines
US5917017A (en) 1994-06-08 1999-06-29 President And Fellows Of Harvard College Diphtheria toxin vaccines bearing a mutated R domain
GB9422096D0 (en) 1994-11-02 1994-12-21 Biocine Spa Combined meningitis vaccine
WO1996029094A1 (en) 1995-03-22 1996-09-26 Andrew Lees Producing immunogenic constructs using soluble carbohydrates activated via organic cyanylating reagents
HUP9802199A3 (en) † 1995-06-07 1999-07-28 Smithkline Beecham Biolog Vaccine comprising a polysaccharide antigen-carrier protein conjugate and free carrier protein and use of
AP812A (en) 1995-06-23 2000-02-24 Smithkline Biologicals S A A vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate.
SE9601158D0 (sv) 1996-03-26 1996-03-26 Stefan Svenson Method of producing immunogenic products and vaccines
EP1271490B1 (en) 1996-10-23 2011-12-21 Panasonic Corporation Optical disk
AU6909098A (en) 1996-10-31 1998-05-22 Human Genome Sciences, Inc. Streptococcus pneumoniae polynucleotides and sequences
WO1998026799A1 (en) 1996-12-18 1998-06-25 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Conjugate vaccine for salmonella paratyphi a
US6299881B1 (en) 1997-03-24 2001-10-09 Henry M. Jackson Foundation For The Advancement Of Military Medicine Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts
FR2763244B1 (fr) 1997-05-14 2003-08-01 Pasteur Merieux Serums Vacc Composition vaccinale multivalente a porteur mixte
GB9713156D0 (en) 1997-06-20 1997-08-27 Microbiological Res Authority Vaccines
GB9717953D0 (en) 1997-08-22 1997-10-29 Smithkline Beecham Biolog Vaccine
EP1028750B1 (en) 1997-09-15 2006-02-01 Sanofi Pasteur MSD Method for preparing multivalent vaccines
WO1999013905A1 (en) 1997-09-18 1999-03-25 The Trustees Of The University Of Pennsylvania Receptor-binding pocket mutants of influenza a virus hemagglutinin for use in targeted gene delivery
US5965714A (en) * 1997-10-02 1999-10-12 Connaught Laboratories, Inc. Method for the covalent attachment of polysaccharides to protein molecules
US7018637B2 (en) 1998-02-23 2006-03-28 Aventis Pasteur, Inc Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
CA2264970A1 (en) 1998-03-10 1999-09-10 American Cyanamid Company Antigenic conjugates of conserved lipolysaccharides of gram negative bacteria
GB9806456D0 (en) 1998-03-25 1998-05-27 Smithkline Beecham Biolog Vaccine composition
GB9808932D0 (en) 1998-04-27 1998-06-24 Chiron Spa Polyepitope carrier protein
JP2002513028A (ja) * 1998-04-28 2002-05-08 ガレニカ ファーマシューティカルズ， インコーポレイテッド ポリサッカリド抗原結合体
DE69941574D1 (de) 1998-08-19 2009-12-03 Baxter Healthcare Sa Immunogenes beta-propionamido-gebundenes polysaccharid-protein konjugat geeignet als impfstoff und hergestellt bei verwendung von n-acryloyliertem polysaccharid
WO2000033882A1 (en) † 1998-12-04 2000-06-15 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services A vi-repa conjugate vaccine for immunization against salmonella typhi
WO2000037105A2 (en) 1998-12-21 2000-06-29 Medimmune, Inc. Streptococcus pneumoniae proteins and immunogenic fragments for vaccines
US6146902A (en) * 1998-12-29 2000-11-14 Aventis Pasteur, Inc. Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions
EP2286792A1 (en) 1999-02-26 2011-02-23 Novartis Vaccines and Diagnostics, Inc. Microemulsions with an adsorbent surface, comprising a microdroplet emulsion
EP1162999B1 (en) 1999-03-19 2006-11-29 Glaxosmithkline Biologicals S.A. Vaccine against Streptococcus pneumoniae
CA2365914A1 (en) 1999-04-09 2000-10-19 Techlab, Inc. Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines
CA2370887A1 (en) * 1999-06-25 2001-01-04 Benjamin J. Metcalf Production of the lipidated form of the peptidoglycan-associated lipoproteins of gram-negative bacteria
GB9918319D0 (en) 1999-08-03 1999-10-06 Smithkline Beecham Biolog Vaccine composition
GB9925559D0 (en) 1999-10-28 1999-12-29 Smithkline Beecham Biolog Novel method
EP1233784B1 (en) 1999-12-02 2008-07-09 Novartis Vaccines and Diagnostics, Inc. Compositions and methods for stabilizing biological molecules upon lyophilization
FR2806304B1 (fr) * 2000-03-17 2002-05-10 Aventis Pasteur Conjugues polysaccharidiques du pneumocoque a usage vaccinal contre le tetanos et la diphterie
GB0007432D0 (en) 2000-03-27 2000-05-17 Microbiological Res Authority Proteins for use as carriers in conjugate vaccines
GB0108364D0 (en) * 2001-04-03 2001-05-23 Glaxosmithkline Biolog Sa Vaccine composition
DK1946769T3 (da) * 2000-06-29 2012-07-16 Smithkline Beecham Biolog Multivalent vaccinesammensætning med nedsat dosis af Haemophilus influenzae type B
MXPA03000822A (es) * 2000-07-27 2004-11-01 Childrens Hosp & Res Ct Oak Vacunas para proteccion de espectro amplio contra enfermedades causadas por neisseria meningitidis.
GB0103170D0 (en) 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
AU2002214127B2 (en) 2000-10-27 2007-06-07 J. Craig Venter Institute, Inc. Nucleic acids and proteins from streptococcus groups A and B
PT1355673E (pt) * 2001-01-23 2012-08-31 Sanofi Pasteur Inc Vacina meningocócica multivalente preparada com um conjugado de polissacárido e proteína
GB0107658D0 (en) * 2001-03-27 2001-05-16 Chiron Spa Streptococcus pneumoniae
GB0107661D0 (en) * 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
AU2002309706A1 (en) 2001-05-11 2002-11-25 Aventis Pasteur, Inc. Novel meningitis conjugate vaccine
US6615062B2 (en) 2001-05-31 2003-09-02 Infraredx, Inc. Referencing optical catheters
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
GB0118249D0 (en) * 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
AR045702A1 (es) * 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
MX339524B (es) * 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
CU23031A1 (es) * 2002-01-24 2005-02-23 Ct Ingenieria Genetica Biotech Antigeno de superficie del virus de la hepatitis b como inmunopotenciador mucosal, formulaciones resultantes
CN100593544C (zh) * 2002-03-15 2010-03-10 惠氏控股有限公司 酶活性减少的非典型流感嗜血杆菌的p4蛋白突变体
MXPA04009339A (es) * 2002-03-26 2005-01-25 Chiron Srl Sacaridos modificados que tienen estabilidad mejorada en agua.
GB0210128D0 (en) * 2002-05-02 2002-06-12 Chiron Spa Nucleic acids and proteins from streptococcus groups A & B
GB0302218D0 (en) * 2003-01-30 2003-03-05 Chiron Sri Vaccine formulation & Mucosal delivery
ATE513560T1 (de) 2002-05-14 2011-07-15 Novartis Vaccines & Diagnostic Kombinationsimpfstoff gegen bakterielle meningitis, der über die schleimhaut appliziert wird
DE60328481D1 (de) * 2002-05-14 2009-09-03 Novartis Vaccines & Diagnostic Schleimhautapplizierter impfstoff, der das adjuvanz chitosan und menigokokkenantigene enthält
GB0211118D0 (en) * 2002-05-15 2002-06-26 Polonelli Luciano Vaccines
US20040096461A1 (en) 2002-07-30 2004-05-20 Baxter Healthcare Corporation Chimeric multivalent polysaccharide conjugate vaccines
GB0220199D0 (en) * 2002-08-30 2002-10-09 Univ Utrecht Mutant protein and refolding method
PL375408A1 (en) 2002-08-02 2005-11-28 Glaxosmithkline Biologicals S.A. Vaccine composition comprising transferrin binding protein and hsf from gram negative bacteria
GB0220194D0 (en) 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
HUE031886T2 (en) * 2002-10-11 2017-08-28 Glaxosmithkline Biologicals Sa Polypeptide vaccines for extensive protection against hypervirulent meningococcal lines
CN1401328A (zh) 2002-10-18 2003-03-12 北京绿竹生物技术有限责任公司 流行性脑脊髓膜炎多糖－蛋白结合疫苗
JP2006504801A (ja) * 2002-11-01 2006-02-09 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 乾燥方法
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
CN1168501C (zh) 2002-12-27 2004-09-29 北京绿竹生物技术有限责任公司 一种多糖-蛋白结合疫苗
CA3042073C (en) * 2003-01-30 2022-09-13 Novartis Vaccines And Diagnostics S.R.L. Injectable vaccines against multiple meningococcal serogroups
RU2340627C2 (ru) * 2003-03-13 2008-12-10 ГлаксоСмитКлайн Байолоджикалз с.а. Способ очистки бактериального цитолизина
EP1603950A2 (en) 2003-03-17 2005-12-14 Wyeth Holdings Corporation Mutant cholera holotoxin as an adjuvant and an antigen carrier protein
US20050002957A1 (en) * 2003-05-07 2005-01-06 Ryall Robert P. Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine
JP5557415B2 (ja) 2003-06-02 2014-07-23 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 吸着させたトキソイドおよび多糖類含有抗原を含む微粒子に基づく免疫原性組成物
GB0313916D0 (en) * 2003-06-16 2003-07-23 Glaxosmithkline Biolog Sa Vaccine composition
AU2004251742A1 (en) 2003-06-23 2005-01-06 Sanofi Pasteur, Inc. Immunization method against Neisseria meningitidis serogroups A and C
KR101034055B1 (ko) 2003-07-18 2011-05-12 엘지이노텍 주식회사 발광 다이오드 및 그 제조방법
US8048432B2 (en) * 2003-08-06 2011-11-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Polysaccharide-protein conjugate vaccines
WO2005014037A2 (en) * 2003-08-06 2005-02-17 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Polysaccharide-protein conjugate vaccines
JP2007502980A (ja) * 2003-08-21 2007-02-15 アプレラ コーポレイション Ｍａｌｄｉ質量分析法のためのマトリックス干渉の軽減
ES2346314T3 (es) * 2003-10-02 2010-10-14 Glaxosmithkline Biolog Sa Antigenos de b. pertussis y uso de los mismos en vacunacion.
WO2005032583A2 (en) * 2003-10-02 2005-04-14 Chiron Srl Liquid vaccines for multiple meningococcal serogroups
US7628995B2 (en) 2003-12-23 2009-12-08 Glaxosmithkline Biologicals S.A. Outer membrane vesicles and uses thereof
GB0405787D0 (en) 2004-03-15 2004-04-21 Chiron Srl Low dose vaccines
CA2561914C (en) * 2004-04-05 2013-09-10 Pfizer Products Inc. Microfluidized oil-in-water emulsions and vaccine compositions
GB0409745D0 (en) * 2004-04-30 2004-06-09 Chiron Srl Compositions including unconjugated carrier proteins
GB0500787D0 (en) 2005-01-14 2005-02-23 Chiron Srl Integration of meningococcal conjugate vaccination
RU2379052C2 (ru) * 2004-04-30 2010-01-20 Чирон С.Р.Л. Вакцинация менингококковыми конъюгатами
GB0413868D0 (en) * 2004-06-21 2004-07-21 Chiron Srl Dimensional anlaysis of saccharide conjugates
EP2305294B1 (en) * 2004-09-22 2015-04-01 GlaxoSmithKline Biologicals SA Immunogenic composition for use in vaccination against staphylococcei
US20060121055A1 (en) * 2004-12-06 2006-06-08 Becton, Dickinson And Company, Inc. Compositions with enhanced immunogenicity
GB0428394D0 (en) * 2004-12-24 2005-02-02 Chiron Srl Saccharide conjugate vaccines
GB0502095D0 (en) * 2005-02-01 2005-03-09 Chiron Srl Conjugation of streptococcal capsular saccharides
EP2351772B1 (en) 2005-02-18 2016-07-13 GlaxoSmithKline Biologicals SA Proteins and nucleic acids from meningitis/sepsis-associated Escherichia coli
GB0505518D0 (en) * 2005-03-17 2005-04-27 Chiron Srl Combination vaccines with whole cell pertussis antigen
KR101730748B1 (ko) 2005-04-08 2017-04-26 와이어쓰 엘엘씨 다가 폐렴구균 다당류-단백질 접합체 조성물
US20070184072A1 (en) * 2005-04-08 2007-08-09 Wyeth Multivalent pneumococcal polysaccharide-protein conjugate composition
RU2412944C2 (ru) * 2005-05-06 2011-02-27 Новартис Вэксинз Энд Дайагностикс Срл Иммуногены для вакцин против менингита а
PE20070163A1 (es) * 2005-06-27 2007-03-01 Glaxosmithkline Biolog Sa Composicion inmunogenica de conjugados de sacaridos de n. meningitidis
CN1709505B (zh) 2005-07-13 2010-06-16 北京绿竹生物制药有限公司 多价细菌荚膜多糖-蛋白质结合物联合疫苗
JP5135220B2 (ja) * 2005-09-01 2013-02-06 ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー 血清群ｃ髄膜炎菌を含む複数ワクチン接種
ES2353516T3 (es) * 2005-09-05 2011-03-02 Glaxosmithkline Biologicals S.A. Ensayo bactericida del suero para antisueros específicos de n. meningitidis.
GB0522765D0 (en) * 2005-11-08 2005-12-14 Chiron Srl Combination vaccine manufacture
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
DK3017827T3 (en) * 2005-12-22 2019-02-18 Glaxosmithkline Biologicals Sa Pneumococcal polysaccharide conjugate VACCINE
EP1940462A2 (en) 2005-12-23 2008-07-09 GlaxoSmithKline Biologicals S.A. Conjugate vaccines
EP1993604B1 (en) * 2006-03-17 2015-12-02 The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services Methods for preparing complex multivalent immunogenic conjugates
AR060187A1 (es) * 2006-03-30 2008-05-28 Glaxosmithkline Biolog Sa Composicion inmunogenica
EA015833B1 (ru) * 2006-03-30 2011-12-30 Глаксосмитклайн Байолоджикалс С.А. Иммуногенная композиция
US8039007B2 (en) * 2006-06-29 2011-10-18 J. Craig Venter Institute, Inc. Polypeptides from Neisseria meningitidis
US7491517B2 (en) 2006-07-19 2009-02-17 Jeeri R Reddy Method of producing meningococcal meningitis vaccine for Neisseria meningitidis serotypes A,C,Y, and W-135
ZA200900379B (en) 2006-07-21 2010-08-25 Univ California Human endogenous retrovirus polypeptide compositions and methods of use thereof
MX2009002561A (es) * 2006-09-07 2009-03-20 Glaxosmithkline Biolog Sa Vacuna.
GB0700136D0 (en) * 2007-01-04 2007-02-14 Glaxosmithkline Biolog Sa Process for manufacturing vaccines
GB0700135D0 (en) 2007-01-04 2007-02-14 Glaxosmithkline Biolog Sa Vaccine
US8885224B2 (en) 2007-03-14 2014-11-11 Konica Minolta Business Technologies, Inc. Information embedding method, its program and information embedding device
WO2008135514A1 (en) * 2007-05-02 2008-11-13 Glaxosmithkline Biologicals S.A. Vaccine
AU2008259423A1 (en) 2007-06-04 2008-12-11 Novartis Ag Formulation of meningitis vaccines
WO2009000826A1 (en) * 2007-06-26 2008-12-31 Glaxosmithkline Biologicals S.A. Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates
GB0714963D0 (en) 2007-08-01 2007-09-12 Novartis Ag Compositions comprising antigens
EP2328613A1 (en) 2008-08-28 2011-06-08 GlaxoSmithKline Biologicals S.A. Vaccine
GB0816447D0 (en) * 2008-09-08 2008-10-15 Glaxosmithkline Biolog Sa Vaccine
US8259461B2 (en) * 2008-11-25 2012-09-04 Micron Technology, Inc. Apparatus for bypassing faulty connections
US8974799B2 (en) * 2009-09-30 2015-03-10 Novartis Ag Conjugation of Staphylococcus aureus type 5 and type 8 capsular polysaccharides
TW201136603A (en) * 2010-02-09 2011-11-01 Merck Sharp & Amp Dohme Corp 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition
GB201003922D0 (en) * 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
CA2792691A1 (en) * 2010-03-11 2011-09-15 Glaxosmithkline Biologicals S.A. Immunogenic composition or vaccine against gram-negative bacterial, for example, neisserial, infection or disease
JP5144836B2 (ja) * 2010-06-11 2013-02-13 パナソニック株式会社 語音聴取の評価システム、その方法およびそのプログラム
EP2776069A1 (en) * 2011-11-07 2014-09-17 Novartis AG Carrier molecule comprising a spr0096 and a spr2021 antigen
GB2495341B (en) * 2011-11-11 2013-09-18 Novartis Ag Fermentation methods and their products
TR201900778T4 (tr) * 2012-01-30 2019-02-21 Serum Institute Of India Private Ltd İmmünojenik bileşim.
AU2013265336A1 (en) * 2012-05-22 2014-12-04 Novartis Ag Meningococcus serogroup X conjugate
WO2014001328A1 (en) 2012-06-25 2014-01-03 Nadiro A/S A lifeboat deployment unit
SI2928489T1 (sl) * 2012-12-05 2019-05-31 Glaxosmithkline Biologicals S.A. Imunogeni sestavek
GB201310008D0 (en) * 2013-06-05 2013-07-17 Glaxosmithkline Biolog Sa Immunogenic composition for use in therapy
EA201790239A1 (ru) * 2014-08-05 2017-07-31 Глаксосмитклайн Байолоджикалс С.А. Молекула-носитель для антигенов
TWI715617B (zh) * 2015-08-24 2021-01-11 比利時商葛蘭素史密斯克藍生物品公司 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物
GB201518684D0 (en) * 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
EP3506935B1 (en) * 2016-09-02 2024-01-10 Sanofi Pasteur, Inc. Neisseria meningitidis vaccine
US11951165B2 (en) * 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
PE20191107A1 (es) * 2017-01-31 2019-08-26 Pfizer Composiciones de neisseria meningitidis y metodos respectivos
US11179453B2 (en) * 2017-07-18 2021-11-23 Serum Institute Of India Pvt Ltd Immunogenic composition having improved stability, enhanced immunogenicity and reduced reactogenicity and process for preparation thereof

Also Published As

Publication number Publication date
NZ564371A (en) 2010-05-28
CN103083657A (zh) 2013-05-08
BRPI0612669B1 (pt) 2019-08-13
HUE046905T2 (hu) 2020-03-30
MA29993B1 (fr) 2008-12-01
FR22C1008I2 (fr) 2024-01-19
JP5965512B2 (ja) 2016-08-03
IL213795A (en) 2013-05-30
EA012528B1 (ru) 2009-10-30
MY147783A (en) 2013-01-31
AU2006263944A1 (en) 2007-01-04
US20090136541A1 (en) 2009-05-28
CA2612963A1 (en) 2007-01-04
EA012214B1 (ru) 2009-08-28
EP1896061B1 (en) 2019-06-12
CA2612957C (en) 2016-07-19
EA200702576A1 (ru) 2008-06-30
US20090041802A1 (en) 2009-02-12
TW200730187A (en) 2007-08-16
NO20076302L (no) 2008-03-26
PL2878307T3 (pl) 2020-01-31
EA200702577A1 (ru) 2008-06-30
KR20080024222A (ko) 2008-03-17
PE20110072A1 (es) 2011-02-04
US20180064806A1 (en) 2018-03-08
EP3009146B1 (en) 2021-10-20
PL1896062T3 (pl) 2010-08-31
EP1896062A1 (en) 2008-03-12
CN103083657B (zh) 2016-06-08
BE2012C042I2 (hr) 2021-07-19
PL2283857T3 (pl) 2020-02-28
US20080199490A1 (en) 2008-08-21
HK1116414A1 (en) 2008-12-24
PE20070499A1 (es) 2007-05-21
TW201336507A (zh) 2013-09-16
ES2340711T3 (es) 2010-06-08
US9789179B2 (en) 2017-10-17
ES2750243T3 (es) 2020-03-25
ES2621780T3 (es) 2017-07-05
BRPI0612670B1 (pt) 2020-04-28
AR056396A1 (es) 2007-10-10
NZ564370A (en) 2011-10-28
PE20070123A1 (es) 2007-02-08
MY148110A (en) 2013-02-28
ES2377075T3 (es) 2012-03-22
AU2010203115C1 (en) 2013-05-02
DK2283857T3 (da) 2019-10-28
KR101408113B1 (ko) 2014-06-16
HRP20110567T1 (hr) 2011-09-30
KR20080018216A (ko) 2008-02-27
PT2351578T (pt) 2017-04-07
ATE516816T1 (de) 2011-08-15
IL213718A0 (en) 2011-07-31
PL1896065T5 (pl) 2014-12-31
JP5769688B2 (ja) 2015-08-26
MA29602B1 (fr) 2008-07-01
CN102526723A (zh) 2012-07-04
HUS1200023I1 (hu) 2021-03-29
MX2007016405A (es) 2008-03-07
PT3009146T (pt) 2021-11-30
DK1896063T3 (da) 2012-03-19
EP1896066B8 (en) 2022-01-19
EP1896065B1 (en) 2011-07-20
EP1896061A2 (en) 2008-03-12
EP2283857A1 (en) 2011-02-16
NO20076350L (no) 2008-03-26
CY1109996T1 (el) 2014-09-10
PL1896065T3 (pl) 2011-12-30
PT2878307T (pt) 2019-10-24
WO2007000322A1 (en) 2007-01-04
PT2283857T (pt) 2019-10-24
EP2351578A1 (en) 2011-08-03
KR20130086087A (ko) 2013-07-30
BRPI0612655A8 (pt) 2018-01-30
DK2878307T3 (da) 2019-10-07
BRPI0612669A2 (pt) 2010-11-30
CY1112698T1 (el) 2016-02-10
TW201414490A (zh) 2014-04-16
KR101351873B1 (ko) 2014-02-17
IL214657A0 (en) 2011-09-27
JP2008543905A (ja) 2008-12-04
US8846049B2 (en) 2014-09-30
EP1896064A2 (en) 2008-03-12
JP5037503B2 (ja) 2012-09-26
EP2351578B1 (en) 2017-01-18
BRPI0612655A2 (pt) 2010-11-30
PE20110096A1 (es) 2011-03-07
MA29569B1 (fr) 2008-06-02
HUE045482T2 (hu) 2019-12-30
EP1896066A2 (en) 2008-03-12
AR053935A1 (es) 2007-05-23
JP5280199B2 (ja) 2013-09-04
AU2006263963A1 (en) 2007-01-04
US10166287B2 (en) 2019-01-01
NL300549I2 (hr) 2017-01-03
FR22C1008I1 (fr) 2022-04-29
EP1896062B1 (en) 2010-03-31
IL188072A0 (en) 2008-03-20
ATE536884T1 (de) 2011-12-15
EP3009146A1 (en) 2016-04-20
US20150044253A1 (en) 2015-02-12
LU92085I2 (fr) 2012-12-19
SI2878307T1 (sl) 2019-11-29
US8883163B2 (en) 2014-11-11
EP1896063B2 (en) 2016-03-02
ES2901378T3 (es) 2022-03-22
KR20080030577A (ko) 2008-04-04
WO2007000314A3 (en) 2007-05-31
CA2611964A1 (en) 2007-01-04
EP2878307B1 (en) 2019-07-24
EA012506B1 (ru) 2009-10-30
ES2377075T5 (es) 2016-04-29
WO2007000343A3 (en) 2007-05-31
PL2351578T3 (pl) 2017-07-31
PE20070163A1 (es) 2007-03-01
HRP20110567T4 (en) 2015-01-16
AU2006263936B2 (en) 2010-05-20
EP2878307A1 (en) 2015-06-03
US8329184B2 (en) 2012-12-11
AU2006263965A1 (en) 2007-01-04
KR101321056B1 (ko) 2013-10-30
CY2012027I2 (el) 2015-10-07
PT1896062E (pt) 2010-05-17
BRPI0612654A2 (pt) 2012-10-02
AU2010212417A1 (en) 2010-09-09
AU2010203115A1 (en) 2010-08-12
US9931397B2 (en) 2018-04-03
MX2007016236A (es) 2008-03-07
US20190298822A1 (en) 2019-10-03
HK1206587A1 (en) 2016-01-15
ES2747025T3 (es) 2020-03-09
JP2015134829A (ja) 2015-07-27
IL188045A0 (en) 2008-03-20
MX2007016402A (es) 2008-03-07
MY147490A (en) 2012-12-14
JP5297800B2 (ja) 2013-09-25
US20100215686A1 (en) 2010-08-26
NO342815B1 (no) 2018-08-13
IL188046A0 (en) 2008-03-20
PT1896065E (pt) 2011-08-31
SI2351578T1 (sl) 2017-05-31
TWI477283B (zh) 2015-03-21
IL222346A (en) 2015-07-30
WO2007000341A3 (en) 2007-05-31
CN102526723B (zh) 2017-07-07
EP2201961A1 (en) 2010-06-30
CA2611960C (en) 2015-05-05
JP5718960B2 (ja) 2015-05-13
CN102218138A (zh) 2011-10-19
KR20130122810A (ko) 2013-11-08
HUE047211T2 (hu) 2020-04-28
IL187924A0 (en) 2008-03-20
US8431136B2 (en) 2013-04-30
AU2006263944B2 (en) 2012-03-01
IL188072A (en) 2017-07-31
CA2611960A1 (en) 2007-01-04
ES2741529T3 (es) 2020-02-11
CA2612980A1 (en) 2007-01-04
IL187924A (en) 2011-11-30
IL213795A0 (en) 2011-07-31
JP2008543909A (ja) 2008-12-04
BRPI0612656A8 (pt) 2018-01-23
MX2007016237A (es) 2008-03-07
US20090252759A1 (en) 2009-10-08
ES2898451T3 (es) 2022-03-07
AU2006263965B2 (en) 2012-09-13
BRPI0612655B1 (pt) 2021-06-15
EP2201961B1 (en) 2018-01-24
BRPI0612656B1 (pt) 2021-09-08
CY1111827T1 (el) 2015-10-07
SI1896063T1 (sl) 2012-03-30
JP2008543907A (ja) 2008-12-04
JP5731737B2 (ja) 2015-06-10
US9486515B2 (en) 2016-11-08
JP2008543904A (ja) 2008-12-04
HUE031380T2 (en) 2017-07-28
WO2007000341A2 (en) 2007-01-04
WO2007000342A3 (en) 2007-05-31
WO2007000342A8 (en) 2008-07-10
EA200702575A1 (ru) 2008-06-30
CA2612957A1 (en) 2007-01-04
AU2006263964B2 (en) 2010-05-20
HK1116413A1 (en) 2008-12-24
AU2006263963B2 (en) 2010-05-13
ES2662651T3 (es) 2018-04-09
HUS000497I2 (hu) 2021-03-29
CA2611964C (en) 2016-11-08
JP2008543908A (ja) 2008-12-04
AU2006263964A1 (en) 2007-01-04
NO345422B1 (no) 2021-01-25
WO2007000343A2 (en) 2007-01-04
BRPI0612669B8 (pt) 2021-05-25
SI1896065T1 (sl) 2011-10-28
NO344452B1 (no) 2019-12-09
CY2012027I1 (el) 2015-10-07
BRPI0612670A2 (pt) 2010-11-30
SI1896062T1 (sl) 2010-07-30
EA200702574A1 (ru) 2008-06-30
AR056397A1 (es) 2007-10-10
HUS2200002I1 (hu) 2022-12-28
TW200738259A (en) 2007-10-16
PT1896061T (pt) 2019-08-01
SI1896065T2 (sl) 2014-12-31
BRPI0612654B1 (pt) 2021-05-04
MA29603B1 (fr) 2008-07-01
DK1896061T3 (da) 2019-08-26
BRPI0612656A2 (pt) 2010-11-30
HRP20100211T1 (hr) 2010-05-31
US10245317B2 (en) 2019-04-02
KR101532068B1 (ko) 2015-06-29
CA2612963C (en) 2016-10-18
BRPI0612654B8 (pt) 2021-05-25
IL188046A (en) 2012-03-29
HK1114011A1 (en) 2008-10-24
NO20076343L (no) 2008-03-25
DK1896065T4 (da) 2014-10-20
NZ590204A (en) 2012-02-24
WO2007000314A2 (en) 2007-01-04
DK1896065T3 (da) 2011-08-29
NZ564606A (en) 2010-10-29
DK1896062T3 (da) 2010-06-28
SI3009146T1 (sl) 2022-02-28
AU2006263936A1 (en) 2007-01-04
UA95238C2 (uk) 2011-07-25
PL1896063T3 (pl) 2012-04-30
DE602006013313D1 (de) 2010-05-12
NO345305B1 (no) 2020-12-07
EP2283857B1 (en) 2019-07-24
EP1896065A2 (en) 2008-03-12
KR101351870B1 (ko) 2014-02-17
HUE056842T2 (hu) 2022-03-28
US20130004532A1 (en) 2013-01-03
EA013374B1 (ru) 2010-04-30
PL1896061T3 (pl) 2020-02-28
TWI537001B (zh) 2016-06-11
PT1896063E (pt) 2012-02-13
WO2007000327A1 (en) 2007-01-04
PL3009146T3 (pl) 2022-02-07
LU92085I9 (hr) 2019-01-04
ATE462444T1 (de) 2010-04-15
EP1896066B1 (en) 2021-10-27
WO2007000342A2 (en) 2007-01-04
EP1896063A1 (en) 2008-03-12
MX2007016403A (es) 2008-03-07
IL213718A (en) 2013-07-31
NO20076363L (no) 2008-03-26
AP2007004274A0 (en) 2007-12-31
LT2351578T (lt) 2017-04-10
NZ564605A (en) 2011-01-28
EP1896063B1 (en) 2011-12-14
US9358279B2 (en) 2016-06-07
KR101359953B1 (ko) 2014-02-21
HRP20120102T1 (hr) 2012-02-29
JP2013209395A (ja) 2013-10-10
US11241495B2 (en) 2022-02-08
JP2013018798A (ja) 2013-01-31
NZ564607A (en) 2011-06-30
US20080193476A1 (en) 2008-08-14
DK2351578T3 (en) 2017-04-24
BRPI0612670B8 (pt) 2021-05-25
JP2013107913A (ja) 2013-06-06
KR20080025184A (ko) 2008-03-19
SI1896061T1 (sl) 2019-10-30
KR20080018226A (ko) 2008-02-27
AU2010203115B2 (en) 2012-03-15
AP2436A (en) 2012-08-31
UA95237C2 (uk) 2011-07-25
US20200000911A1 (en) 2020-01-02
US20130171188A1 (en) 2013-07-04
CY1118646T1 (el) 2017-07-12
TWI407970B (zh) 2013-09-11
EP1896065B2 (en) 2014-09-03
TWI422386B (zh) 2014-01-11
PE20142165A1 (es) 2015-01-09
US20170065714A1 (en) 2017-03-09
US8398983B2 (en) 2013-03-19
CA2612980C (en) 2019-01-15
SI2283857T1 (sl) 2019-11-29

Similar Documents

Publication Publication Date Title
HRP20170457T1 (hr) Postupak proizvodnje cjepiva
Frasch Preparation of bacterial polysaccharide–protein conjugates: Analytical and manufacturing challenges
HRP20161681T1 (hr) Cjepivo protiv bakterije streptococcus pneumoniae
HK1191567A1 (zh) 多價肺炎球菌多糖-蛋白質綴合物組合物
IL186367A (en) A conjugate compound of multi-value polyneural polysaccharide protein
WO2008079732A3 (en) Multivalent pneumococcal polysaccharide-protein conjugate composition
MX336934B (es) Composicion conjugada polisacarido-proteina neumococica multivalente.
AR040922A1 (es) Composicion inmunogenica multivalente, uso de la misma para la fabricacion de un medicamento y procedimiento para preparar dicha composicion inmunogenica multivalente
RU2013144555A (ru) Способ конъюгации
RU2007112794A (ru) Гликозилцерамидный адъювант для сахаридных антигенов
JP2018516962A5 (hr)
Duke et al. Emerging vaccine strategies against the incessant pneumococcal disease
Zou et al. Mitigating base-catalysed degradation of periodate-oxidized capsular polysaccharides: Conjugation by reductive amination in acidic media
CN104383531A (zh) 预防儿童脑膜炎的联合疫苗及其制备方法
Lees et al. Conjugation chemistry