EA201790239A1 - Молекула-носитель для антигенов - Google Patents
Молекула-носитель для антигеновInfo
- Publication number
- EA201790239A1 EA201790239A1 EA201790239A EA201790239A EA201790239A1 EA 201790239 A1 EA201790239 A1 EA 201790239A1 EA 201790239 A EA201790239 A EA 201790239A EA 201790239 A EA201790239 A EA 201790239A EA 201790239 A1 EA201790239 A1 EA 201790239A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- conjugate
- antigens
- antigen
- spb1
- mammal
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 5
- 102000036639 antigens Human genes 0.000 title abstract 5
- 108091007433 antigens Proteins 0.000 title abstract 5
- 241000124008 Mammalia Species 0.000 abstract 2
- 101150078778 SPB1 gene Proteins 0.000 abstract 2
- 241000193985 Streptococcus agalactiae Species 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
Abstract
В изобретении предложен конъюгат, содержащий антиген и молекулу-носитель, где указанная молекула-носитель содержит антиген ВР-2а и антиген spb1. BP-2a и spb1 представляют собой антигены Streptococcus agalactiae.Конъюгат может найти применение в способе индуцирования иммунного ответа у млекопитающего, включающем введение данного конъюгата млекопитающему. Также предложены фармацевтические композиции, в частности вакцины, содержащие конъюгат.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14179945 | 2014-08-05 | ||
PCT/EP2015/068012 WO2016020413A1 (en) | 2014-08-05 | 2015-08-05 | Carrier molecule for antigens |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201790239A1 true EA201790239A1 (ru) | 2017-07-31 |
Family
ID=51298571
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201790239A EA201790239A1 (ru) | 2014-08-05 | 2015-08-05 | Молекула-носитель для антигенов |
Country Status (16)
Country | Link |
---|---|
US (1) | US10245310B2 (ru) |
EP (1) | EP3177324A1 (ru) |
JP (1) | JP2017523985A (ru) |
KR (1) | KR20170039709A (ru) |
CN (1) | CN108064174A (ru) |
AR (1) | AR101455A1 (ru) |
AU (1) | AU2015299008B2 (ru) |
BE (1) | BE1022792B1 (ru) |
BR (1) | BR112017002183A2 (ru) |
CA (1) | CA2957118A1 (ru) |
EA (1) | EA201790239A1 (ru) |
IL (1) | IL250238A0 (ru) |
MX (1) | MX2017001638A (ru) |
SG (1) | SG11201700673RA (ru) |
WO (1) | WO2016020413A1 (ru) |
ZA (1) | ZA201700824B (ru) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8431136B2 (en) * | 2005-06-27 | 2013-04-30 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
US20210108002A1 (en) | 2016-12-06 | 2021-04-15 | Glaxosmithkline Biologicals Sa | Purification Process For Capsular Polysaccharide |
US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
CA3066020A1 (en) | 2017-06-16 | 2018-12-20 | Glaxosmithkline Biologicals Sa | Method of treatment |
WO2019217665A1 (en) * | 2018-05-09 | 2019-11-14 | West Virginia University | Iron-acquisition receptor peptide administration for vaccination against pseudomonas aeruginosa |
KR20210042904A (ko) * | 2018-07-04 | 2021-04-20 | 박사이트, 인코포레이티드 | 면역원성 접합체의 개선 |
WO2020010000A1 (en) * | 2018-07-04 | 2020-01-09 | Sutrovax, Inc. | Improved methods for the preparation of immunogenic conjugates |
CN108840914B (zh) * | 2018-08-13 | 2022-07-01 | 内蒙古民族大学 | 一种具有免疫原性的多肽、其抗体的制备方法以及用途 |
EA202192401A1 (ru) * | 2019-04-02 | 2022-03-30 | Ваксайт, Инк. | Оптимизированный бесклеточный синтез плазмидного антигена инвазии в и родственные композиции и способы применения |
CA3161857A1 (en) | 2019-11-22 | 2021-05-27 | Glaxosmithkline Biologicals Sa | Dosage and administration of a bacterial saccharide glycoconjugate vaccine |
US20230303637A1 (en) | 2020-06-12 | 2023-09-28 | Glaxosmithkline Biologicals Sa | Gbs ferritin nanoparticles |
WO2021250626A2 (en) * | 2020-06-12 | 2021-12-16 | Glaxosmithkline Biologicals Sa | Dock tag system |
CN112979797B (zh) * | 2021-04-28 | 2022-04-01 | 中国检验检疫科学研究院 | 一种抗赤羽病病毒单克隆抗体及其制备方法与应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008508320A (ja) * | 2004-07-29 | 2008-03-21 | カイロン コーポレイション | Streptococcusagalactiaeのようなグラム陽性細菌に対する免疫原性組成物 |
CA2591510A1 (en) * | 2004-12-22 | 2006-06-29 | Novartis Vaccines And Diagnostics, Inc. | Group b streptococcus |
GB0502095D0 (en) * | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
GB0605757D0 (en) * | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
WO2009027768A2 (en) * | 2006-07-26 | 2009-03-05 | Novartis Ag | Immunogenic compositions for gram positive bacteria |
GB0802503D0 (en) * | 2008-02-11 | 2008-03-19 | Novartis Ag | Hybrid polypeptide |
US8465751B2 (en) * | 2009-01-12 | 2013-06-18 | Novartis Ag | Cna—B domain antigens in vaccines against gram positive bacteria |
GB201003333D0 (en) * | 2010-02-26 | 2010-04-14 | Novartis Ag | Immunogenic proteins and compositions |
GB201005625D0 (en) * | 2010-04-01 | 2010-05-19 | Novartis Ag | Immunogenic proteins and compositions |
GB201114923D0 (en) * | 2011-08-30 | 2011-10-12 | Novartis Ag | Immunogenic proteins and compositions |
CA2865028A1 (en) * | 2012-02-24 | 2013-08-29 | Novartis Ag | Pilus proteins and compositions |
-
2015
- 2015-08-05 AR ARP150102512A patent/AR101455A1/es unknown
- 2015-08-05 CN CN201580053997.XA patent/CN108064174A/zh active Pending
- 2015-08-05 MX MX2017001638A patent/MX2017001638A/es unknown
- 2015-08-05 JP JP2017506294A patent/JP2017523985A/ja active Pending
- 2015-08-05 WO PCT/EP2015/068012 patent/WO2016020413A1/en active Application Filing
- 2015-08-05 BE BE2015/5496A patent/BE1022792B1/fr active
- 2015-08-05 SG SG11201700673RA patent/SG11201700673RA/en unknown
- 2015-08-05 EP EP15744610.5A patent/EP3177324A1/en not_active Withdrawn
- 2015-08-05 EA EA201790239A patent/EA201790239A1/ru unknown
- 2015-08-05 US US15/501,474 patent/US10245310B2/en active Active
- 2015-08-05 KR KR1020177005840A patent/KR20170039709A/ko unknown
- 2015-08-05 CA CA2957118A patent/CA2957118A1/en not_active Abandoned
- 2015-08-05 AU AU2015299008A patent/AU2015299008B2/en not_active Expired - Fee Related
- 2015-08-05 BR BR112017002183-8A patent/BR112017002183A2/pt not_active IP Right Cessation
-
2017
- 2017-01-23 IL IL250238A patent/IL250238A0/en unknown
- 2017-02-02 ZA ZA2017/00824A patent/ZA201700824B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2015299008B2 (en) | 2018-08-02 |
AU2015299008A1 (en) | 2017-02-23 |
US10245310B2 (en) | 2019-04-02 |
MX2017001638A (es) | 2017-04-27 |
AR101455A1 (es) | 2016-12-21 |
BE1022792B1 (fr) | 2016-09-06 |
BE1022792A1 (fr) | 2016-09-06 |
BR112017002183A2 (pt) | 2018-01-16 |
IL250238A0 (en) | 2017-03-30 |
KR20170039709A (ko) | 2017-04-11 |
SG11201700673RA (en) | 2017-02-27 |
CA2957118A1 (en) | 2016-02-11 |
US20170224803A1 (en) | 2017-08-10 |
EP3177324A1 (en) | 2017-06-14 |
JP2017523985A (ja) | 2017-08-24 |
WO2016020413A1 (en) | 2016-02-11 |
ZA201700824B (en) | 2019-07-31 |
CN108064174A (zh) | 2018-05-22 |
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