HRP20100211T1 - Imunogeni pripravak - Google Patents
Imunogeni pripravak Download PDFInfo
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- HRP20100211T1 HRP20100211T1 HR20100211T HRP20100211T HRP20100211T1 HR P20100211 T1 HRP20100211 T1 HR P20100211T1 HR 20100211 T HR20100211 T HR 20100211T HR P20100211 T HRP20100211 T HR P20100211T HR P20100211 T1 HRP20100211 T1 HR P20100211T1
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- saccharide
- immunogenic
- immunogenic preparation
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- 230000002163 immunogen Effects 0.000 title claims abstract 31
- 239000000203 mixture Substances 0.000 title claims abstract 8
- 150000001720 carbohydrates Chemical class 0.000 claims abstract 43
- 230000001580 bacterial effect Effects 0.000 claims abstract 16
- 238000002360 preparation method Methods 0.000 claims 27
- 229960005486 vaccine Drugs 0.000 claims 10
- 239000002775 capsule Substances 0.000 claims 7
- 229960000814 tetanus toxoid Drugs 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 229960003983 diphtheria toxoid Drugs 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 241000606768 Haemophilus influenzae Species 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 2
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims 2
- 101000597577 Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / CCUG 37298 / CIP 103539 / LMG 7603 / PAl5) Outer membrane protein Proteins 0.000 claims 2
- 201000009906 Meningitis Diseases 0.000 claims 2
- 101710183389 Pneumolysin Proteins 0.000 claims 2
- 101710188053 Protein D Proteins 0.000 claims 2
- 101710132893 Resolvase Proteins 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000003252 repetitive effect Effects 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 241000588832 Bordetella pertussis Species 0.000 claims 1
- 241000193449 Clostridium tetani Species 0.000 claims 1
- 241000186227 Corynebacterium diphtheriae Species 0.000 claims 1
- 241000991587 Enterovirus C Species 0.000 claims 1
- 241000700721 Hepatitis B virus Species 0.000 claims 1
- 241000588650 Neisseria meningitidis Species 0.000 claims 1
- 241001174901 Neisseria meningitidis alpha275 Species 0.000 claims 1
- 241000921898 Neisseria meningitidis serogroup A Species 0.000 claims 1
- 241000588677 Neisseria meningitidis serogroup B Species 0.000 claims 1
- 241000947238 Neisseria meningitidis serogroup C Species 0.000 claims 1
- 241001573069 Neisseria meningitidis serogroup Y Species 0.000 claims 1
- 201000005702 Pertussis Diseases 0.000 claims 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 231100000676 disease causative agent Toxicity 0.000 claims 1
- 229940047650 haemophilus influenzae Drugs 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
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Abstract
Imunogeni pripravak, naznačen time što sadrži konjugat saharida Hib i najmanje dva dodatna konjugata bakterijskih saharida, gdje konjugat Hib je prisutan u manjoj dozi saharida od srednje doze saharida za sve od najmanje dva dodatna konjugata bakterijskih saharida. Patent sadrži još 29 patentnih zahtjeva.
Claims (30)
1. Imunogeni pripravak, naznačen time što sadrži konjugat saharida Hib i najmanje dva dodatna konjugata bakterijskih saharida, gdje konjugat Hib je prisutan u manjoj dozi saharida od srednje doze saharida za sve od najmanje dva dodatna konjugata bakterijskih saharida.
2. Imunogeni pripravak u skladu s patentnim zahtjevom 1, naznačen time što konjugat Hib je prisutan u manjoj dozi saharida od doze saharida za svaki od najmanje dva dodatna konjugata bakterijskih saharida.
3. Imunogeni pripravak u skladu s patentnim zahtjevom 1 ili 2, naznačen time što najmanje dva dodatna konjugata bakterijskih saharida sadrže saharid iz kapsule bakterije N. meningitidis kojeg se dobiva iz soja kojeg se bira iz skupine koju čine seroskupine A, B, C, W135 i Y.
4. Imunogeni pripravak u skladu s patentnim zahtjevom 3, naznačen time što najmanje dva dodatna konjugata bakterijskih saharida sadrže saharid iz kapsule bakterije N. meningitidis seroskupina C (MenC).
5. Imunogeni pripravak u skladu s patentnim zahtjevom 3 ili 4, naznačen time što najmanje dva dodatna konjugata bakterijskih saharida sadrže saharid iz kapsule bakterije N. meningitidis seroskupina Y (MenY).
6. Imunogeni pripravak u skladu s bilo kojim od patentnih zahtjeva 3-5, naznačen time što najmanje dva dodatna konjugata bakterijskih saharida sadrže saharid iz kapsule bakterije N. meningitidis seroskupina A (MenA).
7. Imunogeni pripravak u skladu s bilo kojim od patentnih zahtjeva 3-6, naznačen time što najmanje dva dodatna konjugata bakterijskih saharida sadrže saharid iz kapsule bakterije N. meningitidis seroskupina W135 (MenW).
8. Imunogeni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što sadrži vezikularni pripravak vanjske membrane bakterije N. meningitidis seroskupina B.
9. Imunogeni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što najmanje dva dodatna konjugata bakterijskih saharida sadrže saharid iz kapsule bakterije S. pneumoniae kojeg se dobiva iz soja kojeg se bira iz skupine koju čine serotipovi 1, 2, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F i 33F.
10. Imunogeni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što najmanje dva dodatna konjugata bakterijskih saharida sadrže saharid Vi iz kapsule bakterije S. typhi.
11. Imunogeni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što doza saharida u konjugatu saharida Hib je između 0,1 i 9 µg, 1 i 5 µg ili 2 i 3 µg saharida.
12. Imunogeni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što doza saharida u svakom od najmanje dva dodatna saharidna konjugata je između 2 i 20 µg, 3 i 10 µg ili 4 i 7 µg saharida.
13. Imunogeni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što isti proteinski nosač se upotrebljava u konjugatu Hib i u dva ili više od najmanje dva dodatna konjugata bakterijskih saharida.
14. Imunogeni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što saharid Hib je konjugiran s proteinskim nosačem kojeg se bira iz skupine koju čine TT, DT, CRM197, C fragment proteina TT, protein D, OMPC i pneumolizin.
15. Imunogeni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što najmanje dva dodatna bakterijska saharida su konjugirani s proteinskim nosačem kojeg se bira iz skupine koju čine TT, DT, CRM197, C fragment proteina TT, protein D, OMPC i pneumolizin.
16. Imunogeni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što saharid MenC, kada je prisutan, ima molekulsku težinu veću od 50 kDa.
17. Imunogeni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što saharid MenY, kada je prisutan, ima molekulsku težinu veću od 50 kDa.
18. Imunogeni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što MenC, kada je prisutan, je u najmanju ruku djelomično O-acetiliran, tako da najmanje 30 % repetitivnih jedinica je O-acetilirano na najmanje jednom položaju.
19. Imunogeni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što MenY, kada je prisutan, je u najmanju ruku djelomično O-acetiliran, tako da najmanje 20 % repetitivnih jedinica je O-acetilirano na najmanje jednom položaju.
20. Imunogeni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što ne sadrži aluminijeve soli.
21. Imunogeni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što ne sadrži adjuvans.
22. Cjepivo, naznačeno time što sadrži imunogeni pripravak u skladu s bilo kojim od patentnih zahtjeva 1-21 i farmaceutski prihvatljivu pomoćnu tvar.
23. Cjepivni komplet za istodobnu ili uzastopnu primjenu, naznačen time što sadrži dva polivalentna imunogena pripravka za postizanje zaštite kod domaćina protiv bolesti koje uzrokuju bakterije Bordetella pertussis, Clostridium tetani, Corynebacterium diphtheriae, te Haemophilus influenzae, gdje navedeni komplet sadrži prvi spremnik, koji sadrži:
tetanusni toksoid (TT),
difterijski toksoid (DT) i
cijele stanice ili nestanične komponente uzročnika hripavca;
i drugi spremnik, koji sadrži imunogeni pripravak u skladu s bilo kojim od patentnih zahtjeva 1-21.
24. Cjepivni komplet u skladu s patentnim zahtjevom 23, naznačen time što prvi spremnik dodatno sadrži površinski antigen virusa hepatitisa B.
25. Cjepivni komplet u skladu s patentnim zahtjevom 23 ili 24, naznačen time što prvi ili drugi spremnik dodatno sadrže inaktivirani polio virus (IPV).
26. Postupak priprave imunogenog pripravka u skladu s bilo kojim od patentnih zahtjeva 1-21, naznačen time što se sastoji u koraku miješanja konjugata saharida Hib s najmanje dva dodatna konjugata bakterijskih saharida kako bi se dobilo pripravak u kojem konjugat Hib je prisutan u manjoj dozi saharida od srednje doze saharida za sve od najmanje dva dodatna konjugata bakterijskih saharida.
27. Imunogeni pripravak, cjepivo ili komplet u skladu s bilo kojim od patentnih zahtjeva 1-25, naznačen time što je namijenjen upotrebi u liječenju ili sprječavanju meningitisa.
28. Imunogeni pripravak, cjepivo ili komplet u skladu s bilo kojim od patentnih zahtjeva 1-25, naznačen time što je namijenjen upotrebi u liječenju ili sprječavanju bolesti koju uzrokuje bakterija Haemophilus influenzae.
29. Upotreba imunogenog pripravka, cjepiva ili kompleta u skladu s bilo kojim od patentnih zahtjeva 1-25, naznačena time što su navedeni pripravak, cjepivo ili komplet namijenjeni proizvodnji medikamenta za liječenje ili sprječavanje meningitisa.
30. Upotreba imunogenog pripravka, cjepiva ili kompleta u skladu s bilo kojim od patentnih zahtjeva 1-25, naznačena time što su navedeni pripravak, cjepivo ili komplet namijenjeni proizvodnji medikamenta za liječenje ili sprječavanje bolesti koju uzrokuje bakterija Haemophilus influenzae.
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GB0515556A GB0515556D0 (en) | 2005-07-28 | 2005-07-28 | Immunogenic composition |
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GB0526041A GB0526041D0 (en) | 2005-12-21 | 2005-12-21 | Immunogenic composition |
PCT/EP2006/006210 WO2007000322A1 (en) | 2005-06-27 | 2006-06-23 | Immunogenic composition |
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HRP20110567TT HRP20110567T4 (en) | 2005-06-27 | 2011-07-29 | Process for manufacturing vaccines |
HR20120102T HRP20120102T1 (hr) | 2005-06-27 | 2012-02-01 | Imunogeni pripravak |
HRP20170457TT HRP20170457T1 (hr) | 2005-06-27 | 2017-03-20 | Postupak proizvodnje cjepiva |
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HR20120102T HRP20120102T1 (hr) | 2005-06-27 | 2012-02-01 | Imunogeni pripravak |
HRP20170457TT HRP20170457T1 (hr) | 2005-06-27 | 2017-03-20 | Postupak proizvodnje cjepiva |
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JP (9) | JP2008543907A (hr) |
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HR (4) | HRP20100211T1 (hr) |
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LT (1) | LT2351578T (hr) |
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