HRP20160914T1 - Farmaceutski pripravak koji sadrži despro36 exendin-4(1-39)-lys6 -nh2 za uporabu za liječenje neurodegenerativne bolesti - Google Patents
Farmaceutski pripravak koji sadrži despro36 exendin-4(1-39)-lys6 -nh2 za uporabu za liječenje neurodegenerativne bolesti Download PDFInfo
- Publication number
- HRP20160914T1 HRP20160914T1 HRP20160914TT HRP20160914T HRP20160914T1 HR P20160914 T1 HRP20160914 T1 HR P20160914T1 HR P20160914T T HRP20160914T T HR P20160914TT HR P20160914 T HRP20160914 T HR P20160914T HR P20160914 T1 HRP20160914 T1 HR P20160914T1
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- Prior art keywords
- disease
- use according
- pharmaceutical preparation
- parkinson
- lys6
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Links
- 230000004770 neurodegeneration Effects 0.000 title claims 6
- 208000015122 neurodegenerative disease Diseases 0.000 title claims 6
- XVVOERDUTLJJHN-IAEQDCLQSA-N lixisenatide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 XVVOERDUTLJJHN-IAEQDCLQSA-N 0.000 title claims 4
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 9
- 208000018737 Parkinson disease Diseases 0.000 claims 5
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 3
- 208000001089 Multiple system atrophy Diseases 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 2
- 208000002381 Brain Hypoxia Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000003930 cognitive ability Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 230000028709 inflammatory response Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 210000002241 neurite Anatomy 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 230000036542 oxidative stress Effects 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000003313 weakening effect Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Peptides Or Proteins (AREA)
Claims (10)
1. Farmaceutski pripravak za uporabu za sprječavanje ili/i liječenje neurodegenerativne bolesti, naznačen time da pripravak sadrži desPro36Exendin-4(1-39)-Lys6-NH2 ili/i njegovu farmaceutski prihvatljivu sol, i proizvoljno farmaceutski prihvatljiv nosač, adjuvant, ili/i pomoćnu tvar.
2. Farmaceutski pripravak za uporabu prema zahtjevu 1, naznačen time da desPro36Exendin-4(1-39)-Lys6-NH2 ili/i njegova farmaceutski prihvatljiva sol je pripremljen za parenteralno davanje.
3. Farmaceutski pripravak za uporabu prema bilo kojem od prethodnih zahtjeva, naznačen time da neurodegenerativna bolest uključuje oksidativni stres, gubitak integriteta neurita, apoptozu, gubitak neurona ili/i upalni odgovor.
4. Farmaceutski pripravak za uporabu prema bilo kojem od prethodnih zahtjeva, naznačen time da je neurodegenerativna bolest povezana sa slabljenjem kognitivnih sposobnosti.
5. Farmaceutski pripravak za uporabu prema bilo kojem od prethodnih zahtjeva, naznačen time da neurodegenerativna bolest je odabrana iz skupine koju čine Alzheimerova bolest, Parkinsonova bolest, progresivna supranuklearna paraliza (PSP), multipla sistemska atrofija (MSA), demencija s Lewyjevim tjelešcima, Parkinsonova bolest s demencijom, epilepsija, kap, Huntingtonova korea, cerebralna hipoksija, multipla skleroza, te periferna neuropatija.
6. Farmaceutski pripravak za uporabu prema zahtjevu 5, naznačen time da je periferna neuropatija povezana s dijabetes melitusom.
7. Farmaceutski pripravak za uporabu prema zahtjevu 5, naznačen time da neurodegenerativna bolest je odabrana iz skupine koju čine Alzheimerova bolest, Parkinsonova bolest,, i kap.
8. Farmaceutski pripravak za uporabu prema zahtjevu 5, naznačen time da Alzheimerova bolest je Alzheimerova bolest u ranoj fazi.
9. Farmaceutski pripravak za uporabu prema zahtjevu 5, naznačen time da Parkinsonova bolest je Parkinsonova bolest u ranoj fazi.
10. Farmaceutski pripravak za uporabu prema bilo kojem od prethodnih zahtjeva, naznačen time da desPro36Exendin-4(1-39)-Lys6-NH2 ili/i njegova farmaceutski prihvatljiva sol je pripremljen za davanje u dnevnoj dozi odabranoj u rasponu od 10 µg do 20 µg.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11179784 | 2011-09-01 | ||
PCT/EP2012/067144 WO2013030409A1 (en) | 2011-09-01 | 2012-09-03 | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
EP12755853.4A EP2750698B1 (en) | 2011-09-01 | 2012-09-03 | Pharmaceutical composition comprising despro36 exendin-4(1-39)-lys6 -nh2 for use in the treatment of a neurodegenerative disease |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20160914T1 true HRP20160914T1 (hr) | 2016-10-07 |
Family
ID=46755008
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20160914TT HRP20160914T1 (hr) | 2011-09-01 | 2016-07-20 | Farmaceutski pripravak koji sadrži despro36 exendin-4(1-39)-lys6 -nh2 za uporabu za liječenje neurodegenerativne bolesti |
Country Status (24)
Country | Link |
---|---|
US (3) | US9364519B2 (hr) |
EP (1) | EP2750698B1 (hr) |
JP (1) | JP6185914B2 (hr) |
KR (1) | KR101986486B1 (hr) |
CN (2) | CN103813801A (hr) |
AR (1) | AR087744A1 (hr) |
AU (1) | AU2012300796B2 (hr) |
BR (1) | BR112014005025A2 (hr) |
CA (1) | CA2842133C (hr) |
CY (1) | CY1120094T1 (hr) |
DK (1) | DK2750698T3 (hr) |
ES (1) | ES2583782T3 (hr) |
HK (1) | HK1196282A1 (hr) |
HR (1) | HRP20160914T1 (hr) |
HU (1) | HUE029294T2 (hr) |
LT (1) | LT2750698T (hr) |
MX (1) | MX349224B (hr) |
PL (1) | PL2750698T3 (hr) |
PT (1) | PT2750698T (hr) |
RS (1) | RS55115B1 (hr) |
RU (1) | RU2618412C2 (hr) |
SI (1) | SI2750698T1 (hr) |
TW (1) | TWI559929B (hr) |
WO (1) | WO2013030409A1 (hr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX344293B (es) | 2008-10-17 | 2016-12-13 | Sanofi Aventis Deutschland | Combinacion de una insulina y un agonista de glp-1. |
KR101772372B1 (ko) | 2009-11-13 | 2017-08-29 | 사노피-아벤티스 도이칠란트 게엠베하 | Glp-1 효능제 및 메티오닌을 포함하는 약제학적 조성물 |
CN103179978A (zh) | 2010-08-30 | 2013-06-26 | 赛诺菲-安万特德国有限公司 | Ave0010用于制造供治疗2型糖尿病用的药物的用途 |
TN2017000235A1 (en) | 2014-12-12 | 2018-10-19 | Sanofi Aventis Deutschland | Insulin glargine/lixisenatide fixed ratio formulation |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
EP3393496B1 (en) | 2015-12-23 | 2023-10-11 | The Johns Hopkins University | Long-acting glp-1r agonist as a therapy of neurological and neurodegenerative conditions |
CA3021140A1 (en) | 2016-04-19 | 2017-10-26 | Ureka Sarl | Peptide-oligourea foldamer compounds and methods of their use |
GB201620611D0 (en) * | 2016-12-05 | 2017-01-18 | Univ Of Lancaster | Treatment of neurological diseases |
CR20190485A (es) * | 2017-08-03 | 2020-02-10 | Alector Llc | Anticuerpos anti-trem2 y métodos para utilizarlos |
JP7137184B2 (ja) | 2018-05-09 | 2022-09-14 | 内山工業株式会社 | 密封装置 |
KR102282240B1 (ko) | 2018-12-06 | 2021-07-28 | 경상국립대학교산학협력단 | 지속형 엑센딘-4 및 이의 용도 |
CN111378733A (zh) * | 2018-12-28 | 2020-07-07 | 康多富国际有限公司 | 神经退化疾病保健食品组合确定方法及其可机读存储介质 |
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WO2014202483A1 (en) | 2013-06-17 | 2014-12-24 | Sanofi-Aventis Deutschland Gmbh | Insulin glargine/lixisenatide fixed ratio formulation |
AR098168A1 (es) | 2013-10-25 | 2016-05-04 | Sanofi Sa | Formulación estable de insulina glulisina |
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2012
- 2012-08-30 TW TW101131466A patent/TWI559929B/zh active
- 2012-08-30 AR ARP120103212A patent/AR087744A1/es unknown
- 2012-09-03 PL PL12755853.4T patent/PL2750698T3/pl unknown
- 2012-09-03 KR KR1020147005574A patent/KR101986486B1/ko active IP Right Grant
- 2012-09-03 MX MX2014002155A patent/MX349224B/es active IP Right Grant
- 2012-09-03 BR BR112014005025A patent/BR112014005025A2/pt not_active Application Discontinuation
- 2012-09-03 PT PT127558534T patent/PT2750698T/pt unknown
- 2012-09-03 HU HUE12755853A patent/HUE029294T2/en unknown
- 2012-09-03 CA CA2842133A patent/CA2842133C/en active Active
- 2012-09-03 EP EP12755853.4A patent/EP2750698B1/en active Active
- 2012-09-03 WO PCT/EP2012/067144 patent/WO2013030409A1/en active Application Filing
- 2012-09-03 CN CN201280038987.5A patent/CN103813801A/zh active Pending
- 2012-09-03 CN CN201810718316.2A patent/CN108969756A/zh active Pending
- 2012-09-03 ES ES12755853.4T patent/ES2583782T3/es active Active
- 2012-09-03 DK DK12755853.4T patent/DK2750698T3/en active
- 2012-09-03 SI SI201230653A patent/SI2750698T1/sl unknown
- 2012-09-03 RU RU2014112370A patent/RU2618412C2/ru active
- 2012-09-03 RS RS20160576A patent/RS55115B1/sr unknown
- 2012-09-03 AU AU2012300796A patent/AU2012300796B2/en active Active
- 2012-09-03 JP JP2014527694A patent/JP6185914B2/ja active Active
- 2012-09-03 LT LTEP12755853.4T patent/LT2750698T/lt unknown
- 2012-09-04 US US13/602,913 patent/US9364519B2/en active Active
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2014
- 2014-09-29 HK HK14109775.6A patent/HK1196282A1/zh unknown
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2016
- 2016-05-04 US US15/146,255 patent/US9987332B2/en active Active
- 2016-07-19 CY CY20161100704T patent/CY1120094T1/el unknown
- 2016-07-20 HR HRP20160914TT patent/HRP20160914T1/hr unknown
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2018
- 2018-04-25 US US15/962,770 patent/US20190070265A1/en not_active Abandoned
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