BR112014007902A2 - composições farmacêuticas compreendendo 40-o-(2-hidróxi)etil-rapamicina - Google Patents

composições farmacêuticas compreendendo 40-o-(2-hidróxi)etil-rapamicina

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Publication number
BR112014007902A2
BR112014007902A2 BR112014007902A BR112014007902A BR112014007902A2 BR 112014007902 A2 BR112014007902 A2 BR 112014007902A2 BR 112014007902 A BR112014007902 A BR 112014007902A BR 112014007902 A BR112014007902 A BR 112014007902A BR 112014007902 A2 BR112014007902 A2 BR 112014007902A2
Authority
BR
Brazil
Prior art keywords
hydroxy
pharmaceutical formulations
ethyl rapamycin
pharmaceutical compositions
dosage forms
Prior art date
Application number
BR112014007902A
Other languages
English (en)
Inventor
Diederich Anke
Liechti Kurt
Kuehl Peter
Cheung Wing
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46968222&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014007902(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112014007902A2 publication Critical patent/BR112014007902A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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    • A—HUMAN NECESSITIES
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    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
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    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
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    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/4833—Encapsulating processes; Filling of capsules
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
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    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

resumo patente de invenção: "composições farmacêuticas compreendendo 40-o-(2-hidróxi)etil-rapamicina". a presente invenção refere-se às formulações farmacêuticas de liberação prolongada na forma de multiparticulados compreendendo a 40-o-(2-hidróxi)etil-rapamicina, às formas de dosagem que compreendem ditas formulações farmacêuticas, aos métodos de preparação de ditas formulações farmacêuticas e ditas formas de dosagem, para uso das ditas formulações farmacêuticas e ditas formas de dosagem para a fabricação de um medicamento para o tratamento ou prevenção de doenças ou condições responsivas à inibição da via de sinalização de mtor, tais como, por exemplo, as doenças proliferativas ou imunossupressão.
BR112014007902A 2011-10-06 2012-10-03 composições farmacêuticas compreendendo 40-o-(2-hidróxi)etil-rapamicina BR112014007902A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161544026P 2011-10-06 2011-10-06
PCT/EP2012/069541 WO2013050419A1 (en) 2011-10-06 2012-10-03 Pharmaceutical compositions comprising 40 - o - ( 2 - hydroxy) ethyl - rapamycin

Publications (1)

Publication Number Publication Date
BR112014007902A2 true BR112014007902A2 (pt) 2017-04-18

Family

ID=46968222

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014007902A BR112014007902A2 (pt) 2011-10-06 2012-10-03 composições farmacêuticas compreendendo 40-o-(2-hidróxi)etil-rapamicina

Country Status (23)

Country Link
US (3) US20140242162A1 (pt)
EP (1) EP2763663B1 (pt)
JP (1) JP6368242B2 (pt)
KR (1) KR101643219B1 (pt)
CN (1) CN103874484B (pt)
AR (1) AR088232A1 (pt)
AU (1) AU2012320563B2 (pt)
BR (1) BR112014007902A2 (pt)
CA (1) CA2850995A1 (pt)
CL (1) CL2014000844A1 (pt)
CO (1) CO6930364A2 (pt)
EA (1) EA025595B1 (pt)
ES (1) ES2663744T3 (pt)
GT (1) GT201400062A (pt)
IL (1) IL231648A0 (pt)
MA (1) MA35513B1 (pt)
MX (1) MX2014004166A (pt)
PE (1) PE20141649A1 (pt)
SG (1) SG11201400730VA (pt)
TN (1) TN2014000114A1 (pt)
TW (1) TWI475993B (pt)
WO (1) WO2013050419A1 (pt)
ZA (1) ZA201401961B (pt)

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BR112017018316A2 (pt) 2015-02-27 2018-04-17 Ebbu Llc composições compreendendo combinações de canabinoides purificados, com pelo menos um flavonoide, terpeno ou mineral
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WO2017018433A1 (ja) * 2015-07-28 2017-02-02 日本化薬株式会社 ラパマイシン又はその誘導体を含有する医薬組成物及びその製造方法
JP6762158B2 (ja) * 2015-07-28 2020-09-30 日本化薬株式会社 ラパマイシン又はその誘導体を含有する医薬組成物
US20190022073A1 (en) * 2015-09-03 2019-01-24 Nippon Kayaku Kabushiki Kaisha Pharmaceutical composition comprising rapamycin or derivative thereof
JP6854639B2 (ja) * 2016-01-06 2021-04-07 日本化薬株式会社 ラパマイシン誘導体を含有する医薬組成物及びその製造方法
WO2018044953A1 (en) 2016-08-29 2018-03-08 Ebbu, LLC Water soluble compositions comprising purified cannabinoids
BR112019010470A2 (pt) 2016-11-23 2019-09-10 Novartis Ag métodos de realce de resposta imune com everolimo, dactolisib ou ambos
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KR102336007B1 (ko) * 2021-06-23 2021-12-07 주식회사 진성이앤지 콘크리트용 우레탄계 방수·방식 도막재 및 이를 이용한 방수·방식 도장 공법
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Publication number Publication date
PE20141649A1 (es) 2014-11-14
TW201318625A (zh) 2013-05-16
IL231648A0 (en) 2014-05-28
CN103874484A (zh) 2014-06-18
CL2014000844A1 (es) 2014-09-12
CA2850995A1 (en) 2013-04-11
WO2013050419A1 (en) 2013-04-11
KR20140058670A (ko) 2014-05-14
US20140242162A1 (en) 2014-08-28
TN2014000114A1 (en) 2015-07-01
US20170049754A1 (en) 2017-02-23
EA025595B1 (ru) 2017-01-30
AU2012320563A1 (en) 2014-04-24
JP2014528431A (ja) 2014-10-27
CO6930364A2 (es) 2014-04-28
JP6368242B2 (ja) 2018-08-01
EP2763663A1 (en) 2014-08-13
MA35513B1 (fr) 2014-10-02
GT201400062A (es) 2015-06-02
EA201490743A1 (ru) 2014-07-30
MX2014004166A (es) 2015-01-15
SG11201400730VA (en) 2014-06-27
KR101643219B1 (ko) 2016-07-27
TWI475993B (zh) 2015-03-11
US20180214424A1 (en) 2018-08-02
AR088232A1 (es) 2014-05-21
EP2763663B1 (en) 2017-12-27
AU2012320563B2 (en) 2016-05-12
ZA201401961B (en) 2015-11-25
CN103874484B (zh) 2016-09-21
ES2663744T3 (es) 2018-04-16

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