EA201490743A1 - Фармацевтические композиции, содержащие 40-о-(2-гидрокси)этилрапамицин - Google Patents

Фармацевтические композиции, содержащие 40-о-(2-гидрокси)этилрапамицин

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Publication number
EA201490743A1
EA201490743A1 EA201490743A EA201490743A EA201490743A1 EA 201490743 A1 EA201490743 A1 EA 201490743A1 EA 201490743 A EA201490743 A EA 201490743A EA 201490743 A EA201490743 A EA 201490743A EA 201490743 A1 EA201490743 A1 EA 201490743A1
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EA
Eurasian Patent Office
Prior art keywords
pharmaceutical compositions
hydroxy
dosage forms
ethylrapamicin
compositions containing
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Application number
EA201490743A
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English (en)
Other versions
EA025595B1 (ru
Inventor
Анке Дидерих
Курт Лихти
Петер Кюль
Винг Чеунг
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Новартис Аг
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Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201490743A1 publication Critical patent/EA201490743A1/ru
Publication of EA025595B1 publication Critical patent/EA025595B1/ru

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Transplantation (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Изобретение относится к фармацевтическим составам длительного высвобождения в форме множественных частиц, содержащим 40-О-(2-гидрокси)этилрапамицин, к дозированным формам, которые содержат указанные фармацевтические составы, к способам приготовления указанных фармацевтических составов и указанных дозированных форм, к применениям указанных фармацевтических составов и указанных дозированных форм для изготовления лекарственного препарата для лечения или профилактики заболеваний или состояний, реагирующих на ингибирование mTOR сигнального пути, таких как, например, пролиферативные заболевания или иммуносупрессия.
EA201490743A 2011-10-06 2012-10-03 Фармацевтические композиции, содержащие 40-о-(2-гидрокси)этилрапамицин EA025595B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161544026P 2011-10-06 2011-10-06
PCT/EP2012/069541 WO2013050419A1 (en) 2011-10-06 2012-10-03 Pharmaceutical compositions comprising 40 - o - ( 2 - hydroxy) ethyl - rapamycin

Publications (2)

Publication Number Publication Date
EA201490743A1 true EA201490743A1 (ru) 2014-07-30
EA025595B1 EA025595B1 (ru) 2017-01-30

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EA201490743A EA025595B1 (ru) 2011-10-06 2012-10-03 Фармацевтические композиции, содержащие 40-о-(2-гидрокси)этилрапамицин

Country Status (23)

Country Link
US (3) US20140242162A1 (ru)
EP (1) EP2763663B1 (ru)
JP (1) JP6368242B2 (ru)
KR (1) KR101643219B1 (ru)
CN (1) CN103874484B (ru)
AR (1) AR088232A1 (ru)
AU (1) AU2012320563B2 (ru)
BR (1) BR112014007902A2 (ru)
CA (1) CA2850995A1 (ru)
CL (1) CL2014000844A1 (ru)
CO (1) CO6930364A2 (ru)
EA (1) EA025595B1 (ru)
ES (1) ES2663744T3 (ru)
GT (1) GT201400062A (ru)
IL (1) IL231648A0 (ru)
MA (1) MA35513B1 (ru)
MX (1) MX2014004166A (ru)
PE (1) PE20141649A1 (ru)
SG (1) SG11201400730VA (ru)
TN (1) TN2014000114A1 (ru)
TW (1) TWI475993B (ru)
WO (1) WO2013050419A1 (ru)
ZA (1) ZA201401961B (ru)

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PL3193840T3 (pl) 2014-09-15 2021-12-06 Orphazyme A/S Preparat arimoklomolu
WO2016138505A1 (en) 2015-02-27 2016-09-01 Ebbu, LLC Compositions comprising combinations of purified cannabinoids, with at least one flavonoid, terpene, or mineral
CN107847491A (zh) 2015-05-20 2018-03-27 诺华公司 依维莫司(everolimus)与达托里昔布(dactolisib)的医药组合
WO2017018433A1 (ja) * 2015-07-28 2017-02-02 日本化薬株式会社 ラパマイシン又はその誘導体を含有する医薬組成物及びその製造方法
JP6762158B2 (ja) * 2015-07-28 2020-09-30 日本化薬株式会社 ラパマイシン又はその誘導体を含有する医薬組成物
EP3345601A4 (en) * 2015-09-03 2019-05-15 Nippon Kayaku Kabushiki Kaisha PHARMACEUTICAL COMPOSITION CONTAINING RAPAMYCIN OR A DERIVATIVE THEREOF
JP6854639B2 (ja) * 2016-01-06 2021-04-07 日本化薬株式会社 ラパマイシン誘導体を含有する医薬組成物及びその製造方法
CN110177543A (zh) 2016-08-29 2019-08-27 凯诺比生长公司 包含纯化大麻素的水溶性组合物
AU2017363970A1 (en) 2016-11-23 2019-06-20 Novartis Ag Methods of enhancing immune response with everolimus, dactolisib or both
EP3576735A4 (en) * 2017-02-06 2020-07-22 Intas Pharmaceuticals Limited PHARMACEUTICAL COMPOSITION OF EVEROLIMUS
KR102051806B1 (ko) * 2018-01-12 2019-12-04 주식회사 종근당 에베로리무스를 포함하는 안정화된 약제학적 제제
US10596165B2 (en) 2018-02-12 2020-03-24 resTORbio, Inc. Combination therapies
MX2022012248A (es) * 2020-03-30 2022-10-27 Igia Pharmaceuticals Inc Formulacion pediatrica de inhibidores de tirosina quinasa.
WO2022219652A1 (en) * 2021-04-17 2022-10-20 Bdr Pharmaceuticals International Private Limited Novel sublingual pharmaceutical formulations for everolimus
KR102336007B1 (ko) * 2021-06-23 2021-12-07 주식회사 진성이앤지 콘크리트용 우레탄계 방수·방식 도막재 및 이를 이용한 방수·방식 도장 공법
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US20170049754A1 (en) 2017-02-23
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CL2014000844A1 (es) 2014-09-12
US20180214424A1 (en) 2018-08-02
AU2012320563B2 (en) 2016-05-12
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