HRP20030793B1 - Parenteralni pripravak za rekonstituciju koji sadrži cox-2 inhibitor - Google Patents

Parenteralni pripravak za rekonstituciju koji sadrži cox-2 inhibitor

Info

Publication number
HRP20030793B1
HRP20030793B1 HRP20030793AA HRP20030793A HRP20030793B1 HR P20030793 B1 HRP20030793 B1 HR P20030793B1 HR P20030793A A HRP20030793A A HR P20030793AA HR P20030793 A HRP20030793 A HR P20030793A HR P20030793 B1 HRP20030793 B1 HR P20030793B1
Authority
HR
Croatia
Prior art keywords
composition
weight
parenterally acceptable
cox
inhibitor
Prior art date
Application number
HRP20030793AA
Other languages
English (en)
Inventor
Tugrul T. Kararli
Sandeep Nema
Aziz Karim
Original Assignee
Pharmacia Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23075770&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20030793(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia Corporation filed Critical Pharmacia Corporation
Publication of HRP20030793A2 publication Critical patent/HRP20030793A2/xx
Publication of HRP20030793B1 publication Critical patent/HRP20030793B1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Farmaceutski pripravak koji uključuje, u praškastom obliku, (a) barem jednu ljekovitu tvar topivu u vodi odabranu između lijekova i prolijekova i njihovih soli koji su selektivni inhibitori COX-2, na primjer natrij parekoksiba, u terapeutski učinkovitoj ukupnoj količini koja čini oko 30% do oko 90% po težini, (b) parenteralno prihvatljivo pufersko sredstvo u količini od oko 5% do oko 60% po težini, i moguće (c) druge parenteralno prihvatljive ekscipijentne sastojke u ukupnoj količini koja nije veća od oko 10% po težini pripravka. Pripravak se može rekonstituirati u parenteralno prihvatljivom tekućem otapalu kako bi nastala otopina za injiciranje. Pruža se postupak liofilizacije za pripravu takvog pripravka.
HRP20030793AA 2001-04-03 2003-10-01 Parenteralni pripravak za rekonstituciju koji sadrži cox-2 inhibitor HRP20030793B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28105801P 2001-04-03 2001-04-03
PCT/US2002/010252 WO2002080912A1 (en) 2001-04-03 2002-04-02 Reconstitutable parenteral composition containing a cox-2 inhibitor

Publications (2)

Publication Number Publication Date
HRP20030793A2 HRP20030793A2 (en) 2005-10-31
HRP20030793B1 true HRP20030793B1 (hr) 2013-05-31

Family

ID=23075770

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20030793AA HRP20030793B1 (hr) 2001-04-03 2003-10-01 Parenteralni pripravak za rekonstituciju koji sadrži cox-2 inhibitor

Country Status (46)

Country Link
US (1) US7695736B2 (hr)
EP (1) EP1372645B1 (hr)
JP (1) JP4511792B2 (hr)
KR (1) KR100980685B1 (hr)
CN (3) CN107115302A (hr)
AP (1) AP1776A (hr)
AR (1) AR033688A1 (hr)
AT (1) ATE310516T1 (hr)
AU (1) AU2002256031B2 (hr)
BG (1) BG66367B1 (hr)
BR (1) BRPI0208652B8 (hr)
CA (1) CA2442906C (hr)
CZ (1) CZ299623B6 (hr)
DE (1) DE60207535T2 (hr)
DK (1) DK1372645T3 (hr)
EA (1) EA006554B1 (hr)
EC (1) ECSP034789A (hr)
EG (1) EG24345A (hr)
ES (1) ES2252448T3 (hr)
GE (1) GEP20063775B (hr)
GT (1) GT200200065A (hr)
HK (2) HK1243338A1 (hr)
HR (1) HRP20030793B1 (hr)
HU (1) HU229264B1 (hr)
IL (2) IL158209A0 (hr)
IS (1) IS2408B (hr)
JO (1) JO2337B1 (hr)
MA (1) MA27008A1 (hr)
ME (1) MEP56908A (hr)
MX (1) MXPA03009013A (hr)
MY (1) MY137736A (hr)
NO (1) NO333381B1 (hr)
NZ (1) NZ528547A (hr)
OA (1) OA12498A (hr)
PA (1) PA8542701A1 (hr)
PE (1) PE20021017A1 (hr)
PL (1) PL205658B1 (hr)
RS (1) RS50430B (hr)
SI (1) SI1372645T1 (hr)
SK (1) SK287754B6 (hr)
SV (1) SV2002000969A (hr)
TN (2) TNSN02039A1 (hr)
TW (1) TWI314867B (hr)
UA (1) UA77173C2 (hr)
WO (1) WO2002080912A1 (hr)
ZA (1) ZA200307630B (hr)

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CN105168152B (zh) * 2015-08-27 2018-06-01 上海华源药业（宁夏）沙赛制药有限公司 一种帕瑞昔布钠冻干粉及其制备方法
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