MX2021015727A - Derivados de piridin-3-ilo. - Google Patents

Derivados de piridin-3-ilo.

Info

Publication number
MX2021015727A
MX2021015727A MX2021015727A MX2021015727A MX2021015727A MX 2021015727 A MX2021015727 A MX 2021015727A MX 2021015727 A MX2021015727 A MX 2021015727A MX 2021015727 A MX2021015727 A MX 2021015727A MX 2021015727 A MX2021015727 A MX 2021015727A
Authority
MX
Mexico
Prior art keywords
sup
pyridin
derivatives
formula
pharmaceuticals
Prior art date
Application number
MX2021015727A
Other languages
English (en)
Inventor
Martin Bolli
Christine Brotschi
Cyrille Lescop
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of MX2021015727A publication Critical patent/MX2021015727A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

La presente invención se refiere a derivados de piridin-3-ilo de Fórmula (I) (ver Fórmula) en donde R1, R2, R3, R4, R5, Ar1, L, m y n son como se describen en la descripción, su preparación, a sales farmacéuticamente aceptables de los mismos, y a su uso como productos farmacéuticos, a composiciones farmacéuticas que contienen uno o más compuestos de Fórmula (I), y especialmente a su uso como moduladores del receptor LPA1.
MX2021015727A 2019-06-18 2020-06-17 Derivados de piridin-3-ilo. MX2021015727A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2019065963 2019-06-18
PCT/EP2020/066767 WO2020254408A1 (en) 2019-06-18 2020-06-17 Pyridin-3-yl derivatives

Publications (1)

Publication Number Publication Date
MX2021015727A true MX2021015727A (es) 2022-01-24

Family

ID=71105482

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021015727A MX2021015727A (es) 2019-06-18 2020-06-17 Derivados de piridin-3-ilo.

Country Status (16)

Country Link
US (1) US20220251068A1 (es)
EP (1) EP3986884A1 (es)
JP (1) JP2022537177A (es)
KR (1) KR20220020921A (es)
CN (1) CN114026082A (es)
AR (1) AR119162A1 (es)
AU (1) AU2020298014A1 (es)
BR (1) BR112021025236A2 (es)
CA (1) CA3143618A1 (es)
CL (1) CL2021003348A1 (es)
IL (1) IL288950A (es)
MA (1) MA56504A (es)
MX (1) MX2021015727A (es)
SG (1) SG11202111162PA (es)
TW (1) TW202115011A (es)
WO (1) WO2020254408A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114761001A (zh) * 2019-12-04 2022-07-15 爱杜西亚药品有限公司 氮杂环丁烷lpa1受体拮抗剂与抗纤维化药剂的组合

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002062389A1 (fr) 2001-02-08 2002-08-15 Ono Pharmaceutical Co., Ltd. Remedes pour des maladies urinaires contenant des agents de regulation du recepteur de lpa
TW200403058A (en) 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
WO2005037269A1 (ja) 2003-10-21 2005-04-28 Dainippon Sumitomo Pharma Co., Ltd. 新規ピペリジン誘導体
MXPA06005550A (es) 2003-11-18 2006-08-17 Warner Lambert Co Agentes antibacterianos.
NZ566793A (en) 2005-08-24 2010-03-26 Eisai R&D Man Co Ltd Novel pyridine derivative and pyrimidine derivative
JP5164510B2 (ja) 2006-10-06 2013-03-21 日本曹達株式会社 含窒素複素環化合物および有害生物防除剤
EP2212322B1 (en) 2007-10-18 2012-04-04 Merck Sharp & Dohme Corp. Quinolizidinone m1 receptor positive allosteric modulators
MX344077B (es) 2008-05-05 2016-12-05 Sanofi - Aventis Derivados de ácido ciclopentanocarboxílico condensados sustituidos con acilamino y su uso como productos farmacéuticos.
KR101678255B1 (ko) * 2009-09-25 2016-11-21 아스텔라스세이야쿠 가부시키가이샤 치환 아미드 화합물
MX2013001437A (es) 2010-08-05 2013-06-05 Zoetis Llc Derivados de isoxazolina como agentes antiparasitarios.
TW201305178A (zh) 2010-10-29 2013-02-01 Glenmark Pharmaceuticals Sa 作為ｍＰＧＥＳ－１抑制物的三環化合物
LT2648726T (lt) 2010-12-07 2018-06-25 Amira Pharmaceuticals, Inc. Policiklinis lap1 antagonistas ir jo panaudojimai
AU2012226475C1 (en) 2011-03-10 2015-08-06 Zoetis Services Llc Spirocyclic isoxazoline derivatives as antiparasitic agents
WO2013096771A1 (en) 2011-12-21 2013-06-27 Ardelyx, Inc. Non-systemic tgr5 agonists
AU2014244183A1 (en) * 2013-03-13 2015-08-13 Abbvie Inc. Pyridine CDK9 kinase inhibitors
AU2019282274A1 (en) * 2018-06-07 2021-01-28 Idorsia Pharmaceuticals Ltd Alkoxy-substituted pyridinyl derivatives as LPA1 receptor antagonists and their use in the treatment of fibrosis

Also Published As

Publication number Publication date
SG11202111162PA (en) 2021-11-29
TW202115011A (zh) 2021-04-16
CN114026082A (zh) 2022-02-08
MA56504A (fr) 2022-04-27
KR20220020921A (ko) 2022-02-21
EP3986884A1 (en) 2022-04-27
CA3143618A1 (en) 2020-12-24
WO2020254408A1 (en) 2020-12-24
US20220251068A1 (en) 2022-08-11
AR119162A1 (es) 2021-12-01
CL2021003348A1 (es) 2022-09-23
BR112021025236A2 (pt) 2022-02-01
AU2020298014A1 (en) 2022-02-10
JP2022537177A (ja) 2022-08-24
IL288950A (en) 2022-02-01

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