BR112021025236A2 - Composto, composição farmacêutica, uso do composto, e, método para a profilaxia ou o tratamento de fibrose, distúrbios dermatológicos, dor, doenças proliferativas malignas, benignas, doenças respiratórias, distúrbios do sistema nervoso central, doenças cardiovasculares, distúrbios inflamatórios, obesidade ou resistência à insulina - Google Patents
Composto, composição farmacêutica, uso do composto, e, método para a profilaxia ou o tratamento de fibrose, distúrbios dermatológicos, dor, doenças proliferativas malignas, benignas, doenças respiratórias, distúrbios do sistema nervoso central, doenças cardiovasculares, distúrbios inflamatórios, obesidade ou resistência à insulinaInfo
- Publication number
- BR112021025236A2 BR112021025236A2 BR112021025236A BR112021025236A BR112021025236A2 BR 112021025236 A2 BR112021025236 A2 BR 112021025236A2 BR 112021025236 A BR112021025236 A BR 112021025236A BR 112021025236 A BR112021025236 A BR 112021025236A BR 112021025236 A2 BR112021025236 A2 BR 112021025236A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- disorders
- diseases
- pharmaceutical composition
- prophylaxis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
composto, composição farmacêutica, e, uso do composto. a presente invenção se refere aos derivados de piridin-3-ila de fórmula (i) em que r1, r2, r3, r4, r5, ar1, l, m e n são como descritos na descrição, à preparação deles, aos sais farmaceuticamente aceitáveis dos mesmos, e ao uso deles como fármacos, às composições farmacêuticas que contêm um ou mais compostos de fórmula (i), e especialmente ao uso deles como moduladores de receptor de lpa1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2019065963 | 2019-06-18 | ||
PCT/EP2020/066767 WO2020254408A1 (en) | 2019-06-18 | 2020-06-17 | Pyridin-3-yl derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021025236A2 true BR112021025236A2 (pt) | 2022-02-01 |
Family
ID=71105482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021025236A BR112021025236A2 (pt) | 2019-06-18 | 2020-06-17 | Composto, composição farmacêutica, uso do composto, e, método para a profilaxia ou o tratamento de fibrose, distúrbios dermatológicos, dor, doenças proliferativas malignas, benignas, doenças respiratórias, distúrbios do sistema nervoso central, doenças cardiovasculares, distúrbios inflamatórios, obesidade ou resistência à insulina |
Country Status (15)
Country | Link |
---|---|
US (1) | US20220251068A1 (pt) |
EP (1) | EP3986884A1 (pt) |
JP (1) | JP7494222B2 (pt) |
KR (1) | KR20220020921A (pt) |
CN (1) | CN114026082B (pt) |
AR (1) | AR119162A1 (pt) |
AU (1) | AU2020298014A1 (pt) |
BR (1) | BR112021025236A2 (pt) |
CA (1) | CA3143618A1 (pt) |
CL (1) | CL2021003348A1 (pt) |
IL (1) | IL288950A (pt) |
MA (1) | MA56504A (pt) |
MX (1) | MX2021015727A (pt) |
SG (1) | SG11202111162PA (pt) |
WO (1) | WO2020254408A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114761001A (zh) * | 2019-12-04 | 2022-07-15 | 爱杜西亚药品有限公司 | 氮杂环丁烷lpa1受体拮抗剂与抗纤维化药剂的组合 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1364659B1 (en) | 2001-02-08 | 2009-11-11 | Ono Pharmaceutical Co., Ltd. | Remedies for urinary diseases comprising lpa receptor controlling agents |
TW200403058A (en) | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
US20070078120A1 (en) | 2003-10-21 | 2007-04-05 | Hitoshi Ban | Novel piperidine derivative |
CN1878551A (zh) | 2003-11-12 | 2006-12-13 | 默克公司 | 4-苯基哌啶磺酰基甘氨酸转运体抑制剂 |
EP1687296A1 (en) | 2003-11-18 | 2006-08-09 | Warner-Lambert Company LLC | Antibacterial aminoquinazolidinedione derivatives |
CN101198590B (zh) | 2005-08-24 | 2012-05-09 | 卫材R&D管理有限公司 | 吡啶衍生物及嘧啶衍生物(3) |
JP5164510B2 (ja) | 2006-10-06 | 2013-03-21 | 日本曹達株式会社 | 含窒素複素環化合物および有害生物防除剤 |
ATE552257T1 (de) | 2007-10-18 | 2012-04-15 | Merck Sharp & Dohme | Positive allosterische chinolizidinon-m1- rezeptormodulatoren |
MX344077B (es) | 2008-05-05 | 2016-12-05 | Sanofi - Aventis | Derivados de ácido ciclopentanocarboxílico condensados sustituidos con acilamino y su uso como productos farmacéuticos. |
TW201117809A (en) * | 2009-09-25 | 2011-06-01 | Astellas Pharma Inc | Substituted amide compounds |
CN103270036B (zh) | 2010-08-05 | 2015-11-25 | 佐蒂斯有限责任公司 | 作为抗寄生物剂的异噁唑啉衍生物 |
TW201305178A (zh) | 2010-10-29 | 2013-02-01 | Glenmark Pharmaceuticals Sa | 作為mPGES-1抑制物的三環化合物 |
AU2011338417B2 (en) | 2010-12-07 | 2016-12-01 | Amira Pharmaceuticals, Inc. | Polycyclic LPA1 antagonist and uses thereof |
CN103517907B (zh) | 2011-03-10 | 2016-07-06 | 硕腾服务有限责任公司 | 作为抗寄生物剂的螺环异噁唑啉衍生物 |
BR112014014909A2 (pt) | 2011-12-21 | 2017-06-13 | Ardelyx Inc | agonistas de tgr5 não sistêmicos |
WO2014160017A1 (en) * | 2013-03-13 | 2014-10-02 | Abbvie Inc. | Pyridine cdk9 kinase inhibitors |
CN105849097A (zh) | 2013-11-06 | 2016-08-10 | 百时美施贵宝公司 | 取代的吡啶衍生物用作gsk-3抑制剂 |
EP3802517B1 (en) | 2018-06-07 | 2022-12-21 | Idorsia Pharmaceuticals Ltd | Alkoxy-substituted pyridinyl derivatives as lpa1 receptor antagonists and their use in the treatment of fibrosis |
-
2020
- 2020-06-16 AR ARP200101686A patent/AR119162A1/es unknown
- 2020-06-17 US US17/620,520 patent/US20220251068A1/en active Pending
- 2020-06-17 CN CN202080044333.8A patent/CN114026082B/zh active Active
- 2020-06-17 SG SG11202111162PA patent/SG11202111162PA/en unknown
- 2020-06-17 CA CA3143618A patent/CA3143618A1/en active Pending
- 2020-06-17 JP JP2021574814A patent/JP7494222B2/ja active Active
- 2020-06-17 WO PCT/EP2020/066767 patent/WO2020254408A1/en unknown
- 2020-06-17 MA MA056504A patent/MA56504A/fr unknown
- 2020-06-17 BR BR112021025236A patent/BR112021025236A2/pt unknown
- 2020-06-17 MX MX2021015727A patent/MX2021015727A/es unknown
- 2020-06-17 EP EP20733601.7A patent/EP3986884A1/en active Pending
- 2020-06-17 KR KR1020227001133A patent/KR20220020921A/ko not_active Application Discontinuation
- 2020-06-17 AU AU2020298014A patent/AU2020298014A1/en active Pending
-
2021
- 2021-12-13 IL IL288950A patent/IL288950A/en unknown
- 2021-12-15 CL CL2021003348A patent/CL2021003348A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2020254408A1 (en) | 2020-12-24 |
CN114026082A (zh) | 2022-02-08 |
CN114026082B (zh) | 2024-06-07 |
MX2021015727A (es) | 2022-01-24 |
EP3986884A1 (en) | 2022-04-27 |
CA3143618A1 (en) | 2020-12-24 |
SG11202111162PA (en) | 2021-11-29 |
TW202115011A (zh) | 2021-04-16 |
AU2020298014A1 (en) | 2022-02-10 |
JP2022537177A (ja) | 2022-08-24 |
IL288950A (en) | 2022-02-01 |
MA56504A (fr) | 2022-04-27 |
AR119162A1 (es) | 2021-12-01 |
KR20220020921A (ko) | 2022-02-21 |
CL2021003348A1 (es) | 2022-09-23 |
JP7494222B2 (ja) | 2024-06-03 |
US20220251068A1 (en) | 2022-08-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12020551870A1 (en) | Tetracyclic heteroaryl compounds | |
PH12019500830A1 (en) | 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer | |
BR112016023679A2 (pt) | derivados de amida e sais farmaceuticamente aceitáveis dos mesmos, método de preparação dos mesmos e aplicação medicinal dos mesmos | |
BR112021017408A2 (pt) | Compostos tricíclicos fundidos úteis como agentes anticancerosos | |
MX2019010354A (es) | Derivado de heteroaril[4,3-c]pirimidina-5-amina, metodo de preparacion del mismo y usos medicos del mismo. | |
BR112015032623A8 (pt) | composto, composição farmacêutica, combinação, e, uso de um composto | |
BR112015023948A2 (pt) | composto de fórmula (i), composição farmacêutica, método para o tratamento e/ou prevenção de uma doença proliferativa e para a inibição ou a diferenciação do crescimento de uma célula tronco do câncer | |
BR112017022604A2 (pt) | composto, composição farmacêutica, uso de um composto e de uma combinação, e, combinação | |
BR112018006448A2 (pt) | derivado de oxaespiro, método de preparação dos mesmos, e aplicações dos mesmos em medicamentos | |
BR112018071408A2 (pt) | “composto inibidor de rip2 quinase, composição farmacêutica, usos de um composto e de uma combinação, e, combinação | |
MY195194A (en) | Substituted Indoline Derivatives as Dengue Viral Replication Inhibitors | |
BR112017023764A2 (pt) | derivados de ciclohexano substituído por amido | |
BR112015022096A8 (pt) | compostos moduladores de canal de sódio, composição que os compreende e uso dos mesmos | |
BRPI0709680B8 (pt) | derivados de pirrol, tiofeno e furano substituídos por piridil e piridimil como inibidores de quinase | |
BR112015000578A2 (pt) | moduladores da via do complemento e usos dos mesmos | |
BR112018069601A2 (pt) | derivados de indolina substituídos como inibidores da replicação viral da dengue | |
MX357780B (es) | Derivados policíclicos, proceso para su preparación y su uso farmacéutico. | |
PH12019500188A1 (en) | Piperidine cxcr7 receptor modulators | |
BR112017010645A2 (pt) | derivados da piridinocarboxamida, método de preparação dos mesmos e usos farmacêuticos dos mesmos | |
PH12019502562A1 (en) | N-substituted indole derivatives | |
PH12019501724A1 (en) | Estrogen receptor modulators | |
BR112022013322A2 (pt) | Derivado de tetra-hidroisoquinolina tricíclico, método de preparação para o mesmo e aplicação do mesmo em medicina | |
BR112022005660A2 (pt) | Inibidores de fxia e método de preparação dos mesmos e uso farmacêutico dos mesmos. | |
BR112021025236A2 (pt) | Composto, composição farmacêutica, uso do composto, e, método para a profilaxia ou o tratamento de fibrose, distúrbios dermatológicos, dor, doenças proliferativas malignas, benignas, doenças respiratórias, distúrbios do sistema nervoso central, doenças cardiovasculares, distúrbios inflamatórios, obesidade ou resistência à insulina | |
EA201992804A1 (ru) | Производные аминогликозида и их применение при лечении генетических заболеваний |