BR112021025236A2 - Composto, composição farmacêutica, uso do composto, e, método para a profilaxia ou o tratamento de fibrose, distúrbios dermatológicos, dor, doenças proliferativas malignas, benignas, doenças respiratórias, distúrbios do sistema nervoso central, doenças cardiovasculares, distúrbios inflamatórios, obesidade ou resistência à insulina - Google Patents
Composto, composição farmacêutica, uso do composto, e, método para a profilaxia ou o tratamento de fibrose, distúrbios dermatológicos, dor, doenças proliferativas malignas, benignas, doenças respiratórias, distúrbios do sistema nervoso central, doenças cardiovasculares, distúrbios inflamatórios, obesidade ou resistência à insulinaInfo
- Publication number
- BR112021025236A2 BR112021025236A2 BR112021025236A BR112021025236A BR112021025236A2 BR 112021025236 A2 BR112021025236 A2 BR 112021025236A2 BR 112021025236 A BR112021025236 A BR 112021025236A BR 112021025236 A BR112021025236 A BR 112021025236A BR 112021025236 A2 BR112021025236 A2 BR 112021025236A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- disorders
- diseases
- pharmaceutical composition
- prophylaxis
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
composto, composição farmacêutica, e, uso do composto. a presente invenção se refere aos derivados de piridin-3-ila de fórmula (i) em que r1, r2, r3, r4, r5, ar1, l, m e n são como descritos na descrição, à preparação deles, aos sais farmaceuticamente aceitáveis dos mesmos, e ao uso deles como fármacos, às composições farmacêuticas que contêm um ou mais compostos de fórmula (i), e especialmente ao uso deles como moduladores de receptor de lpa1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2019065963 | 2019-06-18 | ||
| PCT/EP2020/066767 WO2020254408A1 (en) | 2019-06-18 | 2020-06-17 | Pyridin-3-yl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021025236A2 true BR112021025236A2 (pt) | 2022-02-01 |
Family
ID=71105482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021025236A BR112021025236A2 (pt) | 2019-06-18 | 2020-06-17 | Composto, composição farmacêutica, uso do composto, e, método para a profilaxia ou o tratamento de fibrose, distúrbios dermatológicos, dor, doenças proliferativas malignas, benignas, doenças respiratórias, distúrbios do sistema nervoso central, doenças cardiovasculares, distúrbios inflamatórios, obesidade ou resistência à insulina |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20220251068A1 (pt) |
| EP (1) | EP3986884A1 (pt) |
| JP (1) | JP7494222B2 (pt) |
| KR (1) | KR20220020921A (pt) |
| CN (1) | CN114026082B (pt) |
| AR (1) | AR119162A1 (pt) |
| AU (1) | AU2020298014A1 (pt) |
| BR (1) | BR112021025236A2 (pt) |
| CA (1) | CA3143618A1 (pt) |
| CL (1) | CL2021003348A1 (pt) |
| IL (1) | IL288950A (pt) |
| MA (1) | MA56504A (pt) |
| MX (1) | MX2021015727A (pt) |
| SG (1) | SG11202111162PA (pt) |
| WO (1) | WO2020254408A1 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023504415A (ja) * | 2019-12-04 | 2023-02-03 | イドーシア ファーマシューティカルズ リミテッド | 線維性疾患の治療に使用するためのアゼチジンｌｐａ１受容体アンタゴニストのピルフェニドン及び／又はニンテダニブとの合剤 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1364659B1 (en) | 2001-02-08 | 2009-11-11 | Ono Pharmaceutical Co., Ltd. | Remedies for urinary diseases comprising lpa receptor controlling agents |
| TW200403058A (en) | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
| EP1679069A4 (en) | 2003-10-21 | 2009-05-13 | Dainippon Sumitomo Pharma Co | NEW PIPERIDINE DERIVATIVE |
| WO2005046601A2 (en) | 2003-11-12 | 2005-05-26 | Merck & Co., Inc. | 4-phenyl piperdine sulfonyl glycine transporter inhibitors |
| CA2546339A1 (en) | 2003-11-18 | 2005-06-02 | Warner-Lambert Company Llc | Antibacterial aminoquinazolidinedione derivatives |
| SI1889836T1 (sl) | 2005-08-24 | 2013-10-30 | Eisai R&D Management Co., Ltd. | Nov derivat piridina in derivat piridina (3) |
| JP5164510B2 (ja) | 2006-10-06 | 2013-03-21 | 日本曹達株式会社 | 含窒素複素環化合物および有害生物防除剤 |
| AU2008311971A1 (en) | 2007-10-18 | 2009-04-23 | Merck Sharp & Dohme Corp. | Quinolizidinone M1 receptor positive allosteric modulators |
| EP2303270B1 (en) | 2008-05-05 | 2017-05-17 | Sanofi | Acylamino-substituted fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals |
| PT2481725E (pt) * | 2009-09-25 | 2015-05-21 | Astellas Pharma Inc | Composto de amida substituído |
| JP5409968B2 (ja) | 2010-08-05 | 2014-02-05 | ゾエティス・エルエルシー | 駆虫剤としてのイソオキサゾリン誘導体 |
| TW201305178A (zh) | 2010-10-29 | 2013-02-01 | Glenmark Pharmaceuticals Sa | 作為ｍＰＧＥＳ－１抑制物的三環化合物 |
| EP2648726B1 (en) | 2010-12-07 | 2018-04-04 | Amira Pharmaceuticals, Inc. | Polycyclic lpa1 antagonist and uses thereof |
| RU2566083C3 (ru) | 2011-03-10 | 2017-11-09 | Зоетис Сервисиз ЛЛК | Спироциклические производные изоксазолина в качестве противопаразитарных агентов |
| EP2794576A1 (en) | 2011-12-21 | 2014-10-29 | Ardelyx, Inc. | Non-systemic tgr5 agonists |
| CN105189481A (zh) * | 2013-03-13 | 2015-12-23 | 艾伯维公司 | 吡啶cdk9激酶抑制剂 |
| WO2015069593A1 (en) | 2013-11-06 | 2015-05-14 | Bristol-Myers Squibb Company | Substituted pyridine derivatives useful as gsk-3 inhibitors |
| LT3802517T (lt) * | 2018-06-07 | 2023-03-10 | Idorsia Pharmaceuticals Ltd | Alkoksi-pakeistieji piridinilo dariniai kaip lpa1 receptoriaus antagonistai ir jų panaudojimas fibrozės gydymui |
-
2020
- 2020-06-16 AR ARP200101686A patent/AR119162A1/es unknown
- 2020-06-17 MX MX2021015727A patent/MX2021015727A/es unknown
- 2020-06-17 SG SG11202111162PA patent/SG11202111162PA/en unknown
- 2020-06-17 MA MA056504A patent/MA56504A/fr unknown
- 2020-06-17 US US17/620,520 patent/US20220251068A1/en active Pending
- 2020-06-17 CN CN202080044333.8A patent/CN114026082B/zh active Active
- 2020-06-17 BR BR112021025236A patent/BR112021025236A2/pt unknown
- 2020-06-17 WO PCT/EP2020/066767 patent/WO2020254408A1/en unknown
- 2020-06-17 EP EP20733601.7A patent/EP3986884A1/en active Pending
- 2020-06-17 AU AU2020298014A patent/AU2020298014A1/en active Pending
- 2020-06-17 CA CA3143618A patent/CA3143618A1/en active Pending
- 2020-06-17 JP JP2021574814A patent/JP7494222B2/ja active Active
- 2020-06-17 KR KR1020227001133A patent/KR20220020921A/ko not_active Application Discontinuation
-
2021
- 2021-12-13 IL IL288950A patent/IL288950A/en unknown
- 2021-12-15 CL CL2021003348A patent/CL2021003348A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3986884A1 (en) | 2022-04-27 |
| IL288950A (en) | 2022-02-01 |
| CL2021003348A1 (es) | 2022-09-23 |
| SG11202111162PA (en) | 2021-11-29 |
| TW202115011A (zh) | 2021-04-16 |
| KR20220020921A (ko) | 2022-02-21 |
| CA3143618A1 (en) | 2020-12-24 |
| CN114026082B (zh) | 2024-06-07 |
| JP7494222B2 (ja) | 2024-06-03 |
| MX2021015727A (es) | 2022-01-24 |
| JP2022537177A (ja) | 2022-08-24 |
| MA56504A (fr) | 2022-04-27 |
| CN114026082A (zh) | 2022-02-08 |
| AU2020298014A1 (en) | 2022-02-10 |
| WO2020254408A1 (en) | 2020-12-24 |
| AR119162A1 (es) | 2021-12-01 |
| US20220251068A1 (en) | 2022-08-11 |
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