BR112021025236A2 - Composto, composição farmacêutica, uso do composto, e, método para a profilaxia ou o tratamento de fibrose, distúrbios dermatológicos, dor, doenças proliferativas malignas, benignas, doenças respiratórias, distúrbios do sistema nervoso central, doenças cardiovasculares, distúrbios inflamatórios, obesidade ou resistência à insulina - Google Patents

Composto, composição farmacêutica, uso do composto, e, método para a profilaxia ou o tratamento de fibrose, distúrbios dermatológicos, dor, doenças proliferativas malignas, benignas, doenças respiratórias, distúrbios do sistema nervoso central, doenças cardiovasculares, distúrbios inflamatórios, obesidade ou resistência à insulina

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Publication number
BR112021025236A2
BR112021025236A2 BR112021025236A BR112021025236A BR112021025236A2 BR 112021025236 A2 BR112021025236 A2 BR 112021025236A2 BR 112021025236 A BR112021025236 A BR 112021025236A BR 112021025236 A BR112021025236 A BR 112021025236A BR 112021025236 A2 BR112021025236 A2 BR 112021025236A2
Authority
BR
Brazil
Prior art keywords
compound
disorders
diseases
pharmaceutical composition
prophylaxis
Prior art date
Application number
BR112021025236A
Other languages
English (en)
Inventor
Christine Brotschi
Cyrille Lescop
Martin Bolli
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of BR112021025236A2 publication Critical patent/BR112021025236A2/pt

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

composto, composição farmacêutica, e, uso do composto. a presente invenção se refere aos derivados de piridin-3-ila de fórmula (i) em que r1, r2, r3, r4, r5, ar1, l, m e n são como descritos na descrição, à preparação deles, aos sais farmaceuticamente aceitáveis dos mesmos, e ao uso deles como fármacos, às composições farmacêuticas que contêm um ou mais compostos de fórmula (i), e especialmente ao uso deles como moduladores de receptor de lpa1.
BR112021025236A 2019-06-18 2020-06-17 Composto, composição farmacêutica, uso do composto, e, método para a profilaxia ou o tratamento de fibrose, distúrbios dermatológicos, dor, doenças proliferativas malignas, benignas, doenças respiratórias, distúrbios do sistema nervoso central, doenças cardiovasculares, distúrbios inflamatórios, obesidade ou resistência à insulina BR112021025236A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2019065963 2019-06-18
PCT/EP2020/066767 WO2020254408A1 (en) 2019-06-18 2020-06-17 Pyridin-3-yl derivatives

Publications (1)

Publication Number Publication Date
BR112021025236A2 true BR112021025236A2 (pt) 2022-02-01

Family

ID=71105482

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021025236A BR112021025236A2 (pt) 2019-06-18 2020-06-17 Composto, composição farmacêutica, uso do composto, e, método para a profilaxia ou o tratamento de fibrose, distúrbios dermatológicos, dor, doenças proliferativas malignas, benignas, doenças respiratórias, distúrbios do sistema nervoso central, doenças cardiovasculares, distúrbios inflamatórios, obesidade ou resistência à insulina

Country Status (15)

Country Link
US (1) US20220251068A1 (pt)
EP (1) EP3986884A1 (pt)
JP (1) JP7494222B2 (pt)
KR (1) KR20220020921A (pt)
CN (1) CN114026082B (pt)
AR (1) AR119162A1 (pt)
AU (1) AU2020298014A1 (pt)
BR (1) BR112021025236A2 (pt)
CA (1) CA3143618A1 (pt)
CL (1) CL2021003348A1 (pt)
IL (1) IL288950A (pt)
MA (1) MA56504A (pt)
MX (1) MX2021015727A (pt)
SG (1) SG11202111162PA (pt)
WO (1) WO2020254408A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023504415A (ja) * 2019-12-04 2023-02-03 イドーシア ファーマシューティカルズ リミテッド 線維性疾患の治療に使用するためのアゼチジンlpa1受容体アンタゴニストのピルフェニドン及び/又はニンテダニブとの合剤

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1364659B1 (en) 2001-02-08 2009-11-11 Ono Pharmaceutical Co., Ltd. Remedies for urinary diseases comprising lpa receptor controlling agents
TW200403058A (en) 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
EP1679069A4 (en) 2003-10-21 2009-05-13 Dainippon Sumitomo Pharma Co NEW PIPERIDINE DERIVATIVE
WO2005046601A2 (en) 2003-11-12 2005-05-26 Merck & Co., Inc. 4-phenyl piperdine sulfonyl glycine transporter inhibitors
CA2546339A1 (en) 2003-11-18 2005-06-02 Warner-Lambert Company Llc Antibacterial aminoquinazolidinedione derivatives
SI1889836T1 (sl) 2005-08-24 2013-10-30 Eisai R&D Management Co., Ltd. Nov derivat piridina in derivat piridina (3)
JP5164510B2 (ja) 2006-10-06 2013-03-21 日本曹達株式会社 含窒素複素環化合物および有害生物防除剤
AU2008311971A1 (en) 2007-10-18 2009-04-23 Merck Sharp & Dohme Corp. Quinolizidinone M1 receptor positive allosteric modulators
EP2303270B1 (en) 2008-05-05 2017-05-17 Sanofi Acylamino-substituted fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals
PT2481725E (pt) * 2009-09-25 2015-05-21 Astellas Pharma Inc Composto de amida substituído
JP5409968B2 (ja) 2010-08-05 2014-02-05 ゾエティス・エルエルシー 駆虫剤としてのイソオキサゾリン誘導体
TW201305178A (zh) 2010-10-29 2013-02-01 Glenmark Pharmaceuticals Sa 作為mPGES-1抑制物的三環化合物
EP2648726B1 (en) 2010-12-07 2018-04-04 Amira Pharmaceuticals, Inc. Polycyclic lpa1 antagonist and uses thereof
RU2566083C3 (ru) 2011-03-10 2017-11-09 Зоетис Сервисиз ЛЛК Спироциклические производные изоксазолина в качестве противопаразитарных агентов
EP2794576A1 (en) 2011-12-21 2014-10-29 Ardelyx, Inc. Non-systemic tgr5 agonists
CN105189481A (zh) * 2013-03-13 2015-12-23 艾伯维公司 吡啶cdk9激酶抑制剂
WO2015069593A1 (en) 2013-11-06 2015-05-14 Bristol-Myers Squibb Company Substituted pyridine derivatives useful as gsk-3 inhibitors
LT3802517T (lt) * 2018-06-07 2023-03-10 Idorsia Pharmaceuticals Ltd Alkoksi-pakeistieji piridinilo dariniai kaip lpa1 receptoriaus antagonistai ir jų panaudojimas fibrozės gydymui

Also Published As

Publication number Publication date
EP3986884A1 (en) 2022-04-27
IL288950A (en) 2022-02-01
CL2021003348A1 (es) 2022-09-23
SG11202111162PA (en) 2021-11-29
TW202115011A (zh) 2021-04-16
KR20220020921A (ko) 2022-02-21
CA3143618A1 (en) 2020-12-24
CN114026082B (zh) 2024-06-07
JP7494222B2 (ja) 2024-06-03
MX2021015727A (es) 2022-01-24
JP2022537177A (ja) 2022-08-24
MA56504A (fr) 2022-04-27
CN114026082A (zh) 2022-02-08
AU2020298014A1 (en) 2022-02-10
WO2020254408A1 (en) 2020-12-24
AR119162A1 (es) 2021-12-01
US20220251068A1 (en) 2022-08-11

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