BR112022005660A2 - Inibidores de fxia e método de preparação dos mesmos e uso farmacêutico dos mesmos. - Google Patents
Inibidores de fxia e método de preparação dos mesmos e uso farmacêutico dos mesmos.Info
- Publication number
- BR112022005660A2 BR112022005660A2 BR112022005660A BR112022005660A BR112022005660A2 BR 112022005660 A2 BR112022005660 A2 BR 112022005660A2 BR 112022005660 A BR112022005660 A BR 112022005660A BR 112022005660 A BR112022005660 A BR 112022005660A BR 112022005660 A2 BR112022005660 A2 BR 112022005660A2
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- pharmaceutical use
- fxia
- inhibitors
- fxia inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
- C07D237/16—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
INIBIDORES DE FXIA E MÉTODO DE PREPARAÇÃO DOS MESMOS E USO FARMACÊUTICO DOS MESMOS. É fornecida na presente invenção uma série de inibidores de Fator XIa seletivo (FXIa), relacionados ao campo da técnica de fármacos químicos. A presente invenção também se refere a composições farmacêuticas que contêm as ditas composições e a um uso das ditas composições em fármacos para o tratamento de doenças, tais como tromboembolismo.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910923960 | 2019-09-27 | ||
CN201911318870 | 2019-12-19 | ||
CN202010902000 | 2020-09-01 | ||
PCT/CN2020/117257 WO2021057818A1 (zh) | 2019-09-27 | 2020-09-24 | FXIa抑制剂及其制备方法和医药用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022005660A2 true BR112022005660A2 (pt) | 2022-07-12 |
Family
ID=75165578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022005660A BR112022005660A2 (pt) | 2019-09-27 | 2020-09-24 | Inibidores de fxia e método de preparação dos mesmos e uso farmacêutico dos mesmos. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20230027295A1 (pt) |
EP (1) | EP4036087A4 (pt) |
JP (1) | JP7450024B2 (pt) |
KR (1) | KR20220084301A (pt) |
CN (2) | CN116120240A (pt) |
AU (1) | AU2020355830B2 (pt) |
BR (1) | BR112022005660A2 (pt) |
CA (1) | CA3152667A1 (pt) |
CO (1) | CO2022005082A2 (pt) |
EC (1) | ECSP22032851A (pt) |
MX (1) | MX2022003649A (pt) |
TW (1) | TWI756848B (pt) |
WO (1) | WO2021057818A1 (pt) |
ZA (1) | ZA202202932B (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022083706A1 (zh) * | 2020-10-23 | 2022-04-28 | 深圳信立泰药业股份有限公司 | FXIa抑制剂化合物的盐及其制备方法和医药用途 |
CN115427043B (zh) * | 2020-10-23 | 2023-04-07 | 深圳信立泰药业股份有限公司 | FXIa抑制剂化合物或其盐的医药用途 |
CN117480164A (zh) * | 2020-12-11 | 2024-01-30 | 上海领泰生物医药科技有限公司 | 凝血因子XIa抑制剂及其制备方法和应用 |
TW202246219A (zh) * | 2021-03-18 | 2022-12-01 | 大陸商深圳信立泰藥業股份有限公司 | FXIa抑制劑化合物雜質、其製備方法及其用途 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996030396A1 (en) | 1995-03-24 | 1996-10-03 | Molecumetics Ltd. | β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS |
ATE230414T1 (de) | 1998-02-12 | 2003-01-15 | Molecumetics Ltd | Mimetika von beta-faltblatt und verfahren zur verwendung davon |
AU2003243657A1 (en) | 2002-06-26 | 2004-01-19 | Bristol-Myers Squibb Company | Amino-bicyclic pyrazinones and pyridinones |
RS56168B1 (sr) | 2011-10-14 | 2017-11-30 | Bristol Myers Squibb Co | Supstituisana jedinjenja tetrahidroizohinolina kao inhibitori xia faktora |
GB2497806A (en) * | 2011-12-21 | 2013-06-26 | Ono Pharmaceutical Co | Pyridinone and pyrimidinone derivatives as factor XIa inhibitors |
KR102011534B1 (ko) * | 2011-12-21 | 2019-08-16 | 오노 야꾸힝 고교 가부시키가이샤 | 인자 XIa 억제제로서 피리디논 및 피리미디논 유도체 |
TWI633089B (zh) * | 2013-03-28 | 2018-08-21 | 拜耳製藥股份有限公司 | 經取代的酮基吡啶衍生物 |
WO2016046156A1 (de) * | 2014-09-24 | 2016-03-31 | Bayer Pharma Aktiengesellschaft | Substituierte oxopyridin-derivate |
WO2016046166A1 (de) * | 2014-09-24 | 2016-03-31 | Bayer Pharma Aktiengesellschaft | Substituierte oxopyridin-derivate |
JO3703B1 (ar) * | 2015-07-09 | 2021-01-31 | Bayer Pharma AG | مشتقات أوكسوبيريدين مستبدلة |
ES2754599T3 (es) * | 2015-08-05 | 2020-04-20 | Bristol Myers Squibb Co | Nuevos inhibidores de FXIa derivados de glicina sustituidos |
HUE057289T2 (hu) * | 2016-08-31 | 2022-05-28 | Jiangsu Hengrui Medicine Co | Oxopikolinamid-származék, annak elõállítási módszere és gyógyszerészeti felhasználása |
CN107793396B (zh) * | 2016-08-31 | 2021-02-26 | 江苏恒瑞医药股份有限公司 | 环氧基取代的氧代吡啶类衍生物、其制备方法及其在医药上的应用 |
WO2018081377A1 (en) * | 2016-10-26 | 2018-05-03 | Proteostasis Therapeutics, Inc. | N-phenyl-2-(3-phenyl-6-oxo-1,6-dihydropyridazin-1-yl)acetamide derivatives for treating cystic fibrosis |
CN111094241B (zh) * | 2018-02-27 | 2022-06-21 | 江苏恒瑞医药股份有限公司 | 一种氧代吡啶酰胺类衍生物的晶型及其制备方法 |
-
2020
- 2020-09-24 CN CN202310031498.7A patent/CN116120240A/zh active Pending
- 2020-09-24 AU AU2020355830A patent/AU2020355830B2/en active Active
- 2020-09-24 BR BR112022005660A patent/BR112022005660A2/pt unknown
- 2020-09-24 US US17/764,107 patent/US20230027295A1/en active Pending
- 2020-09-24 EP EP20870084.9A patent/EP4036087A4/en active Pending
- 2020-09-24 WO PCT/CN2020/117257 patent/WO2021057818A1/zh active Application Filing
- 2020-09-24 JP JP2022519398A patent/JP7450024B2/ja active Active
- 2020-09-24 KR KR1020227014153A patent/KR20220084301A/ko unknown
- 2020-09-24 MX MX2022003649A patent/MX2022003649A/es unknown
- 2020-09-24 CA CA3152667A patent/CA3152667A1/en active Pending
- 2020-09-24 CN CN202080057046.0A patent/CN114206854B/zh active Active
- 2020-09-26 TW TW109133517A patent/TWI756848B/zh active
-
2022
- 2022-03-10 ZA ZA2022/02932A patent/ZA202202932B/en unknown
- 2022-04-22 CO CONC2022/0005082A patent/CO2022005082A2/es unknown
- 2022-04-25 EC ECSENADI202232851A patent/ECSP22032851A/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP4036087A4 (en) | 2023-09-20 |
ECSP22032851A (es) | 2022-08-31 |
CN114206854A (zh) | 2022-03-18 |
JP2022550367A (ja) | 2022-12-01 |
TW202112374A (zh) | 2021-04-01 |
WO2021057818A1 (zh) | 2021-04-01 |
JP7450024B2 (ja) | 2024-03-14 |
EP4036087A1 (en) | 2022-08-03 |
TWI756848B (zh) | 2022-03-01 |
MX2022003649A (es) | 2022-06-08 |
CA3152667A1 (en) | 2021-04-01 |
AU2020355830A1 (en) | 2022-03-31 |
AU2020355830A9 (en) | 2022-07-21 |
CO2022005082A2 (es) | 2022-05-20 |
US20230027295A1 (en) | 2023-01-26 |
CN116120240A (zh) | 2023-05-16 |
CN114206854B (zh) | 2023-02-24 |
AU2020355830B2 (en) | 2023-04-13 |
ZA202202932B (en) | 2022-11-30 |
KR20220084301A (ko) | 2022-06-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112022005660A2 (pt) | Inibidores de fxia e método de preparação dos mesmos e uso farmacêutico dos mesmos. | |
MX2019001481A (es) | Derivado de oxopicolinamida, metodo de preparacion y uso farmaceutico del mismo. | |
MX2019005379A (es) | Derivado de pirazolo-heteroarilo, metodo de preparacion y uso medico del mismo. | |
MX2016013529A (es) | Derivados de amidas y sales farmaceuticamente aceptables de los mismos, método de preparación de los mismos y aplicación médica de los mismos. | |
BR112017022604A2 (pt) | composto, composição farmacêutica, uso de um composto e de uma combinação, e, combinação | |
MX2021003655A (es) | Derivado de indol macrociclico, metodo de preparacion del mismo y aplicacion del mismo en medicina. | |
BR112016015818A2 (pt) | Compostos e respectivos usos para tratar pacientes com células cancerosas mutantes em relação a ros1 | |
BR112018071408A2 (pt) | “composto inibidor de rip2 quinase, composição farmacêutica, usos de um composto e de uma combinação, e, combinação | |
UY32158A (es) | Derivados heterociclicos y metodos de uso de los mismos | |
MA37206B1 (fr) | Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
TW201613885A (en) | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication | |
NO20085100L (no) | Nye forbindelser | |
MX357780B (es) | Derivados policíclicos, proceso para su preparación y su uso farmacéutico. | |
CY1122689T1 (el) | Παραγωγα πυραζολιου χρησιμα ως αναστολεις της πρωτεϊνης ενεργοποιησης της 5-λιποξυγενασης (flap) | |
CR20140144A (es) | Derivados de estra-1,3,5 (10), 16-tetraen-3-carboxamida, procedimientos para su preparación, preparados farmacéuticos que los contienen, así como su uso para la preparación de medicamentos | |
DOP2015000005A (es) | Derivados de estra 1,3,5(10), 16 tetraeno 3 sustituidos, métodos para su preparación, preparaciones farmacéuticas que los contienen, así como su uso para la preparación de medicamentos | |
BR112017010645A2 (pt) | derivados da piridinocarboxamida, método de preparação dos mesmos e usos farmacêuticos dos mesmos | |
UA107183C2 (uk) | Феніламіно-ізонікотинамідні сполуки, їх застосування, фармацевтична композиція, що їх містить, та спосіб лікування гіперпроліферативних захворювань | |
BR112021018924A2 (pt) | Derivado de heterocíclico pirrol, método de preparação do mesmo e aplicação do mesmo em medicamento | |
CO2022000749A2 (es) | Inhibidores de monoacilglicerol lipasa (magl) heterocíclicos | |
BR112021017957A2 (pt) | Derivado tienoeterocíclico, método de preparação do mesmo e uso médico do mesmo | |
EA201491651A1 (ru) | Новые соединения для лечения дислипидемии и родственных заболеваний | |
BR112018008076A2 (pt) | derivados de lapachona contendo dois centros redox e métodos de uso dos mesmos | |
BR112017009850A2 (pt) | composto, composição, e, uso de uma quantidade melhoradora de hiv de um composto | |
MA50450B1 (fr) | Nouveaux derives macrocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |