HRP20020693B1 - HUMANIZIRANA PROTUTIJELA KOJA SADRŽE PEPTID Aß - Google Patents

HUMANIZIRANA PROTUTIJELA KOJA SADRŽE PEPTID Aß

Info

Publication number
HRP20020693B1
HRP20020693B1 HR20020693A HRP20020693A HRP20020693B1 HR P20020693 B1 HRP20020693 B1 HR P20020693B1 HR 20020693 A HR20020693 A HR 20020693A HR P20020693 A HRP20020693 A HR P20020693A HR P20020693 B1 HRP20020693 B1 HR P20020693B1
Authority
HR
Croatia
Prior art keywords
heavy chain
light chain
humanized antibodies
chain
abeta peptide
Prior art date
Application number
HR20020693A
Other languages
English (en)
Inventor
M. Holtzman David
Demattos Ronald
R. Bales Kelly
M. Paul Steven
Tsurushita Naoya
Vasquez Maximiliano
Original Assignee
Washington University
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27391859&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20020693(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Washington University, Eli Lilly And Company filed Critical Washington University
Publication of HRP20020693A2 publication Critical patent/HRP20020693A2/hr
Publication of HRP20020693B1 publication Critical patent/HRP20020693B1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Humanizirano protutijelo ili njegov odsječak, naznačeno time da: a. se laki lanac sastoji od tri regije determinacije komplementarnosti (CDR) lakog lanca, koje imaju slijedeće slijedove aminokiselina: CDR1 lakog lanca: ili CDR2 lakog lanca: i CDR3 lakog lanca: i slijed okvira lakog lanca humanog imunoglobulinskog lakog lanca ib. teški lanac koji se sastoji od tri CDR teškog lanca, koje imaju slijedeće slijedove aminokiselina: CDR1 teškog lanca: CDR2 teškog lanca: ilii CDR3 teškog lanca: i slijed okvira teškog lanca humanog imunoglobulinskog teškog lanca; gdje se antitijelo ili odsječak specifično vežu za epitop sadržan unutar pozicija 13-28 A?. Patent sadrži još 26 patentnih zahtjeva.
HR20020693A 2000-02-24 2002-08-22 HUMANIZIRANA PROTUTIJELA KOJA SADRŽE PEPTID Aß HRP20020693B1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18460100P 2000-02-24 2000-02-24
US25449800P 2000-12-08 2000-12-08
US25446500P 2000-12-08 2000-12-08
PCT/US2001/006191 WO2001062801A2 (en) 2000-02-24 2001-02-26 Humanized antibodies that sequester amyloid beta peptide

Publications (2)

Publication Number Publication Date
HRP20020693A2 HRP20020693A2 (en) 2004-12-31
HRP20020693B1 true HRP20020693B1 (hr) 2012-01-31

Family

ID=27391859

Family Applications (2)

Application Number Title Priority Date Filing Date
HR20020693A HRP20020693B1 (hr) 2000-02-24 2002-08-22 HUMANIZIRANA PROTUTIJELA KOJA SADRŽE PEPTID Aß
HRP20080430AA HRP20080430B1 (hr) 2000-02-24 2008-09-03 HUMANIZIRANA PROTUTIJELA KOJA SADRŽE PEPTID αß

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20080430AA HRP20080430B1 (hr) 2000-02-24 2008-09-03 HUMANIZIRANA PROTUTIJELA KOJA SADRŽE PEPTID αß

Country Status (32)

Country Link
US (4) US7195761B2 (hr)
EP (4) EP3150633A1 (hr)
JP (2) JP4738696B2 (hr)
KR (1) KR100767146B1 (hr)
CN (3) CN104341500A (hr)
AT (1) ATE279442T1 (hr)
AU (1) AU4178601A (hr)
BR (1) BRPI0108676B8 (hr)
CA (1) CA2400559C (hr)
CY (1) CY1118381T1 (hr)
CZ (2) CZ2008595A3 (hr)
DE (2) DE1257584T1 (hr)
DK (2) DK1257584T4 (hr)
DZ (1) DZ3295A1 (hr)
EA (1) EA006606B1 (hr)
ES (2) ES2184660T5 (hr)
HK (1) HK1048640B (hr)
HR (2) HRP20020693B1 (hr)
HU (2) HUP0204074A3 (hr)
IL (3) IL151378A0 (hr)
LT (1) LT1481992T (hr)
MX (1) MXPA02008145A (hr)
NO (2) NO329840B1 (hr)
NZ (1) NZ520800A (hr)
PL (2) PL218883B1 (hr)
PT (2) PT1257584E (hr)
SI (2) SI1481992T1 (hr)
SK (2) SK288723B6 (hr)
TR (1) TR200202799T3 (hr)
UA (1) UA75881C2 (hr)
WO (1) WO2001062801A2 (hr)
ZA (1) ZA200206712B (hr)

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