HK67694A - 1,2 bis(aminomethyl)cyclobutane-platinum-complexes - Google Patents

1,2 bis(aminomethyl)cyclobutane-platinum-complexes Download PDF

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Publication number
HK67694A
HK67694A HK67694A HK67694A HK67694A HK 67694 A HK67694 A HK 67694A HK 67694 A HK67694 A HK 67694A HK 67694 A HK67694 A HK 67694A HK 67694 A HK67694 A HK 67694A
Authority
HK
Hong Kong
Prior art keywords
phenyl
platinum
alkoxy
halogen
alkyl
Prior art date
Application number
HK67694A
Other languages
German (de)
English (en)
French (fr)
Inventor
Dr. Wolfgang Schumacher
Dr. Johannes Respondek
Dr. Juergen Engel
Dr. Joerg Pohl
Dr. Rainer Voegeli
Dr. Peter Hilgard
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of HK67694A publication Critical patent/HK67694A/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Luminescent Compositions (AREA)
HK67694A 1988-01-09 1994-07-14 1,2 bis(aminomethyl)cyclobutane-platinum-complexes HK67694A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3800415 1988-01-09

Publications (1)

Publication Number Publication Date
HK67694A true HK67694A (en) 1994-07-22

Family

ID=6344991

Family Applications (1)

Application Number Title Priority Date Filing Date
HK67694A HK67694A (en) 1988-01-09 1994-07-14 1,2 bis(aminomethyl)cyclobutane-platinum-complexes

Country Status (22)

Country Link
US (1) US5023335A (enExample)
EP (1) EP0324154B1 (enExample)
JP (1) JP2710654B2 (enExample)
AT (1) ATE86967T1 (enExample)
AU (1) AU611749B2 (enExample)
CA (1) CA1316177C (enExample)
DE (3) DE8817132U1 (enExample)
DK (1) DK174981B1 (enExample)
EG (1) EG19357A (enExample)
ES (1) ES2054778T3 (enExample)
FI (1) FI90875C (enExample)
GR (1) GR3007408T3 (enExample)
HK (1) HK67694A (enExample)
HU (1) HU203361B (enExample)
IE (1) IE63527B1 (enExample)
IL (1) IL88898A (enExample)
MC (1) MC2001A1 (enExample)
NO (1) NO173390C (enExample)
NZ (1) NZ227549A (enExample)
PT (1) PT89408B (enExample)
YU (2) YU47548B (enExample)
ZA (1) ZA89136B (enExample)

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ES2056721B1 (es) * 1991-06-05 1995-05-01 Ferrer Int Mejoras en el objeto de la patente de invencion n{ 9101355 que se refiere a procedimiento de obtencion de nuevos derivados de platino con aminopirrolidinas.
ES2042364B1 (es) * 1991-06-05 1994-07-16 Ferrer Int Procedimiento de obtencion de nuevos derivados de platino con aminopirrolidinas.
DE4415263C1 (de) * 1994-04-15 1995-11-30 Asta Medica Ag Cis-[trans-1,2-Cyclobutanbis(methylamin)-N,N']-[(2S)-lactato-O·1·, O·2·]-platin(II)-trihydrat (Lobaplatin-Trihydrat), seine Herstellung und arzneiliche Verwendung
EP1013277A4 (en) * 1997-01-14 2002-04-17 Toray Industries LYOPHILIZED PREPARATIONS AND PROCESS FOR PRODUCING THE SAME
FR2772616B1 (fr) * 1997-12-24 2000-02-25 Caster Composition depigmentante
WO2010087976A2 (en) * 2009-01-31 2010-08-05 Igf Oncology, Llc Anti-cancer protein-platinum conjugates
CN102093226B (zh) * 2010-11-24 2013-12-04 贵州益佰制药股份有限公司 二氨甲基环丁烷草酸盐的制备方法
CN102020679B (zh) * 2010-11-24 2013-12-25 贵州益佰制药股份有限公司 一种以草酸盐制备洛铂三水合物的方法
WO2013083058A1 (zh) * 2011-12-07 2013-06-13 北京市丰硕维康技术开发有限责任公司 一类离去基团是含氨基或烷氨基的羟基酸衍生物的铂类化合物及其制备方法和应用
CN103467528B (zh) * 2013-08-21 2016-06-08 江苏奥赛康药业股份有限公司 一种洛铂的制备方法
RU2708311C2 (ru) 2014-04-25 2019-12-05 Блубёрд Био, Инк. Химерные антигенные рецепторы с mnd-промотором
ES2800906T3 (es) 2014-04-25 2021-01-05 Bluebird Bio Inc Métodos mejorados para producir terapias celulares adoptivas
RU2719030C2 (ru) 2014-06-06 2020-04-16 Блубёрд Био, Инк. Улучшенные композиции на основе t-клеток
JP6404461B2 (ja) * 2014-06-20 2018-10-10 貴州益佰制葯股▲ふん▼有限公司 ロバプラチン結晶体、調製方法及び薬物応用
CN105440083B (zh) * 2014-06-20 2018-08-14 贵州益佰制药股份有限公司 一种洛铂晶体、制备方法及药物应用
CN105198932B (zh) * 2014-06-20 2018-09-21 贵州益佰制药股份有限公司 洛铂二水合物、制备方法及药物应用
CN105440082B (zh) * 2014-06-20 2018-08-14 贵州益佰制药股份有限公司 一种洛铂晶体、制备方法及药物应用
CN105198933B (zh) * 2014-06-20 2018-08-14 贵州益佰制药股份有限公司 一种洛铂晶体、制备方法及药物应用
CN105330702B (zh) * 2014-06-20 2018-08-14 贵州益佰制药股份有限公司 一种洛铂晶体、制备方法及药物应用
CN105218587B (zh) * 2014-06-20 2018-08-14 贵州益佰制药股份有限公司 一种洛铂晶体、制备方法及药物应用
RU2747457C2 (ru) 2014-07-24 2021-05-05 Блубёрд Био, Инк. Химерные антигенные рецепторы к bcma
EA036379B1 (ru) 2014-12-12 2020-11-02 Блубёрд Био, Инк. Химерные антигенные рецепторы к bcma
WO2017099712A1 (en) 2015-12-07 2017-06-15 Bluebird Bio, Inc. Improved t cell compositions
CA3042424A1 (en) 2016-11-04 2018-05-11 Bluebird Bio, Inc. Anti-bcma car t cell compositions
CN108047277A (zh) * 2018-01-04 2018-05-18 昆明贵研药业有限公司 具有抗肿瘤活性的脂溶性铂配合物的制备方法
CN111718375A (zh) * 2019-03-19 2020-09-29 海南长安国际制药有限公司 具有g1和g2结构的铂类物质及其制备方法和应用
CN111718378B (zh) * 2019-03-19 2024-01-30 海南长安国际制药有限公司 具有式(k)结构的铂类化合物、制备及其检测方法
CN111721842B (zh) * 2019-03-19 2022-07-12 海南长安国际制药有限公司 洛铂中有关物质的检测方法
CN111718373A (zh) * 2019-03-19 2020-09-29 海南长安国际制药有限公司 具有式（i）结构的铂类化合物、制备及其应用
CN111721840B (zh) * 2019-03-19 2022-07-12 海南长安国际制药有限公司 洛铂中有关物质的检测
CN111718377A (zh) * 2019-03-19 2020-09-29 海南长安国际制药有限公司 具有结构式h1、h2的铂类物质、制备及其应用
CN113173953B (zh) * 2021-04-12 2022-06-10 昆明贵研药业有限公司 用于制备抗肿瘤药物的高纯洛铂三水合物的提纯方法
WO2024092045A1 (en) * 2022-10-25 2024-05-02 University Of Massachusetts Platinum(ii)-based anticancer agents, targeted conjugates, and method of synthesizing thereof

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
DE1618050A1 (de) * 1966-04-08 1970-01-02 Asahi Chemical Ind Verfahren zum Herstellen von 1,2-Diaminocyclobutan
GB1432562A (en) * 1972-04-10 1976-04-22 Rustenburg Platinum Mines Ltd Platinum co-ordination compounds
NL7807334A (nl) * 1978-07-06 1980-01-08 Tno Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een genees- middel met toepassing van een dergelijk platina-dia- minecomplex voor de behandeling van kanker, alsmede al- dus verkregen gevormd geneesmiddel.
NL181434C (nl) * 1980-01-03 1987-08-17 Tno Platina(iv)-diamine-complexen, alsmede hun bereiding en toepassing.
US4322362A (en) * 1980-07-28 1982-03-30 Bristol-Myers Company Salts of 2-hydroxymalonate platinum complexes
JPS5716895A (en) * 1980-07-05 1982-01-28 Otsuka Chem Co Ltd Platinum 2 complex and antitumor agent containing the same as active principle
JPS617283A (ja) * 1984-06-20 1986-01-13 Shionogi & Co Ltd 新規白金錯体および抗悪性腫瘍剤
IL76889A0 (en) * 1984-11-02 1986-02-28 Johnson Matthey Plc Solubilised platinum compound,method for the production thereof and pharmaceutical compositions containing the same
ATE49214T1 (de) * 1984-12-17 1990-01-15 American Cyanamid Co Platinkomplexe von aliphatischen tricarbonsaeuren.
JPS62207283A (ja) * 1986-03-07 1987-09-11 Yoshinori Kitani 新規な白金錯体
EP0290169A3 (en) * 1987-05-04 1990-08-01 Engelhard Corporation Diamineplatinum complexes with phosphonocarboxylate and substituted phosphonocarboxylate ligands as antitumor agents

Also Published As

Publication number Publication date
DE3843571A1 (de) 1989-07-20
DE3879453D1 (en) 1993-04-22
DK5689A (da) 1989-07-10
ES2054778T3 (es) 1994-08-16
HU203361B (en) 1991-07-29
YU47548B (sh) 1995-10-03
DK174981B1 (da) 2004-04-05
IE63527B1 (en) 1995-05-03
US5023335A (en) 1991-06-11
YU73894A (sh) 1997-09-30
EP0324154A3 (en) 1990-03-14
ATE86967T1 (de) 1993-04-15
PT89408B (pt) 1993-09-30
FI890068A7 (fi) 1989-07-10
DK5689D0 (da) 1989-01-06
EP0324154B1 (de) 1993-03-17
IL88898A0 (en) 1989-08-15
YU1689A (en) 1990-12-31
JP2710654B2 (ja) 1998-02-10
IE890041L (en) 1989-07-09
NZ227549A (en) 1990-05-28
NO890059L (no) 1989-07-10
YU49211B (sh) 2004-09-03
NO173390B (no) 1993-08-30
AU2779689A (en) 1989-07-20
AU611749B2 (en) 1991-06-20
GR3007408T3 (enExample) 1993-07-30
PT89408A (pt) 1990-02-08
HUT49363A (en) 1989-09-28
FI890068A0 (fi) 1989-01-06
EG19357A (en) 1994-12-30
IL88898A (en) 1993-07-08
DE8817132U1 (de) 1993-04-22
ZA89136B (en) 1989-10-25
MC2001A1 (fr) 1990-01-26
JPH02795A (ja) 1990-01-05
FI90875B (fi) 1993-12-31
EP0324154A2 (de) 1989-07-19
NO890059D0 (no) 1989-01-06
NO173390C (no) 1993-12-08
CA1316177C (en) 1993-04-13
FI90875C (fi) 1994-04-11

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Effective date: 20081222