YU73894A - Postupak za proizvodnju leka koji sadrži 1,2-bis(aminometil) ciklobutan-platinske komplekse - Google Patents

Postupak za proizvodnju leka koji sadrži 1,2-bis(aminometil) ciklobutan-platinske komplekse

Info

Publication number
YU73894A
YU73894A YU73894A YU73894A YU73894A YU 73894 A YU73894 A YU 73894A YU 73894 A YU73894 A YU 73894A YU 73894 A YU73894 A YU 73894A YU 73894 A YU73894 A YU 73894A
Authority
YU
Yugoslavia
Prior art keywords
phenyl
alkyl
halogen
substituted
alkanoyloxy
Prior art date
Application number
YU73894A
Other languages
English (en)
Other versions
YU49211B (sh
Inventor
Wolfgang Schumacher
Johannes Respondek
Jurgen Engel
Jorg Pohl
Rainer Voehell
Original Assignee
Asta Medica Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag. filed Critical Asta Medica Ag.
Publication of YU73894A publication Critical patent/YU73894A/sh
Publication of YU49211B publication Critical patent/YU49211B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Luminescent Compositions (AREA)

Abstract

POSTUPAK ZA PROIZVODNJU LEKA KOJI SADRŽI 1,2-BIS(AMINOMETIL) CIKLOBUTAN-PLATINSKE KOMPLEKSE - Postupak za proizvodnju leka, koji sadrži 1,2-bis (aininometil)- ciklobutan-platinske komplekse, o d 1 i k uje se t i m e što se jedinjenje sledeće opšte formule u kojima ostaci, isti ili razliCiti, Ri, R2, R3, R4, R5, i R6, oznaCavaju vodonik, Ci-C6-alkil, fenil, fenil-Ci-C6-alkil, Ci- C6-alkil, koji može biti supstituisan pomoću halogena, hidroksi, C2-C6-alkanoil-oksi ili Ci-C6-alkoksi, fenil koji je supstituisan halogenom, hidroksi, C2-C6-alkanoiloksi ili ličiti i označavaju vodonik, Ci-C6-'alkil, fenil, feniI-Ci-C6-alkil, Ci- Ce-alkil koji je supstituisan sa halogenom, hidroksidom, C2-C6- alkanoiloksi ili Ci-Cis-alkoksijen, fenil koji je supstituisan halogenom, hidroksidom, C2-CValkahoiloksi ili Ci-C6-alkoksijem ili fenil-Ci-C6-alkil koji je u fenilnom delu supstituisan sa halogenom, hidroksidom, C2-C6-alkanoiloksi ili Ci-C6-alkoksijein, a X označava ekvivalent jednog fiziološki podnoSljivog aniona ili pak X moze da oznacava takodje i jedan mdlekul vode i u ovom slucaju postojeće pozitivno punjenje atoma platine biva takođe zašićeno pomoću jednog fizioloSki podnoSljivog aniona, a u datom sluCaju i njihove soli, sa upotrebljivim farmaceutskim nosecim materijama ili sredstvima za razređivanje, odnosno drugim pomoćnim materijama prerađuje u farmaceutske preparate, odnosno u neki terapeutski primenljivi oblik.
YU73894A 1988-01-09 1994-12-15 Postupak za proizvodnju leka koji sadrži 1,2-bis-(aminometil)-ciklobutan-platinske komplekse YU49211B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3800415 1988-01-09

Publications (2)

Publication Number Publication Date
YU73894A true YU73894A (sh) 1997-09-30
YU49211B YU49211B (sh) 2004-09-03

Family

ID=6344991

Family Applications (2)

Application Number Title Priority Date Filing Date
YU1689A YU47548B (sh) 1988-01-09 1989-01-06 1,2-bis(aminometil)ciklobutan-platinski kompleksi i postupak za njihovu proizvodnju
YU73894A YU49211B (sh) 1988-01-09 1994-12-15 Postupak za proizvodnju leka koji sadrži 1,2-bis-(aminometil)-ciklobutan-platinske komplekse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU1689A YU47548B (sh) 1988-01-09 1989-01-06 1,2-bis(aminometil)ciklobutan-platinski kompleksi i postupak za njihovu proizvodnju

Country Status (22)

Country Link
US (1) US5023335A (sh)
EP (1) EP0324154B1 (sh)
JP (1) JP2710654B2 (sh)
AT (1) ATE86967T1 (sh)
AU (1) AU611749B2 (sh)
CA (1) CA1316177C (sh)
DE (3) DE3843571A1 (sh)
DK (1) DK174981B1 (sh)
EG (1) EG19357A (sh)
ES (1) ES2054778T3 (sh)
FI (1) FI90875C (sh)
GR (1) GR3007408T3 (sh)
HK (1) HK67694A (sh)
HU (1) HU203361B (sh)
IE (1) IE63527B1 (sh)
IL (1) IL88898A (sh)
MC (1) MC2001A1 (sh)
NO (1) NO173390C (sh)
NZ (1) NZ227549A (sh)
PT (1) PT89408B (sh)
YU (2) YU47548B (sh)
ZA (1) ZA89136B (sh)

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ES2056721B1 (es) * 1991-06-05 1995-05-01 Ferrer Int Mejoras en el objeto de la patente de invencion n{ 9101355 que se refiere a procedimiento de obtencion de nuevos derivados de platino con aminopirrolidinas.
ES2042364B1 (es) * 1991-06-05 1994-07-16 Ferrer Int Procedimiento de obtencion de nuevos derivados de platino con aminopirrolidinas.
DE4415263C1 (de) * 1994-04-15 1995-11-30 Asta Medica Ag Cis-[trans-1,2-Cyclobutanbis(methylamin)-N,N']-[(2S)-lactato-O·1·, O·2·]-platin(II)-trihydrat (Lobaplatin-Trihydrat), seine Herstellung und arzneiliche Verwendung
EP1013277A4 (en) * 1997-01-14 2002-04-17 Toray Industries LYOPHILIZED PREPARATIONS AND PROCESS FOR PRODUCING THE SAME
FR2772616B1 (fr) * 1997-12-24 2000-02-25 Caster Composition depigmentante
US20100197890A1 (en) * 2009-01-31 2010-08-05 Mctavish Hugh Anti-cancer protein-platinum conjugates
CN102093226B (zh) * 2010-11-24 2013-12-04 贵州益佰制药股份有限公司 二氨甲基环丁烷草酸盐的制备方法
CN102020679B (zh) * 2010-11-24 2013-12-25 贵州益佰制药股份有限公司 一种以草酸盐制备洛铂三水合物的方法
CN103703011B (zh) * 2011-12-07 2016-06-22 北京市丰硕维康技术开发有限责任公司 一类离去基团是含氨基或烷氨基的羟基酸衍生物的铂类化合物及其制备方法和应用
CN103467528B (zh) * 2013-08-21 2016-06-08 江苏奥赛康药业股份有限公司 一种洛铂的制备方法
DK3689899T3 (da) 2014-04-25 2021-11-22 2Seventy Bio Inc Kimære mnd-promotor-antigenreceptorer
WO2015188119A1 (en) 2014-06-06 2015-12-10 Bluebird Bio, Inc. Improved t cell compositions
CN105440082B (zh) * 2014-06-20 2018-08-14 贵州益佰制药股份有限公司 一种洛铂晶体、制备方法及药物应用
CN105440083B (zh) * 2014-06-20 2018-08-14 贵州益佰制药股份有限公司 一种洛铂晶体、制备方法及药物应用
CN105198933B (zh) * 2014-06-20 2018-08-14 贵州益佰制药股份有限公司 一种洛铂晶体、制备方法及药物应用
CN105330702B (zh) * 2014-06-20 2018-08-14 贵州益佰制药股份有限公司 一种洛铂晶体、制备方法及药物应用
SG11201609948YA (en) * 2014-06-20 2017-01-27 Guizhou Yibai Pharmaceutical Lobaplatin crystal, preparation method and pharmaceutical application
CN105198932B (zh) * 2014-06-20 2018-09-21 贵州益佰制药股份有限公司 洛铂二水合物、制备方法及药物应用
CN105218587B (zh) * 2014-06-20 2018-08-14 贵州益佰制药股份有限公司 一种洛铂晶体、制备方法及药物应用
AU2015292590B2 (en) 2014-07-24 2020-01-16 2Seventy Bio, Inc. BCMA chimeric antigen receptors
NZ733025A (en) 2014-12-12 2022-01-28 2Seventy Bio Inc Bcma chimeric antigen receptors
WO2017099712A1 (en) 2015-12-07 2017-06-15 Bluebird Bio, Inc. Improved t cell compositions
CN108047277A (zh) * 2018-01-04 2018-05-18 昆明贵研药业有限公司 具有抗肿瘤活性的脂溶性铂配合物的制备方法
CN111718375A (zh) * 2019-03-19 2020-09-29 海南长安国际制药有限公司 具有g1和g2结构的铂类物质及其制备方法和应用
CN111721842B (zh) * 2019-03-19 2022-07-12 海南长安国际制药有限公司 洛铂中有关物质的检测方法
CN111718378B (zh) * 2019-03-19 2024-01-30 海南长安国际制药有限公司 具有式(k)结构的铂类化合物、制备及其检测方法
CN111718377A (zh) * 2019-03-19 2020-09-29 海南长安国际制药有限公司 具有结构式h1、h2的铂类物质、制备及其应用
CN111718373A (zh) * 2019-03-19 2020-09-29 海南长安国际制药有限公司 具有式（i）结构的铂类化合物、制备及其应用
CN111721840B (zh) * 2019-03-19 2022-07-12 海南长安国际制药有限公司 洛铂中有关物质的检测
CN113173953B (zh) * 2021-04-12 2022-06-10 昆明贵研药业有限公司 用于制备抗肿瘤药物的高纯洛铂三水合物的提纯方法
WO2024092045A1 (en) * 2022-10-25 2024-05-02 University Of Massachusetts Platinum(ii)-based anticancer agents, targeted conjugates, and method of synthesizing thereof

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JPS617283A (ja) * 1984-06-20 1986-01-13 Shionogi & Co Ltd 新規白金錯体および抗悪性腫瘍剤
DK500185A (da) * 1984-11-02 1986-05-03 Johnson Matthey Plc Oploeseliggjort platinforbindelse
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Also Published As

Publication number Publication date
DE3879453D1 (en) 1993-04-22
EP0324154A2 (de) 1989-07-19
NO173390C (no) 1993-12-08
FI890068A (fi) 1989-07-10
IE63527B1 (en) 1995-05-03
ATE86967T1 (de) 1993-04-15
IL88898A (en) 1993-07-08
PT89408A (pt) 1990-02-08
CA1316177C (en) 1993-04-13
YU1689A (en) 1990-12-31
JP2710654B2 (ja) 1998-02-10
FI90875B (fi) 1993-12-31
HUT49363A (en) 1989-09-28
ZA89136B (en) 1989-10-25
IL88898A0 (en) 1989-08-15
EG19357A (en) 1994-12-30
DK5689A (da) 1989-07-10
AU611749B2 (en) 1991-06-20
AU2779689A (en) 1989-07-20
NO173390B (no) 1993-08-30
HK67694A (en) 1994-07-22
HU203361B (en) 1991-07-29
US5023335A (en) 1991-06-11
DE3843571A1 (de) 1989-07-20
GR3007408T3 (sh) 1993-07-30
ES2054778T3 (es) 1994-08-16
NZ227549A (en) 1990-05-28
JPH02795A (ja) 1990-01-05
YU49211B (sh) 2004-09-03
DE8817132U1 (de) 1993-04-22
NO890059D0 (no) 1989-01-06
DK5689D0 (da) 1989-01-06
NO890059L (no) 1989-07-10
YU47548B (sh) 1995-10-03
EP0324154B1 (de) 1993-03-17
MC2001A1 (fr) 1990-01-26
FI90875C (fi) 1994-04-11
IE890041L (en) 1989-07-09
PT89408B (pt) 1993-09-30
DK174981B1 (da) 2004-04-05
FI890068A0 (fi) 1989-01-06
EP0324154A3 (en) 1990-03-14

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