HK1244452A1 - 用經不可切割接頭連接的細胞結合劑美登木素生物鹼偶聯物 - Google Patents

用經不可切割接頭連接的細胞結合劑美登木素生物鹼偶聯物

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Publication number
HK1244452A1
HK1244452A1 HK18104043.9A HK18104043A HK1244452A1 HK 1244452 A1 HK1244452 A1 HK 1244452A1 HK 18104043 A HK18104043 A HK 18104043A HK 1244452 A1 HK1244452 A1 HK 1244452A1
Authority
HK
Hong Kong
Prior art keywords
cell
binding agent
linked via
cleavable linker
maytansinoid conjugates
Prior art date
Application number
HK18104043.9A
Other languages
English (en)
Chinese (zh)
Inventor
R‧斯蒂夫斯
R‧盧茨
R‧查裡
H‧謝
Y‧科夫通
Original Assignee
伊繆諾金公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34467962&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1244452(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 伊繆諾金公司 filed Critical 伊繆諾金公司
Publication of HK1244452A1 publication Critical patent/HK1244452A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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HK18104043.9A 2003-10-10 2008-02-27 用經不可切割接頭連接的細胞結合劑美登木素生物鹼偶聯物 HK1244452A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50990103P 2003-10-10 2003-10-10
US10/960,602 US8088387B2 (en) 2003-10-10 2004-10-08 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates

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KR20130102649A (ko) 2013-09-17
US20170226220A1 (en) 2017-08-10
SI1689846T1 (en) 2013-06-28
LU92336I9 (US07989598-20110802-C00010.png) 2019-01-16
EP2596803A3 (en) 2013-09-11
NO2016001I1 (no) 2016-01-26

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