HK1073467A1 - Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds and the compounds as such - Google Patents

Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds and the compounds as such

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Publication number
HK1073467A1
HK1073467A1 HK05104147A HK05104147A HK1073467A1 HK 1073467 A1 HK1073467 A1 HK 1073467A1 HK 05104147 A HK05104147 A HK 05104147A HK 05104147 A HK05104147 A HK 05104147A HK 1073467 A1 HK1073467 A1 HK 1073467A1
Authority
HK
Hong Kong
Prior art keywords
compounds
hiv protease
protease inhibitor
cellular accumulation
phosphonate analogs
Prior art date
Application number
HK05104147A
Other languages
English (en)
Inventor
Arimilli Murty
Becker Mark
Bryant Clifford
Chen James
Chen Xiaowu
Dastgah Azar
Fardis Maria
He Gong-Xin
Jin Haolun
Kim Choung
Lee William
Lee Christopher
Lin Kuei-Ying
Liu Hongtao
Mackman Richard
Mitchel Michael
Nelson Peter
Pyun Hyung-Jung
Rowe Tanisha
Swaminathan Sundaramoorthi
Tario James
Zhang Lijun
Sparacino Mark
Wangjianying
Williams Matthew
Xu Lianhong
Yang Zheng-Yu
Yu Richard
Zhang Jiancun
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of HK1073467A1 publication Critical patent/HK1073467A1/xx

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
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    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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