FI111264B - Uudet erytromysiinijohdannaiset, menetelmät niiden valmistamiseksi ja niiden käyttö lääkkeinä - Google Patents

Uudet erytromysiinijohdannaiset, menetelmät niiden valmistamiseksi ja niiden käyttö lääkkeinä Download PDF

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Publication number
FI111264B
FI111264B FI955913A FI955913A FI111264B FI 111264 B FI111264 B FI 111264B FI 955913 A FI955913 A FI 955913A FI 955913 A FI955913 A FI 955913A FI 111264 B FI111264 B FI 111264B
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FI
Finland
Prior art keywords
methyl
radical
compound
formula
compounds according
Prior art date
Application number
FI955913A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI955913A0 (fi
FI955913A (fi
Inventor
Constantin Agouridas
Yannick Benedetti
Jean-Francois Chantot
Alexis Denis
Martret Odile Le
Original Assignee
Aventis Pharma Sa
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Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of FI955913A0 publication Critical patent/FI955913A0/fi
Publication of FI955913A publication Critical patent/FI955913A/fi
Application granted granted Critical
Publication of FI111264B publication Critical patent/FI111264B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI955913A 1994-04-08 1995-12-08 Uudet erytromysiinijohdannaiset, menetelmät niiden valmistamiseksi ja niiden käyttö lääkkeinä FI111264B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR9404154 1994-04-08
FR9500441 1995-04-06
PCT/FR1995/000441 WO1995027720A1 (fr) 1994-04-08 1995-04-06 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (3)

Publication Number Publication Date
FI955913A0 FI955913A0 (fi) 1995-12-08
FI955913A FI955913A (fi) 1995-12-08
FI111264B true FI111264B (fi) 2003-06-30

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
FI955913A FI111264B (fi) 1994-04-08 1995-12-08 Uudet erytromysiinijohdannaiset, menetelmät niiden valmistamiseksi ja niiden käyttö lääkkeinä

Country Status (49)

Country Link
US (2) US5656607A (is)
EP (1) EP0676409B1 (is)
JP (1) JP3000023B2 (is)
KR (1) KR100317148B1 (is)
CN (1) CN1059445C (is)
AP (1) AP587A (is)
AT (1) ATE234853T1 (is)
AU (1) AU684939B2 (is)
BG (1) BG61916B1 (is)
BR (1) BR9506147A (is)
CA (1) CA2164638C (is)
CO (1) CO4370097A1 (is)
CZ (1) CZ296005B6 (is)
DE (1) DE69529934T2 (is)
DK (1) DK0676409T3 (is)
DZ (1) DZ1869A1 (is)
EE (1) EE04498B1 (is)
ES (1) ES2189820T3 (is)
FI (1) FI111264B (is)
FR (1) FR2718450B1 (is)
GB (1) GB2288174A (is)
GE (1) GEP19991836B (is)
HR (1) HRP950217B1 (is)
HU (1) HU215396B (is)
IL (1) IL112954A (is)
IS (1) IS1865B (is)
JO (1) JO1850B1 (is)
LV (1) LV11182B (is)
MA (1) MA23501A1 (is)
MD (1) MD663G2 (is)
MY (1) MY114672A (is)
NO (1) NO308361B1 (is)
NZ (1) NZ284498A (is)
OA (1) OA10200A (is)
PE (1) PE2896A1 (is)
PL (1) PL180837B1 (is)
PT (1) PT676409E (is)
RO (1) RO115634B1 (is)
RU (1) RU2141965C1 (is)
SA (1) SA97170757A (is)
SI (1) SI0676409T1 (is)
SK (1) SK284079B6 (is)
SV (1) SV1995000018A (is)
TN (1) TNSN95026A1 (is)
TW (1) TW316908B (is)
UA (1) UA44705C2 (is)
WO (1) WO1995027720A1 (is)
YU (1) YU49221B (is)
ZA (1) ZA952059B (is)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
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FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
ATE246199T1 (de) * 1996-05-07 2003-08-15 Abbott Lab 3-descladinose-2,3-anhydroerythromycin-derivate
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
EP1291351B1 (en) * 1996-09-04 2005-07-13 Abbott Laboratories 6-0 substituted ketolides having antibacterial activity
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US6165986A (en) * 1997-03-10 2000-12-26 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
AU6421398A (en) * 1997-03-24 1998-10-20 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
AU6932098A (en) * 1997-05-09 1998-12-08 Pfizer Products Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
ID24529A (id) * 1997-06-11 2000-07-20 Pfizer Prod Inc Turunan-turunan 9-oksima eritromisin
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
AU5299499A (en) * 1998-09-22 2000-04-10 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
WO2000034297A1 (en) 1998-12-10 2000-06-15 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
FR2789392B1 (fr) 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
US6399582B1 (en) 1999-04-16 2002-06-04 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
BR0010680A (pt) * 1999-04-16 2002-02-19 Kosan Biosciences Inc Agentes antiinfecciosos de macrolìdeo
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
AU3832100A (en) * 1999-05-24 2000-12-12 Pfizer Products Inc. 13-methyl-erythromycin derivatives
WO2003004509A2 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
CN105039464A (zh) 2002-07-01 2015-11-11 阿基昂生命科学公司,以生物技术资源部的名义经营 用于生产葡糖胺和n-乙酰氨基葡糖的方法和物质
ES2552682T3 (es) * 2003-03-10 2015-12-01 Merck Sharp & Dohme Corp. Agentes antibacterianos novedosos
CA2523541A1 (en) * 2003-04-25 2004-11-11 Chiron Corporation Novel ketolide derivatives
EP1618119A2 (en) * 2003-04-25 2006-01-25 Chiron Corporation Pyridyl substituted ketolide antibiotics
CN101917850B (zh) 2007-10-25 2016-01-13 森普拉制药公司 大环内酯类抗菌剂的制备方法
US8791080B2 (en) * 2008-10-24 2014-07-29 Cempra Pharmaceuticals, Inc. Methods for treating gastrointestinal diseases
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
ES2608285T3 (es) 2009-09-10 2017-04-07 Cempra Pharmaceuticals, Inc. Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC
WO2011119604A1 (en) 2010-03-22 2011-09-29 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
WO2011146829A1 (en) 2010-05-20 2011-11-24 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
AU2013239696C1 (en) 2012-03-27 2018-11-29 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
CA2905975A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
EP2968384A4 (en) 2013-03-15 2017-02-15 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
AU2014248014B2 (en) 2013-04-04 2018-11-08 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
EP3211997A4 (en) 2014-10-08 2018-10-24 President and Fellows of Harvard College 14-membered ketolides and methods of their preparation and use
JP2018509452A (ja) 2015-03-25 2018-04-05 プレジデント アンド フェローズ オブ ハーバード カレッジ 修飾デソサミン糖をもつマクロライドおよびその使用
MD1222Z (ro) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Procedeu de tratare a materialului săditor al florilor înainte de plantare
JP7199722B2 (ja) 2019-12-25 2023-01-06 旭精工株式会社 硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

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US3868414A (en) * 1973-01-22 1975-02-25 Merck & Co Inc Tetrahydrofluorene carboxylic acids and related compounds
DE2842759A1 (de) * 1978-09-30 1980-04-10 Merck Patent Gmbh Basische aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Also Published As

Publication number Publication date
AP9500743A0 (en) 1995-07-31
DZ1869A1 (fr) 2002-02-17
MY114672A (en) 2002-12-31
SI0676409T1 (en) 2003-06-30
PT676409E (pt) 2003-08-29
ZA952059B (en) 1996-03-13
PL180837B1 (pl) 2001-04-30
PL311871A1 (en) 1996-03-18
NO954942L (no) 1996-02-07
NZ284498A (en) 1997-07-27
AP587A (en) 1997-04-29
FI955913A0 (fi) 1995-12-08
MD663F1 (ro) 1997-01-31
AU2310795A (en) 1995-10-30
EE9500080A (et) 1996-12-16
IS1865B (is) 2003-05-02
PE2896A1 (es) 1996-02-12
CZ322395A3 (en) 1996-08-14
NO308361B1 (no) 2000-09-04
CO4370097A1 (es) 1996-10-07
IL112954A0 (en) 1995-06-29
GB2288174A (en) 1995-10-11
SA97170757A (ar) 2005-12-03
SV1995000018A (es) 1997-10-24
RU2141965C1 (ru) 1999-11-27
TNSN95026A1 (fr) 1996-02-06
OA10200A (fr) 1996-12-18
SK284079B6 (sk) 2004-09-08
CA2164638C (fr) 2003-12-30
CA2164638A1 (fr) 1995-10-19
FR2718450B1 (fr) 1997-01-10
IL112954A (en) 2000-07-16
DE69529934D1 (de) 2003-04-24
SK154695A3 (en) 1996-10-02
IS4309A (is) 1995-11-17
KR100317148B1 (ko) 2002-06-22
JPH07278177A (ja) 1995-10-24
EP0676409B1 (fr) 2003-03-19
JO1850B1 (en) 1995-12-27
YU49221B (sh) 2004-11-25
BG61916B1 (bg) 1998-09-30
CN1126997A (zh) 1996-07-17
AU684939B2 (en) 1998-01-08
HRP950217B1 (en) 2004-06-30
HRP950217A2 (en) 1997-08-31
FR2718450A1 (fr) 1995-10-13
US5656607A (en) 1997-08-12
CN1059445C (zh) 2000-12-13
FI955913A (fi) 1995-12-08
GB9506856D0 (en) 1995-05-24
DK0676409T3 (da) 2003-06-23
HU215396B (hu) 1998-12-28
BR9506147A (pt) 1996-04-16
RO115634B1 (ro) 2000-04-28
TW316908B (is) 1997-10-01
YU21695A (sh) 1997-12-05
EP0676409A1 (fr) 1995-10-11
JP3000023B2 (ja) 2000-01-17
ES2189820T3 (es) 2003-07-16
EE04498B1 (et) 2005-06-15
WO1995027720A1 (fr) 1995-10-19
LV11182A (lv) 1996-04-20
CZ296005B6 (cs) 2005-12-14
DE69529934T2 (de) 2003-09-04
MA23501A1 (fr) 1995-12-31
UA44705C2 (uk) 2002-03-15
MD663G2 (ro) 1997-07-31
HU9503505D0 (en) 1996-02-28
GEP19991836B (en) 1999-11-05
NO954942D0 (no) 1995-12-06
US5760233A (en) 1998-06-02
LV11182B (en) 1997-04-20
ATE234853T1 (de) 2003-04-15
HUT73772A (en) 1996-09-30
BG100150A (bg) 1996-06-28

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Owner name: HOECHST MARION ROUSSEL

MA Patent expired