AP587A - New erythromycin derivatives, their preparation process and their use as medicaments. - Google Patents

New erythromycin derivatives, their preparation process and their use as medicaments. Download PDF

Info

Publication number
AP587A
AP587A APAP/P/1995/000743A AP9500743A AP587A AP 587 A AP587 A AP 587A AP 9500743 A AP9500743 A AP 9500743A AP 587 A AP587 A AP 587A
Authority
AP
ARIPO
Prior art keywords
formula
compounds
methyl
radical
dideoxy
Prior art date
Application number
APAP/P/1995/000743A
Other languages
English (en)
Other versions
AP9500743A0 (en
Inventor
Constantin Agouridas
Yannick Benedetti
Jean-Francis Chantot (Deceased)
Alexis Denis
Martret Odile Le
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of AP9500743A0 publication Critical patent/AP9500743A0/xx
Application granted granted Critical
Publication of AP587A publication Critical patent/AP587A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
APAP/P/1995/000743A 1994-04-08 1995-03-17 New erythromycin derivatives, their preparation process and their use as medicaments. AP587A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Publications (2)

Publication Number Publication Date
AP9500743A0 AP9500743A0 (en) 1995-07-31
AP587A true AP587A (en) 1997-04-29

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1995/000743A AP587A (en) 1994-04-08 1995-03-17 New erythromycin derivatives, their preparation process and their use as medicaments.

Country Status (49)

Country Link
US (2) US5656607A (is)
EP (1) EP0676409B1 (is)
JP (1) JP3000023B2 (is)
KR (1) KR100317148B1 (is)
CN (1) CN1059445C (is)
AP (1) AP587A (is)
AT (1) ATE234853T1 (is)
AU (1) AU684939B2 (is)
BG (1) BG61916B1 (is)
BR (1) BR9506147A (is)
CA (1) CA2164638C (is)
CO (1) CO4370097A1 (is)
CZ (1) CZ296005B6 (is)
DE (1) DE69529934T2 (is)
DK (1) DK0676409T3 (is)
DZ (1) DZ1869A1 (is)
EE (1) EE04498B1 (is)
ES (1) ES2189820T3 (is)
FI (1) FI111264B (is)
FR (1) FR2718450B1 (is)
GB (1) GB2288174A (is)
GE (1) GEP19991836B (is)
HR (1) HRP950217B1 (is)
HU (1) HU215396B (is)
IL (1) IL112954A (is)
IS (1) IS1865B (is)
JO (1) JO1850B1 (is)
LV (1) LV11182B (is)
MA (1) MA23501A1 (is)
MD (1) MD663G2 (is)
MY (1) MY114672A (is)
NO (1) NO308361B1 (is)
NZ (1) NZ284498A (is)
OA (1) OA10200A (is)
PE (1) PE2896A1 (is)
PL (1) PL180837B1 (is)
PT (1) PT676409E (is)
RO (1) RO115634B1 (is)
RU (1) RU2141965C1 (is)
SA (1) SA97170757A (is)
SI (1) SI0676409T1 (is)
SK (1) SK284079B6 (is)
SV (1) SV1995000018A (is)
TN (1) TNSN95026A1 (is)
TW (1) TW316908B (is)
UA (1) UA44705C2 (is)
WO (1) WO1995027720A1 (is)
YU (1) YU49221B (is)
ZA (1) ZA952059B (is)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
DK0922050T3 (da) * 1996-05-07 2003-11-24 Abbott Lab 3-Descladinose-2,3-anhydroerythromycin-derivater
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
ATE299508T1 (de) * 1996-09-04 2005-07-15 Abbott Lab 6-o-substituierte ketoliden mit antibakteriellen wirkung
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US6165986A (en) * 1997-03-10 2000-12-26 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
WO1998042720A1 (fr) * 1997-03-24 1998-10-01 Taisho Pharmaceutical Co., Ltd. Derives d'erythromycine a
AU6932098A (en) * 1997-05-09 1998-12-08 Pfizer Products Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
WO1998056800A1 (en) * 1997-06-11 1998-12-17 Pfizer Products Inc. 9-oxime erythromycin derivatives
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
EP1115732B1 (en) 1998-09-22 2005-06-29 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
ATE344269T1 (de) 1998-12-10 2006-11-15 Pfizer Prod Inc Carbamat und carbazat ketolid antibiotika
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
NZ515027A (en) * 1999-04-16 2004-01-30 Kosan Biosciences Inc Erythromycin derivatives as antibiotics
WO2000062783A2 (en) 1999-04-16 2000-10-26 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
EA200100983A1 (ru) * 1999-05-24 2002-10-31 Пфайзер Продактс Инк. Производные 13-метилэритромицина
JP4509553B2 (ja) * 2001-07-03 2010-07-21 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 抗菌活性を有するｃ１２修飾エリスロマイシンマクロライドおよびケトライド
CN101365785A (zh) 2002-07-01 2009-02-11 阿基昂生命科学公司,以生物技术资源部的名义经营 用于生产葡糖胺和n-乙酰氨基葡糖的方法和物质
WO2004080391A2 (en) 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
CA2523134A1 (en) * 2003-04-25 2004-11-11 Chiron Corporation Pyridyl substituted ketolide antibiotics
EP1618120A2 (en) * 2003-04-25 2006-01-25 Chiron Corporation Novel ketolide derivatives
CA2703475A1 (en) 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
EP2358379B1 (en) * 2008-10-24 2015-12-16 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
PL2550286T3 (pl) 2010-03-22 2016-07-29 Cempra Pharmaceuticals Inc Krystaliczne postaci makrolidu i ich zastosowanie
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
CN104470527B (zh) 2012-03-27 2019-05-28 森普拉制药公司 用于施用大环内酯抗生素的肠胃外制剂
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
US9751908B2 (en) 2013-03-15 2017-09-05 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CA3130061C (en) 2013-04-04 2024-05-28 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
EP3211997A4 (en) 2014-10-08 2018-10-24 President and Fellows of Harvard College 14-membered ketolides and methods of their preparation and use
CA2980315A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Macrolides with modified desosamine sugars and uses thereof
MD1222Z (ro) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Procedeu de tratare a materialului săditor al florilor înainte de plantare
JP7199722B2 (ja) 2019-12-25 2023-01-06 旭精工株式会社 硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692579A1 (fr) * 1992-06-19 1993-12-24 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868414A (en) * 1973-01-22 1975-02-25 Merck & Co Inc Tetrahydrofluorene carboxylic acids and related compounds
DE2842759A1 (de) * 1978-09-30 1980-04-10 Merck Patent Gmbh Basische aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692579A1 (fr) * 1992-06-19 1993-12-24 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.

Also Published As

Publication number Publication date
EP0676409B1 (fr) 2003-03-19
NO954942D0 (no) 1995-12-06
AP9500743A0 (en) 1995-07-31
DZ1869A1 (fr) 2002-02-17
JPH07278177A (ja) 1995-10-24
DE69529934T2 (de) 2003-09-04
AU684939B2 (en) 1998-01-08
JP3000023B2 (ja) 2000-01-17
ATE234853T1 (de) 2003-04-15
HUT73772A (en) 1996-09-30
RU2141965C1 (ru) 1999-11-27
RO115634B1 (ro) 2000-04-28
DE69529934D1 (de) 2003-04-24
FR2718450B1 (fr) 1997-01-10
AU2310795A (en) 1995-10-30
FR2718450A1 (fr) 1995-10-13
PL311871A1 (en) 1996-03-18
MD663F1 (ro) 1997-01-31
EE04498B1 (et) 2005-06-15
HU9503505D0 (en) 1996-02-28
KR100317148B1 (ko) 2002-06-22
HU215396B (hu) 1998-12-28
FI111264B (fi) 2003-06-30
JO1850B1 (en) 1995-12-27
BR9506147A (pt) 1996-04-16
SK154695A3 (en) 1996-10-02
DK0676409T3 (da) 2003-06-23
GB9506856D0 (en) 1995-05-24
YU49221B (sh) 2004-11-25
CZ296005B6 (cs) 2005-12-14
GB2288174A (en) 1995-10-11
CA2164638C (fr) 2003-12-30
EE9500080A (et) 1996-12-16
LV11182B (en) 1997-04-20
BG61916B1 (bg) 1998-09-30
US5656607A (en) 1997-08-12
EP0676409A1 (fr) 1995-10-11
FI955913A (fi) 1995-12-08
YU21695A (sh) 1997-12-05
TW316908B (is) 1997-10-01
IS1865B (is) 2003-05-02
WO1995027720A1 (fr) 1995-10-19
CA2164638A1 (fr) 1995-10-19
MD663G2 (ro) 1997-07-31
HRP950217A2 (en) 1997-08-31
NO308361B1 (no) 2000-09-04
IS4309A (is) 1995-11-17
PL180837B1 (pl) 2001-04-30
GEP19991836B (en) 1999-11-05
ES2189820T3 (es) 2003-07-16
OA10200A (fr) 1996-12-18
FI955913A0 (fi) 1995-12-08
LV11182A (lv) 1996-04-20
ZA952059B (en) 1996-03-13
UA44705C2 (uk) 2002-03-15
IL112954A0 (en) 1995-06-29
BG100150A (bg) 1996-06-28
IL112954A (en) 2000-07-16
US5760233A (en) 1998-06-02
CO4370097A1 (es) 1996-10-07
SV1995000018A (es) 1997-10-24
NZ284498A (en) 1997-07-27
CN1126997A (zh) 1996-07-17
SI0676409T1 (en) 2003-06-30
SK284079B6 (sk) 2004-09-08
PE2896A1 (es) 1996-02-12
PT676409E (pt) 2003-08-29
MA23501A1 (fr) 1995-12-31
CZ322395A3 (en) 1996-08-14
HRP950217B1 (en) 2004-06-30
CN1059445C (zh) 2000-12-13
SA97170757A (ar) 2005-12-03
NO954942L (no) 1996-02-07
TNSN95026A1 (fr) 1996-02-06
MY114672A (en) 2002-12-31

Similar Documents

Publication Publication Date Title
AP587A (en) New erythromycin derivatives, their preparation process and their use as medicaments.
US6147197A (en) 6-O-substituted erythromycin ketolides having antibacterial activity
US5866549A (en) 6-O-substituted ketolides having antibacterial activity
Bright et al. Synthesis, in vitro and in vivo activity of novel 9-deoxo-9a-AZA-9a-homoerythromycin A derivatives; a new class of macrolide antibiotics, the azalides
AU716204B2 (en) Novel erythromycin derivatives, method for preparing same, and use thereof as drugs
US5786339A (en) Erythromycins
US5543400A (en) Erythromycin compounds
US6313101B1 (en) Derivatives of erythromycin, their preparation process and their use as medicaments
US6034069A (en) 3-'N-modified 6-O-substituted erythromycin ketolide derivatives having antibacterial activity
US6433151B1 (en) Erythromycin derivatives, a process for their preparation and their use as medicaments
FR2732023A1 (fr) Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6162793A (en) Erythromycin derivatives, method for preparing same and use thereof as drugs
AP997A (en) Novel erythromycin derivatives, method for preparing them and their use as medicine.
IL108622A (en) History -9) -1-Piperidine-3-Transloxyl Converted (of 3-De) -2,6 Dioxy-C-3-Methyl-O3-Methyl-L-A-Ribuhexopyranosyl (Oxy-O6-Methyl-3-oxo-erythromycin Process for preparation
US5747466A (en) 3-deoxy-3-descladinose derivatives of erythromycins A and B
USRE38520E1 (en) Erythromycin derivatives, method for preparing same, and use thereof as drugs
AU729348C (en) 6-O-substituted ketolides having antibacterial activity
MXPA99005226A (en) Novel erythromycin derivatives, method for preparing them and their use as medicine