FI108640B - Menetelmä puhtaan sitalopraamin valmistamiseksi - Google Patents

Menetelmä puhtaan sitalopraamin valmistamiseksi Download PDF

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Publication number
FI108640B
FI108640B FI20010501A FI20010501A FI108640B FI 108640 B FI108640 B FI 108640B FI 20010501 A FI20010501 A FI 20010501A FI 20010501 A FI20010501 A FI 20010501A FI 108640 B FI108640 B FI 108640B
Authority
FI
Finland
Prior art keywords
citalopram
cyanide
process according
reaction
distillation
Prior art date
Application number
FI20010501A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI20010501A0 (fi
Inventor
Andrea Castellin
Giulio Volpe
Federico Sbrogio
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of FI20010501A0 publication Critical patent/FI20010501A0/fi
Application granted granted Critical
Publication of FI108640B publication Critical patent/FI108640B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI20010501A 2000-12-28 2001-03-13 Menetelmä puhtaan sitalopraamin valmistamiseksi FI108640B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK200001943 2000-12-28
DKPA200001943 2000-12-28

Publications (2)

Publication Number Publication Date
FI20010501A0 FI20010501A0 (fi) 2001-03-13
FI108640B true FI108640B (fi) 2002-02-28

Family

ID=8159933

Family Applications (2)

Application Number Title Priority Date Filing Date
FI20010501A FI108640B (fi) 2000-12-28 2001-03-13 Menetelmä puhtaan sitalopraamin valmistamiseksi
FI20011578A FI20011578A0 (fi) 2000-12-28 2001-07-26 Menetelmä puhtaan sitalopraamin valmistamiseksi

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI20011578A FI20011578A0 (fi) 2000-12-28 2001-07-26 Menetelmä puhtaan sitalopraamin valmistamiseksi

Country Status (41)

Country Link
US (2) US6855834B2 (no)
EP (1) EP1181272B1 (no)
JP (1) JP2003519121A (no)
KR (1) KR100430746B1 (no)
CN (1) CN1366526A (no)
AR (1) AR029898A1 (no)
AT (2) ATE222899T1 (no)
AU (3) AU3920201A (no)
BE (2) BE1013417A6 (no)
BG (1) BG106219A (no)
BR (1) BR0106271A (no)
CA (1) CA2359810C (no)
CH (1) CH691536A5 (no)
CZ (1) CZ293140B6 (no)
DE (1) DE60100016T2 (no)
DK (1) DK1181272T3 (no)
EA (1) EA003459B1 (no)
ES (2) ES2181663T3 (no)
FI (2) FI108640B (no)
FR (1) FR2818977B1 (no)
GB (2) GB2356199B (no)
GR (1) GR20010100131A (no)
HK (1) HK1049332A1 (no)
HR (1) HRP20020005A2 (no)
HU (2) HU0101028D0 (no)
IE (2) IES20010253A2 (no)
IL (1) IL147162A0 (no)
IS (1) IS5884A (no)
IT (1) ITMI20010604A1 (no)
MX (1) MXPA01013336A (no)
NL (1) NL1017534C1 (no)
NO (1) NO313047B1 (no)
NZ (1) NZ516299A (no)
PL (1) PL353369A1 (no)
PT (1) PT1181272E (no)
SE (1) SE0103044L (no)
SK (1) SK284418B6 (no)
TR (1) TR200200018T1 (no)
UA (1) UA71635C2 (no)
WO (1) WO2001047877A2 (no)
ZA (1) ZA200110133B (no)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
EA004033B1 (ru) * 1999-04-14 2003-12-25 Х.Лундбекк А/С Способ получения циталопрама
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
CA2291133C (en) 1999-10-25 2003-06-17 H. Lundbeck A/S Method for the preparation of citalopram
WO2000012044A2 (en) 1999-10-25 2000-03-09 H. Lundbeck A/S Method for the preparation of citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
PL355532A1 (en) 1999-12-28 2004-05-04 H.Lundbeck A/S Method for the preparation of citalopram
IL150367A0 (en) 1999-12-30 2002-12-01 Lundbeck & Co As H Method for the preparation of citalopram
SK286879B6 (sk) 2000-01-14 2009-07-06 H. Lundbeck A/S Spôsob prípravy 5-kyanoftalidu
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
CN1429219A (zh) 2000-03-13 2003-07-09 H·隆德贝克有限公司 制备西酞普兰的方法
WO2001068629A1 (en) * 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
TR200400611T4 (tr) 2000-03-14 2004-04-21 H.Lundbeck A/S Sitalopramın preparasyon metodu
DE10190485T1 (de) * 2000-03-16 2002-03-21 Lundbeck & Co As H Verfahren zur Herstellung von 5-Cyano-1-(4-fluorphenyl)-1,3-dihydroisobenzofuranen
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2354880C (en) 2000-08-18 2003-06-03 H. Lundbeck A/S Method for the preparation of citalopram
EP1181713B1 (en) 2000-12-22 2004-09-29 H. Lundbeck A/S Method for the preparation of pure citalopram
TR200200018T1 (tr) 2000-12-28 2002-06-21 H. Lundbeck A/S Saf sitalopram hazırlanması için yöntem.
GB2376945A (en) * 2001-06-27 2002-12-31 Cipla Ltd Citalopram preparation
US7148364B2 (en) 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
ES2194597B2 (es) * 2002-01-25 2004-08-01 Esteve Quimica, S.A. Procedimiento para la obtencion de citalopram.
GB2386119A (en) * 2002-02-27 2003-09-10 Cipla Ltd Purification of citalopram
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
EP1346989A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Improved process for the preparation of citalopram and its hydrobromide
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
EP1486492A3 (en) * 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. A process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran.
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL135959C (no) 1964-12-23
GB1143703A (no) 1965-03-18
DE1619713A1 (de) * 1967-03-29 1970-12-17 Leybold Heraeus Gmbh & Co Kg Vorrichtung zur Vakuum- und Kurzwegdestillation
DE2135085C3 (de) 1971-07-14 1981-12-03 Basf Ag, 6700 Ludwigshafen Verfahren zur Wiedergewinnung von Caprolactam aus einem Gemisch, das Caprolactam und dessen Oligomere enthält
DE2442426C2 (de) 1974-09-05 1983-04-07 Bayer Ag, 5090 Leverkusen Diisocyanatodiketene, Verfahren zu deren Herstellung und deren Verwendung
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
IT8020902A0 (it) 1980-03-25 1980-03-25 Snia Viscosa Procedimento ed apparecchiatura per la separazione continua per via termica di miscele liquide dicomposti termolabili.
JPS6082101A (ja) 1983-10-13 1985-05-10 Mitsui Toatsu Chem Inc 高沸点重合性化合物の薄膜蒸留による精製方法
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
FR2656305B1 (fr) 1989-12-22 1992-04-10 Norsolor Sa Procede de purification du (meth)acrylate de glycidyle.
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
US5582692A (en) 1994-10-07 1996-12-10 Artisan Industries, Inc. Method for the purification of vitamin E
US6136991A (en) * 1996-05-21 2000-10-24 Exxon Chemical Patents Inc. Glycidyl ester adducts having increased glass transition temperatures
DE69725717T2 (de) 1996-05-21 2004-07-29 Exxonmobil Chemical Patents Inc., Baytown Reinigung von glycidylestern durch dünnschichtverdampfung
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
CZ291440B6 (cs) 1997-07-08 2003-03-12 H. Lundbeck A/S Způsob výroby citalopramu
DE19734673A1 (de) 1997-08-11 1999-02-18 Rwe Dea Ag Verfahren zur Herstellung von metallfreien Guerbetalkoholen
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
ES2149734T3 (es) 1997-11-11 2003-02-16 Lundbeck & Co As H Metodo para la preparacion de citalopram.
DE69920329T3 (de) 1998-06-19 2009-07-09 Shin-Etsu Chemical Co., Ltd. Destillationsverfahren für (Meth)acryloxysilane
SK285719B6 (sk) * 1998-10-20 2007-07-06 H. Lundbeck A/S Spôsob prípravy citalopramu a medziprodukty
DE69906580T2 (de) 1998-12-23 2004-02-12 H. Lundbeck A/S Verfahren zur herstellung von 5-cyanophthalid
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
EA004033B1 (ru) 1999-04-14 2003-12-25 Х.Лундбекк А/С Способ получения циталопрама
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
WO2000012044A2 (en) 1999-10-25 2000-03-09 H. Lundbeck A/S Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
EP1181713B1 (en) 2000-12-22 2004-09-29 H. Lundbeck A/S Method for the preparation of pure citalopram
TR200200018T1 (tr) 2000-12-28 2002-06-21 H. Lundbeck A/S Saf sitalopram hazırlanması için yöntem.
US6781003B1 (en) * 2003-06-09 2004-08-24 Aurobindo Pharma Ltd. Preparation of pure citalopram

Also Published As

Publication number Publication date
NO20011272D0 (no) 2001-03-13
UA71635C2 (uk) 2004-12-15
HU0102818D0 (en) 2001-09-28
HU0101028D0 (en) 2001-05-28
GB2356199B (en) 2001-10-03
CA2359810C (en) 2002-11-05
BE1013417A6 (fr) 2001-12-04
NO313047B1 (no) 2002-08-05
EP1181272B1 (en) 2002-08-28
FR2818977B1 (fr) 2003-12-05
HK1049332A1 (zh) 2003-05-09
CH691536A5 (de) 2001-08-15
BG106219A (en) 2002-08-30
US20020087012A1 (en) 2002-07-04
WO2001047877A2 (en) 2001-07-05
NO20011272L (no) 2002-07-01
SE0103044L (sv) 2002-06-29
PL353369A1 (en) 2003-11-17
IES20010632A2 (en) 2002-03-06
KR20020073379A (ko) 2002-09-26
DE60100016T2 (de) 2003-04-17
AU750006B1 (en) 2002-07-11
DE60100016D1 (de) 2002-10-02
TR200200018T1 (tr) 2002-06-21
AT4368U1 (de) 2001-06-25
DK1181272T3 (da) 2002-12-30
ITMI20010604A1 (it) 2002-09-22
SE0103044D0 (sv) 2001-09-14
ATE222899T1 (de) 2002-09-15
US6855834B2 (en) 2005-02-15
CN1366526A (zh) 2002-08-28
NZ516299A (en) 2002-12-20
ITMI20010604A0 (it) 2001-03-22
AU2001100399A4 (en) 2001-11-01
ES2170733A1 (es) 2002-08-01
PT1181272E (pt) 2003-01-31
EA003459B1 (ru) 2003-06-26
BE1013316A6 (fr) 2001-11-06
EA200200016A1 (ru) 2002-04-25
CZ2001891A3 (cs) 2002-08-14
FI20010501A0 (fi) 2001-03-13
GB2356199A (en) 2001-05-16
CA2359810A1 (en) 2001-07-05
US20030178295A1 (en) 2003-09-25
HUP0102818A3 (en) 2003-07-28
KR100430746B1 (ko) 2004-05-10
IL147162A0 (en) 2002-08-14
ES2170733B1 (es) 2003-12-16
CZ293140B6 (cs) 2004-02-18
FI20011578A0 (fi) 2001-07-26
GB0117095D0 (en) 2001-09-05
HUP0102818A2 (hu) 2001-12-28
ES2181663T3 (es) 2003-03-01
AU3920201A (en) 2001-07-09
AR029898A1 (es) 2003-07-23
EP1181272A2 (en) 2002-02-27
HRP20020005A2 (en) 2003-04-30
IS5884A (is) 2002-06-28
MXPA01013336A (es) 2002-07-09
NL1017534C1 (nl) 2001-04-26
SK284418B6 (sk) 2005-04-01
JP2003519121A (ja) 2003-06-17
ZA200110133B (en) 2003-01-13
GB0105981D0 (en) 2001-05-02
GR20010100131A (el) 2002-10-09
GB2361697A (en) 2001-10-31
AU2001100399B4 (en) 2002-03-21
SK18472001A3 (sk) 2002-05-09
BR0106271A (pt) 2002-05-21
IES20010253A2 (en) 2002-03-06
WO2001047877A3 (en) 2001-12-27
FR2818977A1 (fr) 2002-07-05

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