FI108399B - F÷rfarande f÷r framstõllning av partiklar av farmaceutiska õmnen - Google Patents
F÷rfarande f÷r framstõllning av partiklar av farmaceutiska õmnen Download PDFInfo
- Publication number
- FI108399B FI108399B FI934320A FI934320A FI108399B FI 108399 B FI108399 B FI 108399B FI 934320 A FI934320 A FI 934320A FI 934320 A FI934320 A FI 934320A FI 108399 B FI108399 B FI 108399B
- Authority
- FI
- Finland
- Prior art keywords
- mill
- particles
- polymeric resin
- particle size
- process according
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/02—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
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- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
- G03C1/00—Photosensitive materials
- G03C1/005—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
- Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/84—Manufacture, treatment, or detection of nanostructure
- Y10S977/90—Manufacture, treatment, or detection of nanostructure having step or means utilizing mechanical or thermal property, e.g. pressure, heat
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/927—Diagnostic contrast agent
- Y10S977/928—X-ray agent
Claims (16)
1. Förfarande för framställning av partiklar av ett diagnostiskt avbildande medel, kännetecknat av 5 att det avbildande medlet mals med ett härt malnings-material för att minska partiklarna tili en submikron-partikelstorlek, varvid malningsmaterialet: (a) är väsentligen sfäriskt, (b) dess partikelstorlek är mellan 0,1 och 3 min io och (c) det bestär väsentligen av ett polymeriskt harts eller innehäller kärnor, pä vilka en polymerharts-beläggning vidhäftar.
2. Förfarande enligt patentkrav 1, känneteck- 15. a t av att malningsmaterialet omfattar partiklar, som innehäller en kärna, pä vilken en polymerhartsbeläggning vidhäftar.
3. Förfarande enligt patentkrav 1, kännetecknat av att polymeren är polystyren, som är tvärbundet med 20 divinylbensen.
4. Förfarande enligt patentkrav 1, kännetecknat av att polymeren är polykarbonat.
5. Förfarande enligt patentkrav 1, kännetecknat av att förfarandet är ett vätmalningsförfarande. 25
6. Förfarande enligt patentkrav 1, känneteck nat av att förfarandet är ett torrmalningsförfarande.
7. Förfarande enligt patentkrav 1, kännetecknat av att malningen utförs i en kvarn, som valts frän en tryckluftskvarn, en valskvarn, en kulkvarn, en skivkvarn, 30 en vibrerande kvarn, en planetkvarn, en kollerkvarn och en , *Γ pärlkvarn.
8. Förfarande enligt patentkrav 1, känneteck nat av att det avbildandet medlet är etyl-3,5-bisacetoamido-2,4,6-trijodbensoat (WIN 8883), etyl-(3,5- 35 bis(acetylamino)-2,4,6-trijodbensoyloxi)acetat (WIN 12901), etyi-2- (bis(acetylamino)-2,4,6-trijodbensoyl- ie 108399 oxi)butyrat (WIN 16318) eller 6-etoxi-6-oxohexyl-3,5-bis-(acetylamino)-2,4,6-trijodbensoat (WIN 67722).
9. Förfarande för framställning av partiklar av ett läkemedel, kännetecknat av att läkemedlet mals 5 med ett härt malningsmaterial för att minska partiklarna tili en submikronpartikelstorlek, varvid malningsmate-rialet: (a) är väsentligen sfäriskt, (b) dess partikelstorlek är mellan 0,1 och 3 min 10 och (c) det bestär väsentligen av ett polymeriskt harts eller innehäller kärnor, pä vilka en polymerhartsbe-läggning vidhäftar.
10. Förfarande enligt patentkrav 9, känneteck- 15 nat av att malningsmaterialet omfattar partiklar, som innehäller en kärna, pä vilken en polymerhartsbeläggning vidhäftar.
11. Förfarande enligt patentkrav 9, kännetecknat av att polymeren är polystyren, som är tvärbundet med 20 divinylbensen.
12. Förfarande enligt patentkrav 9, kännetecknat av att polymeren är polykarbonat.
13. Förfarande enligt patentkrav 9, kännetecknat av att förfarandet är ett vätmalningsförfarande. .* 25
14. Förfarande enligt patentkrav 9, känneteck nat av att förfarandet är ett torrmalningsförfarande.
15. Förfarande enligt patentkrav 9, kännetecknat av att malningen utförs i en kvarn, som valts frän en tryckluftskvarn, en valskvarn, en kulkvarn, en skivkvarn, 30 en vibrerande kvarn, en planetkvarn, en kollerkvarn och en pärlkvarn. ,
16. Förfarande enligt patentkrav 9, kännetecknat av att läkemedlet är naproxen.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98163992A | 1992-11-25 | 1992-11-25 | |
US98163992 | 1992-11-25 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI934320A0 FI934320A0 (fi) | 1993-10-01 |
FI934320A FI934320A (fi) | 1994-05-26 |
FI108399B true FI108399B (sv) | 2002-01-31 |
Family
ID=25528539
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI934320A FI108399B (sv) | 1992-11-25 | 1993-10-01 | F÷rfarande f÷r framstõllning av partiklar av farmaceutiska õmnen |
Country Status (24)
Country | Link |
---|---|
US (1) | US5518187A (sv) |
EP (1) | EP0600528B1 (sv) |
JP (2) | JPH06209982A (sv) |
KR (1) | KR100312798B1 (sv) |
AT (1) | ATE193646T1 (sv) |
AU (1) | AU660852B2 (sv) |
CA (1) | CA2107400C (sv) |
CZ (1) | CZ284802B6 (sv) |
DE (1) | DE69328815T2 (sv) |
DK (1) | DK0600528T3 (sv) |
ES (1) | ES2148198T3 (sv) |
FI (1) | FI108399B (sv) |
GR (1) | GR3034227T3 (sv) |
HU (1) | HU210928B (sv) |
IL (1) | IL107191A0 (sv) |
MX (1) | MX9306443A (sv) |
MY (1) | MY109419A (sv) |
NO (1) | NO933719L (sv) |
NZ (1) | NZ248813A (sv) |
PH (1) | PH31118A (sv) |
PT (1) | PT600528E (sv) |
RU (1) | RU2122405C1 (sv) |
SK (1) | SK281078B6 (sv) |
TW (1) | TW239075B (sv) |
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