ATE193646T1 - Verfahren zur zerkleinerung von pharmazeutischen substanzen - Google Patents

Verfahren zur zerkleinerung von pharmazeutischen substanzen

Info

Publication number
ATE193646T1
ATE193646T1 AT93202795T AT93202795T ATE193646T1 AT E193646 T1 ATE193646 T1 AT E193646T1 AT 93202795 T AT93202795 T AT 93202795T AT 93202795 T AT93202795 T AT 93202795T AT E193646 T1 ATE193646 T1 AT E193646T1
Authority
AT
Austria
Prior art keywords
pharmaceutical substances
grinding pharmaceutical
grinding
drug substance
imaging agent
Prior art date
Application number
AT93202795T
Other languages
English (en)
Inventor
Joseph A Bruno
Brian D Doty
Evan Gustow
Kathleen J Illig
Natarajan Rajagopalan
Pramod P Sarpotdar
Original Assignee
Elan Pharma International Limi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharma International Limi filed Critical Elan Pharma International Limi
Application granted granted Critical
Publication of ATE193646T1 publication Critical patent/ATE193646T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/02—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
    • G03C1/00—Photosensitive materials
    • G03C1/005—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/90—Manufacture, treatment, or detection of nanostructure having step or means utilizing mechanical or thermal property, e.g. pressure, heat
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/928—X-ray agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Crushing And Grinding (AREA)
  • Disintegrating Or Milling (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
AT93202795T 1992-11-25 1993-09-30 Verfahren zur zerkleinerung von pharmazeutischen substanzen ATE193646T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98163992A 1992-11-25 1992-11-25

Publications (1)

Publication Number Publication Date
ATE193646T1 true ATE193646T1 (de) 2000-06-15

Family

ID=25528539

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93202795T ATE193646T1 (de) 1992-11-25 1993-09-30 Verfahren zur zerkleinerung von pharmazeutischen substanzen

Country Status (24)

Country Link
US (1) US5518187A (de)
EP (1) EP0600528B1 (de)
JP (2) JPH06209982A (de)
KR (1) KR100312798B1 (de)
AT (1) ATE193646T1 (de)
AU (1) AU660852B2 (de)
CA (1) CA2107400C (de)
CZ (1) CZ284802B6 (de)
DE (1) DE69328815T2 (de)
DK (1) DK0600528T3 (de)
ES (1) ES2148198T3 (de)
FI (1) FI108399B (de)
GR (1) GR3034227T3 (de)
HU (1) HU210928B (de)
IL (1) IL107191A0 (de)
MX (1) MX9306443A (de)
MY (1) MY109419A (de)
NO (1) NO933719L (de)
NZ (1) NZ248813A (de)
PH (1) PH31118A (de)
PT (1) PT600528E (de)
RU (1) RU2122405C1 (de)
SK (1) SK281078B6 (de)
TW (1) TW239075B (de)

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FI934320A (fi) 1994-05-26
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KR940010984A (ko) 1994-06-20
PT600528E (pt) 2000-11-30
DK0600528T3 (da) 2000-10-16
SK281078B6 (sk) 2000-11-07
DE69328815T2 (de) 2001-02-01
US5518187A (en) 1996-05-21
AU4867093A (en) 1994-06-09
RU2122405C1 (ru) 1998-11-27
NO933719D0 (no) 1993-10-15
FI934320A0 (fi) 1993-10-01
JPH06209982A (ja) 1994-08-02
IL107191A0 (en) 1994-01-25
JP2003175341A (ja) 2003-06-24
MX9306443A (es) 1994-05-31
KR100312798B1 (ko) 2001-12-28
HUT67644A (en) 1995-04-28
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TW239075B (de) 1995-01-21
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GR3034227T3 (en) 2000-12-29
DE69328815D1 (de) 2000-07-13
EP0600528B1 (de) 2000-06-07
MY109419A (en) 1997-01-31
EP0600528A1 (de) 1994-06-08
HU210928B (en) 1995-09-28
CA2107400A1 (en) 1994-05-26
CA2107400C (en) 2007-01-23
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NO933719L (no) 1994-05-26
HU9302779D0 (en) 1993-12-28
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