ES2665883T3 - Tratamiento de enfermedades y trastornos pulmonares y pulmonares - Google Patents
Tratamiento de enfermedades y trastornos pulmonares y pulmonares Download PDFInfo
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- ES2665883T3 ES2665883T3 ES09796901.8T ES09796901T ES2665883T3 ES 2665883 T3 ES2665883 T3 ES 2665883T3 ES 09796901 T ES09796901 T ES 09796901T ES 2665883 T3 ES2665883 T3 ES 2665883T3
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13942508P | 2008-12-19 | 2008-12-19 | |
| US139425P | 2008-12-19 | ||
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Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7875272B2 (en) * | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| AU2004252568B2 (en) | 2003-06-27 | 2011-06-30 | Ethicon, Incorporated | Regeneration and repair of neural tissue using postpartum-derived cells |
| US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
| US8518390B2 (en) | 2003-06-27 | 2013-08-27 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells |
| US8491883B2 (en) * | 2003-06-27 | 2013-07-23 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of amyotrophic lateral sclerosis using umbilical derived cells |
| US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
| US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
| BRPI0818183A2 (pt) * | 2007-10-05 | 2019-07-16 | Ethicon Inc | reparo e regeneração do tecido renal usando células derivadas do tecido do cordão umbilical humano |
| US8236538B2 (en) | 2007-12-20 | 2012-08-07 | Advanced Technologies And Regenerative Medicine, Llc | Methods for sterilizing materials containing biologically active agents |
| WO2009085860A1 (en) * | 2007-12-27 | 2009-07-09 | Ethicon, Incorporated | Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells |
| US20130302283A1 (en) * | 2012-05-14 | 2013-11-14 | Advanced Technologies And Regenerative Medicine, Llc | hUTC MODULATION OF PRO-INFLAMMATORY MEDIATORS OF LUNG AND PULMONARY DISEASES AND DISORDERS |
| US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
| WO2010071864A1 (en) | 2008-12-19 | 2010-06-24 | Ethicon, Incorporated | Treatment of lung and pulmonary diseases and disorders |
| WO2010111663A1 (en) | 2009-03-26 | 2010-09-30 | Ethicon, Inc. | Human umbilical cord tissue cells as therapy for alzheimer' s disease |
| CN103889434B (zh) | 2011-06-21 | 2017-02-15 | Bvw控股公司 | 含有乳香酸的医疗装置 |
| US9611513B2 (en) * | 2011-12-23 | 2017-04-04 | DePuy Synthes Products, Inc. | Detection of human umbilical cord tissue derived cells |
| US9888680B2 (en) | 2013-04-04 | 2018-02-13 | The Trustees Of Columbia University In The City Of New York | Functional recovery of human lungs for transplantation |
| US20150265654A1 (en) * | 2014-03-20 | 2015-09-24 | Patrick J. Casey | Method for the treatment of damaged tissue |
| US20190153386A1 (en) * | 2017-11-17 | 2019-05-23 | James R. Musick | Stem cell line for treatment of various medical conditions |
| US20230152303A1 (en) * | 2020-02-17 | 2023-05-18 | Nippon Becton Dickinson Company Ltd | Sample preservation composition |
| JP7589052B2 (ja) * | 2021-01-28 | 2024-11-25 | キヤノンメディカルシステムズ株式会社 | 医用情報処理装置、医用情報処理システム、医用情報処理方法、及び医用情報処理プログラム |
| CN116036229A (zh) * | 2023-01-05 | 2023-05-02 | 安徽科门生物科技有限公司 | 一种含干细胞外泌体的雾化剂及其用于治疗肺部疾病的应用 |
Family Cites Families (249)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3665061A (en) * | 1969-07-16 | 1972-05-23 | United States Banknote Corp | Process for producing collagen sponges |
| JPS5651747B2 (enExample) * | 1973-05-31 | 1981-12-08 | ||
| CH635748A5 (fr) | 1977-08-16 | 1983-04-29 | Cellorgan Laboratoires Sa | Procede d'obtention de cellules placentaires de brebis. |
| US4216144A (en) | 1977-10-20 | 1980-08-05 | Ashmead H H | Soluble iron proteinates |
| JPS6040439B2 (ja) * | 1978-03-29 | 1985-09-11 | 大正製薬株式会社 | ヒドロコルチゾン誘導体 |
| US4352883A (en) | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4487865A (en) * | 1983-12-15 | 1984-12-11 | Biomatrix, Inc. | Polymeric articles modified with hyaluronate |
| US5902741A (en) | 1986-04-18 | 1999-05-11 | Advanced Tissue Sciences, Inc. | Three-dimensional cartilage cultures |
| US4963489A (en) | 1987-04-14 | 1990-10-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
| US5266480A (en) | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
| US5863531A (en) | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
| US4925667A (en) * | 1986-05-27 | 1990-05-15 | Qmax Technology Group, Inc. | Substrate with particulate cosmetic |
| JPS642643A (en) | 1987-06-26 | 1989-01-06 | Bio Material Yunibaasu:Kk | Artificial skin |
| NZ226750A (en) | 1987-10-29 | 1990-09-26 | Amrad Corp Ltd | Immortalisation of neural precursor cells by introducing a retrovirus vector containing a myc-oncogene |
| US5192553A (en) | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
| US5004681B1 (en) | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| US20030032178A1 (en) | 1988-08-04 | 2003-02-13 | Williams Robert Lindsay | In vitro propagation of embryonic stem cells |
| FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
| US5437994A (en) | 1989-06-15 | 1995-08-01 | Regents Of The University Of Michigan | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
| US5574205A (en) | 1989-07-25 | 1996-11-12 | Cell Genesys | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| US5840580A (en) | 1990-05-01 | 1998-11-24 | Becton Dickinson And Company | Phenotypic characterization of the hematopoietic stem cell |
| US5612205A (en) | 1990-08-29 | 1997-03-18 | Genpharm International, Incorporated | Homologous recombination in mammalian cells |
| US5342761A (en) | 1990-10-01 | 1994-08-30 | Research Development Foundation | Oncofetal gene, gene product and uses therefor |
| US5811094A (en) | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5286632A (en) | 1991-01-09 | 1994-02-15 | Jones Douglas H | Method for in vivo recombination and mutagenesis |
| NL9100038A (nl) * | 1991-01-11 | 1992-08-03 | Stamicarbon | Enzym-gekatalyseerde bereiding van optisch aktieve carbonzuren. |
| US6399369B1 (en) | 1991-07-08 | 2002-06-04 | Neurospheres Holdings Ltd. | Multipotent neural stem cell cDNA libraries |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| AU4543193A (en) | 1992-06-22 | 1994-01-24 | Henry E. Young | Scar inhibitory factor and use thereof |
| US5320962A (en) | 1992-07-22 | 1994-06-14 | Duke University | DNA encoding the human A1 adenosine receptor |
| US5589376A (en) | 1992-07-27 | 1996-12-31 | California Institute Of Technology | Mammalian neural crest stem cells |
| US20040224409A1 (en) | 1992-09-25 | 2004-11-11 | Laurent Pradier | Recombinant adenoviruses coding for brain-derived neurotrophic factor (BDNF) |
| AU673865B2 (en) | 1992-10-29 | 1996-11-28 | Australian National University, The | Angiogenesis inhibitory antibodies |
| US5955343A (en) | 1992-12-28 | 1999-09-21 | Massachusetts Institute Of Technology | Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor |
| US5670483A (en) | 1992-12-28 | 1997-09-23 | Massachusetts Insititute Of Technology | Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor |
| US5707643A (en) | 1993-02-26 | 1998-01-13 | Santen Pharmaceutical Co., Ltd. | Biodegradable scleral plug |
| WO1994025584A1 (en) | 1993-04-28 | 1994-11-10 | Johns Hopkins University School Of Medicine | Chronic endothelial cell culture under flow |
| IL110589A0 (en) | 1993-08-10 | 1994-11-11 | Bioph Biotech Entw Pharm Gmbh | Growth/differentiation factor of the TGF- beta family |
| JP3680114B2 (ja) | 1993-09-17 | 2005-08-10 | 敏一 中村 | 脳神経障害治療剤 |
| US6686198B1 (en) | 1993-10-14 | 2004-02-03 | President And Fellows Of Harvard College | Method of inducing and maintaining neuronal cells |
| US6432711B1 (en) | 1993-11-03 | 2002-08-13 | Diacrin, Inc. | Embryonic stem cells capable of differentiating into desired cell lines |
| US5456835A (en) * | 1993-11-08 | 1995-10-10 | Hemasure, Inc. | Device and process for removing free hemoglobin from blood |
| DE4406073A1 (de) | 1994-02-24 | 1995-08-31 | Univ Ludwigs Albert | Verfahren zur Herstellung von humanen, klonogenen Fibroblasten, Verfahren zur Gentransfizierung von Fibroblasten und so erhaltene Fibroblasten |
| US5698518A (en) | 1994-03-30 | 1997-12-16 | Oklahoma Medical Research Foundation | Method for regulating inflammation and tumor growth with calmodulin, calmodulin analogues or calmodulin antagonists |
| US6703017B1 (en) | 1994-04-28 | 2004-03-09 | Ixion Biotechnology, Inc. | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
| US6001647A (en) | 1994-04-28 | 1999-12-14 | Ixion Biotechnology, Inc. | In vitro growth of functional islets of Langerhans and in vivo uses thereof |
| US5834308A (en) | 1994-04-28 | 1998-11-10 | University Of Florida Research Foundation, Inc. | In vitro growth of functional islets of Langerhans |
| JPH10505250A (ja) * | 1994-06-06 | 1998-05-26 | ケース ウエスターン リザーブ ユニバーシティ | 組織再生のためのバイオマトリックス |
| IL114397A0 (en) | 1994-07-01 | 1995-10-31 | Bioph Biotech Entw Pharm Gmbh | Growth/differentiation factor of the TGF-beta-family |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US5789147A (en) | 1994-12-05 | 1998-08-04 | New York Blood Center, Inc. | Method for concentrating white cells from whole blood by adding a red cell sedimentation reagent to whole anticoagulated blood |
| US5725493A (en) | 1994-12-12 | 1998-03-10 | Avery; Robert Logan | Intravitreal medicine delivery |
| US5684032A (en) | 1994-12-13 | 1997-11-04 | Smithkline Beecham Corporation | Compounds |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5736396A (en) | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US5906934A (en) | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
| US5869079A (en) | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| US5641750A (en) | 1995-11-29 | 1997-06-24 | Amgen Inc. | Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product |
| US6200606B1 (en) | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
| US5842477A (en) | 1996-02-21 | 1998-12-01 | Advanced Tissue Sciences, Inc. | Method for repairing cartilage |
| AU733382B2 (en) | 1996-03-15 | 2001-05-10 | Munin Corporation | Extracellular matrix signalling molecules |
| AU2808397A (en) | 1996-04-26 | 1997-11-19 | Case Western Reserve University | Skin regeneration using mesenchymal stem cells |
| US6787355B1 (en) | 1996-08-26 | 2004-09-07 | Mcgill University | Multipotent neural stem cells from peripheral tissues and uses thereof |
| US5919702A (en) | 1996-10-23 | 1999-07-06 | Advanced Tissue Science, Inc. | Production of cartilage tissue using cells isolated from Wharton's jelly |
| CA2288690A1 (en) | 1997-05-13 | 1998-11-19 | Osiris Therapeutics, Inc. | Osteoarthritis cartilage regeneration using human mesenchymal stem cells |
| EP0983062A4 (en) * | 1997-05-21 | 2002-10-23 | Sloan Kettering Inst Cancer | METHOD FOR INCREASING THE CONCENTRATION OF ASCOBIC ACID IN PERSONAL BRAIN TISSUE |
| ATE412383T1 (de) | 1997-05-30 | 2008-11-15 | Osteobiologics Inc | Faserverstärkte,poröse,biologisch abbaubare implantatvorrichtung |
| DE69831957T3 (de) | 1997-07-14 | 2009-07-23 | Osiris Therapeutics, Inc. | Herzmuskelregenerierung unter verwendung mesenchymaler stammzellen |
| US5902598A (en) | 1997-08-28 | 1999-05-11 | Control Delivery Systems, Inc. | Sustained release drug delivery devices |
| DE69841850D1 (de) | 1997-12-02 | 2010-09-30 | Artecel Sciences Inc | Differenzierung in osteoblasten der fettgewebe-stromalen zellen und ihre verwendungen |
| US6291240B1 (en) | 1998-01-29 | 2001-09-18 | Advanced Tissue Sciences, Inc. | Cells or tissues with increased protein factors and methods of making and using same |
| JP4441115B2 (ja) | 1998-03-13 | 2010-03-31 | オシリス セラピューティクス，インコーポレイテッド | ヒト非自己間葉幹細胞を使用する方法と利用 |
| US9585916B2 (en) * | 1999-03-26 | 2017-03-07 | Northern Therapeutics Inc. | Cell based therapy for the pulmonary system |
| US6171610B1 (en) | 1998-04-24 | 2001-01-09 | University Of Massachusetts | Guided development and support of hydrogel-cell compositions |
| EP1096941B1 (en) | 1998-05-07 | 2005-08-10 | University Of South Florida | Bone marrow cells as a source of neurons for brain and spinal cord repair |
| DE69936720T2 (de) | 1998-05-29 | 2008-04-30 | Osiris Therapeutics, Inc. | Menschliche cd45+ und/oder fibroblasten+ mesenchymale stammzellen |
| US6323188B1 (en) | 1998-07-01 | 2001-11-27 | Donald L. Weissman | Treatment and prevention of cardiovascular diseases, heart attack, and stroke, primary and subsequent, with help of aspirin and certain vitamins |
| US20040037818A1 (en) | 1998-07-30 | 2004-02-26 | Brand Stephen J. | Treatment for diabetes |
| ES2335066T3 (es) | 1998-08-10 | 2010-03-18 | The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services | Diferenciacion de celulas no productoras de insulina en celulas productoras de insulina glp-1 o exendina-4 y utilizaciones de las mismas. |
| US5958767A (en) | 1998-08-14 | 1999-09-28 | The Children's Medical Center Corp. | Engraftable human neural stem cells |
| US6284245B1 (en) | 1998-08-25 | 2001-09-04 | Diacrin, Inc. | Neural retinal cells and retinal pigment epithelium cells and their use in treatment of retinal disorders |
| US6444205B2 (en) | 1998-09-30 | 2002-09-03 | Diacrin, Inc. | Transplantation of neural cells for the treatment of chronic pain or spasticity |
| US6610540B1 (en) | 1998-11-18 | 2003-08-26 | California Institute Of Technology | Low oxygen culturing of central nervous system progenitor cells |
| MXPA01007810A (es) | 1999-02-04 | 2003-06-04 | Univ Mcgill | Plataforma para la diferenciacion de celulas. |
| US6326201B1 (en) | 1999-02-10 | 2001-12-04 | Curis, Inc. | Pancreatic progenitor cells, methods and uses related thereto |
| EP1165830B1 (en) | 1999-03-10 | 2017-07-12 | University of Pittsburgh of the Commonwealth System of Higher Education | Adipose-derived stem cells and lattices |
| US20030007954A1 (en) | 1999-04-12 | 2003-01-09 | Gail K. Naughton | Methods for using a three-dimensional stromal tissue to promote angiogenesis |
| KR100619611B1 (ko) | 1999-04-16 | 2006-09-01 | 더블유엠. 마쉬 라이스 유니버시티 | 작용화 폴리(프로필렌 푸마레이트) 및 폴리(프로필렌푸마레이트-코-에틸렌 글리콜 |
| US6372494B1 (en) | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
| US6287340B1 (en) | 1999-05-14 | 2001-09-11 | Trustees Of Tufts College | Bioengineered anterior cruciate ligament |
| AU4860900A (en) | 1999-06-02 | 2000-12-18 | Lifebank Services, L.L.C. | Methods of isolation, cryopreservation, and therapeutic use of human amniotic epithelial cells |
| US6261841B1 (en) | 1999-06-25 | 2001-07-17 | The Board Of Trustees Of Northwestern University | Compositions, kits, and methods for modulating survival and differentiation of multi-potential hematopoietic progenitor cells |
| US6333029B1 (en) * | 1999-06-30 | 2001-12-25 | Ethicon, Inc. | Porous tissue scaffoldings for the repair of regeneration of tissue |
| US7621606B2 (en) | 2001-08-27 | 2009-11-24 | Advanced Cell Technology, Inc. | Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies |
| US6355699B1 (en) * | 1999-06-30 | 2002-03-12 | Ethicon, Inc. | Process for manufacturing biomedical foams |
| JP5398941B2 (ja) | 1999-08-05 | 2014-01-29 | エイビーティー ホールディング カンパニー | 多能性成体幹細胞およびそれを単離する方法 |
| US6429013B1 (en) | 1999-08-19 | 2002-08-06 | Artecel Science, Inc. | Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair |
| US6555374B1 (en) | 1999-08-19 | 2003-04-29 | Artecel Sciences, Inc. | Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof |
| AU7378600A (en) | 1999-09-14 | 2001-04-17 | Children's Medical Center Corporation | Methods for treating muscular dystrophy |
| US6331313B1 (en) | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
| US20030129745A1 (en) | 1999-10-28 | 2003-07-10 | Robl James M. | Gynogenetic or androgenetic production of pluripotent cells and cell lines, and use thereof to produce differentiated cells and tissues |
| EP1099754A1 (en) | 1999-11-10 | 2001-05-16 | Universiteit Leiden | Mesenchymal stem cells and/or progenitor cells, their isolation and use |
| US20030082155A1 (en) | 1999-12-06 | 2003-05-01 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| CA2392615A1 (en) | 1999-12-06 | 2001-06-07 | The General Hospital Corporation | Pancreatic stem cells and their use in transplantation |
| US20020164307A1 (en) | 1999-12-06 | 2002-11-07 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| WO2001053503A1 (en) | 2000-01-18 | 2001-07-26 | Cornell Research Foundation, Inc. | Neural progenitor cells from hippocampal tissue and a method for isolating and purifying them |
| US7544509B2 (en) | 2000-01-24 | 2009-06-09 | Mcgill University | Method for preparing stem cell preparations |
| US6610535B1 (en) | 2000-02-10 | 2003-08-26 | Es Cell International Pte Ltd. | Progenitor cells and methods and uses related thereto |
| DE60129943T2 (de) | 2000-02-11 | 2008-05-08 | Philadelphia Health And Education Corp. | Differenzierung von knochenmarkzellen in neuronale zellen und deren verwendungen |
| AU3499801A (en) | 2000-02-11 | 2001-08-20 | Schepens Eye Res Inst | Isolation and transplantation of retinal stem cells |
| EP1263930A4 (en) | 2000-03-09 | 2004-07-21 | Saneron Ccel Therapeutics Inc | HUMAN CORD BLOOD BLOOD AS A SOURCE FOR NEURAL TISSUE FOR HEALING THE BRAIN AND BACK MARK |
| US6436704B1 (en) | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
| US6673606B1 (en) | 2000-04-12 | 2004-01-06 | The Children's Hospital Of Philadelphia | Therapeutic uses for mesenchymal stromal cells |
| US6375972B1 (en) | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
| WO2001088103A2 (en) | 2000-05-12 | 2001-11-22 | University Of Utah Research Foundation | Compositions and methods for tissue dedifferentiation and regeneration |
| US8273570B2 (en) | 2000-05-16 | 2012-09-25 | Riken | Process of inducing differentiation of embryonic cell to cell expressing neural surface marker using OP9 or PA6 cells |
| US7049072B2 (en) | 2000-06-05 | 2006-05-23 | University Of South Florida | Gene expression analysis of pluri-differentiated mesenchymal progenitor cells and methods for diagnosing a leukemic disease state |
| US6759039B2 (en) | 2000-06-30 | 2004-07-06 | Amcyte, Inc. | Culturing pancreatic stem cells having a specified, intermediate stage of development |
| US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| AU2001293586A1 (en) | 2000-09-29 | 2002-04-08 | Vincent Tropepe | Primitive neural stem cells and method for differentiation of stem cells to neural cells |
| US20020098584A1 (en) | 2000-11-06 | 2002-07-25 | Palmer Theo D. | Postmortem stem cells |
| EP1395652A2 (en) | 2000-11-30 | 2004-03-10 | Stemron, Inc. | Isolated homozygous stem cells differentiated cells derived therefrom and materials and methods for making and using same |
| US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| EP2305795B1 (en) | 2000-12-06 | 2019-07-03 | Celularity, Inc. | Method of collecting placental stem cells |
| US6599323B2 (en) | 2000-12-21 | 2003-07-29 | Ethicon, Inc. | Reinforced tissue implants and methods of manufacture and use |
| CA2435826A1 (en) | 2001-01-24 | 2002-08-01 | The Government Of The United States Of America | Differentiation of stem cells to pancreatic endocrine cells |
| US7449180B2 (en) | 2001-02-06 | 2008-11-11 | John Kisiday | Macroscopic scaffold containing amphiphilic peptides encapsulating cells |
| WO2002062969A2 (en) | 2001-02-06 | 2002-08-15 | Massachusetts Institute Of Technology | Cellular reprogramming in peptide hydrogel and uses thereof |
| AU2002243980B2 (en) | 2001-02-14 | 2007-08-23 | Robert J. Hariri | Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells |
| JP2004529621A (ja) | 2001-02-14 | 2004-09-30 | ティー ファークト，レオ | 多能性成体幹細胞、その起源、それを得る方法および維持する方法、それを分化させる方法、その使用法、ならびにそれ由来の細胞 |
| WO2002064755A2 (en) | 2001-02-14 | 2002-08-22 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| EP1385935A4 (en) | 2001-03-29 | 2004-09-15 | Ixion Biotechnology Inc | METHOD FOR TRANSDIFFERENTIATION OF NON-PANCREATIC STEM CELLS IN THE PANCREAS DIFFERENTIATION PATHWAY |
| US7838292B1 (en) | 2001-03-29 | 2010-11-23 | University Of Louisville Research Foundation, Inc. | Methods for obtaining adult human olfactory progenitor cells |
| US20050054102A1 (en) | 2001-04-19 | 2005-03-10 | Anna Wobus | Method for differentiating stem cells into insulin-producing cells |
| US20030211605A1 (en) | 2001-05-01 | 2003-11-13 | Lee Sang-Hun | Derivation of midbrain dopaminergic neurons from embryonic stem cells |
| US20030022369A1 (en) | 2001-05-18 | 2003-01-30 | Helen Fillmore | Differentiation of specialized dermal and epidermal cells into neuronal cells |
| CA2451838A1 (en) | 2001-05-25 | 2002-12-05 | Cythera, Inc. | Stem cell differentiation |
| DE60233805D1 (de) | 2001-08-08 | 2009-11-05 | Levesque Biosciences Inc | Zusammensetzungen und verfahren zur isolierung, vermehrung und differenzierung nicht-embryonale menschlicher stammzellen und deren verwendungen |
| US20030211603A1 (en) | 2001-08-14 | 2003-11-13 | Earp David J. | Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells |
| US20030104997A1 (en) | 2001-09-05 | 2003-06-05 | Black Ira B. | Multi-lineage directed induction of bone marrow stromal cell differentiation |
| CN1195055C (zh) | 2001-09-06 | 2005-03-30 | 周胜利 | 从胎盘组织中提取造血干细胞用于建立造血干细胞库的新方法 |
| US20050064587A1 (en) | 2001-09-07 | 2005-03-24 | Lawrence Rosenberg | Pancreatic small cells and uses thereof |
| US9969980B2 (en) | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| EP1298201A1 (en) | 2001-09-27 | 2003-04-02 | Cardion AG | Process for the production of cells exhibiting an islet-beta-cell-like state |
| JP2005503822A (ja) | 2001-09-28 | 2005-02-10 | イーエス・セル・インターナショナル・プライヴェート・リミテッド | 無フィーダーマトリックス上での未分化ヒト胚性幹（ｈｅｓ）細胞の導出および増殖方法ならびにヒトフィーダー層 |
| CA2463914A1 (en) | 2001-10-18 | 2003-04-24 | Ixion Biotechnology, Inc. | Conversion of liver stem and progenitor cells to pancreatic functional cells |
| US7129034B2 (en) | 2001-10-25 | 2006-10-31 | Cedars-Sinai Medical Center | Differentiation of whole bone marrow |
| EP1453954A4 (en) | 2001-11-09 | 2004-12-15 | Artecel Sciences Inc | Endocrine pancreas differentiation of adipose tissue-derived stromal cells and uses thereof |
| JP4330995B2 (ja) * | 2001-11-15 | 2009-09-16 | チルドレンズ メディカル センター コーポレーション | 絨毛膜絨毛、羊水、および胎盤からの胎児性幹細胞を単離、増殖、および分化させる方法、ならびにその治療的使用方法 |
| JP3728750B2 (ja) | 2001-11-22 | 2005-12-21 | ニプロ株式会社 | 培養皮膚及びその製造方法 |
| EP1449542B1 (en) | 2001-11-28 | 2012-06-13 | AnGes MG, Inc. | Hgf as genetic remedy for parkinson's disease |
| CA2469209C (en) | 2001-12-04 | 2012-04-24 | Jianjian Jin | Cultured cells from pancreatic islets |
| WO2003054171A1 (en) | 2001-12-06 | 2003-07-03 | The Regents Of The University Of California | Method for differentiating islet precursor cells into beta cells |
| KR101008868B1 (ko) | 2001-12-07 | 2011-01-17 | 제론 코포레이션 | 인간 배아 줄기세포 유래의 섬세포 |
| JP3934539B2 (ja) | 2001-12-12 | 2007-06-20 | 独立行政法人科学技術振興機構 | 胎盤等由来の成体又は生後組織の前駆細胞 |
| US20030113910A1 (en) | 2001-12-18 | 2003-06-19 | Mike Levanduski | Pluripotent stem cells derived without the use of embryos or fetal tissue |
| JP2005512592A (ja) | 2001-12-21 | 2005-05-12 | マウント・シナイ・ホスピタル | 細胞性組成物ならびに細胞性組成物の作製法および細胞性組成物の使用法 |
| US7101546B2 (en) | 2001-12-21 | 2006-09-05 | Amcyte, Inc. | In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development |
| CA2471540A1 (en) | 2001-12-28 | 2003-07-10 | Cellartis Ab | A method for the establishment of a pluripotent human blastocyst-derived stem cell line |
| WO2003060085A2 (en) | 2002-01-14 | 2003-07-24 | The Board Of Trustees Of The University Of Illinois | Mammalian neural stem cells, compositions and uses thereof |
| US20030162290A1 (en) | 2002-01-25 | 2003-08-28 | Kazutomo Inoue | Method for inducing differentiation of embryonic stem cells into functioning cells |
| AU2003217357A1 (en) | 2002-02-07 | 2003-09-02 | The Research Foundation Of The State University Of New York | Generation of new insulin cells from progenitor cells present in adult pancreatic islets |
| KR20110036114A (ko) | 2002-02-13 | 2011-04-06 | 안트로제네시스 코포레이션 | 산후 포유류 태반으로부터 유래한 배아-유사 줄기 세포와 그 세포를 사용한 용도 및 치료방법 |
| US7576065B2 (en) | 2002-02-15 | 2009-08-18 | Cornell Research Foundation, Inc. | Enhancing neurotrophin-induced neurogenesis by endogenous neural progenitor cells by concurrent overexpression of brain derived neurotrophic factor and an inhibitor of a pro-gliogenic bone morphogenetic protein |
| EP1483371B1 (en) | 2002-02-19 | 2007-06-27 | Medipost, Co., Ltd. | Isolation and culture-expansion methods of mesenchymal stem/progenitor cells from umbilical cord blood, and differentiation method of umbilical cord blood-derived mesenchymal stem/progenitor cells into various mesenchymal tissues |
| WO2003072728A2 (en) | 2002-02-22 | 2003-09-04 | University Of Florida | Cellular trans-differentiation |
| US7736892B2 (en) | 2002-02-25 | 2010-06-15 | Kansas State University Research Foundation | Cultures, products and methods using umbilical cord matrix cells |
| US20030161818A1 (en) | 2002-02-25 | 2003-08-28 | Kansas State University Research Foundation | Cultures, products and methods using stem cells |
| US7150990B2 (en) | 2002-03-06 | 2006-12-19 | Reprocell, Inc. | Self-renewing pluripotent hepatic stem cells |
| WO2003080822A1 (en) | 2002-03-27 | 2003-10-02 | Nipro Corporation | Placenta-origin mesenchymal cells and medicinal use thereof |
| AU2003262187A1 (en) | 2002-04-12 | 2003-10-27 | Celgene Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| JP4136434B2 (ja) | 2002-04-17 | 2008-08-20 | 進 清野 | インスリン産生細胞の誘導 |
| WO2003089619A2 (en) | 2002-04-19 | 2003-10-30 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Placental derived stem cells and uses thereof |
| US20040161419A1 (en) | 2002-04-19 | 2004-08-19 | Strom Stephen C. | Placental stem cells and uses thereof |
| AU2003239176A1 (en) | 2002-04-25 | 2003-11-10 | Wisconsin Alumni Research Foundation | Neurodegenerative disorder treatment using gdnf secreting neural cells |
| US20040029269A1 (en) | 2002-05-07 | 2004-02-12 | Goldman Steven A | Promoter-based isolation, purification, expansion, and transplantation of neuronal progenitor cells, oligodendrocyte progenitor cells, or neural stem cells from a population of embryonic stem cells |
| US20040014662A1 (en) | 2002-05-08 | 2004-01-22 | Per Lindquist | Modulation of neural stem cells and neural progenitor cells |
| AU2003273573A1 (en) | 2002-05-28 | 2003-12-19 | Becton, Dickinson And Company | Expansion and transdifferentiation of human acinar cells |
| WO2003102151A2 (en) | 2002-05-30 | 2003-12-11 | Celgene Corporation | Modulating cell differentiation and treating myeloprolifertive disorders with jnk/mkk inhibitors |
| WO2003104442A1 (en) | 2002-06-07 | 2003-12-18 | Es Cell International Pte Ltd | Methods of regulating differentiation in stem cells |
| AU2003247514A1 (en) | 2002-06-11 | 2003-12-22 | Roy Ogle | Meningeal-derived stem cells |
| US7285415B2 (en) | 2002-07-11 | 2007-10-23 | The Regents Of The University Of California | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
| US7390659B2 (en) | 2002-07-16 | 2008-06-24 | The Trustees Of Columbia University In The City Of New York | Methods for inducing differentiation of embryonic stem cells and uses thereof |
| EP1551955A4 (en) | 2002-07-16 | 2006-11-29 | Yissum Res Dev Co | METHOD FOR IMPLANTING MESENCHYMAL STEM CELLS FOR TISSUE PAIRING AND FORMATION |
| EP1539930A4 (en) | 2002-07-29 | 2006-08-09 | Es Cell Int Pte Ltd | METHOD IN MULTIPLE STAGES OF DIFFERENTIATION OF POSITIVE INSULIN-SENSITIVE CELLS, GLUCOSE |
| EP1531838A2 (en) | 2002-07-29 | 2005-05-25 | Asahi Kasei Kabushiki Kaisha | Stem cells for treating pancreatic damage |
| AU2003262628A1 (en) | 2002-08-14 | 2004-03-03 | University Of Florida | Bone marrow cell differentiation |
| AU2003265094A1 (en) * | 2002-08-26 | 2004-03-11 | Neuronova Ab | Method for culturing stem cells |
| WO2004020601A2 (en) | 2002-08-28 | 2004-03-11 | University Of Florida | Neurogenesis from hepatic stem cells |
| JP2005537803A (ja) | 2002-09-06 | 2005-12-15 | アムサイト インコーポレーティッド | Ｃｄ５６陽性ヒト成体膵臓内分泌前駆細胞 |
| US9969977B2 (en) | 2002-09-20 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| JP4571387B2 (ja) | 2003-02-07 | 2010-10-27 | 宣男 櫻川 | ヒト羊膜由来サイドポピュレーション細胞及びその用途 |
| ATE478941T1 (de) | 2003-02-11 | 2010-09-15 | John E Davies | Vorläuferzellen aus der wharton sulze von humanen nabelschnüren |
| WO2004111207A1 (en) | 2003-06-09 | 2004-12-23 | Centelion | Multicellular in vitro model of angiogenesis and methods for using the same |
| US20100158880A1 (en) | 2008-12-19 | 2010-06-24 | Ethicon, Incorporated | Regeneration and repair of neural tissue following injury |
| US8518390B2 (en) * | 2003-06-27 | 2013-08-27 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells |
| AU2004252568B2 (en) * | 2003-06-27 | 2011-06-30 | Ethicon, Incorporated | Regeneration and repair of neural tissue using postpartum-derived cells |
| US9572840B2 (en) * | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
| US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
| US7875272B2 (en) | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| CA2536909A1 (en) | 2003-08-29 | 2005-03-10 | Regents Of The University Of Minnesota | Kidney derived stem cells and methods for their isolation, differentiation and use |
| US20050089513A1 (en) | 2003-10-28 | 2005-04-28 | Norio Sakuragawa | Side population cells originated from human amnion and their uses |
| GB0404656D0 (en) | 2004-03-02 | 2004-04-07 | Univ Manchester | Treatment of spinal conditions |
| US8039258B2 (en) | 2004-09-28 | 2011-10-18 | Ethicon, Inc. | Tissue-engineering scaffolds containing self-assembled-peptide hydrogels |
| JP5424559B2 (ja) | 2004-11-17 | 2014-02-26 | ニューラルステム・インコーポレーテッド | 神経変性状態を治療するためのヒト神経細胞の移植 |
| US20060153815A1 (en) | 2004-12-21 | 2006-07-13 | Agnieszka Seyda | Tissue engineering devices for the repair and regeneration of tissue |
| US20060166361A1 (en) | 2004-12-21 | 2006-07-27 | Agnieszka Seyda | Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same |
| US20060171930A1 (en) | 2004-12-21 | 2006-08-03 | Agnieszka Seyda | Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same |
| JP5425400B2 (ja) | 2004-12-23 | 2014-02-26 | エシコン・インコーポレイテッド | 産褥由来細胞を用いた脳卒中および他の急性神経変性障害の治療 |
| PL1831356T3 (pl) | 2004-12-23 | 2017-07-31 | DePuy Synthes Products, Inc. | Komórki poporodowe pochodzące z tkanki pępowinowej i sposoby ich wytwarzania i stosowania |
| WO2006071773A2 (en) | 2004-12-23 | 2006-07-06 | Ethicon Incoporated | Treatment of osteochondral diseases using postpartum-derived cells and products thereof |
| EP1831355A2 (en) | 2004-12-23 | 2007-09-12 | Ethicon, Inc. | Soft tissue repair and regeneration using postpartum-derived cells and cell products |
| US7741311B2 (en) | 2005-01-03 | 2010-06-22 | Shaker Mousa | Composition and method for treating occlusive vascular diseases, nerve regeneration, and wound healing |
| ES2387402T3 (es) | 2005-03-31 | 2012-09-21 | Stemnion, Inc. | Composiciones celulares derivadas del amnios, procedimientos de fabricación y usos de las mismas |
| WO2006117237A2 (en) | 2005-05-05 | 2006-11-09 | Georg-August-Universität-Göttingen | Regeneration system, its production and use |
| US7923007B2 (en) | 2005-08-08 | 2011-04-12 | Academia Sinica | Brain tissue damage therapies |
| EP1943335A2 (en) | 2005-11-02 | 2008-07-16 | Georg-August-Universität Göttingen | Compositions and methods for producing pluripotent cells from adult testis |
| US9175261B2 (en) | 2005-12-16 | 2015-11-03 | DePuy Synthes Products, Inc. | Human umbilical cord tissue cells for inhibiting adverse immune response in histocompatibility-mismatched transplantation |
| ES2391034T3 (es) | 2005-12-19 | 2012-11-20 | Ethicon, Inc. | Expansión in vitro de células derivadas postparto en frascos rotatorios |
| US9125906B2 (en) * | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
| SG170789A1 (en) | 2005-12-28 | 2011-05-30 | Ethicon Inc | Treatment of peripheral vascular disease using postpartum-derived cells |
| EP2471903B1 (en) | 2005-12-29 | 2018-02-14 | Anthrogenesis Corporation | Placental stem cell populations |
| WO2007079184A2 (en) | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
| US20070178073A1 (en) * | 2006-02-01 | 2007-08-02 | Samsung Life Public Welfare Foundation | Composition Comprising Separated or Proliferated Cells from Umbilical Cord Blood for Treating Developmental and/or Chronic Lung Disease |
| MX2008012085A (es) | 2006-03-23 | 2009-01-22 | Pluristem Ltd | Metodos para expansion de celulas y usos de celulas y medios acondicionados producidos de esta manera para terapia. |
| CA2705450A1 (en) * | 2006-04-27 | 2007-11-08 | Cell Therapy Technologies, Inc. Et Al | Stem cells for treating lung diseases |
| WO2007142651A1 (en) | 2006-06-09 | 2007-12-13 | Caritas St. Elizabeth Medical Center Of Boston, Inc. | Methods and compositions for the treatment of neuropathy |
| WO2008002250A1 (en) | 2006-06-30 | 2008-01-03 | Elena Kozlova | Improved stem cells for transplantation and methods for production thereof |
| TW200817019A (en) | 2006-07-10 | 2008-04-16 | Univ Columbia | De novo formation and regeneration of vascularized tissue from tissue progenitor cells and vascular progenitor cells |
| US7993918B2 (en) * | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
| GB0619500D0 (en) * | 2006-10-03 | 2006-11-08 | Univ Keele | Treatment of fibrosis |
| DK2078073T3 (da) | 2006-10-12 | 2013-10-28 | Ethicon Inc | Nyreafledte celler og fremgangsmåder til anvendelse deraf til vævsreparation og -regenerering |
| WO2008085221A2 (en) | 2006-10-27 | 2008-07-17 | Caritas St. Elizabeth Medical Center Of Boston, Inc. | Therapeutic use of cd31 expressing cells |
| EP2089511B1 (en) | 2006-11-13 | 2014-09-17 | DePuy Synthes Products, LLC | In vitro expansion of postpartum-derived cells using microcarriers |
| PL2120977T3 (pl) * | 2007-02-12 | 2013-12-31 | Anthrogenesis Corp | Leczenie chorób zapalnych z zastosowaniem łożyskowych komórek macierzystych |
| US20080305148A1 (en) | 2007-03-19 | 2008-12-11 | National Yang Ming University | Treatment of spinal injuries using human umbilical mesenchymal stem cells |
| BRPI0818183A2 (pt) | 2007-10-05 | 2019-07-16 | Ethicon Inc | reparo e regeneração do tecido renal usando células derivadas do tecido do cordão umbilical humano |
| US8236538B2 (en) | 2007-12-20 | 2012-08-07 | Advanced Technologies And Regenerative Medicine, Llc | Methods for sterilizing materials containing biologically active agents |
| WO2009085860A1 (en) | 2007-12-27 | 2009-07-09 | Ethicon, Incorporated | Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells |
| AU2009316376B2 (en) * | 2008-11-21 | 2015-08-20 | Celularity Inc. | Treatment of diseases, disorders or conditions of the lung using placental cells |
| US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
| US20130302283A1 (en) | 2012-05-14 | 2013-11-14 | Advanced Technologies And Regenerative Medicine, Llc | hUTC MODULATION OF PRO-INFLAMMATORY MEDIATORS OF LUNG AND PULMONARY DISEASES AND DISORDERS |
| WO2010071864A1 (en) | 2008-12-19 | 2010-06-24 | Ethicon, Incorporated | Treatment of lung and pulmonary diseases and disorders |
| WO2010071862A1 (en) | 2008-12-19 | 2010-06-24 | Ethicon, Incorporated | Umbilical cord tissue derived cells for treating neuropathic pain and spasticity |
| WO2010111663A1 (en) | 2009-03-26 | 2010-09-30 | Ethicon, Inc. | Human umbilical cord tissue cells as therapy for alzheimer' s disease |
| DK2624847T3 (en) * | 2010-10-05 | 2017-10-09 | Aal Scient Inc | HUMAN LUNG STEM CELLS AND APPLICATIONS THEREOF |
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| CA2747794C (en) | 2018-10-30 |
| CN107028983A (zh) | 2017-08-11 |
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| BRPI0923068A2 (pt) | 2019-10-01 |
| EP2379088B1 (en) | 2018-02-28 |
| CA2747794A1 (en) | 2010-06-24 |
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| US20100158877A1 (en) | 2010-06-24 |
| US10557116B2 (en) | 2020-02-11 |
| CN102387807A (zh) | 2012-03-21 |
| BRPI0923068B1 (pt) | 2021-05-25 |
| EP2379088A1 (en) | 2011-10-26 |
| JP5518893B2 (ja) | 2014-06-11 |
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