ES2543004T3 - Composiciones y métodos para inhibir la expresión de transtiretina - Google Patents

Composiciones y métodos para inhibir la expresión de transtiretina Download PDF

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Publication number
ES2543004T3
ES2543004T3 ES09810834.3T ES09810834T ES2543004T3 ES 2543004 T3 ES2543004 T3 ES 2543004T3 ES 09810834 T ES09810834 T ES 09810834T ES 2543004 T3 ES2543004 T3 ES 2543004T3
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Prior art keywords
ttr
seq
strand
rnads
sequence
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ES09810834.3T
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English (en)
Spanish (es)
Inventor
Dinah Wen-Yee Sah
Gregory Hinkle
Rene Alvarez
Stuart Milstein
Qingmin Chen
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
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ES09810834.3T 2008-10-20 2009-10-20 Composiciones y métodos para inhibir la expresión de transtiretina Active ES2543004T3 (es)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US156670P 1999-09-29
US10695608P 2008-10-20 2008-10-20
US106956P 2008-10-20
US11573808P 2008-11-18 2008-11-18
US115738P 2008-11-18
US15667009P 2009-03-02 2009-03-02
US18554509P 2009-06-09 2009-06-09
US185545P 2009-06-09
US24278309P 2009-09-15 2009-09-15
US242783P 2009-09-15
US24479409P 2009-09-22 2009-09-22
US244794P 2009-09-22
PCT/US2009/061381 WO2010048228A2 (en) 2008-10-20 2009-10-20 Compositions and methods for inhibiting expression of transthyretin

Publications (1)

Publication Number Publication Date
ES2543004T3 true ES2543004T3 (es) 2015-08-13

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ID=42062316

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Application Number Title Priority Date Filing Date
ES09810834.3T Active ES2543004T3 (es) 2008-10-20 2009-10-20 Composiciones y métodos para inhibir la expresión de transtiretina
ES15151452.8T Active ES2656516T3 (es) 2008-10-20 2009-10-20 Composiciones y métodos para inhibir la expresión de transtiretina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES15151452.8T Active ES2656516T3 (es) 2008-10-20 2009-10-20 Composiciones y métodos para inhibir la expresión de transtiretina

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US (9) US8168775B2 (enExample)
EP (4) EP3354733B1 (enExample)
JP (7) JP5791505B2 (enExample)
KR (6) KR102354558B1 (enExample)
CN (3) CN106834291B (enExample)
AU (1) AU2009307677C1 (enExample)
CA (3) CA2739895C (enExample)
CY (3) CY1116944T1 (enExample)
DK (2) DK2344639T3 (enExample)
EA (3) EA029762B1 (enExample)
ES (2) ES2543004T3 (enExample)
HR (2) HRP20150796T1 (enExample)
HU (3) HUE026604T2 (enExample)
IL (5) IL302142B2 (enExample)
LT (2) LT2937418T (enExample)
LU (1) LUC00098I2 (enExample)
MX (4) MX344354B (enExample)
NL (1) NL300965I2 (enExample)
NO (2) NO2937418T3 (enExample)
NZ (2) NZ592867A (enExample)
PL (2) PL2344639T3 (enExample)
PT (2) PT2937418T (enExample)
SG (3) SG10201809460SA (enExample)
SI (2) SI2344639T1 (enExample)
SM (2) SMT201800027T1 (enExample)
WO (1) WO2010048228A2 (enExample)
ZA (1) ZA201102876B (enExample)

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