EA029762B1 - Композиции и способы для ингибирования экспрессии транстиретина - Google Patents

Композиции и способы для ингибирования экспрессии транстиретина Download PDF

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Publication number
EA029762B1
EA029762B1 EA201400170A EA201400170A EA029762B1 EA 029762 B1 EA029762 B1 EA 029762B1 EA 201400170 A EA201400170 A EA 201400170A EA 201400170 A EA201400170 A EA 201400170A EA 029762 B1 EA029762 B1 EA 029762B1
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EA
Eurasian Patent Office
Prior art keywords
dsrna
nucleotide
ttc
pharmaceutical composition
lipid
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Application number
EA201400170A
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English (en)
Russian (ru)
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EA201400170A1 (ru
Inventor
Динах Вен-Йи Сах
Грегори Хинкл
Рене Альварес
Стюарт Милстейн
Цинминь Чэнь
Original Assignee
Элнилэм Фармасьютикалз, Инк.
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Publication of EA201400170A1 publication Critical patent/EA201400170A1/ru
Publication of EA029762B1 publication Critical patent/EA029762B1/ru

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
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EA201400170A 2008-10-20 2009-10-20 Композиции и способы для ингибирования экспрессии транстиретина EA029762B1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US10695608P 2008-10-20 2008-10-20
US11573808P 2008-11-18 2008-11-18
US15667009P 2009-03-02 2009-03-02
US18554509P 2009-06-09 2009-06-09
US24278309P 2009-09-15 2009-09-15
US24479409P 2009-09-22 2009-09-22

Publications (2)

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EA201400170A1 EA201400170A1 (ru) 2015-03-31
EA029762B1 true EA029762B1 (ru) 2018-05-31

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Application Number Title Priority Date Filing Date
EA201400170A EA029762B1 (ru) 2008-10-20 2009-10-20 Композиции и способы для ингибирования экспрессии транстиретина
EA201170591A EA020312B1 (ru) 2008-10-20 2009-10-20 Композиции и способы для ингибирования экспрессии транстиретина
EA201792626A EA036772B1 (ru) 2008-10-20 2009-10-20 Композиции и способы для ингибирования экспрессии транстиретина

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EA201170591A EA020312B1 (ru) 2008-10-20 2009-10-20 Композиции и способы для ингибирования экспрессии транстиретина
EA201792626A EA036772B1 (ru) 2008-10-20 2009-10-20 Композиции и способы для ингибирования экспрессии транстиретина

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US (9) US8168775B2 (enExample)
EP (4) EP2344639B1 (enExample)
JP (7) JP5791505B2 (enExample)
KR (6) KR102031027B1 (enExample)
CN (3) CN102186978B (enExample)
AU (1) AU2009307677C1 (enExample)
CA (3) CA2739895C (enExample)
CY (3) CY1116944T1 (enExample)
DK (2) DK2937418T3 (enExample)
EA (3) EA029762B1 (enExample)
ES (2) ES2543004T3 (enExample)
HR (2) HRP20150796T1 (enExample)
HU (3) HUE037875T2 (enExample)
IL (5) IL302142B2 (enExample)
LT (2) LT2937418T (enExample)
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NO (2) NO2937418T3 (enExample)
NZ (2) NZ602404A (enExample)
PL (2) PL2344639T3 (enExample)
PT (2) PT2937418T (enExample)
SG (3) SG10201703242XA (enExample)
SI (2) SI2937418T1 (enExample)
SM (2) SMT201800027T1 (enExample)
WO (1) WO2010048228A2 (enExample)
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