EA201792626A1 - Композиции и способы для ингибирования экспрессии транстиретина - Google Patents

Композиции и способы для ингибирования экспрессии транстиретина

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Publication number
EA201792626A1
EA201792626A1 EA201792626A EA201792626A EA201792626A1 EA 201792626 A1 EA201792626 A1 EA 201792626A1 EA 201792626 A EA201792626 A EA 201792626A EA 201792626 A EA201792626 A EA 201792626A EA 201792626 A1 EA201792626 A1 EA 201792626A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
transtiretin
inhibiting
expression
compositions
Prior art date
Application number
EA201792626A
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English (en)
Other versions
EA036772B1 (ru
Inventor
Динах Вен-Йи Сах
Грегори Хинкл
Рене Альварес
Стюарт Милстейн
Цинминь Чэнь
Original Assignee
Элнилэм Фармасьютикалз, Инк.
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Application filed by Элнилэм Фармасьютикалз, Инк. filed Critical Элнилэм Фармасьютикалз, Инк.
Publication of EA201792626A1 publication Critical patent/EA201792626A1/ru
Publication of EA036772B1 publication Critical patent/EA036772B1/ru

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28—HEAT EXCHANGE IN GENERAL
    • F28C—HEAT-EXCHANGE APPARATUS, NOT PROVIDED FOR IN ANOTHER SUBCLASS, IN WHICH THE HEAT-EXCHANGE MEDIA COME INTO DIRECT CONTACT WITHOUT CHEMICAL INTERACTION
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Abstract

Данное изобретение относится к двухцепочечной рибонуклеиновой кислоте (дцРНК), поражающей ген транстиретина (TTR), и способам применения этой дцРНК для ингибирования TTR.
EA201792626A 2008-10-20 2009-10-20 Композиции и способы для ингибирования экспрессии транстиретина EA036772B1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US10695608P 2008-10-20 2008-10-20
US11573808P 2008-11-18 2008-11-18
US15667009P 2009-03-02 2009-03-02
US18554509P 2009-06-09 2009-06-09
US24278309P 2009-09-15 2009-09-15
US24479409P 2009-09-22 2009-09-22

Publications (2)

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EA201792626A1 true EA201792626A1 (ru) 2018-08-31
EA036772B1 EA036772B1 (ru) 2020-12-18

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
EA201400170A EA029762B1 (ru) 2008-10-20 2009-10-20 Композиции и способы для ингибирования экспрессии транстиретина
EA201170591A EA020312B1 (ru) 2008-10-20 2009-10-20 Композиции и способы для ингибирования экспрессии транстиретина
EA201792626A EA036772B1 (ru) 2008-10-20 2009-10-20 Композиции и способы для ингибирования экспрессии транстиретина

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EA201400170A EA029762B1 (ru) 2008-10-20 2009-10-20 Композиции и способы для ингибирования экспрессии транстиретина
EA201170591A EA020312B1 (ru) 2008-10-20 2009-10-20 Композиции и способы для ингибирования экспрессии транстиретина

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US (8) US8168775B2 (ru)
EP (4) EP3354733B1 (ru)
JP (6) JP5791505B2 (ru)
KR (6) KR102354558B1 (ru)
CN (3) CN103937793B (ru)
AU (1) AU2009307677C1 (ru)
CA (3) CA3222620A1 (ru)
CY (3) CY1116944T1 (ru)
DK (2) DK2344639T3 (ru)
EA (3) EA029762B1 (ru)
ES (2) ES2656516T3 (ru)
HK (3) HK1156348A1 (ru)
HR (2) HRP20150796T1 (ru)
HU (3) HUE026604T2 (ru)
IL (5) IL302142B1 (ru)
LT (2) LT2937418T (ru)
LU (1) LUC00098I2 (ru)
MX (4) MX360460B (ru)
NL (1) NL300965I2 (ru)
NO (2) NO2937418T3 (ru)
NZ (2) NZ592867A (ru)
PL (2) PL2937418T3 (ru)
PT (2) PT2937418T (ru)
SG (3) SG10201703242XA (ru)
SI (2) SI2937418T1 (ru)
SM (1) SMT201500176B (ru)
WO (1) WO2010048228A2 (ru)
ZA (1) ZA201102876B (ru)

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