CN102186978B - 抑制运甲状腺素蛋白表达的组合物和方法 - Google Patents

抑制运甲状腺素蛋白表达的组合物和方法 Download PDF

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CN102186978B
CN102186978B CN200980141740.4A CN200980141740A CN102186978B CN 102186978 B CN102186978 B CN 102186978B CN 200980141740 A CN200980141740 A CN 200980141740A CN 102186978 B CN102186978 B CN 102186978B
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dsrna
ttr
seq
nucleotides
expression
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CN102186978A (zh
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D·W·萨
G·辛克尔
R·阿尔瓦雷兹
S·米尔斯泰恩
陈庆敏
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Alnylam Pharmaceuticals Inc
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CN200980141740.4A 2008-10-20 2009-10-20 抑制运甲状腺素蛋白表达的组合物和方法 Active CN102186978B (zh)

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CN201710064263.2A CN106834291B (zh) 2008-10-20 2009-10-20 抑制运甲状腺素蛋白表达的组合物和方法
CN201410053075.6A CN103937793B (zh) 2008-10-20 2009-10-20 抑制运甲状腺素蛋白表达的组合物和方法

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US10695608P 2008-10-20 2008-10-20
US61/106,956 2008-10-20
US11573808P 2008-11-18 2008-11-18
US61/115,738 2008-11-18
US15667009P 2009-03-02 2009-03-02
US61/156,670 2009-03-02
US18554509P 2009-06-09 2009-06-09
US61/185,545 2009-06-09
US24278309P 2009-09-15 2009-09-15
US61/242,783 2009-09-15
US24479409P 2009-09-22 2009-09-22
US61/244,794 2009-09-22
PCT/US2009/061381 WO2010048228A2 (en) 2008-10-20 2009-10-20 Compositions and methods for inhibiting expression of transthyretin

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CN201410053075.6A Division CN103937793B (zh) 2008-10-20 2009-10-20 抑制运甲状腺素蛋白表达的组合物和方法

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