ECSP13012703A - Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak - Google Patents
Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jakInfo
- Publication number
- ECSP13012703A ECSP13012703A ECSP13012703A ECSP13012703A EC SP13012703 A ECSP13012703 A EC SP13012703A EC SP13012703 A ECSP13012703 A EC SP13012703A EC SP13012703 A ECSP13012703 A EC SP13012703A
- Authority
- EC
- Ecuador
- Prior art keywords
- cyclobutyl
- pyrrolopyridine
- derivatives substituted
- jak inhibitors
- pyrrolopyrimidine derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
Abstract
La presente invención provee pirrolopirimidinas y pirrolopiridinas sustituidas con ciclobutilo de la fórmula I:en donde X, Y, Z, L, A, R5, n y m se definen con anterioridad, así como sus composiciones y métodos de uso que modulan la actividad de Janus quinasas (JAKs) y son de utilidad en el tratamiento de enfermedades relacionadas con la actividad de JAKs que incluyen, por ejemplo, trastornos inflamatorios, trastornos autoinmunes, cáncer y otras enfermedades.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41570510P | 2010-11-19 | 2010-11-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP13012703A true ECSP13012703A (es) | 2013-08-30 |
Family
ID=45094278
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSP13012703 ECSP13012703A (es) | 2010-11-19 | 2013-06-19 | Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak |
Country Status (22)
Country | Link |
---|---|
US (3) | US8933085B2 (es) |
EP (1) | EP2640723A1 (es) |
JP (1) | JP5917545B2 (es) |
KR (1) | KR20140019300A (es) |
CN (1) | CN103415515B (es) |
AR (1) | AR083933A1 (es) |
AU (1) | AU2011329734B2 (es) |
BR (1) | BR112013012502A2 (es) |
CA (1) | CA2818542A1 (es) |
CL (1) | CL2013001412A1 (es) |
CO (1) | CO6761386A2 (es) |
CR (1) | CR20130280A (es) |
EA (1) | EA026201B1 (es) |
EC (1) | ECSP13012703A (es) |
IL (1) | IL226407A (es) |
MX (1) | MX344478B (es) |
NZ (1) | NZ611151A (es) |
PE (1) | PE20140146A1 (es) |
SG (1) | SG190839A1 (es) |
TW (1) | TW201249845A (es) |
UA (1) | UA113156C2 (es) |
WO (1) | WO2012068450A1 (es) |
Families Citing this family (109)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2970354T3 (es) * | 2005-12-13 | 2024-05-28 | Incyte Holdings Corp | Derivados de pirrolo[2,3-d]pirimidina como inhibidores de Janus quinasas |
CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
TR201903488T4 (tr) | 2007-06-13 | 2019-04-22 | Incyte Holdings Corp | Janus kinaz inhibitörü (r)-3-(4-(7h-pirolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3-siklopentilpropannitril tuzlarının kullanımı. |
JOP20190230A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
KR101771401B1 (ko) * | 2009-05-22 | 2017-08-25 | 인사이트 홀딩스 코포레이션 | 야누스 키나제 억제제로서 피라졸4일피롤로[2,3d]피리미딘 및 피롤3일피롤로[2,3d]피리미딘의 N(헤테로)아릴피롤리딘 유도체 |
TWI484962B (zh) * | 2009-05-22 | 2015-05-21 | Incyte Corp | 作為jak抑制劑之3-〔4-(7h-吡咯并〔2,3-d〕嘧啶-4-基)-1h-吡唑-1-基〕辛烷或庚腈 |
BRPI1015135B1 (pt) | 2009-06-29 | 2021-08-03 | Incyte Holdings Corporation | Pirimidinonas inibidoras de pi3k, composição compreendendo tais compostos, bem como usos dos mesmos |
US9249145B2 (en) | 2009-09-01 | 2016-02-02 | Incyte Holdings Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
DK2545045T3 (en) | 2010-03-10 | 2016-01-25 | Incyte Holdings Corp | PIPERIDINE-4-YL-azetidine derivatives AS JAK1 INHIBITORS |
CN103002875B (zh) | 2010-05-21 | 2016-05-04 | 因塞特控股公司 | Jak抑制剂的局部用制剂 |
US9034884B2 (en) | 2010-11-19 | 2015-05-19 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors |
US8933085B2 (en) | 2010-11-19 | 2015-01-13 | Incyte Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
WO2012087881A1 (en) | 2010-12-20 | 2012-06-28 | Incyte Corporation | N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors |
PT2675451E (pt) | 2011-02-18 | 2015-10-16 | Incyte Corp | Terapia de combinação com inibidores mtor/jak |
MX344479B (es) | 2011-06-20 | 2016-12-16 | Incyte Holdings Corp | Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de cinasa janus (jak). |
CA2844507A1 (en) | 2011-08-10 | 2013-02-14 | Novartis Pharma Ag | Jak pi3k/mtor combination therapy |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
EP3255041A1 (en) * | 2011-09-02 | 2017-12-13 | Purdue Pharma L.P. | Pyrimidines as sodium channel blockers |
ES2722524T3 (es) | 2011-09-02 | 2019-08-13 | Incyte Holdings Corp | Heterociclaminas como inhibidores de pi3k |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
AR091079A1 (es) * | 2012-05-18 | 2014-12-30 | Incyte Corp | Derivados de pirrolopirimidina y pirrolopiridina sustituida con piperidinilciclobutilo como inhibidores de jak |
US9181271B2 (en) | 2012-11-01 | 2015-11-10 | Incyte Holdings Corporation | Tricyclic fused thiophene derivatives as JAK inhibitors |
KR20210037012A (ko) | 2012-11-15 | 2021-04-05 | 인사이트 홀딩스 코포레이션 | 룩솔리티니브의 서방성 제형 |
BR112015010120A2 (pt) * | 2012-11-16 | 2017-07-11 | Hoffmann La Roche | processo para a preparação de ácido 2-trifluorometil isonicotínico e ésteres |
JP6437452B2 (ja) | 2013-01-14 | 2018-12-12 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Pimキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物 |
KR102311840B1 (ko) | 2013-01-15 | 2021-10-14 | 인사이트 홀딩스 코포레이션 | Pim 키나제 저해제로서 유용한 티아졸카복스아마이드 및 피리딘카복스아마이드 화합물 |
WO2014118388A1 (en) | 2013-02-04 | 2014-08-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for assaying jak2 activity in red blood cells and uses thereof |
CA2903418C (en) | 2013-03-06 | 2021-03-23 | Incyte Corporation | Processes and intermediates for making a jak inhibitor |
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-
2011
- 2011-11-18 US US13/300,094 patent/US8933085B2/en active Active
- 2011-11-18 KR KR1020137015801A patent/KR20140019300A/ko not_active Application Discontinuation
- 2011-11-18 CN CN201180065119.1A patent/CN103415515B/zh not_active Expired - Fee Related
- 2011-11-18 SG SG2013038740A patent/SG190839A1/en unknown
- 2011-11-18 MX MX2013005603A patent/MX344478B/es active IP Right Grant
- 2011-11-18 CA CA2818542A patent/CA2818542A1/en not_active Abandoned
- 2011-11-18 PE PE2013001220A patent/PE20140146A1/es not_active Application Discontinuation
- 2011-11-18 EA EA201390736A patent/EA026201B1/ru not_active IP Right Cessation
- 2011-11-18 UA UAA201307763A patent/UA113156C2/uk unknown
- 2011-11-18 AR ARP110104324A patent/AR083933A1/es not_active Application Discontinuation
- 2011-11-18 AU AU2011329734A patent/AU2011329734B2/en not_active Ceased
- 2011-11-18 BR BR112013012502-0A patent/BR112013012502A2/pt not_active IP Right Cessation
- 2011-11-18 NZ NZ611151A patent/NZ611151A/en not_active IP Right Cessation
- 2011-11-18 EP EP11791155.2A patent/EP2640723A1/en not_active Withdrawn
- 2011-11-18 JP JP2013540049A patent/JP5917545B2/ja active Active
- 2011-11-18 WO PCT/US2011/061374 patent/WO2012068450A1/en active Application Filing
- 2011-11-18 TW TW100142377A patent/TW201249845A/zh unknown
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2013
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- 2013-06-10 CR CR20130280A patent/CR20130280A/es unknown
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2014
- 2014-12-01 US US14/556,775 patent/US20150087632A1/en not_active Abandoned
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CO6761386A2 (es) | 2013-09-30 |
AR083933A1 (es) | 2013-04-10 |
US8933085B2 (en) | 2015-01-13 |
KR20140019300A (ko) | 2014-02-14 |
EP2640723A1 (en) | 2013-09-25 |
BR112013012502A2 (pt) | 2019-03-06 |
CN103415515B (zh) | 2015-08-26 |
TW201249845A (en) | 2012-12-16 |
NZ611151A (en) | 2015-06-26 |
MX2013005603A (es) | 2013-06-13 |
IL226407A0 (en) | 2013-07-31 |
JP2014500260A (ja) | 2014-01-09 |
AU2011329734B2 (en) | 2015-05-28 |
IL226407A (en) | 2017-04-30 |
WO2012068450A1 (en) | 2012-05-24 |
US20190135813A1 (en) | 2019-05-09 |
CL2013001412A1 (es) | 2013-12-20 |
JP5917545B2 (ja) | 2016-05-18 |
EA026201B1 (ru) | 2017-03-31 |
PE20140146A1 (es) | 2014-02-06 |
EA201390736A1 (ru) | 2013-11-29 |
AU2011329734A1 (en) | 2013-05-02 |
MX344478B (es) | 2016-12-16 |
US20150087632A1 (en) | 2015-03-26 |
CR20130280A (es) | 2013-08-09 |
SG190839A1 (en) | 2013-07-31 |
UA113156C2 (xx) | 2016-12-26 |
US20120149681A1 (en) | 2012-06-14 |
US10640506B2 (en) | 2020-05-05 |
CA2818542A1 (en) | 2012-05-24 |
CN103415515A (zh) | 2013-11-27 |
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