PE20151940A1 - Derivados de triazina - Google Patents

Derivados de triazina

Info

Publication number
PE20151940A1
PE20151940A1 PE2015002303A PE2015002303A PE20151940A1 PE 20151940 A1 PE20151940 A1 PE 20151940A1 PE 2015002303 A PE2015002303 A PE 2015002303A PE 2015002303 A PE2015002303 A PE 2015002303A PE 20151940 A1 PE20151940 A1 PE 20151940A1
Authority
PE
Peru
Prior art keywords
triazine
triazine derivatives
imidazo
cyclopropyl
tetrahydrofuran
Prior art date
Application number
PE2015002303A
Other languages
English (en)
Inventor
Thomas Allen Chappie
Christopher John Helal
Patrick Robert Verhoest
Jamison Bryce Tuttle
Bethany Lyn Kormos
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20151940A1 publication Critical patent/PE20151940A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invencion se refiere a derivados de triazina, como se describe en la siguiente Formula I, y al uso de los compuestos como inhibidores de PDE10. Donde: A junto con X y el atomo de carbono al que esta unido, forma un C6-C10 arilo, etc. X es N o C, R1 es C1-C6 alquilo, etc. R2 y R3 son hidrogeno, C1-C6 alquilo, etc. compuestos preferidos son: 4-(3-ciclopropil-6,7-dihidro[1,2]oxazolo[4,3-c]piridin-5(4H)-il)-7-metil-5-[3S)-tetrahidrofuran-3-il]imidazo[5,1-f][1,2,4]triazina, 4-(2-ciclopropil-2,4,6,7-tetrahidro-5H-pirazolo[4,3-c]piridin-5-il)-7-metil-5-[(3S)-tetrahidrofuran-3-il]imidazo[5,1-f][1,2,4]triazina
PE2015002303A 2013-05-02 2014-04-23 Derivados de triazina PE20151940A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361818650P 2013-05-02 2013-05-02

Publications (1)

Publication Number Publication Date
PE20151940A1 true PE20151940A1 (es) 2016-01-21

Family

ID=50841902

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2015002303A PE20151940A1 (es) 2013-05-02 2014-04-23 Derivados de triazina

Country Status (34)

Country Link
US (3) US8933224B2 (es)
EP (1) EP2991989B1 (es)
JP (1) JP6263606B2 (es)
KR (1) KR101770905B1 (es)
CN (1) CN105164134B (es)
AP (1) AP2015008843A0 (es)
AR (1) AR096161A1 (es)
AU (1) AU2014261070A1 (es)
BR (1) BR112015027760A8 (es)
CA (1) CA2910759C (es)
CL (1) CL2015003037A1 (es)
CR (1) CR20150591A (es)
CU (1) CU20150144A7 (es)
DK (1) DK2991989T3 (es)
DO (1) DOP2015000271A (es)
EA (1) EA027936B1 (es)
EC (1) ECSP15050110A (es)
ES (1) ES2637816T3 (es)
GE (1) GEP201706675B (es)
HK (1) HK1213885A1 (es)
MA (1) MA38559B1 (es)
MD (1) MD20150103A2 (es)
MX (1) MX2015015163A (es)
NI (1) NI201500157A (es)
NZ (1) NZ712949A (es)
PE (1) PE20151940A1 (es)
PH (1) PH12015502462A1 (es)
SG (1) SG11201508201VA (es)
TN (1) TN2015000490A1 (es)
TW (1) TWI508966B (es)
UA (1) UA111696C2 (es)
UY (1) UY35547A (es)
WO (1) WO2014177977A1 (es)
ZA (1) ZA201508968B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014261070A1 (en) * 2013-05-02 2015-10-29 Pfizer Inc. Imidazo-triazine derivatives as PDE10 inhibitors
KR102411532B1 (ko) 2016-09-09 2022-06-22 노파르티스 아게 엔도솜 톨-유사 수용체의 억제제로서의 화합물 및 조성물
BR112022007491A2 (pt) * 2019-10-21 2022-07-12 Sk Biopharmaceuticals Co Ltd Medicamento, composição farmacêutica e método para prevenção, alívio ou tratamento de distúrbio cognitivo, e, uso de um composto de imidazopirimidina ou imidazotriazina

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US20010007867A1 (en) 1999-12-13 2001-07-12 Yuhpyng L. Chen Substituted 6,5-hetero-bicyclic derivatives
DE10130167A1 (de) 2001-06-22 2003-01-02 Bayer Ag Imidazotriazine
US7220862B2 (en) 2002-06-05 2007-05-22 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
DE10230604A1 (de) 2002-07-08 2004-01-29 Bayer Ag Heterocyclisch substituierte Imidazotriazine
US20070032404A1 (en) 2003-07-31 2007-02-08 Bayer Pharmaceuticals Corporation Methods for treating diabetes and related disorders using pde10a inhibitors
JP4559749B2 (ja) * 2004-02-16 2010-10-13 あすか製薬株式会社 ピペラジニルピリジン誘導体
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AU2014261070A1 (en) * 2013-05-02 2015-10-29 Pfizer Inc. Imidazo-triazine derivatives as PDE10 inhibitors

Also Published As

Publication number Publication date
KR20160003234A (ko) 2016-01-08
CL2015003037A1 (es) 2016-04-22
JP2016517877A (ja) 2016-06-20
CA2910759C (en) 2018-01-16
MD20150103A2 (ro) 2016-02-29
MX2015015163A (es) 2016-02-22
AU2014261070A1 (en) 2015-10-29
TWI508966B (zh) 2015-11-21
DK2991989T3 (en) 2017-07-31
EA201591819A1 (ru) 2016-05-31
PH12015502462A1 (en) 2016-02-22
UA111696C2 (uk) 2016-05-25
CU20150144A7 (es) 2016-04-25
US8933224B2 (en) 2015-01-13
US20140329820A1 (en) 2014-11-06
NI201500157A (es) 2015-11-30
US9145427B2 (en) 2015-09-29
ECSP15050110A (es) 2017-08-31
WO2014177977A1 (en) 2014-11-06
TN2015000490A1 (fr) 2017-04-06
EA027936B1 (ru) 2017-09-29
CR20150591A (es) 2016-01-04
ZA201508968B (en) 2017-11-29
CA2910759A1 (en) 2014-11-06
SG11201508201VA (en) 2015-11-27
MA38559B1 (fr) 2018-04-30
JP6263606B2 (ja) 2018-01-17
AP2015008843A0 (en) 2015-11-30
AR096161A1 (es) 2015-12-09
KR101770905B1 (ko) 2017-08-23
DOP2015000271A (es) 2016-02-29
US20150080401A1 (en) 2015-03-19
UY35547A (es) 2014-11-28
ES2637816T3 (es) 2017-10-17
US20150353579A1 (en) 2015-12-10
US9296761B2 (en) 2016-03-29
NZ712949A (en) 2017-04-28
CN105164134A (zh) 2015-12-16
EP2991989B1 (en) 2017-06-28
BR112015027760A8 (pt) 2018-05-08
GEP201706675B (en) 2017-05-25
CN105164134B (zh) 2017-09-22
TW201506027A (zh) 2015-02-16
HK1213885A1 (zh) 2016-07-15
EP2991989A1 (en) 2016-03-09

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