MA38559B1 - Dérivés d'imidazo-triazine utilisés comme inhibiteurs de la pde10 - Google Patents

Dérivés d'imidazo-triazine utilisés comme inhibiteurs de la pde10

Info

Publication number
MA38559B1
MA38559B1 MA38559A MA38559A MA38559B1 MA 38559 B1 MA38559 B1 MA 38559B1 MA 38559 A MA38559 A MA 38559A MA 38559 A MA38559 A MA 38559A MA 38559 B1 MA38559 B1 MA 38559B1
Authority
MA
Morocco
Prior art keywords
imidazo
triazine derivatives
derivatives used
pde10 inhibitors
pde10
Prior art date
Application number
MA38559A
Other languages
English (en)
Inventor
Patrick Verhoest
Thomas CHAPPIE
Christopher HELAL
Bethany Kormos
Jamison Tuttle
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA38559B1 publication Critical patent/MA38559B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La présente invention concerne une nouvelle classe de dérivés de triazine tels que décrits par la formule i ci-dessous dans laquelle a, x, r
MA38559A 2013-05-02 2014-04-23 Dérivés d'imidazo-triazine utilisés comme inhibiteurs de la pde10 MA38559B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361818650P 2013-05-02 2013-05-02
PCT/IB2014/060945 WO2014177977A1 (fr) 2013-05-02 2014-04-23 Dérivés d'imidazo-triazine utilisés comme inhibiteurs de la pde10

Publications (1)

Publication Number Publication Date
MA38559B1 true MA38559B1 (fr) 2018-04-30

Family

ID=50841902

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38559A MA38559B1 (fr) 2013-05-02 2014-04-23 Dérivés d'imidazo-triazine utilisés comme inhibiteurs de la pde10

Country Status (34)

Country Link
US (3) US8933224B2 (fr)
EP (1) EP2991989B1 (fr)
JP (1) JP6263606B2 (fr)
KR (1) KR101770905B1 (fr)
CN (1) CN105164134B (fr)
AP (1) AP2015008843A0 (fr)
AR (1) AR096161A1 (fr)
AU (1) AU2014261070A1 (fr)
BR (1) BR112015027760A8 (fr)
CA (1) CA2910759C (fr)
CL (1) CL2015003037A1 (fr)
CR (1) CR20150591A (fr)
CU (1) CU20150144A7 (fr)
DK (1) DK2991989T3 (fr)
DO (1) DOP2015000271A (fr)
EA (1) EA027936B1 (fr)
EC (1) ECSP15050110A (fr)
ES (1) ES2637816T3 (fr)
GE (1) GEP201706675B (fr)
HK (1) HK1213885A1 (fr)
MA (1) MA38559B1 (fr)
MD (1) MD20150103A2 (fr)
MX (1) MX2015015163A (fr)
NI (1) NI201500157A (fr)
NZ (1) NZ712949A (fr)
PE (1) PE20151940A1 (fr)
PH (1) PH12015502462A1 (fr)
SG (1) SG11201508201VA (fr)
TN (1) TN2015000490A1 (fr)
TW (1) TWI508966B (fr)
UA (1) UA111696C2 (fr)
UY (1) UY35547A (fr)
WO (1) WO2014177977A1 (fr)
ZA (1) ZA201508968B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201508201VA (en) * 2013-05-02 2015-11-27 Pfizer Imidazo-triazine derivatives as pde10 inhibitors
KR102411532B1 (ko) 2016-09-09 2022-06-22 노파르티스 아게 엔도솜 톨-유사 수용체의 억제제로서의 화합물 및 조성물
AU2020370958A1 (en) * 2019-10-21 2022-06-09 Sk Biopharmaceuticals Co., Ltd. Use of imidazopyrimidine or imidazotriazine compounds for prevention, alleviation, or treatment of cognitive disorders, or for improving cognitive function

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US20010007867A1 (en) 1999-12-13 2001-07-12 Yuhpyng L. Chen Substituted 6,5-hetero-bicyclic derivatives
DE10130167A1 (de) 2001-06-22 2003-01-02 Bayer Ag Imidazotriazine
US7220862B2 (en) 2002-06-05 2007-05-22 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
DE10230604A1 (de) 2002-07-08 2004-01-29 Bayer Ag Heterocyclisch substituierte Imidazotriazine
WO2005012485A2 (fr) 2003-07-31 2005-02-10 Bayer Pharmaceuticals Corporation Procedes pour traiter le diabete, et les troubles associes, au moyen d'inhibiteurs des pde10a
JP4559749B2 (ja) * 2004-02-16 2010-10-13 あすか製薬株式会社 ピペラジニルピリジン誘導体
EP1595881A1 (fr) 2004-05-12 2005-11-16 Pfizer Limited Dérivés de tetrahydronaphthyridine en tant que ligands de récepteur H3 d'histamine
US20070167426A1 (en) 2004-06-02 2007-07-19 Schering Corporation Compounds for the treatment of inflammatory disorders and microbial diseases
TW200716102A (en) 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
US20080051419A1 (en) 2006-07-26 2008-02-28 Pfizer Inc. Amine derivatives useful as anticancer agents
EP2067769A1 (fr) 2006-09-26 2009-06-10 Kaneka Corporation Procédé de fabrication d'un ester d'acide bêta-hydroxy-alpha-aminocarboxylique optiquement actif
WO2008057402A2 (fr) 2006-11-02 2008-05-15 Cytovia, Inc. N-aryl-isoxazolopyrimidin-4-amines et composés associés servant d'activateurs de caspases et d'inducteurs d'apoptose et leur utilisation
EP2203171A2 (fr) 2007-08-21 2010-07-07 Merck Sharp & Dohme Corp. Ligands de récepteur cb2 pour le traitement de la douleur
DE102007059723A1 (de) 2007-12-12 2009-06-18 Siemens Medical Instruments Pte. Ltd. Hörvorrichtung mit Batterieklappenmodul
PE20091057A1 (es) 2007-12-19 2009-07-20 Lilly Co Eli Antagonistas del receptor mineralcorticoide y metodos de uso
WO2009117157A1 (fr) 2008-03-20 2009-09-24 Amgen Inc. Modulateurs d’aurora kinase et procédé d’utilisation
JP5641664B2 (ja) * 2009-10-30 2014-12-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ イミダゾ［１，２−ｂ］ピリダジン誘導体およびＰＤＥ１０阻害剤としてのそれらの使用
WO2011089400A1 (fr) 2010-01-22 2011-07-28 Centro Nacional De Investigaciones Oncológicas (Cnio) Inhibiteurs de la pi3 kinase
AR080754A1 (es) * 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
TW201200518A (en) 2010-03-10 2012-01-01 Kalypsys Inc Heterocyclic inhibitors of histamine receptors for the treatment of disease
US20130131057A1 (en) 2010-05-13 2013-05-23 Centro Nacional De Investigaciones Oncologicas (Cnio New bicyclic compounds as pi3-k and mtor inhibitors
CN102971323A (zh) 2010-05-28 2013-03-13 拜奥克里斯特制药公司 作为janus激酶抑制剂的杂环化合物
JP2013532149A (ja) 2010-06-17 2013-08-15 ノバルティス アーゲー ピペリジニル置換１，３−ジヒドロ−ベンゾイミダゾール−２−イリデンアミン誘導体
EP2681218A1 (fr) * 2011-02-23 2014-01-08 Pfizer Inc IMIDAZO[5,1-f][1,2,4] TRIAZINES POUR TRAITER LES TROUBLES NEUROLOGIQUES
SG11201508201VA (en) * 2013-05-02 2015-11-27 Pfizer Imidazo-triazine derivatives as pde10 inhibitors

Also Published As

Publication number Publication date
GEP201706675B (en) 2017-05-25
TWI508966B (zh) 2015-11-21
JP2016517877A (ja) 2016-06-20
US8933224B2 (en) 2015-01-13
NZ712949A (en) 2017-04-28
TN2015000490A1 (fr) 2017-04-06
CA2910759A1 (fr) 2014-11-06
US20150080401A1 (en) 2015-03-19
US20140329820A1 (en) 2014-11-06
KR20160003234A (ko) 2016-01-08
HK1213885A1 (zh) 2016-07-15
MD20150103A2 (ro) 2016-02-29
US20150353579A1 (en) 2015-12-10
PH12015502462A1 (en) 2016-02-22
NI201500157A (es) 2015-11-30
US9145427B2 (en) 2015-09-29
MX2015015163A (es) 2016-02-22
DOP2015000271A (es) 2016-02-29
ZA201508968B (en) 2017-11-29
EA201591819A1 (ru) 2016-05-31
AU2014261070A1 (en) 2015-10-29
EA027936B1 (ru) 2017-09-29
EP2991989A1 (fr) 2016-03-09
CU20150144A7 (es) 2016-04-25
AR096161A1 (es) 2015-12-09
JP6263606B2 (ja) 2018-01-17
PE20151940A1 (es) 2016-01-21
KR101770905B1 (ko) 2017-08-23
CL2015003037A1 (es) 2016-04-22
UY35547A (es) 2014-11-28
WO2014177977A1 (fr) 2014-11-06
ECSP15050110A (es) 2017-08-31
SG11201508201VA (en) 2015-11-27
TW201506027A (zh) 2015-02-16
CR20150591A (es) 2016-01-04
DK2991989T3 (en) 2017-07-31
CA2910759C (fr) 2018-01-16
US9296761B2 (en) 2016-03-29
ES2637816T3 (es) 2017-10-17
CN105164134B (zh) 2017-09-22
UA111696C2 (uk) 2016-05-25
EP2991989B1 (fr) 2017-06-28
AP2015008843A0 (en) 2015-11-30
CN105164134A (zh) 2015-12-16
BR112015027760A8 (pt) 2018-05-08

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