ECSP12012158A - Derivado de piridina y pirazina para el tratamiento de fibrosis quística (cf) - Google Patents
Derivado de piridina y pirazina para el tratamiento de fibrosis quística (cf)Info
- Publication number
- ECSP12012158A ECSP12012158A ECSP12012158A ECSP12012158A EC SP12012158 A ECSP12012158 A EC SP12012158A EC SP12012158 A ECSP12012158 A EC SP12012158A EC SP12012158 A ECSP12012158 A EC SP12012158A
- Authority
- EC
- Ecuador
- Prior art keywords
- treatment
- cystic fibrosis
- chysical
- pirazine
- piridine
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract
La presente invención proporciona derivados de piridina y pirazina, los cuales restablecen o mejoran la función del regulador de conductancia transmembrana de fibrosis quística (CFTR) mutante y/o de tipo silvestre, para el tratamiento de fibrosis quística, dipielesia ciliar primaria, bronquitis crónica, enfermedad pulmonar obstructiva crónica, asma, infecciones del tracto respiratorio, carcinoma pulmonar, xerostomia y queratoconjuntivitis sire, o estreñimiento (síndrome de intestino irritable (IBS), enfermedad de intestino irritable (IBD), inducido por opioide). También se abarcan composiciones farmacéuticas que comprenden tales derivados.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31550910P | 2010-03-19 | 2010-03-19 | |
US201161441853P | 2011-02-11 | 2011-02-11 |
Publications (1)
Publication Number | Publication Date |
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ECSP12012158A true ECSP12012158A (es) | 2012-10-30 |
Family
ID=44647718
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ECSP12012158 ECSP12012158A (es) | 2010-03-19 | 2012-09-17 | Derivado de piridina y pirazina para el tratamiento de fibrosis quística (cf) |
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US (8) | US8247436B2 (es) |
EP (2) | EP2845593B1 (es) |
JP (1) | JP5643349B2 (es) |
KR (1) | KR101473546B1 (es) |
CN (1) | CN102892758B (es) |
AR (1) | AR080765A1 (es) |
AU (1) | AU2011229022B2 (es) |
BR (1) | BR112012023578B1 (es) |
CA (1) | CA2793392C (es) |
CO (1) | CO6620008A2 (es) |
CR (1) | CR20120468A (es) |
CU (1) | CU24149B1 (es) |
CY (1) | CY1118823T1 (es) |
DK (2) | DK2845593T3 (es) |
EA (1) | EA028305B1 (es) |
EC (1) | ECSP12012158A (es) |
ES (2) | ES2552503T3 (es) |
GT (1) | GT201200261A (es) |
HK (1) | HK1175170A1 (es) |
HN (1) | HN2012001930A (es) |
HR (2) | HRP20151430T1 (es) |
JO (1) | JO3150B1 (es) |
LT (1) | LT2845593T (es) |
MA (1) | MA34938B1 (es) |
MX (1) | MX2012010815A (es) |
MY (1) | MY158621A (es) |
NZ (1) | NZ602435A (es) |
PE (1) | PE20130343A1 (es) |
PL (2) | PL2845593T3 (es) |
PT (2) | PT2547656E (es) |
RS (2) | RS54425B1 (es) |
SG (1) | SG184018A1 (es) |
SI (2) | SI2547656T1 (es) |
TN (1) | TN2012000446A1 (es) |
TW (2) | TWI551598B (es) |
WO (1) | WO2011113894A1 (es) |
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2012
- 2012-07-09 US US13/544,182 patent/US8476269B2/en not_active Ceased
- 2012-09-11 ZA ZA2012/06775A patent/ZA201206775B/en unknown
- 2012-09-17 HN HN2012001930A patent/HN2012001930A/es unknown
- 2012-09-17 TN TNP2012000446A patent/TN2012000446A1/en unknown
- 2012-09-17 CR CR20120468A patent/CR20120468A/es unknown
- 2012-09-17 EC ECSP12012158 patent/ECSP12012158A/es unknown
- 2012-09-19 GT GT201200261A patent/GT201200261A/es unknown
- 2012-09-19 CO CO12162310A patent/CO6620008A2/es active IP Right Grant
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2013
- 2013-02-25 HK HK13102328.4A patent/HK1175170A1/xx unknown
- 2013-06-20 US US13/923,349 patent/US20140135329A1/en not_active Abandoned
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2014
- 2014-10-23 US US14/521,843 patent/US9365552B2/en active Active
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2015
- 2015-06-30 US US14/755,691 patent/USRE46757E1/en active Active
- 2015-12-29 HR HRP20151430TT patent/HRP20151430T1/hr unknown
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2016
- 2016-05-17 US US15/156,528 patent/US10117858B2/en active Active
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2017
- 2017-04-11 CY CY20171100430T patent/CY1118823T1/el unknown
- 2017-04-20 HR HRP20170624TT patent/HRP20170624T1/hr unknown
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2018
- 2018-09-26 US US16/143,202 patent/US20190262324A1/en not_active Abandoned
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2021
- 2021-04-02 US US17/221,555 patent/US11911371B2/en active Active
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