CY1120509T1 - Ενωσεις 3,4-διαμινο-6-χλωροπυραζινο-2-καρβοξαμιδιου για τη θεραπευτικη αντιμετωπιση ασθενειων που επαγωνται απο ton enac - Google Patents
Ενωσεις 3,4-διαμινο-6-χλωροπυραζινο-2-καρβοξαμιδιου για τη θεραπευτικη αντιμετωπιση ασθενειων που επαγωνται απο ton enacInfo
- Publication number
- CY1120509T1 CY1120509T1 CY20181100750T CY181100750T CY1120509T1 CY 1120509 T1 CY1120509 T1 CY 1120509T1 CY 20181100750 T CY20181100750 T CY 20181100750T CY 181100750 T CY181100750 T CY 181100750T CY 1120509 T1 CY1120509 T1 CY 1120509T1
- Authority
- CY
- Cyprus
- Prior art keywords
- treatment
- enac
- chloropyrazine
- diamino
- ton
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
- C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει μία ένωση του τύπου (I): ή ένα φαρμακευτικώς αποδεκτό άλας αυτής· μία διαδικασία παρασκευής της εν λόγω ένωσης· και τη χρήση της εν λόγω ένωσης στη θεραπευτική αντιμετώπιση μίας παθολογικής κατάστασης που επάγεται από τον ENaC (όπως το άσθμα, η κυστική ίνωση (CF) ή η χρόνια αποφρακτική πνευμονοπάθεια (COPD)).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461954674P | 2014-03-18 | 2014-03-18 | |
| PCT/GB2015/050765 WO2015140527A1 (en) | 2014-03-18 | 2015-03-17 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1120509T1 true CY1120509T1 (el) | 2019-07-10 |
Family
ID=52780553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20181100750T CY1120509T1 (el) | 2014-03-18 | 2018-07-18 | Ενωσεις 3,4-διαμινο-6-χλωροπυραζινο-2-καρβοξαμιδιου για τη θεραπευτικη αντιμετωπιση ασθενειων που επαγωνται απο ton enac |
Country Status (38)
| Country | Link |
|---|---|
| US (3) | US9873678B2 (el) |
| EP (1) | EP3119752B1 (el) |
| JP (1) | JP6502469B2 (el) |
| KR (1) | KR102296041B1 (el) |
| CN (1) | CN106103423B (el) |
| AP (1) | AP2016009447A0 (el) |
| AR (1) | AR099790A1 (el) |
| AU (1) | AU2015233195B2 (el) |
| CA (1) | CA2941807C (el) |
| CL (1) | CL2016002303A1 (el) |
| CR (1) | CR20160479A (el) |
| CY (1) | CY1120509T1 (el) |
| DK (1) | DK3119752T3 (el) |
| DO (1) | DOP2016000232A (el) |
| EA (1) | EA029952B1 (el) |
| ES (1) | ES2679618T3 (el) |
| GT (1) | GT201600190A (el) |
| HR (1) | HRP20181123T1 (el) |
| HU (1) | HUE039425T2 (el) |
| IL (1) | IL247610B (el) |
| LT (1) | LT3119752T (el) |
| ME (1) | ME03056B (el) |
| MX (1) | MX368577B (el) |
| NI (1) | NI201600134A (el) |
| NZ (1) | NZ724063A (el) |
| PE (1) | PE20170205A1 (el) |
| PH (1) | PH12016501808A1 (el) |
| PL (1) | PL3119752T3 (el) |
| PT (1) | PT3119752T (el) |
| RS (1) | RS57487B1 (el) |
| SG (1) | SG11201607751SA (el) |
| SI (1) | SI3119752T1 (el) |
| SV (1) | SV2016005278A (el) |
| TR (1) | TR201810207T4 (el) |
| TW (1) | TWI687410B (el) |
| UY (1) | UY36034A (el) |
| WO (1) | WO2015140527A1 (el) |
| ZA (1) | ZA201607136B (el) |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3577418A (en) | 1969-02-12 | 1971-05-04 | Merck & Co Inc | Pyrazinamide derivatives and processes for their preparation |
| US3573306A (en) | 1969-03-05 | 1971-03-30 | Merck & Co Inc | Process for preparation of n-substituted 3,5-diamino-6-halopyrazinamides |
| FI820266L (fi) | 1981-02-02 | 1982-08-03 | Ici Plc | Alkanolaminderivater |
| US4550111A (en) | 1982-01-29 | 1985-10-29 | Imperial Chemical Industries Plc | Alkanolamine derivatives |
| GB8810933D0 (en) | 1987-05-26 | 1988-06-15 | Ici America Inc | Heterocyclic compounds |
| GB8810934D0 (en) | 1987-05-26 | 1988-06-15 | Ici America Inc | Amides |
| US4803206A (en) | 1988-03-07 | 1989-02-07 | Schering Corporation | Antihypertensive acylpyrazines |
| GB8812342D0 (en) | 1988-05-25 | 1988-06-29 | Ici America Inc | Bicyclic compounds |
| GB8812343D0 (en) | 1988-05-25 | 1988-06-29 | Ici America Inc | Amino compounds |
| CN1248968A (zh) | 1997-02-26 | 2000-03-29 | 辉瑞大药厂 | 杂芳基－己酸酰胺衍生物、其制备方法及其作为MIP－1α与其CCRI受体结合的选择性抑制剂的用途 |
| GB9930557D0 (en) | 1999-12-23 | 2000-02-16 | Rolic Ag | Optically active materials |
| CA2408408C (en) | 2000-05-12 | 2013-07-09 | Genzyme Corporation | Modulators of tnf- alpha signaling |
| NZ533107A (en) | 2001-11-08 | 2007-04-27 | Upjohn Co | N, N'-substituted-1,3-diamino-2-hydroxypropane derivatives |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20040087571A1 (en) | 2002-10-30 | 2004-05-06 | Pfizer Inc | Methods of using CCR1 antagonists as immunomodulatory agents |
| CA2510815A1 (en) | 2002-12-20 | 2004-07-08 | Pfizer Products Inc. | Microsomal triglyceride transfer protein inhibitors |
| US6903105B2 (en) | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
| EP1812378A2 (en) | 2004-10-13 | 2007-08-01 | University of Connecticut | Cannabinergic lipid ligands |
| GB0511065D0 (en) | 2005-05-31 | 2005-07-06 | Novartis Ag | Organic compounds |
| GB0526244D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| GB0526240D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| MX2009009304A (es) | 2007-03-01 | 2009-11-18 | Novartis Ag | Inhibidores de cinasa pim y metodos para su uso. |
| BRPI0811562A2 (pt) | 2007-05-07 | 2014-12-09 | Novartis Ag | Compostos orgânicos |
| TWI439462B (zh) | 2007-12-10 | 2014-06-01 | Novartis Ag | 作為ｅｎａｃ阻抑劑之螺環胍化合物 |
| AU2008345225A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| CA2723938A1 (en) | 2008-05-13 | 2009-11-19 | Novartis Ag | 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid derivatives and their use as epithelial sodium channel blockers for the treatment of airway diseases |
| US9315449B2 (en) | 2008-05-15 | 2016-04-19 | Duke University | Substituted pyrazoles as heat shock transcription factor activators |
| CN102112130A (zh) | 2008-06-10 | 2011-06-29 | 诺瓦提斯公司 | 作为上皮钠通道阻滞剂的吡嗪衍生物 |
| WO2011028740A1 (en) | 2009-09-03 | 2011-03-10 | Glaxo Group Limited | ENaC BLOCKERS |
| WO2011079087A1 (en) | 2009-12-23 | 2011-06-30 | Glaxo Group Limited | Enac blockers |
| US8372845B2 (en) | 2010-09-17 | 2013-02-12 | Novartis Ag | Pyrazine derivatives as enac blockers |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| US9505735B2 (en) | 2012-06-21 | 2016-11-29 | Whitehead Institute For Biomedical Research | Compounds for treating infectious diseases |
| RS55618B1 (sr) | 2012-12-17 | 2017-06-30 | Parion Sciences Inc | Derivati hloropirazin karboksamida korisni za lečenje bolesti kojima pogoduje nedovoljna hidracija sluznica |
| ES2674665T3 (es) | 2012-12-17 | 2018-07-03 | Parion Sciences, Inc. | Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida |
| BR112015014178A2 (pt) | 2012-12-17 | 2017-07-11 | Parion Sciences Inc | compostos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil)carbamimidoil) pirazina-2- carboxamida |
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2015
- 2015-03-16 UY UY0001036034A patent/UY36034A/es not_active Application Discontinuation
- 2015-03-17 NZ NZ724063A patent/NZ724063A/en not_active IP Right Cessation
- 2015-03-17 LT LTEP15713339.8T patent/LT3119752T/lt unknown
- 2015-03-17 CR CR20160479A patent/CR20160479A/es unknown
- 2015-03-17 HU HUE15713339A patent/HUE039425T2/hu unknown
- 2015-03-17 CN CN201580013691.1A patent/CN106103423B/zh active Active
- 2015-03-17 PL PL15713339T patent/PL3119752T3/pl unknown
- 2015-03-17 EA EA201691641A patent/EA029952B1/ru not_active IP Right Cessation
- 2015-03-17 MX MX2016011681A patent/MX368577B/es active IP Right Grant
- 2015-03-17 ES ES15713339.8T patent/ES2679618T3/es active Active
- 2015-03-17 TW TW104108476A patent/TWI687410B/zh active
- 2015-03-17 DK DK15713339.8T patent/DK3119752T3/en active
- 2015-03-17 US US15/124,393 patent/US9873678B2/en active Active
- 2015-03-17 SG SG11201607751SA patent/SG11201607751SA/en unknown
- 2015-03-17 KR KR1020167028483A patent/KR102296041B1/ko active IP Right Grant
- 2015-03-17 WO PCT/GB2015/050765 patent/WO2015140527A1/en active Application Filing
- 2015-03-17 EP EP15713339.8A patent/EP3119752B1/en active Active
- 2015-03-17 SI SI201530318T patent/SI3119752T1/en unknown
- 2015-03-17 PE PE2016001600A patent/PE20170205A1/es unknown
- 2015-03-17 AP AP2016009447A patent/AP2016009447A0/en unknown
- 2015-03-17 CA CA2941807A patent/CA2941807C/en active Active
- 2015-03-17 RS RS20180833A patent/RS57487B1/sr unknown
- 2015-03-17 JP JP2017500446A patent/JP6502469B2/ja active Active
- 2015-03-17 TR TR2018/10207T patent/TR201810207T4/tr unknown
- 2015-03-17 AU AU2015233195A patent/AU2015233195B2/en active Active
- 2015-03-17 ME MEP-2018-185A patent/ME03056B/me unknown
- 2015-03-17 PT PT157133398T patent/PT3119752T/pt unknown
- 2015-03-18 AR ARP150100820A patent/AR099790A1/es unknown
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2016
- 2016-09-04 IL IL247610A patent/IL247610B/en not_active IP Right Cessation
- 2016-09-07 DO DO2016000232A patent/DOP2016000232A/es unknown
- 2016-09-13 NI NI201600134A patent/NI201600134A/es unknown
- 2016-09-13 CL CL2016002303A patent/CL2016002303A1/es unknown
- 2016-09-14 SV SV2016005278A patent/SV2016005278A/es unknown
- 2016-09-14 GT GT201600190A patent/GT201600190A/es unknown
- 2016-09-16 PH PH12016501808A patent/PH12016501808A1/en unknown
- 2016-10-17 ZA ZA2016/07136A patent/ZA201607136B/en unknown
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2017
- 2017-12-13 US US15/840,339 patent/US10336725B2/en active Active
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2018
- 2018-07-16 HR HRP20181123TT patent/HRP20181123T1/hr unknown
- 2018-07-18 CY CY20181100750T patent/CY1120509T1/el unknown
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2019
- 2019-05-10 US US16/408,741 patent/US10954211B2/en active Active
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