PT3119752T - Compostos 3,4-diamino-6-cloropirazina-2-carboxamida para o tratamento de doenças mediadas por enac - Google Patents
Compostos 3,4-diamino-6-cloropirazina-2-carboxamida para o tratamento de doenças mediadas por enacInfo
- Publication number
- PT3119752T PT3119752T PT157133398T PT15713339T PT3119752T PT 3119752 T PT3119752 T PT 3119752T PT 157133398 T PT157133398 T PT 157133398T PT 15713339 T PT15713339 T PT 15713339T PT 3119752 T PT3119752 T PT 3119752T
- Authority
- PT
- Portugal
- Prior art keywords
- chloropyrazine
- diamino
- treatment
- mediated diseases
- carboxamide compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
- C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461954674P | 2014-03-18 | 2014-03-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3119752T true PT3119752T (pt) | 2018-07-24 |
Family
ID=52780553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT157133398T PT3119752T (pt) | 2014-03-18 | 2015-03-17 | Compostos 3,4-diamino-6-cloropirazina-2-carboxamida para o tratamento de doenças mediadas por enac |
Country Status (38)
| Country | Link |
|---|---|
| US (3) | US9873678B2 (pt) |
| EP (1) | EP3119752B1 (pt) |
| JP (1) | JP6502469B2 (pt) |
| KR (1) | KR102296041B1 (pt) |
| CN (1) | CN106103423B (pt) |
| AP (1) | AP2016009447A0 (pt) |
| AR (1) | AR099790A1 (pt) |
| AU (1) | AU2015233195B2 (pt) |
| CA (1) | CA2941807C (pt) |
| CL (1) | CL2016002303A1 (pt) |
| CR (1) | CR20160479A (pt) |
| CY (1) | CY1120509T1 (pt) |
| DK (1) | DK3119752T3 (pt) |
| DO (1) | DOP2016000232A (pt) |
| EA (1) | EA029952B1 (pt) |
| ES (1) | ES2679618T3 (pt) |
| GT (1) | GT201600190A (pt) |
| HR (1) | HRP20181123T1 (pt) |
| HU (1) | HUE039425T2 (pt) |
| IL (1) | IL247610B (pt) |
| LT (1) | LT3119752T (pt) |
| ME (1) | ME03056B (pt) |
| MX (1) | MX368577B (pt) |
| NI (1) | NI201600134A (pt) |
| NZ (1) | NZ724063A (pt) |
| PE (1) | PE20170205A1 (pt) |
| PH (1) | PH12016501808B1 (pt) |
| PL (1) | PL3119752T3 (pt) |
| PT (1) | PT3119752T (pt) |
| RS (1) | RS57487B1 (pt) |
| SG (1) | SG11201607751SA (pt) |
| SI (1) | SI3119752T1 (pt) |
| SV (1) | SV2016005278A (pt) |
| TR (1) | TR201810207T4 (pt) |
| TW (1) | TWI687410B (pt) |
| UY (1) | UY36034A (pt) |
| WO (1) | WO2015140527A1 (pt) |
| ZA (1) | ZA201607136B (pt) |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3577418A (en) | 1969-02-12 | 1971-05-04 | Merck & Co Inc | Pyrazinamide derivatives and processes for their preparation |
| US3573306A (en) | 1969-03-05 | 1971-03-30 | Merck & Co Inc | Process for preparation of n-substituted 3,5-diamino-6-halopyrazinamides |
| FI820266L (fi) | 1981-02-02 | 1982-08-03 | Ici Plc | Alkanolaminderivater |
| EP0086564B1 (en) | 1982-01-29 | 1985-11-21 | Imperial Chemical Industries Plc | Alkanolamine derivatives |
| GB8810934D0 (en) | 1987-05-26 | 1988-06-15 | Ici America Inc | Amides |
| GB8810933D0 (en) | 1987-05-26 | 1988-06-15 | Ici America Inc | Heterocyclic compounds |
| US4803206A (en) | 1988-03-07 | 1989-02-07 | Schering Corporation | Antihypertensive acylpyrazines |
| GB8812343D0 (en) | 1988-05-25 | 1988-06-29 | Ici America Inc | Amino compounds |
| GB8812342D0 (en) | 1988-05-25 | 1988-06-29 | Ici America Inc | Bicyclic compounds |
| KR100447553B1 (ko) | 1997-02-26 | 2004-09-08 | 화이자 인코포레이티드 | 헤테로아릴-헥사노산 아미드 유도체, 그의 제조 방법 및 ｍｉｐ-1 알파의 ｃｃｒ1 수용체로의 결합에 대한 선택적 저해제로서의 용도 |
| GB9930557D0 (en) | 1999-12-23 | 2000-02-16 | Rolic Ag | Optically active materials |
| US6969728B2 (en) | 2000-05-12 | 2005-11-29 | Genzyme Corporation | Modulators of TNF-α signaling |
| BR0214035A (pt) | 2001-11-08 | 2005-04-26 | Elan Pharm Inc | Composto |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20040087571A1 (en) | 2002-10-30 | 2004-05-06 | Pfizer Inc | Methods of using CCR1 antagonists as immunomodulatory agents |
| WO2004056775A1 (en) | 2002-12-20 | 2004-07-08 | Pfizer Products Inc. | Microsomal triglyceride transfer protein inhibitors |
| US6903105B2 (en) | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
| WO2006044381A2 (en) | 2004-10-13 | 2006-04-27 | University Of Connecticut | Cannabinergic lipid ligands |
| GB0511065D0 (en) | 2005-05-31 | 2005-07-06 | Novartis Ag | Organic compounds |
| GB0526244D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| GB0526240D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| AU2008221263B2 (en) | 2007-03-01 | 2012-02-23 | Novartis Ag | Pim kinase inhibitors and methods of their use |
| PT2155721E (pt) | 2007-05-07 | 2011-05-09 | Novartis Ag | Compostos org?nicos |
| TWI439462B (zh) | 2007-12-10 | 2014-06-01 | Novartis Ag | 作為ｅｎａｃ阻抑劑之螺環胍化合物 |
| WO2009086303A2 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| AU2009248179A1 (en) | 2008-05-13 | 2009-11-19 | Novartis Ag | 3,5-Diamino-6-chloro-pyrazine-2-carboxylic acid derivatives and their use as epithelial sodium channel blockers for the treatment of arway diseases |
| US9315449B2 (en) | 2008-05-15 | 2016-04-19 | Duke University | Substituted pyrazoles as heat shock transcription factor activators |
| BRPI0915018A2 (pt) * | 2008-06-10 | 2015-10-27 | Novartis Ag | compostos orgânicos |
| WO2011028740A1 (en) * | 2009-09-03 | 2011-03-10 | Glaxo Group Limited | ENaC BLOCKERS |
| WO2011079087A1 (en) | 2009-12-23 | 2011-06-30 | Glaxo Group Limited | Enac blockers |
| US8372845B2 (en) | 2010-09-17 | 2013-02-12 | Novartis Ag | Pyrazine derivatives as enac blockers |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| US9505735B2 (en) | 2012-06-21 | 2016-11-29 | Whitehead Institute For Biomedical Research | Compounds for treating infectious diseases |
| EP2931712B8 (en) | 2012-12-17 | 2018-05-23 | Parion Sciences, Inc. | 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds |
| CA2896686A1 (en) | 2012-12-17 | 2014-06-26 | Parion Sciences, Inc. | 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds |
| AP2015008556A0 (en) | 2012-12-17 | 2015-06-30 | Parion Sciences Inc | Chloro-pyrazine carboxamide derivatives useful forthe treatment of diseases favoured by insufficien t mucosal hydration |
-
2015
- 2015-03-16 UY UY0001036034A patent/UY36034A/es not_active Application Discontinuation
- 2015-03-17 DK DK15713339.8T patent/DK3119752T3/en active
- 2015-03-17 EP EP15713339.8A patent/EP3119752B1/en active Active
- 2015-03-17 KR KR1020167028483A patent/KR102296041B1/ko active IP Right Grant
- 2015-03-17 PL PL15713339T patent/PL3119752T3/pl unknown
- 2015-03-17 TW TW104108476A patent/TWI687410B/zh active
- 2015-03-17 AU AU2015233195A patent/AU2015233195B2/en active Active
- 2015-03-17 LT LTEP15713339.8T patent/LT3119752T/lt unknown
- 2015-03-17 ES ES15713339.8T patent/ES2679618T3/es active Active
- 2015-03-17 ME MEP-2018-185A patent/ME03056B/me unknown
- 2015-03-17 NZ NZ724063A patent/NZ724063A/en not_active IP Right Cessation
- 2015-03-17 WO PCT/GB2015/050765 patent/WO2015140527A1/en active Application Filing
- 2015-03-17 AP AP2016009447A patent/AP2016009447A0/en unknown
- 2015-03-17 RS RS20180833A patent/RS57487B1/sr unknown
- 2015-03-17 CR CR20160479A patent/CR20160479A/es unknown
- 2015-03-17 PE PE2016001600A patent/PE20170205A1/es unknown
- 2015-03-17 US US15/124,393 patent/US9873678B2/en active Active
- 2015-03-17 CN CN201580013691.1A patent/CN106103423B/zh active Active
- 2015-03-17 MX MX2016011681A patent/MX368577B/es active IP Right Grant
- 2015-03-17 HU HUE15713339A patent/HUE039425T2/hu unknown
- 2015-03-17 SI SI201530318T patent/SI3119752T1/en unknown
- 2015-03-17 PT PT157133398T patent/PT3119752T/pt unknown
- 2015-03-17 EA EA201691641A patent/EA029952B1/ru not_active IP Right Cessation
- 2015-03-17 TR TR2018/10207T patent/TR201810207T4/tr unknown
- 2015-03-17 JP JP2017500446A patent/JP6502469B2/ja active Active
- 2015-03-17 SG SG11201607751SA patent/SG11201607751SA/en unknown
- 2015-03-17 CA CA2941807A patent/CA2941807C/en active Active
- 2015-03-18 AR ARP150100820A patent/AR099790A1/es unknown
-
2016
- 2016-09-04 IL IL247610A patent/IL247610B/en not_active IP Right Cessation
- 2016-09-07 DO DO2016000232A patent/DOP2016000232A/es unknown
- 2016-09-13 NI NI201600134A patent/NI201600134A/es unknown
- 2016-09-13 CL CL2016002303A patent/CL2016002303A1/es unknown
- 2016-09-14 GT GT201600190A patent/GT201600190A/es unknown
- 2016-09-14 SV SV2016005278A patent/SV2016005278A/es unknown
- 2016-09-16 PH PH12016501808A patent/PH12016501808B1/en unknown
- 2016-10-17 ZA ZA2016/07136A patent/ZA201607136B/en unknown
-
2017
- 2017-12-13 US US15/840,339 patent/US10336725B2/en active Active
-
2018
- 2018-07-16 HR HRP20181123TT patent/HRP20181123T1/hr unknown
- 2018-07-18 CY CY20181100750T patent/CY1120509T1/el unknown
-
2019
- 2019-05-10 US US16/408,741 patent/US10954211B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1244280B (zh) | 用於治療感染性疾病的吡嗪化合物 | |
| IL264049A (en) | Compounds, preparations and methods for treating the disease | |
| IL264156A (en) | Compounds, preparations and methods for treating the disease | |
| HK1244485A1 (zh) | 用於治療神經母細胞瘤的組合物 | |
| HK1232220A1 (zh) | 用於治療心血管疾病的 -苄基異喹啉衍生物 | |
| IL249502B (en) | New therapeutic uses of benzylideneguanidine derivatives for the treatment of diseases caused by structurally abnormal proteins | |
| EP3169405A4 (en) | Methods, compounds, and compositions for the treatment of musculoskeletal diseases | |
| IL259381B (en) | Miravegron for the treatment of retinal diseases | |
| HRP20181123T1 (hr) | Spojevi 3,4-diamino-6-kloropirazin-2-karboksamida za liječenje bolesti posredovanih s enac | |
| SG11201703330YA (en) | Iminosugars useful for the treatment of viral diseases | |
| SI3903774T1 (sl) | N,N-bis-2-merkaptoetil izoftalamid za zdravljenje nevrodegenerativnih bolezni | |
| PL3164110T3 (pl) | Kompozycje farmaceutyczne do leczenia łuszczycy | |
| ZA201704589B (en) | Compounds for the treatment of cancer |