MX2018012331A - Atomos de silicona que contienen analogos de ivacaftor. - Google Patents

Atomos de silicona que contienen analogos de ivacaftor.

Info

Publication number
MX2018012331A
MX2018012331A MX2018012331A MX2018012331A MX2018012331A MX 2018012331 A MX2018012331 A MX 2018012331A MX 2018012331 A MX2018012331 A MX 2018012331A MX 2018012331 A MX2018012331 A MX 2018012331A MX 2018012331 A MX2018012331 A MX 2018012331A
Authority
MX
Mexico
Prior art keywords
analogues
atoms containing
silicone atoms
ivacaftor
containing ivacaftor
Prior art date
Application number
MX2018012331A
Other languages
English (en)
Inventor
M Bastos Cecilia
Munoz Benito
Parks Daniel
Original Assignee
Proteostasis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteostasis Therapeutics Inc filed Critical Proteostasis Therapeutics Inc
Publication of MX2018012331A publication Critical patent/MX2018012331A/es

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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Endocrinology (AREA)
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  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
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  • Reproductive Health (AREA)
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  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente descripción se refiere a compuestos descritos que modulan, por ejemplo, que están dirigidos a los defectos subyacentes en el procesamiento celular de la actividad del CFTR.
MX2018012331A 2016-04-07 2017-04-07 Atomos de silicona que contienen analogos de ivacaftor. MX2018012331A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662319439P 2016-04-07 2016-04-07
PCT/US2017/026579 WO2017177124A1 (en) 2016-04-07 2017-04-07 Silicone atoms containing ivacaftor analogues

Publications (1)

Publication Number Publication Date
MX2018012331A true MX2018012331A (es) 2019-05-23

Family

ID=58549338

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018012331A MX2018012331A (es) 2016-04-07 2017-04-07 Atomos de silicona que contienen analogos de ivacaftor.

Country Status (16)

Country Link
US (3) US10662207B2 (es)
EP (1) EP3440057B1 (es)
JP (1) JP7061076B2 (es)
KR (1) KR102448404B1 (es)
CN (1) CN109563047A (es)
AR (1) AR108203A1 (es)
AU (1) AU2017248253B2 (es)
BR (1) BR112018070747B1 (es)
CA (1) CA3019663A1 (es)
IL (1) IL262030B (es)
MA (1) MA43775A (es)
MX (1) MX2018012331A (es)
NZ (1) NZ746793A (es)
SA (1) SA518400164B1 (es)
SG (1) SG11201808682XA (es)
WO (1) WO2017177124A1 (es)

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