EA202090931A3 - Композиции и способы перепрограммирования tcr с помощью гибридных белков - Google Patents

Композиции и способы перепрограммирования tcr с помощью гибридных белков

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Publication number
EA202090931A3
EA202090931A3 EA202090931A EA202090931A EA202090931A3 EA 202090931 A3 EA202090931 A3 EA 202090931A3 EA 202090931 A EA202090931 A EA 202090931A EA 202090931 A EA202090931 A EA 202090931A EA 202090931 A3 EA202090931 A3 EA 202090931A3
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EA
Eurasian Patent Office
Prior art keywords
methods
compositions
hybrid proteins
tcr
reprogramming
Prior art date
Application number
EA202090931A
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English (en)
Russian (ru)
Other versions
EA202090931A2 (ru
Inventor
Патрик Баеуерле
Грегори Сичкевич
Роберт Хофмайстер
Original Assignee
Тср2 Терапьютикс Инк.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57320750&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA202090931(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Тср2 Терапьютикс Инк. filed Critical Тср2 Терапьютикс Инк.
Publication of EA202090931A2 publication Critical patent/EA202090931A2/ru
Publication of EA202090931A3 publication Critical patent/EA202090931A3/ru

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N5/0634—Cells from the blood or the immune system
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    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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EA202090931A 2015-05-18 2016-05-18 Композиции и способы перепрограммирования tcr с помощью гибридных белков EA202090931A3 (ru)

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US201562163342P 2015-05-18 2015-05-18

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EA202090931A2 EA202090931A2 (ru) 2020-07-31
EA202090931A3 true EA202090931A3 (ru) 2020-10-30

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EA202090931A EA202090931A3 (ru) 2015-05-18 2016-05-18 Композиции и способы перепрограммирования tcr с помощью гибридных белков
EA201792420A EA035618B1 (ru) 2015-05-18 2016-05-18 Композиции и способы перепрограммирования tcr с помощью гибридных белков

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US (7) US10442849B2 (https=)
EP (3) EP3298033B2 (https=)
JP (4) JP2018515123A (https=)
KR (1) KR20180029201A (https=)
CN (2) CN107995913B (https=)
AU (2) AU2016264323B2 (https=)
BR (1) BR112017024757A2 (https=)
DK (1) DK3298033T4 (https=)
EA (2) EA202090931A3 (https=)
ES (1) ES2819976T5 (https=)
FI (1) FI3298033T4 (https=)
HU (1) HUE051661T2 (https=)
IL (2) IL303905A (https=)
MX (1) MX2017014822A (https=)
PL (1) PL3298033T5 (https=)
PT (1) PT3298033T (https=)
SG (1) SG10201914069SA (https=)
WO (1) WO2016187349A1 (https=)
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ES2819976T5 (es) 2024-02-23
PL3298033T3 (pl) 2021-02-22
EA202090931A2 (ru) 2020-07-31
FI3298033T4 (fi) 2023-09-22
US10358473B2 (en) 2019-07-23
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JP2021184749A (ja) 2021-12-09
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ZA201708000B (en) 2025-04-30
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US20180244747A1 (en) 2018-08-30
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HUE051661T2 (hu) 2021-03-29
AU2016264323A1 (en) 2017-12-14
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