DK2753621T3 - Fremgangsmåder og mellemprodukter til fremstilling af en jak-inhibitor - Google Patents
Fremgangsmåder og mellemprodukter til fremstilling af en jak-inhibitor Download PDFInfo
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- DK2753621T3 DK2753621T3 DK12770334.6T DK12770334T DK2753621T3 DK 2753621 T3 DK2753621 T3 DK 2753621T3 DK 12770334 T DK12770334 T DK 12770334T DK 2753621 T3 DK2753621 T3 DK 2753621T3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (23)
1. Fremgangsmåde, omfattende omsætning afen forbindelse med formel III:
eller et salt deraf, med en forbindelse med formel IV:
i tilstedeværelse af et reduktionsmiddel for at danne en forbindelse med formel II:
eller et salt deraf, forudsat at reduktionsmidlet ikke er natriumcyanobordeuterid; hvor P1 er en beskyttelsesgruppe.
2. Fremgangsmåden ifølge krav 1, hvor beskyttelsesgruppen er -CH2OCH2CH2Si(CH3)3.
3. Fremgangsmåden ifølge et hvilket som helst af kravene 1 til 2, hvor reduktionsmidlet er valgt fra natriumcyanoborhydrid og natriumtriacetoxyborhydrid.
4. Fremgangsmåden ifølge et hvilket som helst af kravene 1 til 2, hvor reduktionsmidlet er natriumtriacetoxyborhydrid.
5. Fremgangsmåden ifølge et hvilket som helst af kravene 1 til 4, hvor forbindelsen med formel II, III, og IV hver er en fri base.
6. Fremgangsmåden ifølge et hvilket som helst af kravene 1 til 5, yderligere omfattende afbeskyttelse af en forbindelse med formel II, eller salt deraf, for at danne en forbindelse med formel I:
eller et salt deraf.
7. Fremgangsmåden ifølge krav 6, hvor afbeskyttelsen omfatter behandling med bortrifluoridetherat, efterfulgt af behandling med vandig ammoniumhydroxid.
8. Fremgangsmåden ifølge et hvilket som helst af kravene 6 til 7, hvor fremgangsmåden yderligere omfatter omsætning af forbindelsen med formel I med adipinsyre til dannelse af adipat-salt.
9. Fremgangsmåden ifølge et hvilket som helst af kravene 6 til 8, hvor forbindelserne med formel I, II, III, og IV hver er en fri base.
10. Fremgangsmåden ifølge et hvilket som helst af kravene 6 til 7, hvor fremgangsmåden yderligere omfatter: (a) opvarme forbindelsen med formel I i methanol ved tilbagestrømning for at få en blanding; (b) efter (a), tilsætte methylisobutylketon til blandingen; (c) efter (b), fjerne en del af opløsningsmidlet ved destillation ved en indre temperatur på 40°C til 50°C for at danne en koncentreret blanding; (d) efter (c), tilsætte methanol til den koncentrerede blanding for at danne en fortyndet blanding; (e) efter (d), opvarme den fortyndede blanding ved tilbagesvaling for at få en blanding; (f) efter (e), tilsætte methylisobutylketon til blandingen; (g) efter (f), fjerne en del af opløsningsmidlet ved destillation ved en indre temperatur på 40°C til 50°C for at danne en koncentreret blanding; (h) efter (g), tilsætte adipinsyre og methanol til den koncentrerede blanding; (i) efter (h), opvarme blandingen ved tilbagestrømning; and (j) efter (i), fjerne en del af opløsningsmidlet ved destillation ved en indre temperatur på 40°C til 50°C for at danne en koncentreret blanding; (k) efter (j), tilsætte heptan til blandingen; og (l) efter (k), omrøre blandingen ved stuetemperatur for at danne adipinsyresaltet af forbindelsen med formel I.
11. Fremgangsmåden ifølge et hvilket som helst af kravene 6 til 10, hvor forbindelsen med formel IV, eller et salt deraf, fremstilles ved en fremgangsmåde omfattende afbeskyttelse af en forbindelse med formel V:
eller et salt deraf.
12. Fremgangsmåden ifølge krav 11, hvor afbeskyttelsen omfatter omsætning med vandig syre.
13. Fremgangsmåden ifølge krav 12, hvor syren er saltsyre.
14. Fremgangsmåden ifølge et hvilket som helst af kravene 11 til 13, hvor forbindelserne med formel I, II, III, IV, og V hver er en fri base.
15. Fremgangsmåden ifølge et hvilket som helst af kravene 11 til 14, hvor forbindelsen med formel V, eller et salt deraf, fremstilles ved en fremgangsmåde omfattende omsætning af en forbindelse med formel VI:
med en forbindelse med formel VII:
i tilstedeværelse af et koblingsmiddel.
16. Fremgangsmåden ifølge krav 15, hvor koblingsmidlet er benzotriazol-l-yloxy-tris(dimethylamino)-phosphonium-hexafluorphosphat (BOP).
17. Fremgangsmåde til fremstilling af en forbindelse med formel IV:
eller et salt deraf, omfattende afbeskyttelse af en forbindelse med formel V:
eller et salt deraf, for at danne en forbindelse med formel IV, eller salt deraf.
18. Fremgangsmåden ifølge krav 17, hvor afbeskyttelsen omfatter omsætning med vandig syre.
19. Fremgangsmåden ifølge krav 18, hvor syren er saltsyre.
20. Fremgangsmåden ifølge et hvilket som helst af kravene 17 til 19, hvor forbindelserne med formel IV og V hver er en fri base.
21. Fremgangsmåde til fremstilling af en forbindelse med formel V:
eller et salt deraf, omfattende omsætning afen forbindelse med formel VI:
eller et salt deraf, med en forbindelse med formel VII: eller et salt deraf, i tilstedeværelse af et koblingsmiddel for at danne forbindelsen med formel V, eller salt deraf.
22. Fremgangsmåden ifølge krav 21, hvor koblingsmidlet er benzotriazol-l-yloxy-tris(dimethylamino)-phosphonium-hexafluorphosphat (BOP).
23. Forbindelse med formel V:
eller et salt deraf.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161531896P | 2011-09-07 | 2011-09-07 | |
PCT/US2012/053921 WO2013036611A1 (en) | 2011-09-07 | 2012-09-06 | Processes and intermediates for making a jak inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2753621T3 true DK2753621T3 (da) | 2016-01-25 |
Family
ID=47010724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12770334.6T DK2753621T3 (da) | 2011-09-07 | 2012-09-06 | Fremgangsmåder og mellemprodukter til fremstilling af en jak-inhibitor |
Country Status (35)
Country | Link |
---|---|
US (2) | US9487521B2 (da) |
EP (1) | EP2753621B1 (da) |
JP (2) | JP5977354B2 (da) |
KR (1) | KR102002277B1 (da) |
CN (1) | CN104024256B (da) |
AR (2) | AR087794A1 (da) |
AU (1) | AU2012304650B2 (da) |
BR (1) | BR112014005174B1 (da) |
CA (1) | CA2847728C (da) |
CL (1) | CL2014000534A1 (da) |
CO (1) | CO6910194A2 (da) |
CR (1) | CR20140120A (da) |
CY (1) | CY1117276T1 (da) |
DK (1) | DK2753621T3 (da) |
EA (1) | EA026122B1 (da) |
ES (1) | ES2564133T3 (da) |
HK (1) | HK1199445A1 (da) |
HR (1) | HRP20160241T1 (da) |
HU (1) | HUE026497T2 (da) |
IL (1) | IL231389A (da) |
IN (1) | IN2014DN02177A (da) |
ME (1) | ME02458B (da) |
MX (1) | MX339715B (da) |
MY (1) | MY169617A (da) |
PE (1) | PE20142360A1 (da) |
PL (1) | PL2753621T3 (da) |
PT (1) | PT2753621E (da) |
RS (1) | RS54615B1 (da) |
SG (1) | SG11201400414XA (da) |
SI (1) | SI2753621T1 (da) |
SM (1) | SMT201600060B (da) |
TW (1) | TWI577690B (da) |
UA (1) | UA111854C2 (da) |
WO (1) | WO2013036611A1 (da) |
ZA (1) | ZA201402163B (da) |
Families Citing this family (66)
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EP2426129B1 (en) | 2005-12-13 | 2016-11-02 | Incyte Holdings Corporation | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors |
CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
PT3070090T (pt) | 2007-06-13 | 2019-03-20 | Incyte Holdings Corp | Utilização de sais do inibidor da janus cinase (r)-3-(4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanonitrilo |
JOP20190230A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
RS59632B1 (sr) | 2009-05-22 | 2020-01-31 | Incyte Holdings Corp | 3-[4-(7h-pirolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]oktan- ili heptan-nitril kao jak inhibitori |
WO2010135650A1 (en) | 2009-05-22 | 2010-11-25 | Incyte Corporation | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS |
US9249145B2 (en) | 2009-09-01 | 2016-02-02 | Incyte Holdings Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
KR102354472B1 (ko) | 2010-03-10 | 2022-01-21 | 인사이트 홀딩스 코포레이션 | Jak1 저해제로서의 피페리딘4일 아제티딘 유도체 |
HUE029035T2 (en) | 2010-05-21 | 2017-01-30 | Incyte Holdings Corp | Topical formulation for use as JAK inhibitor |
CA2818545C (en) | 2010-11-19 | 2019-04-16 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors |
TW201249845A (en) | 2010-11-19 | 2012-12-16 | Incyte Corp | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
KR102024948B1 (ko) | 2011-02-18 | 2019-11-04 | 노파르티스 파르마 아게 | mTOR/JAK 저해제 병용 요법 |
AR086983A1 (es) | 2011-06-20 | 2014-02-05 | Incyte Corp | Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak |
CA2844507A1 (en) | 2011-08-10 | 2013-02-14 | Novartis Pharma Ag | Jak pi3k/mtor combination therapy |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) * | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
AR091079A1 (es) | 2012-05-18 | 2014-12-30 | Incyte Corp | Derivados de pirrolopirimidina y pirrolopiridina sustituida con piperidinilciclobutilo como inhibidores de jak |
CN104918945B (zh) | 2012-11-01 | 2018-01-05 | 因赛特公司 | 作为jak抑制剂的三环稠合噻吩衍生物 |
CN113384546A (zh) | 2012-11-15 | 2021-09-14 | 因赛特公司 | 鲁索利替尼的缓释剂型 |
WO2014110574A1 (en) | 2013-01-14 | 2014-07-17 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
ES2790419T3 (es) | 2013-01-15 | 2020-10-27 | Incyte Holdings Corp | Los compuestos de tiazolcarboxamidas y piridinacarboxamida útiles como inhibidores de quinasa de PIM |
EP3985008A1 (en) * | 2013-03-06 | 2022-04-20 | Incyte Holdings Corporation | Processes and intermediates for making a jak inhibitor |
WO2014146249A1 (en) | 2013-03-19 | 2014-09-25 | Merck Sharp & Dohme Corp. | Geminally substituted cyanoethylpyrazolo pyridones as janus kinase inhibitors |
PL3527263T3 (pl) | 2013-05-17 | 2021-05-17 | Incyte Corporation | Pochodne bipirazolu jako inhibitory jak |
RS60469B1 (sr) | 2013-08-07 | 2020-07-31 | Incyte Corp | Dozni oblici sa produženim oslobađanjem za jak1 inhibitor |
US9556197B2 (en) | 2013-08-23 | 2017-01-31 | Incyte Corporation | Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors |
DK3129021T3 (da) | 2014-04-08 | 2020-11-09 | Incyte Corp | Behandling af b-celle-maligniteter ved en kombination af jak- og pi3k-inhibitorer |
EA201692193A1 (ru) | 2014-04-30 | 2017-07-31 | Инсайт Корпорейшн | Способы получения ингибитора jak1 и его новых форм |
US9498467B2 (en) | 2014-05-30 | 2016-11-22 | Incyte Corporation | Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 |
US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
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CN104230974B (zh) * | 2014-07-30 | 2017-02-08 | 斯芬克司药物研发(天津)股份有限公司 | 一种吡咯并吡啶类化合物及其制备方法 |
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