DK175719B1 - Vævstransplantationsmateriale - Google Patents
Vævstransplantationsmateriale Download PDFInfo
- Publication number
- DK175719B1 DK175719B1 DK198903405A DK340589A DK175719B1 DK 175719 B1 DK175719 B1 DK 175719B1 DK 198903405 A DK198903405 A DK 198903405A DK 340589 A DK340589 A DK 340589A DK 175719 B1 DK175719 B1 DK 175719B1
- Authority
- DK
- Denmark
- Prior art keywords
- tissue
- graft
- transplant
- sis
- grafts
- Prior art date
Links
Classifications
-
- E—FIXED CONSTRUCTIONS
- E02—HYDRAULIC ENGINEERING; FOUNDATIONS; SOIL SHIFTING
- E02D—FOUNDATIONS; EXCAVATIONS; EMBANKMENTS; UNDERGROUND OR UNDERWATER STRUCTURES
- E02D5/00—Bulkheads, piles, or other structural elements specially adapted to foundation engineering
- E02D5/02—Sheet piles or sheet pile bulkheads
- E02D5/03—Prefabricated parts, e.g. composite sheet piles
- E02D5/04—Prefabricated parts, e.g. composite sheet piles made of steel
- E02D5/08—Locking forms; Edge joints; Pile crossings; Branch pieces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3629—Intestinal tissue, e.g. small intestinal submucosa
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
- Y10T428/139—Open-ended, self-supporting conduit, cylinder, or tube-type article
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
- Y10T428/24008—Structurally defined web or sheet [e.g., overall dimension, etc.] including fastener for attaching to external surface
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Vascular Medicine (AREA)
- Structural Engineering (AREA)
- Botany (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Composite Materials (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Mining & Mineral Resources (AREA)
- Paleontology (AREA)
- Civil Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Prostheses (AREA)
Description
I DK 175719 B1
Den foreliggende opfindelse angår et hidtil ukendt vævstransplantationsmateriale, som udviser styrke, åbenhed (eng: patency), infektionsresistens, ikke-immunogenicitet, ik-ke-thrombogenecitet og resistens overfor aneurismedannelse, hvilket overgår mange syntetiske transplantationsmaterialer. Den foreliggende opfindelse er nærmere bestemt 5 rettet mod vævstransplantationsmaterialer, som omfatter de submucosale og basil are mucosale dele af tyndtarmen.
Vævstransplantationsmaterialer har i dag opnået en betragtelig klinisk og økonomisk betydning. Det er beregnet, at der i 1986 blev brugt 130 millioner US dollars alene på 10 vaskulære transplantationer, herunder ikke medtaget kranspulsåreomløbstransplantationer (eng: coronary artery bypass grafts). Graden af succes for vaskulære transplantationsprocedurer er endnu svag i sammenligning med de fleste andre kirurgiske procedurer. F.eks. regnes en 5-års kumulativ åbenhed på 50% som fremragende for vaskulære transplantater med små diametre. Sådanne lave grader af succes er i stort 15 omfang resultat af en eller flere fysiske eller funktionelle mangler i transplantationsma-terialeme, der for tiden anvendes klinisk.
Identifikation af materialer, som er velegnede til vævstransplantationer, er særligt vanskeligt, fordi sådanne materialer skal udvise en varietet af uligeartede egenskaber.
20 F.eks. må vaskulære transplantationsmaterialer ikke kun udvise mekanisk stabilitet under kontinuerlig spænding, men de skal også have porøsitet, som er tilstrækkelig til ka- i pillarisation, eftergivenhed svarende til den for værtsvævet og høje negative Ze-ta-potentialer (således at de er ikke-thrombogene). Endvidere skal de være ik-ke-allergene, ikke-carcinogene og fortrinsvis billige at fremstille.
25 Få om overhovedet nogen vævstransplantationsmaterialer udviser alle de ønskelige egenskaber. Litteraturrapporter over forskning og udvikling inden for området af vaskulære transplantationer afspejler en betydelig igangværende anstrengelse for at overvinde de skavanker, som er almindelige for de for tiden værende kendte transplan-30 tationsmaterialer.
I DK 175719 B1
I 2 I
I Både syntetiske og autogene materialer er blevet anvendt til vaskulære transplantatio- I
I ner. Blandt syntetiske er ekspanderet polytetrafluorethylen (PTFE) et almindeligt an- I
I vendt vaskulært transplantationsmateriale, især til små kar-omløbskirurgier. Ekspande- I
rede PTFE-transplantater er imidlertid følsomme overfor neointimal hyperplasi og sen I
I 5 transplantationsthrombose (f.eks. 6-års åbenhedsgrader på ca. 50% for femoropoplitea- I
I le omløb). PTFE-transplantationer er rapporteret at have endnu lavere grad af succes I
I ved anvendelse i det venøse kredsløb. I
I Et andet syntetisk materiale, Dacron®, anvendes ofte til vaskulære transplantationspro- I
10 cedurer med store diametre (f.eks. inffarenale aortatransplantationer). Strikket (eng: I
I knitted) Dacron® har imidlertid en relativt høj porøsitet og skal præsammenklumpes I
forud for implantation for at undgå umådeholden blødning. Denne præsammenklump- I
ningsprocedure er ikke altid praktisk eller succesiuld. Vævet Dacron®, som er mindre j I
porøst, udviser en eftergivenhed på kun 20% af den, som findes i en normal aorta. En- I
15 delig fungerer Dacron®-transplantater dårligt i arterier eller vener med små diametre, ' I
hvor blodgennemstrømningen er relativt langsom. I
Et af de mere signifikante problemer i forbindelse med anvendelsen af syntetiske mate- I
rialer som vævstransplantationsmaterialer er den kendsgerning, at syntetiske materialer I
20 har lav infektionsmodstandsdygtighed. Infektionshyppigheder efter implantation af I
syntetisk transplantat, er forbundet med en dødelighedskoefficient på 66%. Syntetiske I
H materialer har tendens til at huse mikroorganismer i deres mellemrum, og ved kontami- I
H nering er de yderst modstandsdygtige over for antibakteriel terapi. Eksplantation af in- I
H ficerede, syntetiske transplantater er i realiteten uundgåeligt. I
H For nyligt har forskere rapporteret om fremstilling af syntetiske hud- og blodkarsækvi- I
H valenter under anvendelse af levende humanceller. Se US patentskrifter nr. 4.604.346, I
I 4.546.500,4.539.716,4.485.097 og 4.485.096. I
30 Blandt autogene materialer er den saphenøse vene, den humane navlevene, den inverte- I
rede tyndtarm og spolebensarterien alle blevet anvendt, men hvert af disse materialer I
I DK 175719 B1 har også udvist betydelige skavanker. Den saphenøse vene kan have en uhensigtsmæssig størrelse til visse procedurer eller kan være utilgængelig på grund af skade ved sygdom. Endvidere kan den saphenøse vene have uacceptable varikøsiteter og lide af accelereret atherogenese efter "arteriolisation”. Både navletransplantateme og transplan-5 taterne af inverteret tyndtarm er plaget af tidlig thrombose og sen aneurismedannelse.
Endvidere har spolebensarterien begrænset anvendelighed, fordi den er vanskelig at høste og kan forringes efter transplantatimplantation.
Det er derfor et formål med den foreliggende opfindelse at tilvejebringe et 10 vævstransplantationsmateriale, som ikke udviser mange af de skavanker, som er forbundet med mange transplantationsmaterialer, som nu anvendes klinisk.
. Tegningens figur viser delvis i snit en del af tyndtarmen.
15 Den foreliggende opfindelse er rettet mod et vævstransplantationsmateriale, som primært omfatter tunica submucosa af et segment af tyndtarmen hos et varmblodet hvirveldyr. Tunica submucosaen er delamineret fra tunica muscularis og mindst den lumi-nale del af tunica mucosaen af tyndtarmsdelen. Idet det omhandlede vævstransplantationsmateriale har vist sig at have fremragende funktionelle egenskaber i anvendelse 20 som vaskulære autotransplantater og vaskulære allotransplantater, forventes det, at vævstransplantationsmaterialer ifølge den foreliggende opfindelse vil finde bred anvendelse selv som heterotransplantater i både vaskulære og i andre vævstransplantationsanvendelser. Det har vist sig, at det pågældende vævstransplantationsmateriale udviser mangfoldige fysiske og biologiske egenskaber, som gør det særligt velegnet til 25 vævstransplantationsformål.
I en foretrukken udførelsesform for den foreliggende opfindelse omfatter vævstransplantationsmaterialet submucosavæv og basilar mucosavæv, som er delamineret fra et segment af tyndtarmen, mere foretrukket jenunum, en del af tyndtarmen, 30 der strækker sig mellem duodenum og ileum. Tyndtarmen er forud for dens manipulation (delaminering) til opnåelse af transplantationsmateriale i overensstemmelse med I DK 175719 B1 I 4
I den foreliggende opfindelse opbygget af en række adskilte vævslag. Fig. 1 viser delvis i I
I snit tyndtarmen, hvoraf fremgår dens adskilte vævslag, som er mærket A til G (hen- I holdsvis ydre til indre), og som tilsammen definerer tarmvæggen. Det yderste vævslag I A repræsenterer mesenterialvævene. Mesenterial vævene er afbildet som et adskilt lag I 5 kun til illustrationsfonnål. Sådanne væv forekommer almindeligvis ikke som et adskilt lag, men fremtræder snarere som diskontinuerlige vævssegmenter. Lag B og lag C re- præsenterer henholdsvis tunica serosa og tunica muscularis. Lag D, som repræsenterer I tunica submucosa, er et tæt, uregelmæssigt, kollagent bindevæv, der ofte huser adskil- I lige mastceller. Heparin, som hidrører fra disse mastceller, er sandsynligvis i det mind- 10 ste delvis ansvarlig for manglen på tidlig thrombogenecitet hos transplantationsmateria-
Lag E, F og G repræsenterer tilsammen den såkaldte tunica mucosa. Lag E er et lag af glatte muskelceller, der kendes som lamina muscularis mucosa. Lag F, stratum com- 15 pactum, består af acellulært kollagen og elastinfibre. Lag G består af lamina epithelialis mucosa og dens lamina propria, som tilsammen og arrangeret i villi udviser en række fingerlignende udvækster på den mukøse membran.
Efter den nedenfor detaljeret beskrevne manipulation af tarmvævssegmentet til frem- H 20 stilling af transplantationsmaterialet ifølge den foreliggende opfindelse viser histolo- H gisk undersøgelse, at lamina epithelialis mucosa og dens lamina propria er blevet fjer- net, ligesom tunica muscularis og tunica serosa. Det foretrukne transplantationsmateria- H le ifølge den foreliggende opfindelse omfatter således tunica submocosa D, sammen med basilare dele af tunica mucosa, især lamina muscularis mucosa E og stratum com- H 25 pactum D. Disse lag refereres i det efterfølgende samlet til som tyndtarmssubmucosa I ("SIS").
Et SIS-autotransplantationsmateriale ifølge den foreliggende opfindelse kan fremstilles f.eks. ved først at foretage resektion af et segment af autogen, proksimal jejunum efter-30 fulgt af en midtlinie-laparotomi-indskæring. Det operativt fjernede segment af jejunum indpakkes derefter i kirurgiske svampe (eng: sponges), som er blevet neddyppet i fysio- I DK 175719 B1 logisk saltvand. Efter afslutning på tarmanastomosen fremstilles det udskårne tarmsegment i overensstemmelse med den herefter beskrevne fremgangsmåde ifølge den foreliggende opfindelse til anvendelse som et vævstransplantationsmateriale. På tilsvarende måde fremstilles allotransplantationsmaterialer ud fra tarmvæv, der er fjernet fra 5 organ/vævs-donorer af den samme art. Heterotransplantationsmaterialer kan fremstilles f.eks. ud fra katte-, svine- eller oksetarmvæv, som er genvundet fra euthaniserede dyr ved si agteri operati oner. Indtil dato har der vist sig minimale morfologiske forskelle i tarmvæv fra forskellige arter. Den histologiske forekomst af humant transplantationsvæv i overensstemmelse med den foreliggende opfindelse viste sig faktisk at 10 være næsten identisk med det for hunden. Den eneste morfologiske forskel, som kunne erkendes, var en lidt mindre tæt stratum compactum i humanvævet.
Vævstransplantationsmaterialet ifølge den foreliggende opfindelse fremstilles ved afslidning af tarmvævet til fjernelse af de ydre lag, herunder både tunica serosa og I
15 tunica muscularis (lag B og C i fig. 1) og det indre lag omfattende mindst den luminale I
del (lag G) af tunica mucosa (lag E til G i fig. 1). Under milde afslidningsforhold I
delamineres tunica mucosa mellem stratum compactum (lag F) og lamina propria aflag I
G. Efter fjernelse af hvilke som helst mesenterialvæv fra tarmsegmentet under I
anvendelse af f.eks. Adson-Brown-pincetter og Metzenbaum-sakse, delamineres I
20 nærmere bestemt tunica serosa og tunica muscularis (det ydre vævslag) fra I
tarmsegmentet ved afslidning under anvendelse af en gnidende bevægelse på langs med I
et skalpelskaft (eng: scalpel handle) og fugtet gaze. Efter udkrængning af tarm- I
segmentet delamineres den luminale del af tunica mucosa fra det underliggende væv I
under anvendelse af den samme gnidende bevægelse. Der udvises forsigtighed for at I
25 forhindre perforation af submucosaen. Endvidere fjernes alle "vævsstumper" (eng: I
tissue "tags") fra det delaminerede lag, som forbliver på transplantatoverfladen. I
Tarmsegmentet kan eventuelt først udkrænges, derefter strippes for det luminale lag og I
derefter genindsættes i dets oprindelige orientation til fjernelse af tunica serosa og I
tunica muscularis. Transplantationsmaterialet er et hvidligt, gennemskinneligt rør af I
30 væv ca. 0,1 mm tykt og består typisk af tunica submucosa med den tilknyttede lamina I
muscularis mucosa og stratum compactum. Til fremstilling af vaskulære I
transplantationsmaterialer udkrænges det fremstillede transplantationsmateriale i dets I
IH
DK 175719 B1 I I
H
H
teriale i dets oprindelige orientation, således at stratum compactum tjener som trans- I
plantationsmaterialets luminale overflade. I
Det fremstillede transplantationsmateriale skylles typisk med saltvand og anbringes i I
5 en 10% neomycinsulfatopløsning i ca. 20 min., efter hvilket tidsrum transplantations- I
materialet er parat til anvendelse. Transplantationsmaterialeme anbringes under anven- I
delse af rutinemæssige kirurgiske procedurer, som sædvanligvis anvendes til I
vævstransplantationsformål. Til anvendelse til ikke-vaskulære vævstransplantations- I
formål kan det rørformede transplantationsmateriale skæres på langs og udrulles til I
10 dannelse af en "lap" af væv. Hele den ovenfor beskrevne vævsdelamineringsprocedure I
kan faktisk udføres på "lapper" af tarmvæv, som er fremstillet ved at skære tarmseg- I
mentet på langs og "udrulle" det til dannelse af en prætransplantationslap. De fremstil- I
lede transplantationsvævslapper kan f.eks. anvendes som et hudtransplan- I
tationsmateriale eller til reparation af andre legemsvævsdefekter, som er egnede til ki- I
15 rurgisk anvendelse af en vævstransplantationslap med de fysiske og funktionelle egen- I
skaber ifølge det foreliggende transplantationsmateriale. I
Til anvendelse i vaskulære transplantationer skal transplantationsmaterialets diameter I
være ca. den samme som diameteren hos det modtagende blodkar. Dette gennemføres I
20 ved at manipulere vævstransplantationsmaterialet til at definere en cylinder med en di- I
ameter, der ca. er den samme som den for det modtagende blodkar, og ved at foretage I
en sutur eller på anden måde fastgøre vævstransplantatet på langs til dannelse af det I
vaskulære transplantat. Således kan f.eks. et vaskulært transplantationsmateriale frem- I
stilles ved at udvælge en steril glasstang med en ydre diameter, som svarer til den for i I
25 det modtagende blodkar, og ved at indføre glasstangen i transplantatlumenet. Overflø- I
digt væv samles derefter, og den ønskede hulrumsdiameter opnås ved at foretage en su- I
tur langs transplantatets længde (f.eks. under anvendelse af to kontinuerlige sutursnore I
eller en enkelt afbrudt sutursnor) eller ved at anvende andre inden for området kendte I
vævsfastgøringsteknikker. I
I I
7 DK 175719 B1 1 overensstemmelse med formålene ifølge den foreliggende opfindelse udviser SIS-materialet mekaniske egenskaber, som er meget ønskelige for vævstransplanta-tionsmaterialer, herunder et lavt porøsitetsindeks, en høj eftergivenhed og et højt bristetrykspunkt. Vedrørende porøsitet vil en fagmand indenfor området forstå, at 5 vævstransplantationsmateriale skal have tilstrækkelig lav porøsitet til at forhindre in-traoperativ blødning og dog en tilstrækkeligt høj porøsitet til at muliggøre udvidelse af en nyudviklet vasa vasorum gennem transplantationsmaterialet til at nære neointima og den luminale overflade. Et transplantationsmateriales porøsitet måles typisk i antal ml vand, der passerer per cm2 per min. ved en trykhøjde på 120 mm Hg.
10 SIS-transplantationsmaterialets porøsitetsindeks er 10, hvilket er meget lavere end for andre transplantationsmaterialer, der for tiden er kendt inden for området. (Vævet Dacron® har f.eks. et porøsitetsindeks på 50). Trods dette lave porøsitetsindeks er SIS dog tilstrækkeligt porøst til at muliggøre, at neokapillarisation finder sted inden i SIS-transplantatet. Ved vaskulære transplantationsanvendelser muliggør SIS-materialer 15 dannelsen af blodfyldte kapillærer inden for transplantatvæggen, der strækker sig til den luminale overflade, så tidligt som fire dage efter kirurgi.
Angående transplantateftergivenhed er der inden for området blevet beskrevet eksistensen af et direkte forhold mellem eftergivenhed og åbenhed. Ideelt set skal et transplan-20 tationsmateriale være mindst lige så eftergivent som det væv, det erstatter. Eftergivenhed på langs hos SlS-transplantationsmaterialet blev målt ved anvendelse af en simpel trækprøve. En indledende målelængde blev dannet med to blækmærker 5,0 cm fra hinanden. Forlængelsen og den påførte kraft blev målt, idet prøverne blev belastet ved en trækhastighed på 32 cm/cm/min., hvilket gav de følgende resultater: 25
Eftergivenhed af SIS-transplantationsmateriale: 0,045 cm/N
per cm længde
Eftergivenhed af normal hundeaorta: 0,017 cm/N
per cm længde.
30
I DK 175719 B1 I
I I
I SIS-transplantationsmaterialeme udviser således aktuelt eftergivenhed, som er større I
I end den for den normale aorta. Dette er en betydelig fordel i forhold til tidligere teknik I
I inden for det vaskulære transplantationsområde. Alle for tiden værende tilgængelige I
I syntetiske transplantationsmaterialer er 3 til 10 gange mindre eftergivende end den na- I
I 5 turlige arterie og i tilsvarende grad mere udsat for thrombose end den naturlige arterie. I
Den tidligere kendte metode til at kompensere for denne ikke-sammenstemmende ef- I
tergivenhed er at anvende et transplantationsmateriale med større diameter end den til- I
I stødende naturlige arterie. Denne teknik har imidlertid ført til yderligere problemer. I
I Blodhastighed er langsommere gennem transplantatsegmenter med større diameter. Der I
10 er derfor mindre forskydningskraft på transplantatvæggen. Under sådanne betingelser I
er blodplade- og fibrinaflejring og efterfølgende thrombose mere sandsynlig. I mod- I
sætning hertil kan isodiametriske SIS-transplantater anvendes uden forekomst af så- I
danne problemer, idet SIS-materialet udviser sådanne høje eftergivenheder. I
15 Det foreliggende SIS-transplantationsmateriale har vist sig at have et bristetrykspunkt I
langt uden for, hvad man vil støde på fysiologisk. Et bristetryksforsøg blev udført ved I
at fastgøre et rørformet SIS-transplantationssegment til to cylindre med en diameter på I
25 mm og sætte transplantatet under tryk med nitrogengas ved en konstant strømnings- I
hastighed. To strømningshastigheder blev anvendt. Ved den lave strømningshastighed I
20 steg trykket indledningsvis og faldt derefter og blev stabilt, efterhånden som gas- I
udstrømningen gennem transplantatvæggen blev ækvilibreret med gasindstrømningen. I
Ved den højere strømningshastighed opbyggedes trykket øjeblikkeligt til bristeforhold I
ved ca. 400 mm Hg, hvilket indikerer, at transplantationsmaterialet let kan modstå de I
kontinuerlige, pulserende tryk, der findes ved normalt, fysiologisk, vaskulært trans- I
25 plantatbrug. I
DK 175719 B1 9
EKSEMPLER
Eksempel 1. Tvndtarmssubmucosa som et arterielt transplantat med stor diameter.
5 En række forsøg er blevet udført, hvori man undersøgte evnen hos tre forskellige konfigurationer af tyndtarm til at tjene som et vaskulært transplantat i den infrarenale aorta hos hunden. Ved det første forsøg anvendtes et ikke-inverteret segment af jejunum i fuld tykkelse, enten med en intakt mesenterial neurovaskulær forsyning eller med et frit, isoleret segment som transplantationsmaterialet. Tarmmucosa var blodtransplan-10 tatgrænsefladen. Alle fire hunde i dette forsøg døde inden for 18 timers kirurgi af thrombose i transplantatsegmentet og blødning fra sutursnorene.
Ved det andet forsøg anvendtes et isoleret og inverteret segment af jejunum som transplantatet, hvor tunica serosa tjener som blodtransplantatgrænsefladen. Der var to hunde 15 i dette forsøg. Transplantatet i den første hund blev thromboseret inden for 4 timers kirurgi, og den anden hund døde af akut blødning ved det proksimale anastomosested fire dage efter kirurgi.
I det tredje forsøg undersøgtes anvendelsen af kun en del af tarmvæggen som trans-20 plantationsmaterialet Et frit segment af autogent øvre jejunum blev høstet fra hver hund, og derefter blev størstedelen af mucosa fjernet ved ligefrem afskrabning af den luminale overflade med et skalpelskaft. Ved den samme metode fjernedes derefter serosa og tunica muscularis. Vævet, som blev tilbage efter denne tilsyneladende brutale manipulation af tarmsegmentet, var en 100 μ tyk del af submucosa og basilar mucosa.
25 Dette transplantationsmateriale blev derefter anbragt i den infrarenale aorta hos 15 hunde og har været bemærkelsesværdigt succesfuld. Resultaterne af dette tredje forsøg er opsummeret nedenfor.
Tretten af de femten hunde bevarede åbne transplantater, indtil tidspunktet for euthana-30 si. Elleve hunde døde ved euthanasi på forskellige tidspunkter efter kirurgi gående fra fire dage indtil et år. Dyrene viste ingen tegn på transplantatinfektion, aneurismedan- Η Η
I DK 175719 B1 I
I 10 I
I nelse eller thrombose. Det observerede uheldige udfald af transplantation hos to af I
I hundene var forårsaget af teknisk fejl, herunder fejlplacering af metalligaclips og dårlig I
I anastomoseteknik. To dyr var i live på tidspunktet for skrivning af nærværende beskri- I
I velse og krav og observeres for mere langsigtet transplantatåbenhed. I
I 5 I
I Transplantaternes åbenhed blev verificeret ved positiv kontrastradiografi inden for fire I
I til syv dage efter kirurgi og hver sjette til ottende uge derefter. Endvidere blev trans- I
plantatåbenhed overvåget klinisk ved observation af tilstedeværelsen af stærk lårpuls I
og manglen på bagbensødemer. I
I 10 I
I Elleve af de hunde, som bevarede åbne transplantater, blev aflivet med forskellige tid- I
I sintervaller efter kirurgi (4, 7,10 og 14 dage og 9, 11, 13, 17,26, 44 og 52 uger). Lige I
I forud for euthanasi fik dyrene optegnet et yderligere angiogram til bekræftelse af trans- I
plantatåbenhed og til tilvejebringelse af et sammenligningsradiografi til bedømmelse af I
15 transplantatdilatation, stenose og aneurismedannelse. Alle elleve dyr viste fuldstændig I
åbenhed uden noget tegn på skadelige luminale ændringer. I
Patologisk bedømmelse, som kan ses med det blotte øje, af disse transplantatsegmenter I
viste en glinsende luminaloverflade med tilfældigt arrangerede røde og hvide områder I
20 og ingen tegn på udbredelse af thrombedannelse. Der var en omsluttende fast binde- I
vævsakkumulering, som var sammenløbende med transplantatvæggen. Ingen arter, der I
blev undersøgt før 6 måneder efter kirurgi, viste tegn på endothelialcellevækst på I
transplantatets overflade. Disse transplantaters overflade var dækket med et fladt, mo- I
H derat tæt og organiseret lag af kollagen. I
I 25 I
Histopatologisk undersøgelse af 26-, 44- og 52-uge arterne viste en udfladet, "endothe- I
lial-lignende" celle, som delvis dækkede et tyndt (ca. 500 μ) lag af tæt organiseret fi- I
brin. Hele vævet var infiltreret med blodfyldte kapillærer, og den ydre grænse af det I
H oprindelige transplantationsmateriale kunne ikke skelnes fra det omsluttende bindevæv. I
H 30 Skanderende elektronmikroskopisk undersøgelse af luminaloverfladen viste et lag af I
H udfladede celler, som ikke kunne skelnes ffa endothelialceller, med udstrakt "pseudo- I
- I
DK 175719 B1 ; . i π i podia". Transmissionselektronmikroskopisk bedømmelse af disse transplantatsegmenter antydede også tilstedeværelsen af en endothelialcelletildækning af lu-minaloverfladen. Endvidere antydede tilstedeværelsen af faktor VIII: beslægtet antigen, som påvises ved immunofluoroscensfarvning, yderligere den endotheliale oprindelse af 5 disse transplantatluminaloverfladeceller. Transplantationsmaterialet blev også undersøgt for tilstedeværelse af endothelialceller ved undersøgelse af tilstedeværelsen af en-dothelafledt afslappende faktor. Acetylcholin blev påført overfladen af transplantatarter, og det udstrømmende materiale blev opsamlet. Det udstrømmende materiale blev ved observation af afslappelse af glatte muskler i et rotte aortapræparat vist at indehol-10 de endothel-afledt afslappende faktor.
Blodtrykket cephalt til, distalt til og inden i SIS-transplantatet blev bestemt i hver af de ti euthaniserede hunde. Trykkene var identiske på alle tre steder i hver af hundene, hvilket afspejler en mangel på uheldige hæmodynamiske virkninger som følge af an-15 vendelse af SIS-transplantationsmaterialet.
De følgende laboratorieparametre blev målt før kirurgi, en dag efter kirurgi og derefter på yderligere tidspunkter i de følgende måneder hos alle hunde: hæmatokritværdi, prothrombintid, aktiveret partiel thromboplastintid, blodpladetælling, fuldstændig blod-20 tælling og en forkortet serumkemiprofil. Resultater viste, at alle dyr var normale ved disse laboratoriemålinger på alle tidspunkterne. Disse dyr fik behandling med lave doser af heparin (600 enheder IV) under det kirurgiske indgreb, men fik ikke antikoagula-tionsbehandling under den post- operative periode. Manglen på enhver forandring i ko-. agulationsforsøgene og blodpladetællingeme var særligt opmuntrende i lyset af det re- 25 lativt hyperaktive koaguleringssystem hos hunden sammenlignet med mennesket.
Eksempel 2. Tvndtarmssubmucosa som arterielt transplantat med en lille diameter.
Dette forsøg involverede implantation i atten hunde af et total på 36 transplantater i bå-30 de lårbensarterien og halspulsåren. Treogtredive af de seksogtredive transplantater forblev åbne. Laboratoriemålinger blev foretaget hos disse dyr, hvilke målinger var identi-
I DK 175719 B1 I
I I
I ske med dem, der blev foretaget i den første undersøgelse, og der observeredes ingen I
I abnormiteter. Endvidere blev konventionel todimensional ultralydsbilleddannelse an- I
I vendt til måling af åbenhed og kartværsnitsdiameter. I
I 5 Patologisk undersøgelse af transplantatvæv fra en hund, der blev eutaniseret fire dage I
I efter kirurgi, viste en ikke-thrombotisk luminaloverflade og en svagt stenotisk proksi- I
I mal anastomose. Histologisk undersøgelse afslørede den tidlige tilstedeværelse af blod- I
fyldte kapillærer inden i transplantatvæggen, et potentielt naturligt legemsforsvar mod I
infektion. Fem af disse hunde forblev i live på tidspunktet for skrivning af nærværende I
I 10 beskrivelse og krav til yderligere bedømmelse. Den længst overlevende hund i dette I
I forsøg har nu overlevet syv måneder efter kirurgi. I
H Eksempel 3. Tvndtarmssubmucosa som et venetransplantat I
15 1 dette forsøg blev SIS-transplantatet anbragt i posterior vena cava (analog med "infe- I
I rior" vena cava i mennesket) i to hunde og i anterior vena cava (analog med "superior" I
vena cava i mennesket) i fem hunde. Selv om posterior vena cava-transplantateme kun I
forblev åbne i henholdsvis 11 og 14 dage, viste patologisk undersøgelse, at de uheldige I
udfald af transplantationerne kunne henføres til tekniske fejl, hvori inferior anastomo- I
20 sestedet var stenotisk (8 mm i diameter i modsætning til den naboliggende naturlige I
H vena cava med en diameter på 16 mm og det proksimale transplantat med en diameter I
på 16 mm). Endvidere var de luminale overflader af begge transplantater dækket med I
et ikke-thrombotisk "pseudoendothel", som var sammensat af tæt pakket fibren og I
umodent, kollagent bindevæv. I
I I
Anterior vena cava-transplantateme forblev åbne indtil euthanasi af tre af hundene I
henholdsvis 7, 14 og 21 dage efter kirurgi. To af disse hunde var i live på tidspunktet I
for skrivning af nærværende beskrivelse og krav med åbne transplantater syv uger efter I
kirurgi. Den proksimale sutursnor i alle tre hunde viste tegn på tidlig thrombose, hvor I
30 en klap af transplantatet var blevet inverteret og forårsagede turbulent blod- I
H gennemstrømning, men resten af transplantatet var ikke-thrombotisk. Endvidere viste I
Claims (1)
- 5 Eksempel 4. Tvndtarmssubmucosa som et arterielt allotransplantat I SIS er blevet anvendt som et allotransplantat med stor diameter i hundeaorta. Al- lotransplantateme blev konstrueret på samme måde som dem, der er beskrevet ovenfor I til undersøgelse af aortaautotransplantater. På tidspunktet for skrivning af nærværende I 10 beskrivelse og krav er testdyrene kun otte uger efter kirurgi, men de viser ikke noget I tegn på transplantatthrombose, infektion eller aneurismedannelse (som dokumenteret I ved angiogrammer). I Eksempel 5. Tvndtarmssubmucosa som et arterielt heterotransplantat. SIS er blevet anvendt som et heterotransplantat i hunden. Et SIS-transplantationsmateriale af katteoprindelse blev fremstillet i overensstemmelse med de tidligere heri beskrevne procedurer og anbragt i en hund. På tidspunktet for 20 skrivning af nærværende beskrivelse og krav var testdyret to uger postkirurgi og viste ikke nogen uønskede tegn.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21729988 | 1988-07-11 | ||
US07/217,299 US4902508A (en) | 1988-07-11 | 1988-07-11 | Tissue graft composition |
Publications (4)
Publication Number | Publication Date |
---|---|
DK340589D0 DK340589D0 (da) | 1989-07-10 |
DK340589A DK340589A (da) | 1990-01-12 |
DK175719B1 true DK175719B1 (da) | 2005-02-07 |
DK175719B2 DK175719B2 (da) | 2008-10-20 |
Family
ID=22810477
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK198903405A DK175719B2 (da) | 1988-07-11 | 1989-07-10 | Vævstransplantationsmateriale |
Country Status (25)
Country | Link |
---|---|
US (1) | US4902508A (da) |
EP (1) | EP0424463B1 (da) |
JP (1) | JP2539934B2 (da) |
KR (1) | KR0131821B1 (da) |
CN (1) | CN1018893B (da) |
AR (1) | AR244539A1 (da) |
AT (1) | ATE112963T1 (da) |
AU (1) | AU613499B2 (da) |
BR (1) | BR8907538A (da) |
CA (1) | CA1335432C (da) |
CH (2) | CH681506A5 (da) |
DE (1) | DE68918943T2 (da) |
DK (1) | DK175719B2 (da) |
ES (1) | ES2019146A6 (da) |
FI (1) | FI910113A0 (da) |
HU (1) | HU207448B (da) |
IE (1) | IE67279B1 (da) |
IL (1) | IL90622A (da) |
MX (1) | MX171671B (da) |
NZ (1) | NZ229797A (da) |
OA (1) | OA09633A (da) |
PH (1) | PH26921A (da) |
PT (1) | PT91096B (da) |
WO (1) | WO1990000395A1 (da) |
ZA (1) | ZA894551B (da) |
Families Citing this family (618)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6171338B1 (en) * | 1988-11-10 | 2001-01-09 | Biocon, Oy | Biodegradable surgical implants and devices |
US5281422A (en) * | 1991-09-24 | 1994-01-25 | Purdue Research Foundation | Graft for promoting autogenous tissue growth |
ES2133393T3 (es) * | 1992-03-13 | 1999-09-16 | Atrium Medical Corp | Productos de fluoropolimeros (por ejemplo, politetrafluoroetileno) expandidos de porosidad controlada y su fabricacion. |
EP0656939B1 (en) * | 1992-08-07 | 2004-03-31 | TEI Biosciences, Inc. | Production of graft tissue from extracellular matrix |
US5800537A (en) * | 1992-08-07 | 1998-09-01 | Tissue Engineering, Inc. | Method and construct for producing graft tissue from an extracellular matrix |
US5300306A (en) * | 1992-09-29 | 1994-04-05 | Alvarado Carlos A | Tissue-equivalent membrane from bovine esophageal tissue |
US5352463A (en) * | 1992-11-13 | 1994-10-04 | Badylak Steven F | Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor |
US5641518A (en) * | 1992-11-13 | 1997-06-24 | Purdue Research Foundation | Method of repairing bone tissue |
US5275826A (en) * | 1992-11-13 | 1994-01-04 | Purdue Research Foundation | Fluidized intestinal submucosa and its use as an injectable tissue graft |
US6653291B1 (en) | 1992-11-13 | 2003-11-25 | Purdue Research Foundation | Composition and method for production of transformed cells |
DE69531859T2 (de) * | 1994-02-18 | 2004-07-29 | Organogenesis, Inc., Canton | Bioumbaubare collagentransplantat prothese |
US5942496A (en) * | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
US5763416A (en) * | 1994-02-18 | 1998-06-09 | The Regent Of The University Of Michigan | Gene transfer into bone cells and tissues |
US5962427A (en) * | 1994-02-18 | 1999-10-05 | The Regent Of The University Of Michigan | In vivo gene transfer methods for wound healing |
US6334872B1 (en) * | 1994-02-18 | 2002-01-01 | Organogenesis Inc. | Method for treating diseased or damaged organs |
US20020193338A1 (en) * | 1994-02-18 | 2002-12-19 | Goldstein Steven A. | In vivo gene transfer methods for wound healing |
US6074840A (en) * | 1994-02-18 | 2000-06-13 | The Regents Of The University Of Michigan | Recombinant production of latent TGF-beta binding protein-3 (LTBP-3) |
US6551618B2 (en) * | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
EP1217101B8 (en) | 1994-04-29 | 2006-02-01 | Boston Scientific Scimed, Inc. | Stent with collagen |
US6475232B1 (en) * | 1996-12-10 | 2002-11-05 | Purdue Research Foundation | Stent with reduced thrombogenicity |
US5702419A (en) | 1994-09-21 | 1997-12-30 | Wake Forest University | Expandable, intraluminal stents |
US5562946A (en) * | 1994-11-02 | 1996-10-08 | Tissue Engineering, Inc. | Apparatus and method for spinning and processing collagen fiber |
US5891558A (en) * | 1994-11-22 | 1999-04-06 | Tissue Engineering, Inc. | Biopolymer foams for use in tissue repair and reconstruction |
US5709934A (en) * | 1994-11-22 | 1998-01-20 | Tissue Engineering, Inc. | Bipolymer foams having extracellular matrix particulates |
US6485723B1 (en) * | 1995-02-10 | 2002-11-26 | Purdue Research Foundation | Enhanced submucosal tissue graft constructs |
US5695998A (en) * | 1995-02-10 | 1997-12-09 | Purdue Research Foundation | Submucosa as a growth substrate for islet cells |
EP0734736A1 (en) * | 1995-03-31 | 1996-10-02 | Toyo Boseki Kabushiki Kaisha | Medical device and method for producing the same |
US5554389A (en) * | 1995-04-07 | 1996-09-10 | Purdue Research Foundation | Urinary bladder submucosa derived tissue graft |
US5711969A (en) * | 1995-04-07 | 1998-01-27 | Purdue Research Foundation | Large area submucosal tissue graft constructs |
DE69622548T2 (de) * | 1995-04-07 | 2003-09-18 | Purdue Research Foundation West Lafayette | Gewebetransplantat zur blasenrekonstruktion |
US5733337A (en) * | 1995-04-07 | 1998-03-31 | Organogenesis, Inc. | Tissue repair fabric |
US20020095218A1 (en) | 1996-03-12 | 2002-07-18 | Carr Robert M. | Tissue repair fabric |
US5569273A (en) * | 1995-07-13 | 1996-10-29 | C. R. Bard, Inc. | Surgical mesh fabric |
US5911942A (en) * | 1995-11-02 | 1999-06-15 | Tissue Engineering, Inc. | Method for spinning and processing collagen fiber |
US5788625A (en) | 1996-04-05 | 1998-08-04 | Depuy Orthopaedics, Inc. | Method of making reconstructive SIS structure for cartilaginous elements in situ |
US5755791A (en) * | 1996-04-05 | 1998-05-26 | Purdue Research Foundation | Perforated submucosal tissue graft constructs |
US5668288A (en) * | 1996-04-16 | 1997-09-16 | Depuy Orthopaedics, Inc. | Polyester ionomers for implant fabrication |
US5733868A (en) * | 1996-04-16 | 1998-03-31 | Depuy Orthopaedics, Inc. | Poly(amino acid) adhesive tissue grafts |
US6299905B1 (en) | 1996-04-16 | 2001-10-09 | Depuy Orthopaedics, Inc. | Bioerodable polymeric adhesives for tissue repair |
US5730933A (en) * | 1996-04-16 | 1998-03-24 | Depuy Orthopaedics, Inc. | Radiation sterilization of biologically active compounds |
US6171344B1 (en) | 1996-08-16 | 2001-01-09 | Children's Medical Center Corporation | Bladder submucosa seeded with cells for tissue reconstruction |
JP3816534B2 (ja) * | 1996-08-16 | 2006-08-30 | チルドレンズ メディカル センター コーポレーション | 細胞を接種された組織再建術用膀胱粘膜下組織 |
US8716227B2 (en) * | 1996-08-23 | 2014-05-06 | Cook Biotech Incorporated | Graft prosthesis, materials and methods |
US6666892B2 (en) * | 1996-08-23 | 2003-12-23 | Cook Biotech Incorporated | Multi-formed collagenous biomaterial medical device |
DE69725592T2 (de) * | 1996-08-23 | 2004-08-05 | Cook Biotech, Inc., West Lafayette | Verfahren zur gewinnung einer gereignigten matrix auf kollagenbasis aus submukosa gewebe |
US20020173806A1 (en) * | 1996-08-30 | 2002-11-21 | Verigen Transplantation Service International (Vtsi) Ag | Method for autologous transplantation |
US20060025786A1 (en) * | 1996-08-30 | 2006-02-02 | Verigen Transplantation Service International (Vtsi) Ag | Method for autologous transplantation |
EP1430899B1 (en) * | 1996-09-16 | 2010-07-07 | Purdue Research Foundation | Graft from submucosal intestinal tissue for repairing neurological tissue |
ES2213835T3 (es) * | 1996-09-16 | 2004-09-01 | Purdue Research Foundation | Injerto de tejidos intestinales submucosales para la reparacion de tejidos neurologicos. |
US5902228A (en) * | 1996-10-11 | 1999-05-11 | Cornell Research Foundation, Inc. | Method and apparatus for support and tubularization of surgical grafts |
AU722065B2 (en) * | 1996-11-05 | 2000-07-20 | Purdue Research Foundation | Myocardial graft constructs |
CA2267310C (en) * | 1996-12-10 | 2012-09-18 | Purdue Research Foundation | Stomach submucosa derived tissue graft |
DE69706710T2 (de) * | 1996-12-10 | 2002-07-04 | Purdue Research Foundation West Lafayette | Durch submukosales gewebe erzeugte inhibierung des neoplastischen zellwachstums |
JP4046358B2 (ja) | 1996-12-10 | 2008-02-13 | パーデュー・リサーチ・ファウンデーション | 粘膜下組織抽出物 |
PL184497B1 (pl) * | 1996-12-10 | 2002-11-29 | Purdue Research Foundation | Cylindryczna proteza z tkanki podśluzówkowej i sposób wytwarzania cylindrycznej protezy z tkanki podśluzówkowej |
US6379710B1 (en) * | 1996-12-10 | 2002-04-30 | Purdue Research Foundation | Biomaterial derived from vertebrate liver tissue |
JP2001505807A (ja) * | 1996-12-10 | 2001-05-08 | パーデュー・リサーチ・ファウンデーション | 人工血管弁 |
US6696270B2 (en) | 1996-12-10 | 2004-02-24 | Purdue Research Foundation | Gastric submucosal tissue as a novel diagnostic tool |
JP2001509700A (ja) | 1996-12-10 | 2001-07-24 | クック バイオテック、インク. | ステント移植片含有精製粘膜下組織 |
AU774634B2 (en) * | 1996-12-10 | 2004-07-01 | Purdue Research Foundation | Tubular submucosal graft constructs |
EP1007673B1 (en) | 1997-07-30 | 2008-12-17 | Emory University | Novel bone mineralization proteins, dna, vectors, expression systems |
US7923250B2 (en) | 1997-07-30 | 2011-04-12 | Warsaw Orthopedic, Inc. | Methods of expressing LIM mineralization protein in non-osseous cells |
DE69802815T2 (de) * | 1997-09-11 | 2002-08-01 | Purdue Research Foundation West Lafayette | Durch galactosidase modifiziertes submucosales gewebe |
US6254627B1 (en) * | 1997-09-23 | 2001-07-03 | Diseno Y Desarrollo Medico S.A. De C.V. | Non-thrombogenic stent jacket |
WO1999015095A1 (en) | 1997-09-24 | 1999-04-01 | Depuy Orthopaedics, Inc. | Acl fixation pin and method |
US6485969B1 (en) | 1997-12-23 | 2002-11-26 | Purdue Research Foundation | Biomaterial derived from follicle basement membranes |
US7070607B2 (en) * | 1998-01-27 | 2006-07-04 | The Regents Of The University Of California | Bioabsorbable polymeric implants and a method of using the same to create occlusions |
CA2321117C (en) | 1998-02-27 | 2014-07-15 | Purdue Research Foundation | Submucosa gel compositions |
US7452371B2 (en) * | 1999-06-02 | 2008-11-18 | Cook Incorporated | Implantable vascular device |
AU753773B2 (en) * | 1998-06-05 | 2002-10-31 | Organogenesis Inc. | Bioengineered vascular graft prostheses |
EP1082057B1 (en) * | 1998-06-05 | 2009-02-25 | Organogenesis Inc. | Bioengineered tubular graft prostheses |
AU763724B2 (en) | 1998-06-05 | 2003-07-31 | Duke University School Of Medicine | Bioengineered vascular graft support prostheses |
AU754838B2 (en) * | 1998-06-05 | 2002-11-28 | Organogenesis Inc. | Bioengineered flat sheet graft prostheses |
US6933326B1 (en) * | 1998-06-19 | 2005-08-23 | Lifecell Coporation | Particulate acellular tissue matrix |
US6458109B1 (en) * | 1998-08-07 | 2002-10-01 | Hill-Rom Services, Inc. | Wound treatment apparatus |
DE69939685D1 (de) * | 1998-12-01 | 2008-11-20 | Univ Washington | Vorrichtung zur intravaskulären embolisierung |
DE69939370D1 (de) * | 1998-12-01 | 2008-10-02 | Cook Biotech Inc | Medizinischer artikel aus unterschiedlich hergestelltem kollagen-biomaterial |
CA2352767C (en) * | 1998-12-01 | 2010-05-11 | Purdue Research Foundation | Method for vocal cord reconstruction |
WO2000032209A2 (en) * | 1998-12-01 | 2000-06-08 | Purdue Research Foundation | Submucosa modulation of mammalian immune response |
US8882850B2 (en) * | 1998-12-01 | 2014-11-11 | Cook Biotech Incorporated | Multi-formed collagenous biomaterial medical device |
US6918396B1 (en) | 1998-12-01 | 2005-07-19 | Purdue Research Foundation | Method for vocal cord reconstruction |
US20020165611A1 (en) | 1998-12-22 | 2002-11-07 | Robert-Jan Enzerink | Graft material convenience package |
US20020095157A1 (en) * | 1999-07-23 | 2002-07-18 | Bowman Steven M. | Graft fixation device combination |
US6179840B1 (en) | 1999-07-23 | 2001-01-30 | Ethicon, Inc. | Graft fixation device and method |
ATE424162T1 (de) * | 1999-08-06 | 2009-03-15 | Cook Biotech Inc | Rohrförmige transplantatkonstruktion |
US6824533B2 (en) | 2000-11-29 | 2004-11-30 | Hill-Rom Services, Inc. | Wound treatment apparatus |
US6764462B2 (en) | 2000-11-29 | 2004-07-20 | Hill-Rom Services Inc. | Wound treatment apparatus |
US6576265B1 (en) * | 1999-12-22 | 2003-06-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US20040043006A1 (en) * | 2002-08-27 | 2004-03-04 | Badylak Stephen F. | Tissue regenerative composition |
US6579538B1 (en) | 1999-12-22 | 2003-06-17 | Acell, Inc. | Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof |
DK1749543T3 (da) * | 1999-12-22 | 2009-06-15 | Acell Inc | Sammensætning til vævsregeneration |
US6461364B1 (en) * | 2000-01-05 | 2002-10-08 | Integrated Vascular Systems, Inc. | Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use |
US7842068B2 (en) * | 2000-12-07 | 2010-11-30 | Integrated Vascular Systems, Inc. | Apparatus and methods for providing tactile feedback while delivering a closure device |
US9579091B2 (en) * | 2000-01-05 | 2017-02-28 | Integrated Vascular Systems, Inc. | Closure system and methods of use |
US8758400B2 (en) * | 2000-01-05 | 2014-06-24 | Integrated Vascular Systems, Inc. | Closure system and methods of use |
US6391048B1 (en) * | 2000-01-05 | 2002-05-21 | Integrated Vascular Systems, Inc. | Integrated vascular device with puncture site closure component and sealant and methods of use |
US7635390B1 (en) * | 2000-01-14 | 2009-12-22 | Marctec, Llc | Joint replacement component having a modular articulating surface |
CA2397760A1 (en) | 2000-01-18 | 2001-07-26 | Timothy G. Slater | Wafer bonding techniques to minimize built-in stress of silicon microstructures and micro-mirrors |
US6866686B2 (en) * | 2000-01-28 | 2005-03-15 | Cryolife, Inc. | Tissue graft |
ES2286097T7 (es) * | 2000-01-31 | 2009-11-05 | Cook Biotech, Inc | Valvulas de endoprotesis. |
JP4404240B2 (ja) | 2000-02-03 | 2010-01-27 | クック インコーポレイティド | 弁及び移植可能な脈管弁 |
AU2001240956A1 (en) * | 2000-03-09 | 2001-09-17 | Diseno Y Desarrollo Medico, S.A. De C.V. | Stent with cover connectors |
AU2001261200B2 (en) | 2000-05-04 | 2006-02-09 | Oregon Health Sciences University | Endovascular stent graft |
US7910791B2 (en) * | 2000-05-22 | 2011-03-22 | Coffey Arthur C | Combination SIS and vacuum bandage and method |
AU2001269936A1 (en) * | 2000-06-20 | 2002-01-02 | Phycotransgenics, Llc | Transgenic algae for delivering antigens to an animal |
US6638312B2 (en) * | 2000-08-04 | 2003-10-28 | Depuy Orthopaedics, Inc. | Reinforced small intestinal submucosa (SIS) |
US8366787B2 (en) | 2000-08-04 | 2013-02-05 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
CA2421856A1 (en) * | 2000-09-08 | 2002-03-14 | James E. Coleman | Surgical staple |
EP1320390A2 (en) * | 2000-09-18 | 2003-06-25 | Organogenesis Inc. | Bioengineered flat sheet graft prosthesis and its use |
US6626918B1 (en) * | 2000-10-06 | 2003-09-30 | Medical Technology Group | Apparatus and methods for positioning a vascular sheath |
US6685681B2 (en) * | 2000-11-29 | 2004-02-03 | Hill-Rom Services, Inc. | Vacuum therapy and cleansing dressing for wounds |
US6855135B2 (en) * | 2000-11-29 | 2005-02-15 | Hill-Rom Services, Inc. | Vacuum therapy and cleansing dressing for wounds |
DE10060443A1 (de) * | 2000-11-29 | 2002-06-06 | Biotronik Mess & Therapieg | Stent aus menschlichem oder tierischem Gewebe |
US7806904B2 (en) * | 2000-12-07 | 2010-10-05 | Integrated Vascular Systems, Inc. | Closure device |
US7905900B2 (en) * | 2003-01-30 | 2011-03-15 | Integrated Vascular Systems, Inc. | Clip applier and methods of use |
US8690910B2 (en) | 2000-12-07 | 2014-04-08 | Integrated Vascular Systems, Inc. | Closure device and methods for making and using them |
US7211101B2 (en) * | 2000-12-07 | 2007-05-01 | Abbott Vascular Devices | Methods for manufacturing a clip and clip |
US6623510B2 (en) | 2000-12-07 | 2003-09-23 | Integrated Vascular Systems, Inc. | Closure device and methods for making and using them |
EP1341484B1 (en) * | 2000-12-08 | 2009-05-06 | Osteotech, Inc. | Implant for orthopedic applications |
US6752831B2 (en) * | 2000-12-08 | 2004-06-22 | Osteotech, Inc. | Biocompatible osteogenic band for repair of spinal disorders |
US6599323B2 (en) * | 2000-12-21 | 2003-07-29 | Ethicon, Inc. | Reinforced tissue implants and methods of manufacture and use |
CA2365376C (en) * | 2000-12-21 | 2006-03-28 | Ethicon, Inc. | Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration |
US6852330B2 (en) * | 2000-12-21 | 2005-02-08 | Depuy Mitek, Inc. | Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration |
US20030211793A1 (en) * | 2001-03-05 | 2003-11-13 | Eugene Bell | Injectable bio-compatible material and methods of use |
CA2446362A1 (en) * | 2001-05-07 | 2002-11-14 | Crosscart, Inc. | Submucosal xenografts |
IES20010547A2 (en) * | 2001-06-07 | 2002-12-11 | Christy Cummins | Surgical Staple |
JP4170897B2 (ja) | 2001-06-08 | 2008-10-22 | モリス イノヴェイティヴ リサーチ, インコーポレイテッド | 生体刺入口を封印するための方法および装置 |
US7993365B2 (en) | 2001-06-08 | 2011-08-09 | Morris Innovative, Inc. | Method and apparatus for sealing access |
US20070038244A1 (en) * | 2001-06-08 | 2007-02-15 | Morris Edward J | Method and apparatus for sealing access |
US20060004408A1 (en) * | 2001-06-08 | 2006-01-05 | Morris Edward J | Method and apparatus for sealing access |
AU2002320189B2 (en) * | 2001-06-28 | 2007-04-26 | Cook Biotech Incorporated | Graft prosthesis devices containing renal capsule collagen |
US8877233B2 (en) * | 2001-06-29 | 2014-11-04 | Cook Biotech Incorporated | Porous sponge matrix medical devices and methods |
JP4302515B2 (ja) * | 2001-07-16 | 2009-07-29 | デピュイ・プロダクツ・インコーポレイテッド | 単体型外科装置および方法 |
JP2004535245A (ja) * | 2001-07-16 | 2004-11-25 | デピュイ・プロダクツ・インコーポレイテッド | 多孔質細胞外基質支持骨格材料および方法 |
US7914808B2 (en) * | 2001-07-16 | 2011-03-29 | Depuy Products, Inc. | Hybrid biologic/synthetic porous extracellular matrix scaffolds |
US7201917B2 (en) * | 2001-07-16 | 2007-04-10 | Depuy Products, Inc. | Porous delivery scaffold and method |
US8025896B2 (en) * | 2001-07-16 | 2011-09-27 | Depuy Products, Inc. | Porous extracellular matrix scaffold and method |
WO2003007787A2 (en) * | 2001-07-16 | 2003-01-30 | Depuy Products, Inc. | Cartilage repair and regeneration device and method |
US20030032961A1 (en) | 2001-07-16 | 2003-02-13 | Pelo Mark Joseph | Devices from naturally occurring biologically derived materials |
US7819918B2 (en) * | 2001-07-16 | 2010-10-26 | Depuy Products, Inc. | Implantable tissue repair device |
WO2003007805A2 (en) | 2001-07-16 | 2003-01-30 | Depuy Products, Inc. | Cartilage repair apparatus and method |
WO2003007847A1 (en) | 2001-07-16 | 2003-01-30 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorable scaffolds |
EP1416888A4 (en) * | 2001-07-16 | 2007-04-25 | Depuy Products Inc | DEVICE AND METHOD FOR REGENERATING THE MENISCUS |
US7622129B1 (en) | 2002-08-05 | 2009-11-24 | Purdue Research Foundation | Nano-structured polymers for use as implants |
WO2003015836A1 (en) * | 2001-08-16 | 2003-02-27 | Purdue Research Foundation | Material and method for promoting tissue growth |
US7708741B1 (en) | 2001-08-28 | 2010-05-04 | Marctec, Llc | Method of preparing bones for knee replacement surgery |
US20060052821A1 (en) * | 2001-09-06 | 2006-03-09 | Ovalis, Inc. | Systems and methods for treating septal defects |
US6776784B2 (en) * | 2001-09-06 | 2004-08-17 | Core Medical, Inc. | Clip apparatus for closing septal defects and methods of use |
US20090054912A1 (en) * | 2001-09-06 | 2009-02-26 | Heanue Taylor A | Systems and Methods for Treating Septal Defects |
US20050267495A1 (en) * | 2004-05-17 | 2005-12-01 | Gateway Medical, Inc. | Systems and methods for closing internal tissue defects |
US20070112358A1 (en) * | 2001-09-06 | 2007-05-17 | Ryan Abbott | Systems and Methods for Treating Septal Defects |
US20070129755A1 (en) * | 2005-12-05 | 2007-06-07 | Ovalis, Inc. | Clip-based systems and methods for treating septal defects |
US6702835B2 (en) | 2001-09-07 | 2004-03-09 | Core Medical, Inc. | Needle apparatus for closing septal defects and methods for using such apparatus |
CA2462877A1 (en) * | 2001-10-11 | 2003-04-17 | Hill-Rom Services, Inc. | Waste container for negative pressure therapy |
JP2005525140A (ja) * | 2001-10-26 | 2005-08-25 | クック・バイオテック・インコーポレーテッド | 網状構造を付与した医用移植片デバイス |
KR20050044507A (ko) * | 2001-11-16 | 2005-05-12 | 칠드런'즈 메디컬 센터 코포레이션 | 장기 기능의 확장 |
AU2002360695A1 (en) * | 2001-12-19 | 2003-07-09 | Nmt Medical, Inc. | Septal occluder and associated methods |
US7318833B2 (en) | 2001-12-19 | 2008-01-15 | Nmt Medical, Inc. | PFO closure device with flexible thrombogenic joint and improved dislodgement resistance |
US20030118560A1 (en) * | 2001-12-20 | 2003-06-26 | Kelly Sheila J. | Composite biocompatible matrices |
US7723560B2 (en) * | 2001-12-26 | 2010-05-25 | Lockwood Jeffrey S | Wound vacuum therapy dressing kit |
ATE387919T1 (de) * | 2001-12-26 | 2008-03-15 | Hill Rom Services Inc | Vakuumbindenverpackung |
EP1478313B2 (en) * | 2001-12-26 | 2018-03-07 | KCI Medical Resources | Vented vacuum bandage |
AU2003202261A1 (en) * | 2002-01-11 | 2003-07-30 | Purdue Research Foundation | Biomaterial derived from vertebrate liver tissue |
AU2003202264A1 (en) * | 2002-01-11 | 2003-07-30 | Clarian Health Partners, Inc. | Composition and method for inhibiting hypersensitivity |
AU2003210510A1 (en) * | 2002-01-14 | 2003-07-30 | Nmt Medical, Inc. | Patent foramen ovale (pfo) closure method and device |
US6749621B2 (en) | 2002-02-21 | 2004-06-15 | Integrated Vascular Systems, Inc. | Sheath apparatus and methods for delivering a closure device |
US20030171801A1 (en) * | 2002-03-06 | 2003-09-11 | Brian Bates | Partially covered intraluminal support device |
US8529956B2 (en) * | 2002-03-18 | 2013-09-10 | Carnell Therapeutics Corporation | Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
US20100254900A1 (en) * | 2002-03-18 | 2010-10-07 | Campbell Phil G | Biocompatible polymers and Methods of use |
JP2005521447A (ja) * | 2002-03-25 | 2005-07-21 | エヌエムティー メディカル インコーポレイテッド | 卵円孔開存(pfo)の閉鎖クリップ |
US6939369B2 (en) * | 2002-04-03 | 2005-09-06 | Cook Incorporated | Intraluminal graft assembly and vessel repair system |
EP1496822B1 (en) | 2002-04-10 | 2018-08-29 | KCI Medical Resources | Access openings in vacuum bandage |
CA2479765C (en) | 2002-04-15 | 2009-01-27 | Cook Biotech Incorporated | Apparatus and method for producing a reinforced surgical staple line |
EP1503789A4 (en) * | 2002-05-02 | 2006-08-02 | Purdue Research Foundation | IMPROVED VASCULARIZATION BY GRAFT CONSTRUCTIONS |
JP2005524426A (ja) * | 2002-05-02 | 2005-08-18 | パーデュー・リサーチ・ファウンデーション | 血管新生が促進された移植片構成物 |
WO2003092471A2 (en) * | 2002-05-02 | 2003-11-13 | Cook Biotech Incorporated | Cell-seeded extracellular matrix grafts |
WO2003092474A2 (en) * | 2002-05-02 | 2003-11-13 | Purdue Research Foundation | Vascularization enhanced graft constructs |
US20040117004A1 (en) * | 2002-05-16 | 2004-06-17 | Osborne Thomas A. | Stent and method of forming a stent with integral barbs |
US7828839B2 (en) * | 2002-05-16 | 2010-11-09 | Cook Incorporated | Flexible barb for anchoring a prosthesis |
US20030225446A1 (en) * | 2002-05-29 | 2003-12-04 | William A. Cook Australia Pty Ltd. | Multi-piece prosthesis deployment apparatus |
CA2486919C (en) * | 2002-06-03 | 2011-03-15 | Nmt Medical, Inc. | Device with biological tissue scaffold for percutaneous closure of an intracardiac defect and methods thereof |
US7850709B2 (en) | 2002-06-04 | 2010-12-14 | Abbott Vascular Inc. | Blood vessel closure clip and delivery device |
WO2003103476A2 (en) | 2002-06-05 | 2003-12-18 | Nmt Medical, Inc. | Patent foramen ovale (pfo) closure device with radial and circumferential support |
EP1515666B1 (en) * | 2002-06-26 | 2011-11-16 | Cook Medical Technologies LLC | Stent-graft fastening |
US7160326B2 (en) * | 2002-06-27 | 2007-01-09 | Depuy Products, Inc. | Method and apparatus for implantation of soft tissue implant |
US20040166169A1 (en) * | 2002-07-15 | 2004-08-26 | Prasanna Malaviya | Porous extracellular matrix scaffold and method |
AU2003262660B2 (en) * | 2002-08-12 | 2009-07-16 | Warsaw Orthopedic, Inc. | Synthesis of a bone-polymer composite material |
EP1545392B1 (en) | 2002-08-15 | 2013-10-02 | Cook Medical Technologies LLC | Implantable vascular device |
US7550004B2 (en) * | 2002-08-20 | 2009-06-23 | Cook Biotech Incorporated | Endoluminal device with extracellular matrix material and methods |
WO2004018020A1 (en) | 2002-08-21 | 2004-03-04 | Hill-Rom Services, Inc. | Wound packing for preventing wound closure |
US20060136047A1 (en) * | 2002-09-06 | 2006-06-22 | Obermiller F J | Tissue graft prosthesis devices containing juvenile or small diameter submucosa |
US20040136968A1 (en) * | 2002-09-27 | 2004-07-15 | Verigen Ag | Autologous cells on a support matrix for tissue repair |
US7824701B2 (en) * | 2002-10-18 | 2010-11-02 | Ethicon, Inc. | Biocompatible scaffold for ligament or tendon repair |
US20040078090A1 (en) * | 2002-10-18 | 2004-04-22 | Francois Binette | Biocompatible scaffolds with tissue fragments |
AU2003284976A1 (en) | 2002-10-25 | 2004-05-13 | Nmt Medical, Inc. | Expandable sheath tubing |
US7682392B2 (en) * | 2002-10-30 | 2010-03-23 | Depuy Spine, Inc. | Regenerative implants for stabilizing the spine and devices for attachment of said implants |
AU2003287554A1 (en) * | 2002-11-06 | 2004-06-03 | Nmt Medical, Inc. | Medical devices utilizing modified shape memory alloy |
US20040098121A1 (en) * | 2002-11-07 | 2004-05-20 | Nmt Medical, Inc. | Patent foramen ovale (PFO) closure with magnetic force |
US7627373B2 (en) * | 2002-11-30 | 2009-12-01 | Cardiac Pacemakers, Inc. | Method and apparatus for cell and electrical therapy of living tissue |
US20040158289A1 (en) * | 2002-11-30 | 2004-08-12 | Girouard Steven D. | Method and apparatus for cell and electrical therapy of living tissue |
WO2004049978A1 (en) * | 2002-12-04 | 2004-06-17 | Cook Incorporated | Method and device for treating aortic dissection |
US20040191226A1 (en) * | 2002-12-04 | 2004-09-30 | Badylak Stephen F. | Method for repair of body wall |
US20040187877A1 (en) * | 2002-12-04 | 2004-09-30 | Badylak Stephen F. | Method for repair of liver tissue |
AU2003294682A1 (en) * | 2002-12-09 | 2004-06-30 | Nmt Medical, Inc. | Septal closure devices |
US20050251267A1 (en) * | 2004-05-04 | 2005-11-10 | John Winterbottom | Cell permeable structural implant |
US9125733B2 (en) | 2003-01-14 | 2015-09-08 | The Cleveland Clinic Foundation | Branched vessel endoluminal device |
AU2004206815C1 (en) | 2003-01-14 | 2008-05-29 | The Cleveland Clinic Foundation | Branched vessel endoluminal device |
US8398656B2 (en) * | 2003-01-30 | 2013-03-19 | Integrated Vascular Systems, Inc. | Clip applier and methods of use |
US8905937B2 (en) * | 2009-02-26 | 2014-12-09 | Integrated Vascular Systems, Inc. | Methods and apparatus for locating a surface of a body lumen |
US8758398B2 (en) | 2006-09-08 | 2014-06-24 | Integrated Vascular Systems, Inc. | Apparatus and method for delivering a closure element |
US8202293B2 (en) | 2003-01-30 | 2012-06-19 | Integrated Vascular Systems, Inc. | Clip applier and methods of use |
US8821534B2 (en) | 2010-12-06 | 2014-09-02 | Integrated Vascular Systems, Inc. | Clip applier having improved hemostasis and methods of use |
US7857828B2 (en) * | 2003-01-30 | 2010-12-28 | Integrated Vascular Systems, Inc. | Clip applier and methods of use |
US7985414B2 (en) * | 2003-02-04 | 2011-07-26 | Warsaw Orthopedic, Inc. | Polyurethanes for osteoimplants |
ES2541909T3 (es) * | 2003-02-04 | 2015-07-28 | Warsaw Orthopedic, Inc. | Poliuretanos para osteoimplantes |
US8197837B2 (en) | 2003-03-07 | 2012-06-12 | Depuy Mitek, Inc. | Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof |
US20040175366A1 (en) * | 2003-03-07 | 2004-09-09 | Acell, Inc. | Scaffold for cell growth and differentiation |
US20040176855A1 (en) * | 2003-03-07 | 2004-09-09 | Acell, Inc. | Decellularized liver for repair of tissue and treatment of organ deficiency |
US7658747B2 (en) * | 2003-03-12 | 2010-02-09 | Nmt Medical, Inc. | Medical device for manipulation of a medical implant |
US7524332B2 (en) * | 2003-03-17 | 2009-04-28 | Cook Incorporated | Vascular valve with removable support component |
WO2004096085A2 (en) * | 2003-03-27 | 2004-11-11 | Purdue Research Foundation | Nanofibers as a neural biomaterial |
US7871434B2 (en) * | 2003-04-01 | 2011-01-18 | Cook Incorporated | Percutaneously deployed vascular valves |
FR2853394B1 (fr) * | 2003-04-03 | 2006-03-10 | Valeo Vision | Dispositif de projection pour vehicule automobile eclairant des points de portique |
US20050064042A1 (en) * | 2003-04-29 | 2005-03-24 | Musculoskeletal Transplant Foundation | Cartilage implant plug with fibrin glue and method for implantation |
US7067123B2 (en) * | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
US20050222687A1 (en) * | 2004-04-02 | 2005-10-06 | Gordana Vunjak-Novakovic | Cartilage implant assembly and method for implantation |
US7488348B2 (en) * | 2003-05-16 | 2009-02-10 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US7901457B2 (en) * | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US20090291112A1 (en) * | 2003-05-16 | 2009-11-26 | Truncale Katherine G | Allograft osteochondral plug combined with cartilage particle mixture |
US7105001B2 (en) * | 2003-05-21 | 2006-09-12 | Mandelbaum Jon A | Surgical method and composition utilizing submucosal tissue to prevent incisional hernias |
US20040260315A1 (en) * | 2003-06-17 | 2004-12-23 | Dell Jeffrey R. | Expandable tissue support member and method of forming the support member |
US20050025838A1 (en) * | 2003-06-25 | 2005-02-03 | Badylak Stephen F. | Conditioned compositions for tissue restoration |
US8226715B2 (en) * | 2003-06-30 | 2012-07-24 | Depuy Mitek, Inc. | Scaffold for connective tissue repair |
US8480706B2 (en) * | 2003-07-14 | 2013-07-09 | W.L. Gore & Associates, Inc. | Tubular patent foramen ovale (PFO) closure device with catch system |
US9861346B2 (en) | 2003-07-14 | 2018-01-09 | W. L. Gore & Associates, Inc. | Patent foramen ovale (PFO) closure device with linearly elongating petals |
US7678123B2 (en) * | 2003-07-14 | 2010-03-16 | Nmt Medical, Inc. | Tubular patent foramen ovale (PFO) closure device with catch system |
WO2005011534A1 (en) * | 2003-07-31 | 2005-02-10 | Cook Incorporated | Prosthetic valve devices and methods of making such devices |
US10583220B2 (en) * | 2003-08-11 | 2020-03-10 | DePuy Synthes Products, Inc. | Method and apparatus for resurfacing an articular surface |
WO2005018728A2 (en) * | 2003-08-19 | 2005-03-03 | Nmt Medical, Inc. | Expandable sheath tubing |
US8021692B2 (en) | 2003-08-25 | 2011-09-20 | Cook Biotech Incorporated | Graft materials containing bioactive substances, and methods for their manufacture |
AU2004270239C1 (en) * | 2003-09-04 | 2011-07-07 | Cook Biotech Incorporated | Extracellular matrix composite materials, and manufacture and use thereof |
US7645229B2 (en) * | 2003-09-26 | 2010-01-12 | Armstrong David N | Instrument and method for endoscopic visualization and treatment of anorectal fistula |
CA2540830C (en) | 2003-10-10 | 2012-08-14 | William A. Cook Australia Pty. Ltd. | Fenestrated stent grafts |
US8734501B2 (en) | 2003-10-10 | 2014-05-27 | Cook Medical Technologies Llc | Composite stent graft |
US8043357B2 (en) | 2003-10-10 | 2011-10-25 | Cook Medical Technologies Llc | Ring stent |
DE602004022842D1 (de) * | 2003-10-10 | 2009-10-08 | Cleveland Clinic Foundation | Endoluminale prothese mit verbindbaren modulen |
US6976679B2 (en) * | 2003-11-07 | 2005-12-20 | The Boeing Company | Inter-fluid seal assembly and method therefor |
US7316822B2 (en) * | 2003-11-26 | 2008-01-08 | Ethicon, Inc. | Conformable tissue repair implant capable of injection delivery |
US8133500B2 (en) * | 2003-12-04 | 2012-03-13 | Kensey Nash Bvf Technology, Llc | Compressed high density fibrous polymers suitable for implant |
US20050125033A1 (en) * | 2003-12-04 | 2005-06-09 | Mcnally-Heintzelman Karen M. | Wound closure apparatus |
US20050125015A1 (en) * | 2003-12-04 | 2005-06-09 | Mcnally-Heintzelman Karen M. | Tissue-handling apparatus, system and method |
US8389588B2 (en) | 2003-12-04 | 2013-03-05 | Kensey Nash Corporation | Bi-phasic compressed porous reinforcement materials suitable for implant |
US7901461B2 (en) * | 2003-12-05 | 2011-03-08 | Ethicon, Inc. | Viable tissue repair implants and methods of use |
US20050273119A1 (en) | 2003-12-09 | 2005-12-08 | Nmt Medical, Inc. | Double spiral patent foramen ovale closure clamp |
CA2550431A1 (en) * | 2003-12-19 | 2005-07-14 | Osteotech, Inc. | Tissue-derived mesh for orthopedic regeneration |
WO2005070302A1 (en) | 2004-01-21 | 2005-08-04 | Cook Incorporated | Implantable graft to close a fistula |
US8262694B2 (en) * | 2004-01-30 | 2012-09-11 | W.L. Gore & Associates, Inc. | Devices, systems, and methods for closure of cardiac openings |
AU2005212334B2 (en) * | 2004-02-09 | 2011-06-16 | Cook Medical Technologies Llc | Stent graft devices having collagen coating |
US8337545B2 (en) | 2004-02-09 | 2012-12-25 | Cook Medical Technologies Llc | Woven implantable device |
US11395865B2 (en) * | 2004-02-09 | 2022-07-26 | DePuy Synthes Products, Inc. | Scaffolds with viable tissue |
GB2451777B (en) | 2004-02-17 | 2009-04-08 | Cook Biotech Inc | Medical devices and methods useful for applying bolster material |
US7840263B2 (en) * | 2004-02-27 | 2010-11-23 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression |
US7871419B2 (en) * | 2004-03-03 | 2011-01-18 | Nmt Medical, Inc. | Delivery/recovery system for septal occluder |
KR20070002057A (ko) | 2004-03-17 | 2007-01-04 | 레비비코르 인코포레이션 | 기능성 알파 1,3 갈락토실트랜스펙션스페라제의 어떠한발현도 결여된 동물로부터 유래된 조직 산물 |
US7449027B2 (en) * | 2004-03-29 | 2008-11-11 | Cook Incorporated | Modifying fluid flow in a body vessel lumen to promote intraluminal flow-sensitive processes |
WO2005094694A2 (en) | 2004-03-29 | 2005-10-13 | Cook Biotech Incorporated | Medical graft products with differing regions and methods and systems for producing the same |
US20050234509A1 (en) * | 2004-03-30 | 2005-10-20 | Mmt Medical, Inc. | Center joints for PFO occluders |
DE602005020754D1 (de) * | 2004-03-31 | 2010-06-02 | Cook Inc | Transplantatmaterial und gefässprothese mit extrazellulärer kollagenmatrix und dessen herstellungsverfahren |
ATE491416T1 (de) * | 2004-03-31 | 2011-01-15 | Cook Inc | Stentablagevorrichtung |
US9498322B2 (en) * | 2004-03-31 | 2016-11-22 | Cook Medical Technologies Llc | Multi-portion endoluminal prosthesis |
JP2007532153A (ja) * | 2004-03-31 | 2007-11-15 | クック インコーポレイテッド | Ecmを基材としたグラフト材料 |
US8216299B2 (en) * | 2004-04-01 | 2012-07-10 | Cook Medical Technologies Llc | Method to retract a body vessel wall with remodelable material |
US20050267524A1 (en) * | 2004-04-09 | 2005-12-01 | Nmt Medical, Inc. | Split ends closure device |
US8221780B2 (en) * | 2004-04-20 | 2012-07-17 | Depuy Mitek, Inc. | Nonwoven tissue scaffold |
US8137686B2 (en) | 2004-04-20 | 2012-03-20 | Depuy Mitek, Inc. | Nonwoven tissue scaffold |
US8657881B2 (en) * | 2004-04-20 | 2014-02-25 | Depuy Mitek, Llc | Meniscal repair scaffold |
US7922759B1 (en) * | 2004-04-22 | 2011-04-12 | Cook Medical Technologies Llc | Apparatus and methods for vascular treatment |
US8361110B2 (en) * | 2004-04-26 | 2013-01-29 | W.L. Gore & Associates, Inc. | Heart-shaped PFO closure device |
US20050249772A1 (en) * | 2004-05-04 | 2005-11-10 | Prasanna Malaviya | Hybrid biologic-synthetic bioabsorbable scaffolds |
US7569233B2 (en) * | 2004-05-04 | 2009-08-04 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
US7842053B2 (en) | 2004-05-06 | 2010-11-30 | Nmt Medical, Inc. | Double coil occluder |
US8308760B2 (en) * | 2004-05-06 | 2012-11-13 | W.L. Gore & Associates, Inc. | Delivery systems and methods for PFO closure device with two anchors |
CA2563298A1 (en) | 2004-05-07 | 2005-11-24 | Nmt Medical, Inc. | Catching mechanisms for tubular septal occluder |
US7704268B2 (en) * | 2004-05-07 | 2010-04-27 | Nmt Medical, Inc. | Closure device with hinges |
IES20040368A2 (en) * | 2004-05-25 | 2005-11-30 | James E Coleman | Surgical stapler |
US7764995B2 (en) | 2004-06-07 | 2010-07-27 | Cardiac Pacemakers, Inc. | Method and apparatus to modulate cellular regeneration post myocardial infarct |
AU2005269864B2 (en) * | 2004-07-07 | 2011-01-06 | Cook Medical Technologies Llc | Graft, stent graft and method for manufacture |
CA2575240A1 (en) * | 2004-07-30 | 2006-02-09 | Cook Biotech Incorporated | Graft with increased resistance to enzymatic degradation |
US20060029633A1 (en) * | 2004-08-03 | 2006-02-09 | Arthrotek, Inc | Biological patch for use in medical procedures |
US8257715B1 (en) | 2004-08-26 | 2012-09-04 | University Of Notre Dame | Tissue vaccines and uses thereof |
CA2581677C (en) * | 2004-09-24 | 2014-07-29 | Nmt Medical, Inc. | Occluder device double securement system for delivery/recovery of such occluder device |
US20080220044A1 (en) * | 2007-03-06 | 2008-09-11 | Semler Eric J | Cancellous construct with support ring for repair of osteochondral defects |
US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US7442206B2 (en) * | 2004-10-28 | 2008-10-28 | Cook Incorporated | Methods and systems for modifying vascular valves |
WO2006050460A1 (en) * | 2004-10-29 | 2006-05-11 | Cook Incorporated | Vascular valves having implanted and target configurations and methods of preparing the same |
US7513866B2 (en) * | 2004-10-29 | 2009-04-07 | Depuy Products, Inc. | Intestine processing device and associated method |
US7905826B2 (en) * | 2004-11-03 | 2011-03-15 | Cook Incorporated | Methods for modifying vascular vessel walls |
US8329202B2 (en) | 2004-11-12 | 2012-12-11 | Depuy Products, Inc. | System and method for attaching soft tissue to an implant |
US7744621B2 (en) * | 2004-12-06 | 2010-06-29 | Cook Incorporated | Inflatable occlusion devices, methods, and systems |
WO2006062976A2 (en) | 2004-12-07 | 2006-06-15 | Cook Incorporated | Methods for modifying vascular vessel walls |
US20060134071A1 (en) * | 2004-12-20 | 2006-06-22 | Jeffrey Ross | Use of extracellular matrix and electrical therapy |
US8874204B2 (en) * | 2004-12-20 | 2014-10-28 | Cardiac Pacemakers, Inc. | Implantable medical devices comprising isolated extracellular matrix |
US7981065B2 (en) * | 2004-12-20 | 2011-07-19 | Cardiac Pacemakers, Inc. | Lead electrode incorporating extracellular matrix |
US8060219B2 (en) * | 2004-12-20 | 2011-11-15 | Cardiac Pacemakers, Inc. | Epicardial patch including isolated extracellular matrix with pacing electrodes |
US7354627B2 (en) * | 2004-12-22 | 2008-04-08 | Depuy Products, Inc. | Method for organizing the assembly of collagen fibers and compositions formed therefrom |
EP1833384B1 (en) * | 2004-12-30 | 2017-08-16 | Cook Medical Technologies LLC | Inverting occlusion devices and systems |
US20070150051A1 (en) * | 2005-01-10 | 2007-06-28 | Duke Fiduciary, Llc | Vascular implants and methods of fabricating the same |
US8287583B2 (en) * | 2005-01-10 | 2012-10-16 | Taheri Laduca Llc | Apparatus and method for deploying an implantable device within the body |
US8128680B2 (en) | 2005-01-10 | 2012-03-06 | Taheri Laduca Llc | Apparatus and method for deploying an implantable device within the body |
US20060206139A1 (en) * | 2005-01-19 | 2006-09-14 | Tekulve Kurt J | Vascular occlusion device |
US20060246033A1 (en) * | 2005-03-02 | 2006-11-02 | Cook Biotech Incorporated | Injectable bulking agent compositions |
US8303647B2 (en) * | 2005-03-03 | 2012-11-06 | Cook Medical Technologies Llc | Medical valve leaflet structures with peripheral region receptive to tissue ingrowth |
US9138445B2 (en) * | 2005-03-09 | 2015-09-22 | Cook Biotech Incorporated | Medical graft materials with adherent extracellular matrix fibrous mass |
US20060257447A1 (en) * | 2005-03-09 | 2006-11-16 | Providence Health System | Composite graft |
US7840266B2 (en) * | 2005-03-11 | 2010-11-23 | Cardiac Pacemakers, Inc. | Integrated lead for applying cardiac resynchronization therapy and neural stimulation therapy |
EP1868507A1 (en) | 2005-03-18 | 2007-12-26 | NMT Medical, Inc. | Catch member for pfo occluder |
US8454678B2 (en) * | 2005-03-19 | 2013-06-04 | Cook Biotech Incorporated | Prosthetic implants including ECM composite material |
US8197534B2 (en) | 2005-03-31 | 2012-06-12 | Cook Medical Technologies Llc | Valve device with inflatable chamber |
US20060229670A1 (en) * | 2005-04-01 | 2006-10-12 | Bates Brian L | Method and a medical closure system for sealing a puncture |
WO2006113501A1 (en) | 2005-04-13 | 2006-10-26 | The Cleveland Clinic Foundation | Endoluminal prosthesis |
CN103654880B (zh) * | 2005-04-29 | 2016-05-18 | 库克生物科技公司 | 治疗瘘的立体移植物和相关方法与系统 |
EP1874365B1 (en) | 2005-04-29 | 2015-05-27 | Cook Biotech Incorporated | Fistula graft with deformable sheet-form material |
AU2006244393B2 (en) * | 2005-05-05 | 2012-06-21 | Cook Biotech Incorporated | Implantable materials and methods for inhibiting tissue adhesion formation |
WO2006124946A2 (en) * | 2005-05-16 | 2006-11-23 | Purdue Research Foundation | Engineered extracellular matrices |
EP1887980B1 (en) * | 2005-05-17 | 2012-09-05 | Cook Medical Technologies LLC | Frameless valve prosthesis and system for its deployment |
US20080109058A1 (en) * | 2005-06-01 | 2008-05-08 | Cook Incorporated | Intraoperative Anastomosis Method |
US20060276883A1 (en) * | 2005-06-01 | 2006-12-07 | Cook Incorporated | Tapered and distally stented elephant trunk stent graft |
JP2008543504A (ja) | 2005-06-21 | 2008-12-04 | クック・インコーポレイテッド | 瘻孔を閉鎖する移植可能なグラフト |
US20060292227A1 (en) * | 2005-06-23 | 2006-12-28 | Mcpherson Timothy B | Extracellular matrix material particles and methods of preparation |
US8926633B2 (en) | 2005-06-24 | 2015-01-06 | Abbott Laboratories | Apparatus and method for delivering a closure element |
US8313497B2 (en) | 2005-07-01 | 2012-11-20 | Abbott Laboratories | Clip applier and methods of use |
US20080312686A1 (en) * | 2005-07-01 | 2008-12-18 | Abbott Laboratories | Antimicrobial closure element and closure element applier |
US7850985B2 (en) | 2005-07-05 | 2010-12-14 | Cook Biotech Incorporated | Tissue augmentation devices and methods |
US8579936B2 (en) * | 2005-07-05 | 2013-11-12 | ProMed, Inc. | Centering of delivery devices with respect to a septal defect |
US9271817B2 (en) * | 2005-07-05 | 2016-03-01 | Cook Biotech Incorporated | Tissue augmentation devices and methods |
US7815926B2 (en) * | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
US7833259B2 (en) * | 2005-07-25 | 2010-11-16 | Cook Incorporated | Fenestrated endoluminal stent system |
US7595062B2 (en) | 2005-07-28 | 2009-09-29 | Depuy Products, Inc. | Joint resurfacing orthopaedic implant and associated method |
EP2093256A3 (en) | 2005-07-28 | 2009-10-14 | Carnegie Mellon University | Biocompatible polymers and methods of use |
US20070038295A1 (en) * | 2005-08-12 | 2007-02-15 | Cook Incorporated | Artificial valve prosthesis having a ring frame |
US20070038299A1 (en) * | 2005-08-12 | 2007-02-15 | Arthrotek, Inc | Multilayer microperforated implant |
US9456811B2 (en) * | 2005-08-24 | 2016-10-04 | Abbott Vascular Inc. | Vascular closure methods and apparatuses |
US20070060895A1 (en) | 2005-08-24 | 2007-03-15 | Sibbitt Wilmer L Jr | Vascular closure methods and apparatuses |
US8920442B2 (en) * | 2005-08-24 | 2014-12-30 | Abbott Vascular Inc. | Vascular opening edge eversion methods and apparatuses |
US8771340B2 (en) * | 2005-08-25 | 2014-07-08 | Cook Medical Technologies Llc | Methods and devices for the endoluminal deployment and securement of prostheses |
US8470022B2 (en) * | 2005-08-31 | 2013-06-25 | Cook Biotech Incorporated | Implantable valve |
US20070061002A1 (en) * | 2005-09-01 | 2007-03-15 | Cook Incorporated | Attachment of material to an implantable frame by cross-linking |
US7846179B2 (en) * | 2005-09-01 | 2010-12-07 | Ovalis, Inc. | Suture-based systems and methods for treating septal defects |
US9259267B2 (en) | 2005-09-06 | 2016-02-16 | W.L. Gore & Associates, Inc. | Devices and methods for treating cardiac tissue |
WO2007030433A2 (en) * | 2005-09-06 | 2007-03-15 | Nmt Medical, Inc. | Removable intracardiac rf device |
AU2006292224B2 (en) | 2005-09-19 | 2013-08-01 | Histogenics Corporation | Cell-support matrix and a method for preparation thereof |
US20070088388A1 (en) * | 2005-09-19 | 2007-04-19 | Opolski Steven W | Delivery device for implant with dual attachment sites |
US7503928B2 (en) | 2005-10-21 | 2009-03-17 | Cook Biotech Incorporated | Artificial valve with center leaflet attachment |
JP2009512521A (ja) * | 2005-10-24 | 2009-03-26 | エヌエムティー メディカル, インコーポレイティッド | 放射線不透過性生体吸収性オクルダ |
US7563277B2 (en) * | 2005-10-24 | 2009-07-21 | Cook Incorporated | Removable covering for implantable frame projections |
US8778362B2 (en) | 2005-10-27 | 2014-07-15 | University Of Notre Dame | Anti-tumor/cancer heterologous acellular collagenous preparations and uses thereof |
US9308252B2 (en) * | 2005-10-27 | 2016-04-12 | Cook Biotech, Inc. | Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins |
US8802113B2 (en) * | 2005-10-27 | 2014-08-12 | University Of Notre Dame | Extracellular matrix cancer vaccine adjuvant |
US8778360B2 (en) * | 2005-10-27 | 2014-07-15 | University Of Notre Dame | Extracellular matrix cancer vaccine adjuvant |
US20070100351A1 (en) * | 2005-10-31 | 2007-05-03 | Deffenbaugh Daren L | Multiple suture anchor delivery device, suture anchor delivery kit and associated method |
US20070100350A1 (en) * | 2005-10-31 | 2007-05-03 | Deffenbaugh Daren L | Suture anchor cartridge holder, suture anchor cartridge and associated method |
US20070100352A1 (en) * | 2005-10-31 | 2007-05-03 | Deffenbaugh Daren L | Cartridge suture anchor delivery device, suture anchor delivery device and associated method |
US8343204B2 (en) * | 2005-10-31 | 2013-01-01 | Cook Medical Technologies Llc | Composite stent graft |
US20070112360A1 (en) * | 2005-11-15 | 2007-05-17 | Patrick De Deyne | Bioprosthetic device |
WO2007064819A2 (en) * | 2005-12-02 | 2007-06-07 | Cook Incorporated | Devices, systems, and methods for occluding a defect |
WO2007073566A1 (en) | 2005-12-22 | 2007-06-28 | Nmt Medical, Inc. | Catch members for occluder devices |
US7815923B2 (en) | 2005-12-29 | 2010-10-19 | Cook Biotech Incorporated | Implantable graft material |
EP1965732B1 (en) * | 2005-12-29 | 2010-05-05 | Med Institute, Inc. | Endoluminal device including a mechanism for proximal or distal fixation, and sealing and methods of use thereof |
WO2007081530A2 (en) * | 2006-01-03 | 2007-07-19 | Med Institute, Inc. | Endoluminal medical device for local delivery of cathepsin inhibitors |
WO2007084278A2 (en) * | 2006-01-06 | 2007-07-26 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Extracellular matrix based gastroesophageal junction reinforcement device |
US9532943B2 (en) | 2010-12-20 | 2017-01-03 | Cormatrix Cardiovascular, Inc. | Drug eluting patch for the treatment of localized tissue disease or defect |
EP1976460A4 (en) * | 2006-01-19 | 2012-06-20 | Warsaw Orthopedic Inc | INJECTABLE AND FORMABLE BONE REPLACEMENT MATERIALS |
CA2637450A1 (en) * | 2006-01-31 | 2007-08-09 | Cook Biotech Incorporated | Fistula grafts and related methods and systems for treating fistulae |
WO2007098234A2 (en) * | 2006-02-21 | 2007-08-30 | Med Institute, Inc. | Graft material for prostheses |
US7648527B2 (en) * | 2006-03-01 | 2010-01-19 | Cook Incorporated | Methods of reducing retrograde flow |
US8551135B2 (en) * | 2006-03-31 | 2013-10-08 | W.L. Gore & Associates, Inc. | Screw catch mechanism for PFO occluder and method of use |
US8870913B2 (en) | 2006-03-31 | 2014-10-28 | W.L. Gore & Associates, Inc. | Catch system with locking cap for patent foramen ovale (PFO) occluder |
US8814947B2 (en) * | 2006-03-31 | 2014-08-26 | W.L. Gore & Associates, Inc. | Deformable flap catch mechanism for occluder device |
AU2007240703C1 (en) * | 2006-04-19 | 2012-06-14 | Cleveland Clinic Foundation | Twin bifurcated stent graft |
US8808310B2 (en) * | 2006-04-20 | 2014-08-19 | Integrated Vascular Systems, Inc. | Resettable clip applier and reset tools |
US20070269476A1 (en) | 2006-05-16 | 2007-11-22 | Voytik-Harbin Sherry L | Engineered extracellular matrices control stem cell behavior |
DE112007001197T5 (de) | 2006-05-16 | 2009-04-16 | Purdue Research Foundation, West Lafayette | Dreidimensionale gereinigte Kollagenmatrices |
US8038710B2 (en) * | 2006-05-30 | 2011-10-18 | Cook Medical Technologies Llc | Artificial valve prosthesis |
WO2007147127A2 (en) | 2006-06-15 | 2007-12-21 | Cook Incorporated | Methods, systems, and devices for the delivery of endoluminal prostheses |
EP2037817B1 (en) | 2006-06-21 | 2016-01-27 | Cook Biotech Incorporated | Fistula graft |
US8974542B2 (en) * | 2006-06-27 | 2015-03-10 | University of Pittsburgh—of the Commonwealth System of Higher Education | Biodegradable elastomeric patch for treating cardiac or cardiovascular conditions |
US8556930B2 (en) | 2006-06-28 | 2013-10-15 | Abbott Laboratories | Vessel closure device |
WO2008008266A2 (en) * | 2006-07-07 | 2008-01-17 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Biohybrid elastomeric scaffolds and methods of use thereof |
US20080109070A1 (en) * | 2006-08-10 | 2008-05-08 | Wagner William R | Biodegradable elastomeric scaffolds containing microintegrated cells |
AU2007286657B2 (en) * | 2006-08-24 | 2012-11-15 | Cook Medical Technologies Llc | Devices and methods for occluding a fistula |
US8870914B2 (en) * | 2006-09-12 | 2014-10-28 | Cook Medical Technologies Llc | Medical device and a method for sealing a puncture or an opening |
US20080063627A1 (en) * | 2006-09-12 | 2008-03-13 | Surmodics, Inc. | Tissue graft materials containing biocompatible agent and methods of making and using same |
AU2007297611B2 (en) * | 2006-09-21 | 2013-02-07 | Purdue Research Foundation | Collagen preparation and method of isolation |
US20080082083A1 (en) * | 2006-09-28 | 2008-04-03 | Forde Sean T | Perforated expandable implant recovery sheath |
US8529961B2 (en) | 2006-10-17 | 2013-09-10 | Carmell Therapeutics Corporation | Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
JP2010507462A (ja) * | 2006-10-23 | 2010-03-11 | クック・バイオテック・インコーポレーテッド | 増強した成分プロファイルを有する加工したecm材料 |
US20080103505A1 (en) * | 2006-10-26 | 2008-05-01 | Hendrik Raoul Andre Fransen | Containment device for site-specific delivery of a therapeutic material and methods of use |
US7871440B2 (en) * | 2006-12-11 | 2011-01-18 | Depuy Products, Inc. | Unitary surgical device and method |
WO2008086469A1 (en) * | 2007-01-10 | 2008-07-17 | Cook Biotech Incorporated | Implantable devices useful for reinforcing a surgically created stoma |
US8343536B2 (en) | 2007-01-25 | 2013-01-01 | Cook Biotech Incorporated | Biofilm-inhibiting medical products |
BRPI0807261B8 (pt) | 2007-02-09 | 2021-06-22 | Taheri Laduca Llc | conjuntos de cateter carregado com stent |
WO2008098252A2 (en) | 2007-02-09 | 2008-08-14 | Taheri Laduca Llc | Vascular implants and methods of fabricating the same |
ATE515244T1 (de) | 2007-02-15 | 2011-07-15 | Cook Inc | Künstliche klappenprothese mit freiem blattabschnitt |
WO2008109407A2 (en) | 2007-03-02 | 2008-09-12 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Extracellular matrix-derived gels and related methods |
US8435551B2 (en) * | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
WO2008124603A1 (en) | 2007-04-05 | 2008-10-16 | Nmt Medical, Inc. | Septal closure device with centering mechanism |
WO2008124361A2 (en) * | 2007-04-06 | 2008-10-16 | Cook Biotech Incorporated | Fistula plugs having increased column strength and fistula plug delivery apparatuses and methods |
WO2008131167A1 (en) | 2007-04-18 | 2008-10-30 | Nmt Medical, Inc. | Flexible catheter system |
EP2148887B1 (en) * | 2007-04-19 | 2014-04-30 | Fibralign Corporation | Oriented collagen-based materials, films and methods of making same |
CA2685146C (en) * | 2007-04-24 | 2016-03-29 | The University Of Western Australia | Tenocyte containing bioscaffolds and treatment using the same |
ATE528025T1 (de) * | 2007-04-27 | 2011-10-15 | Cook Biotech Inc | Wachstumsfaktor-modifiziertes extrazelluläres matrixmaterial und verfahren zu seiner herstellung und verwendung |
US9283302B2 (en) | 2011-12-16 | 2016-03-15 | Cormatrix Cardiovascular, Inc. | Extracellular matrix encasement structures and methods |
US20080279833A1 (en) * | 2007-05-10 | 2008-11-13 | Matheny Robert G | Laminate sheet articles for tissue regeneration |
CA2725953A1 (en) | 2007-05-29 | 2008-12-11 | Christopher B. Reid | Methods for production and uses of multipotent cell populations, pluripotent cell populations, neuronal cell populations, and muscle cell populations |
US20090142400A1 (en) * | 2007-05-31 | 2009-06-04 | Hiles Michael C | Analgesic coated medical product |
US8226681B2 (en) * | 2007-06-25 | 2012-07-24 | Abbott Laboratories | Methods, devices, and apparatus for managing access through tissue |
US8535349B2 (en) * | 2007-07-02 | 2013-09-17 | Cook Biotech Incorporated | Fistula grafts having a deflectable graft body portion |
US20090024106A1 (en) * | 2007-07-17 | 2009-01-22 | Morris Edward J | Method and apparatus for maintaining access |
EP2182889B1 (en) | 2007-08-08 | 2014-09-17 | The Cleveland Clinic Foundation | Branched stent graft system |
US9113851B2 (en) | 2007-08-23 | 2015-08-25 | Cook Biotech Incorporated | Fistula plugs and apparatuses and methods for fistula plug delivery |
US20090069843A1 (en) * | 2007-09-10 | 2009-03-12 | Agnew Charles W | Fistula plugs including a hydration resistant component |
EP2187983B1 (en) | 2007-09-12 | 2014-04-16 | Cook Incorporated | Enhanced remodelable materials for occluding bodily vessels |
WO2009042768A1 (en) * | 2007-09-25 | 2009-04-02 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Triggerably dissolvable hollow fibers for controlled delivery |
WO2009040768A2 (en) * | 2007-09-27 | 2009-04-02 | Carlos Alvarado | Tissue grafting method |
US9023342B2 (en) | 2007-09-27 | 2015-05-05 | Carlos A. Alvarado | Tissue grafting method |
US10500309B2 (en) * | 2007-10-05 | 2019-12-10 | Cook Biotech Incorporated | Absorbable adhesives and their formulation for use in medical applications |
US20090112238A1 (en) * | 2007-10-26 | 2009-04-30 | Vance Products Inc., D/B/A Cook Urological Inc. | Fistula brush device |
US20100262183A1 (en) * | 2007-11-07 | 2010-10-14 | Ovalis Inc. | Systems devices and methods for achieving transverse orientation in the treatment of septal defects |
JP5214223B2 (ja) * | 2007-11-15 | 2013-06-19 | 船井電機株式会社 | プロジェクタ |
US7846199B2 (en) * | 2007-11-19 | 2010-12-07 | Cook Incorporated | Remodelable prosthetic valve |
US8057532B2 (en) * | 2007-11-28 | 2011-11-15 | Cook Medical Technologies Llc | Implantable frame and valve design |
CA2708147A1 (en) * | 2007-12-05 | 2009-06-18 | Musculoskeletal Transplant Foundation | Cancellous bone implant for cartilage repair |
US9867905B2 (en) * | 2007-12-10 | 2018-01-16 | Purdue Research Foundation | Collagen-based matrices with stem cells |
US20090157101A1 (en) | 2007-12-17 | 2009-06-18 | Abbott Laboratories | Tissue closure system and methods of use |
US8893947B2 (en) * | 2007-12-17 | 2014-11-25 | Abbott Laboratories | Clip applier and methods of use |
US8679176B2 (en) | 2007-12-18 | 2014-03-25 | Cormatrix Cardiovascular, Inc | Prosthetic tissue valve |
US7815687B2 (en) * | 2007-12-18 | 2010-10-19 | Med Institute, Inc. | Method of promoting cell proliferation and ingrowth by injury to the native tissue |
US7841502B2 (en) * | 2007-12-18 | 2010-11-30 | Abbott Laboratories | Modular clip applier |
US20090157170A1 (en) * | 2007-12-18 | 2009-06-18 | Matheny Robert G | Trileaflet Semi-Lunar Prosthetic Tissue Valve |
US20090157177A1 (en) * | 2007-12-18 | 2009-06-18 | Matheny Robert G | Sewing Ring for a Prosthetic Tissue Valve |
US8257434B2 (en) * | 2007-12-18 | 2012-09-04 | Cormatrix Cardiovascular, Inc. | Prosthetic tissue valve |
US20090187215A1 (en) * | 2007-12-19 | 2009-07-23 | Abbott Laboratories | Methods and apparatus to reduce a dimension of an implantable device in a smaller state |
US8211165B1 (en) | 2008-01-08 | 2012-07-03 | Cook Medical Technologies Llc | Implantable device for placement in a vessel having a variable size |
US9283266B2 (en) * | 2008-02-28 | 2016-03-15 | University Of Notre Dame | Metastasis inhibition preparations and methods |
EP2259809B1 (en) * | 2008-02-29 | 2016-05-25 | Cook Biotech Incorporated | Coated embolization device |
EP2265220A1 (en) * | 2008-03-05 | 2010-12-29 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
US20130165967A1 (en) | 2008-03-07 | 2013-06-27 | W.L. Gore & Associates, Inc. | Heart occlusion devices |
US20100008965A1 (en) * | 2008-04-01 | 2010-01-14 | Pavalko Fredrick M | Biocompatible medical products having enhanced anti-thrombogenic properties |
WO2009129481A1 (en) * | 2008-04-18 | 2009-10-22 | Cook Incorporated | Branched vessel prosthesis |
CN102056619A (zh) | 2008-04-18 | 2011-05-11 | 科尔普兰特有限公司 | 产生和使用原胶原的方法 |
EP2113262B1 (en) * | 2008-04-29 | 2013-11-06 | Proxy Biomedical Limited | A Tissue Repair Implant |
WO2009134949A1 (en) * | 2008-05-02 | 2009-11-05 | Cook Biotech Incorporated | Self deploying sis in needle |
WO2009137755A2 (en) * | 2008-05-09 | 2009-11-12 | University Of Pittsburgh- Commonwealth System Of Higher Education | Biologic matrix for cardiac repair |
US9282965B2 (en) * | 2008-05-16 | 2016-03-15 | Abbott Laboratories | Apparatus and methods for engaging tissue |
AU2009249063A1 (en) * | 2008-05-20 | 2009-11-26 | Ovalis, Inc. | Wire-like and other devices for treating septal defects and systems and methods for delivering the same |
WO2009146369A1 (en) * | 2008-05-29 | 2009-12-03 | Cook Biotech Incorporated | Devices and methods for treating rectovaginal and other fistulae |
US9295757B2 (en) * | 2008-06-10 | 2016-03-29 | Cook Biotech Incorporated | Quilted implantable graft |
BRPI0914996B1 (pt) * | 2008-06-10 | 2018-10-30 | Cook Biotech Inc | enxerto cirúrgico e método para a fabricação de um enxerto cirúrgico |
US8118832B1 (en) | 2008-06-16 | 2012-02-21 | Morris Innovative, Inc. | Method and apparatus for sealing access |
CN102176929B (zh) | 2008-07-01 | 2014-03-26 | 库克生物科技公司 | 包含浆膜下筋膜的分离的细胞外基质材料 |
EP2907531A1 (en) * | 2008-07-30 | 2015-08-19 | Mesynthes Limited | Method of separating or decellularising layers of tissue |
US10086079B2 (en) | 2008-08-11 | 2018-10-02 | Fibralign Corporation | Biocomposites and methods of making the same |
US8513382B2 (en) * | 2008-08-11 | 2013-08-20 | Fibralign Corporation | Biocomposites and methods of making the same |
EP3184552B1 (en) | 2008-09-02 | 2020-08-12 | Tautona Group LP | Threads of hyaluronic acid, methods of making thereof and uses thereof |
CN101366975B (zh) * | 2008-09-03 | 2011-07-20 | 陕西瑞盛生物科技有限公司 | 脱细胞小肠粘膜下层生物材料的制备方法 |
WO2010037092A1 (en) * | 2008-09-29 | 2010-04-01 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Self-regulating device for modulating inflammation |
US9241696B2 (en) * | 2008-10-30 | 2016-01-26 | Abbott Vascular Inc. | Closure device |
WO2010065843A2 (en) | 2008-12-05 | 2010-06-10 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Biologic scaffold for prevention of pulmonary fibrosis |
US8734502B2 (en) | 2008-12-17 | 2014-05-27 | Cook Medical Technologies Llc | Tapered stent and flexible prosthesis |
US8323312B2 (en) * | 2008-12-22 | 2012-12-04 | Abbott Laboratories | Closure device |
US8858594B2 (en) * | 2008-12-22 | 2014-10-14 | Abbott Laboratories | Curved closure device |
WO2010078478A1 (en) | 2008-12-31 | 2010-07-08 | Cook Biotech Incorporated | Tissue adjuvants and medical products including the same |
US8469779B1 (en) | 2009-01-02 | 2013-06-25 | Lifecell Corporation | Method for debristling animal skin |
US20100179589A1 (en) * | 2009-01-09 | 2010-07-15 | Abbott Vascular Inc. | Rapidly eroding anchor |
US9089311B2 (en) * | 2009-01-09 | 2015-07-28 | Abbott Vascular Inc. | Vessel closure devices and methods |
US9486191B2 (en) | 2009-01-09 | 2016-11-08 | Abbott Vascular, Inc. | Closure devices |
US9414820B2 (en) * | 2009-01-09 | 2016-08-16 | Abbott Vascular Inc. | Closure devices, systems, and methods |
US9173644B2 (en) | 2009-01-09 | 2015-11-03 | Abbott Vascular Inc. | Closure devices, systems, and methods |
US20100185234A1 (en) * | 2009-01-16 | 2010-07-22 | Abbott Vascular Inc. | Closure devices, systems, and methods |
US20100183523A1 (en) | 2009-01-22 | 2010-07-22 | Wagner Richard E | Dental composition and method |
WO2010088678A2 (en) | 2009-02-02 | 2010-08-05 | Cook Biotech Incorporated | Medical bead products |
WO2010096458A1 (en) * | 2009-02-18 | 2010-08-26 | Cormatrix Cardiovascular, Inc. | Compositions and methods for preventing cardiac arrhythmia |
US9277999B2 (en) * | 2009-02-27 | 2016-03-08 | University of Pittsburgh—of the Commonwealth System of Higher Education | Joint bioscaffolds |
WO2010111583A1 (en) | 2009-03-26 | 2010-09-30 | Cook Incorporated | Stent graft |
EP2427141B1 (en) | 2009-05-06 | 2022-08-10 | Hansa Medical Products, Inc. | Self-adjusting medical device |
US20120029556A1 (en) | 2009-06-22 | 2012-02-02 | Masters Steven J | Sealing device and delivery system |
US8956389B2 (en) | 2009-06-22 | 2015-02-17 | W. L. Gore & Associates, Inc. | Sealing device and delivery system |
US8652500B2 (en) | 2009-07-22 | 2014-02-18 | Acell, Inc. | Particulate tissue graft with components of differing density and methods of making and using the same |
US8298586B2 (en) | 2009-07-22 | 2012-10-30 | Acell Inc | Variable density tissue graft composition |
US20110054492A1 (en) * | 2009-08-26 | 2011-03-03 | Abbott Laboratories | Medical device for repairing a fistula |
ES2644599T3 (es) * | 2009-09-02 | 2017-11-29 | Lifecell Corporation | Injertos vasculares procedentes de matrices de tejido acelular |
WO2011031827A2 (en) | 2009-09-09 | 2011-03-17 | Cook Biotech Incorporated | Manufacture of extracellular matrix products using supercritical or near supercritical fluids |
US8663086B2 (en) | 2009-09-28 | 2014-03-04 | Cook Biotech Incorporated | Medical reinforcement graft |
US8716438B2 (en) | 2009-10-09 | 2014-05-06 | University of Pittsburgh—of the Commonwealth System of Higher Education | Matricryptic ECM peptides for tissue reconstruction |
US8846059B2 (en) | 2009-12-08 | 2014-09-30 | University Of Notre Dame | Extracellular matrix adjuvant and methods for prevention and/or inhibition of ovarian tumors and ovarian cancer |
US20110150934A1 (en) * | 2009-12-18 | 2011-06-23 | University Of Notre Dame | Ovarian Tumor Tissue Cell Preparations/Vaccines for the Treatment/Inhibition of Ovarian Tumors and Ovarian Cancer |
US8329219B2 (en) * | 2009-12-22 | 2012-12-11 | Cook Biotech Incorporated | Methods for producing ECM-based biomaterials |
US9814744B2 (en) | 2009-12-22 | 2017-11-14 | University of Pittsburg—Of the Commonwealth System of Higher Education | Decellularized adipose cell growth scaffold |
US8303624B2 (en) * | 2010-03-15 | 2012-11-06 | Abbott Cardiovascular Systems, Inc. | Bioabsorbable plug |
AU2010201676B1 (en) | 2010-04-23 | 2010-07-22 | Cook Medical Technologies Llc | Curve forming stent graft |
WO2011150328A1 (en) | 2010-05-27 | 2011-12-01 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Wet-electrospun biodegradable scaffold and uses therefor |
WO2011156338A2 (en) | 2010-06-07 | 2011-12-15 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods for modeling hepatic inflammation |
US10065046B2 (en) | 2010-07-15 | 2018-09-04 | Fibralign Corporation | Conductive biopolymer implant for enhancing tissue repair and regeneration using electromagnetic fields |
EP2598181B1 (en) | 2010-07-31 | 2021-04-21 | Cook Medical Technologies LLC | Collagenous tissue pocket for an implantable medical device, and manufacturing method therefor |
US8758399B2 (en) | 2010-08-02 | 2014-06-24 | Abbott Cardiovascular Systems, Inc. | Expandable bioabsorbable plug apparatus and method |
US8603116B2 (en) | 2010-08-04 | 2013-12-10 | Abbott Cardiovascular Systems, Inc. | Closure device with long tines |
CA2747610C (en) | 2010-08-13 | 2014-09-16 | Cook Medical Technologies Llc | Precannulated fenestration |
US9101455B2 (en) | 2010-08-13 | 2015-08-11 | Cook Medical Technologies Llc | Preloaded wire for endoluminal device |
US9421307B2 (en) | 2010-08-17 | 2016-08-23 | University of Pittsburgh—of the Commonwealth System of Higher Education | Biohybrid composite scaffold |
EP2608777B1 (en) | 2010-08-24 | 2019-07-24 | The Regents of the University of California | Compositions and methods for cardiac therapy |
US9724308B2 (en) | 2010-09-10 | 2017-08-08 | Fibralign Corporation | Biodegradable multilayer constructs |
EP2621549B1 (en) | 2010-09-28 | 2015-10-21 | Cook Biotech Incorporated | Device for treating fistulae and other bodily openings and passageways |
DE112011102907T5 (de) | 2010-10-01 | 2013-06-20 | Cook Biotech Incorporated | Kits, Komponeten und Verfahren zur Geweberekonstrution |
US9788933B2 (en) | 2010-10-29 | 2017-10-17 | Cook Medical Technologies Llc | Medical device delivery system and deployment method |
US9198787B2 (en) | 2010-12-31 | 2015-12-01 | Cook Medical Technologies Llc | Conformable prosthesis delivery system and method for deployment thereof |
AU2011200858B1 (en) | 2011-02-28 | 2012-04-05 | Cook Medical Technologies Llc | Stent graft with valve arrangement |
US9149276B2 (en) | 2011-03-21 | 2015-10-06 | Abbott Cardiovascular Systems, Inc. | Clip and deployment apparatus for tissue closure |
EP2696908B1 (en) | 2011-04-14 | 2015-03-11 | Lifecell Corporation | Regenerative materials |
US8845719B2 (en) | 2011-05-27 | 2014-09-30 | Cormatrix Cardiovascular, Inc | Extracellular matrix material conduits and methods of making and using same |
SG194878A1 (en) | 2011-05-27 | 2013-12-30 | Cormatrix Cardiovascular Inc | Extracellular matrix material conduits and methods of making and using same |
WO2012170538A2 (en) | 2011-06-06 | 2012-12-13 | Cook Medical Technologies Llc | Vascular occlusion devices and methods |
EP2720619B1 (en) | 2011-06-14 | 2016-10-26 | Cook Medical Technologies LLC | Fistula closure devices |
WO2013010169A1 (en) | 2011-07-14 | 2013-01-17 | Cook Medical Technologies Llc | A sling to be used in the treatment of obstructive sleep apnea |
US9089523B2 (en) | 2011-07-28 | 2015-07-28 | Lifecell Corporation | Natural tissue scaffolds as tissue fillers |
US9770232B2 (en) | 2011-08-12 | 2017-09-26 | W. L. Gore & Associates, Inc. | Heart occlusion devices |
EP2750614B1 (en) | 2011-09-01 | 2015-04-29 | Cook Medical Technologies LLC | Aneurysm closure clip |
US8728148B2 (en) | 2011-11-09 | 2014-05-20 | Cook Medical Technologies Llc | Diameter reducing tie arrangement for endoluminal prosthesis |
US20130138219A1 (en) | 2011-11-28 | 2013-05-30 | Cook Medical Technologies Llc | Biodegradable stents having one or more coverings |
US9332976B2 (en) | 2011-11-30 | 2016-05-10 | Abbott Cardiovascular Systems, Inc. | Tissue closure device |
EP2788038A1 (en) | 2011-12-09 | 2014-10-15 | Acell, Inc. | Hemostatic device |
ES2864104T3 (es) | 2011-12-20 | 2021-10-13 | Lifecell Corp | Productos tisulares laminados |
BR112014014975B1 (pt) | 2011-12-20 | 2019-06-25 | Lifecell Corporation | Produto de tecido, e método para produzir uma composição de tecido |
EP2985007B1 (en) | 2011-12-22 | 2019-11-13 | Cook Medical Technologies LLC | Preloaded wire for endoluminal device |
AU2013212592B2 (en) | 2012-01-24 | 2016-06-30 | Lifecell Corporation | Elongated tissue matrices |
WO2013119630A1 (en) | 2012-02-06 | 2013-08-15 | Cook Medical Technologies Llc | Artificial device deployment apparatus |
EP2811939B8 (en) | 2012-02-10 | 2017-11-15 | CVDevices, LLC | Products made of biological tissues for stents and methods of manufacturing |
US9504458B2 (en) | 2012-02-17 | 2016-11-29 | Cook Biotech Incorporated | Methods and systems for treating complex fistulae |
EP2841116A1 (en) | 2012-04-24 | 2015-03-04 | Lifecell Corporation | Flowable tissue matrices |
BR112015000547B1 (pt) | 2012-07-13 | 2020-11-10 | Lifecell Corporation | método para tratar tecido |
US9308107B2 (en) | 2012-08-27 | 2016-04-12 | Cook Medical Technologies Llc | Endoluminal prosthesis and delivery device |
AU2013323747B2 (en) | 2012-09-26 | 2017-02-02 | Lifecell Corporation | Processed adipose tissue |
US20140121750A1 (en) | 2012-10-31 | 2014-05-01 | Cook Medical Technologies Llc | Fixation Process For Nesting Stents |
US9669190B2 (en) * | 2012-11-28 | 2017-06-06 | Cook Medical Technologies Llc | Selectively positionable catheter cuff |
EP2745813A1 (en) | 2012-12-18 | 2014-06-25 | Cook Medical Technologies LLC | Preloaded wire for endoluminal device |
US9364209B2 (en) | 2012-12-21 | 2016-06-14 | Abbott Cardiovascular Systems, Inc. | Articulating suturing device |
US9861466B2 (en) | 2012-12-31 | 2018-01-09 | Cook Medical Technologies Llc | Endoluminal prosthesis |
US10828019B2 (en) | 2013-01-18 | 2020-11-10 | W.L. Gore & Associates, Inc. | Sealing device and delivery system |
EP3659633A1 (en) | 2013-02-06 | 2020-06-03 | LifeCell Corporation | Methods for localized modification of tissue products |
JP6164782B2 (ja) | 2013-02-08 | 2017-07-19 | アセル,インコーポレイテッド | 細胞外マトリックス材料から生理活性ゲルを製造する方法 |
AU2014214700B2 (en) | 2013-02-11 | 2018-01-18 | Cook Medical Technologies Llc | Expandable support frame and medical device |
AU2013379748A1 (en) | 2013-03-01 | 2015-09-17 | Cormatrix Cardiovascular, Inc. | Two-piece prosthetic valve |
EP2797556B1 (en) | 2013-03-01 | 2018-08-01 | Cormatrix Cardiovascular, Inc. | Anchored cardiovascular valve |
EP2964162B1 (en) | 2013-03-07 | 2018-01-17 | Cook Medical Technologies LLC | Tissue ingrowth intestinal bypass sleeve |
US9993330B2 (en) | 2013-03-13 | 2018-06-12 | Cook Medical Technologies Llc | Endoluminal prosthesis system |
AU2014227794B2 (en) | 2013-03-15 | 2018-03-01 | Cook Biotech Incorporated | Drug eluting graft constructs and methods |
WO2014144370A1 (en) | 2013-03-15 | 2014-09-18 | Cook Biotech Incorporated | Ecm implant compositions and methods |
WO2014178971A1 (en) | 2013-05-03 | 2014-11-06 | Cormatrix Cardiovascular, Inc. | Prosthetic tissue valves and methods for anchoring same to cardiovascular structures |
US10199950B1 (en) | 2013-07-02 | 2019-02-05 | Vlt, Inc. | Power distribution architecture with series-connected bus converter |
US9861662B2 (en) | 2013-07-03 | 2018-01-09 | University of Pittsburgh—of the Commonwealth System of Higher Education | Bone-derived extra cellular matrix gel |
EP3027149B1 (en) | 2013-08-01 | 2019-04-10 | Cook Medical Technologies LLC | Tissue adjustment implant |
US20150080940A1 (en) | 2013-09-13 | 2015-03-19 | Cook Medical Technologies Llc | Anti-tumor macrophage m1 morphology inducer |
US9878071B2 (en) | 2013-10-16 | 2018-01-30 | Purdue Research Foundation | Collagen compositions and methods of use |
AU2013254913B1 (en) | 2013-11-04 | 2014-09-25 | Cook Medical Technologies Llc | Stent graft with valve arrangement |
CN104758089B (zh) | 2014-01-08 | 2018-03-30 | 库克医学技术有限责任公司 | 用于塞住经皮心脏瓣膜泄漏的ecm条带 |
US10286119B2 (en) | 2014-01-24 | 2019-05-14 | University of Pittsburgh—of the Commonwealth System of Higher Education | Extracellular matrix mesh coating |
US10213526B2 (en) | 2014-03-21 | 2019-02-26 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix |
US9808230B2 (en) | 2014-06-06 | 2017-11-07 | W. L. Gore & Associates, Inc. | Sealing device and delivery system |
CN107073172B (zh) | 2014-09-25 | 2021-03-12 | 阿塞尔公司 | 衍生自胞外基质的多孔泡沫、多孔泡沫ecm医疗装置及其使用方法和制造方法 |
US10959826B2 (en) | 2014-10-16 | 2021-03-30 | Cook Medical Technology LLC | Support structure for scalloped grafts |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
US10183152B2 (en) | 2014-12-12 | 2019-01-22 | Cook Medical Technologies Llc | Cinching peritoneal dialysis catheter |
CA2970903C (en) | 2014-12-22 | 2023-09-19 | Aroa Biosurgery Limited | Laminated tissue graft product |
US9238090B1 (en) | 2014-12-24 | 2016-01-19 | Fettech, Llc | Tissue-based compositions |
EP3261584A4 (en) | 2015-02-27 | 2018-10-10 | University of Pittsburgh of the Commonwealth System of Higher Education | Double component mandrel for electrospun stentless, multi-leaflet valve fabrication |
WO2016138423A1 (en) | 2015-02-27 | 2016-09-01 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Retrievable self-expanding non-thrombogenic low-profile percutaneous atrioventricular valve prosthesis |
WO2016172365A1 (en) | 2015-04-21 | 2016-10-27 | Purdue Research Foundation Office Of Technology Commercialization | Cell-collagen-silica composites and methods of making and using the same |
ES2873519T3 (es) | 2015-09-18 | 2021-11-03 | Univ Pittsburgh Commonwealth Sys Higher Education | Matriz extracelular soluble no gelificante con actividad biológica |
US10173027B2 (en) | 2015-10-07 | 2019-01-08 | Cook Medical Technologies Llc | Methods, medical devices and kits for modifying the luminal profile of a body vessel |
US20190046211A1 (en) | 2015-12-02 | 2019-02-14 | Cook Biotech Incorporated | Filamentous graft implants and methods of their manufacture and use |
EP3386558B1 (en) | 2015-12-10 | 2023-10-04 | Cook Biotech Incorporated | Sterilisation methods for a poly(ester urea) fiber material |
EP3423038B1 (en) | 2016-03-02 | 2023-11-01 | University of Pittsburgh- Of the Commonwealth System of Higher Education | Matrix bound nanovesicles and their use |
CA3017747A1 (en) | 2016-03-14 | 2017-09-21 | Regentys Corporation | Method and composition for treating inflammatory bowel disease |
WO2017189986A1 (en) | 2016-04-28 | 2017-11-02 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Compositions comprising extracellular matrix of primitive animal species and related methods |
US10792394B2 (en) | 2016-06-03 | 2020-10-06 | Lifecell Corporation | Methods for localized modification of tissue products |
US20170354500A1 (en) | 2016-06-08 | 2017-12-14 | Cook Medical Technologies Llc | Mitral prolapse valve restrictor |
US10687934B2 (en) | 2016-07-05 | 2020-06-23 | Carlos A. Alvarado | Serous membrane for ocular surface disorders |
CA3010717A1 (en) | 2016-07-11 | 2018-01-18 | Cormatrix Cardiovascular, Inc. | Prosthetic tissue valves |
WO2018017611A1 (en) | 2016-07-18 | 2018-01-25 | Cook Biotech Incorporated | Implantable pouch with segmental lamination structure, and related methods of manufacture and use |
US20180071526A1 (en) | 2016-09-10 | 2018-03-15 | Cook Biotech Incorporated | Electrostimulative graft products, and related methods of use and manufacture |
US10500079B2 (en) | 2016-10-27 | 2019-12-10 | Cook Medical Technologies Llc | Preloaded branch wire loop constraint |
US11191632B2 (en) | 2016-11-10 | 2021-12-07 | Cook Medical Technologies Llc | Temporary diameter reduction constraint arrangement for a stent graft in combination with a stent graft |
EP3320881B1 (en) | 2016-11-10 | 2019-09-04 | Cook Medical Technologies LLC | Diameter reduction constraint arrangement for a stent graft in combination with a stent graft |
EP3558405A1 (en) | 2016-12-22 | 2019-10-30 | LifeCell Corporation | Devices and methods for tissue cryomilling |
US11337799B2 (en) | 2017-02-23 | 2022-05-24 | University of Pittsburgh—of the Commonwealth System of Higher Education | Stentless biopolymer heart valve replacement capable of living tissue regeneration |
AU2018226871B2 (en) | 2017-03-02 | 2023-08-10 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Extracellular matrix (ECM) hydrogel and soluble fraction thereof for the treatment of cancer |
WO2018161028A1 (en) | 2017-03-02 | 2018-09-07 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Ecm hydrogel for treating esophageal inflammation |
US11389569B2 (en) | 2017-04-03 | 2022-07-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Biodegradable, porous, thermally responsive injectable hydrogel as soft tissue defect filler |
US11739291B2 (en) | 2017-04-25 | 2023-08-29 | Purdue Research Foundation | 3-dimensional (3D) tissue-engineered muscle for tissue restoration |
ES2945740T3 (es) | 2017-05-05 | 2023-07-06 | Univ Pittsburgh Commonwealth Sys Higher Education | Aplicaciones oculares de vesículas unidas a matriz (MBV) |
CN111093572A (zh) | 2017-06-29 | 2020-05-01 | 库克医学技术有限责任公司 | 用于重新定位组织的可植入医疗装置 |
US11634716B2 (en) | 2017-10-16 | 2023-04-25 | University of Pittsburgh—of the Commonwealth System of Higher Education | Genetically modified mesenchymal stem cells for use in cardiovascular prosthetics |
CN111201046B (zh) | 2017-10-18 | 2022-06-28 | 生命细胞公司 | 脂肪组织产品以及产生方法 |
US11123375B2 (en) | 2017-10-18 | 2021-09-21 | Lifecell Corporation | Methods of treating tissue voids following removal of implantable infusion ports using adipose tissue products |
US11246994B2 (en) | 2017-10-19 | 2022-02-15 | Lifecell Corporation | Methods for introduction of flowable acellular tissue matrix products into a hand |
ES2960617T3 (es) | 2017-10-19 | 2024-03-05 | Lifecell Corp | Productos de matriz de tejido acelular fluida y métodos de producción |
US11291570B2 (en) | 2018-04-27 | 2022-04-05 | Cook Medical Technologies Llc | Hybrid stent and delivery system |
AU2018214103B1 (en) | 2018-08-09 | 2018-10-04 | Cook Medical Technologies Llc | A stent-graft |
AU2019385332A1 (en) | 2018-11-19 | 2021-05-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Biodegradable tissue replacement implant and its use |
KR20210142003A (ko) | 2019-03-13 | 2021-11-23 | 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 음향 세포외 기질 하이드로겔 및 이의 용도 |
US11633521B2 (en) | 2019-05-30 | 2023-04-25 | Lifecell Corporation | Biologic breast implant |
EP4121073B1 (en) | 2020-03-16 | 2024-07-03 | Biosearch S.A. | Biocomposites comprising probiotics, collagen and bacterial extracellular polysaccharide and uses thereof |
EP4188237A1 (en) | 2020-07-27 | 2023-06-07 | Cook Biotech Incorporated | System and methods for supplying surgical staple line reinforcement |
CN116322809A (zh) | 2020-07-27 | 2023-06-23 | 库克生物技术股份有限公司 | 用于手术缝合线增强的粘合剂 |
US11826490B1 (en) | 2020-12-29 | 2023-11-28 | Acell, Inc. | Extracellular matrix sheet devices with improved mechanical properties and method of making |
CA3220433A1 (en) | 2021-05-28 | 2022-12-01 | Arvydas Maminishkis | Biodegradable tissue scaffold with secondary matrix to host weakly adherent cells |
WO2022251499A1 (en) | 2021-05-28 | 2022-12-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods to generate macular, central and peripheral retinal pigment epithelial cells |
WO2023215885A1 (en) | 2022-05-05 | 2023-11-09 | Cook Biotech Incorporated | Subtissue implant material |
WO2023215883A1 (en) | 2022-05-05 | 2023-11-09 | Cook Biotech Incorporated | Photocrosslinkable synthetic polymers |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT261800B (de) * | 1966-08-22 | 1968-05-10 | Braun Internat Gmbh B | Verfahren zur Herstellung von röhrenförmigen, glatten bzw. mit einem Gewinde versehenen Gewebe-Blutgefäß-Prothesen |
US4502159A (en) * | 1982-08-12 | 1985-03-05 | Shiley Incorporated | Tubular prostheses prepared from pericardial tissue |
-
1988
- 1988-07-11 US US07/217,299 patent/US4902508A/en not_active Expired - Lifetime
-
1989
- 1989-06-15 IL IL9062289A patent/IL90622A/en unknown
- 1989-06-15 ZA ZA894551A patent/ZA894551B/xx unknown
- 1989-06-23 WO PCT/US1989/002776 patent/WO1990000395A1/en active IP Right Grant
- 1989-06-23 EP EP89908901A patent/EP0424463B1/en not_active Expired - Lifetime
- 1989-06-23 JP JP1508210A patent/JP2539934B2/ja not_active Expired - Lifetime
- 1989-06-23 AT AT89908901T patent/ATE112963T1/de not_active IP Right Cessation
- 1989-06-23 KR KR1019900700514A patent/KR0131821B1/ko not_active IP Right Cessation
- 1989-06-23 BR BR898907538A patent/BR8907538A/pt not_active IP Right Cessation
- 1989-06-23 CH CH902/90A patent/CH681506A5/de not_active IP Right Cessation
- 1989-06-23 HU HU894789A patent/HU207448B/hu not_active IP Right Cessation
- 1989-06-23 DE DE68918943T patent/DE68918943T2/de not_active Expired - Lifetime
- 1989-06-23 CH CH3792/91A patent/CH681856A5/de not_active IP Right Cessation
- 1989-06-27 AU AU37091/89A patent/AU613499B2/en not_active Expired
- 1989-06-30 PH PH38883A patent/PH26921A/en unknown
- 1989-07-03 NZ NZ229797A patent/NZ229797A/xx unknown
- 1989-07-06 MX MX016707A patent/MX171671B/es unknown
- 1989-07-07 CA CA000605031A patent/CA1335432C/en not_active Expired - Lifetime
- 1989-07-07 PT PT91096A patent/PT91096B/pt not_active IP Right Cessation
- 1989-07-10 DK DK198903405A patent/DK175719B2/da not_active IP Right Cessation
- 1989-07-10 ES ES8902418A patent/ES2019146A6/es not_active Expired - Lifetime
- 1989-07-10 CN CN89104864A patent/CN1018893B/zh not_active Expired
- 1989-07-11 IE IE222289A patent/IE67279B1/en not_active IP Right Cessation
- 1989-07-11 AR AR89314366A patent/AR244539A1/es active
-
1990
- 1990-12-21 OA OA59928A patent/OA09633A/en unknown
-
1991
- 1991-01-09 FI FI910113A patent/FI910113A0/fi unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK175719B1 (da) | Vævstransplantationsmateriale | |
US4956178A (en) | Tissue graft composition | |
US5131908A (en) | Tubular prosthesis for vascular reconstructive surgery and process for preparing same | |
US4990131A (en) | Tubular prostheses for vascular reconstructive surgery and process for preparing same | |
Huynh et al. | Remodeling of an acellular collagen graft into a physiologically responsive neovessel | |
Badylak et al. | Small intestinal submucosa as a large diameter vascular graft in the dog | |
US5879383A (en) | Blood contact surfaces using endothelium on a subendothelial matrix | |
US11648011B2 (en) | Luminal grafts and methods of making and using the same | |
JPH09512463A (ja) | 天然内皮下基質を利用した改善された血液接触表面並びにその製造及び利用方法 | |
JPH03198846A (ja) | 人工血管とその製造方法及び人工血管用基質 | |
US20080268017A1 (en) | Method of producing tissue by placing a molding support within a body cavity | |
KR102659840B1 (ko) | 생체 유래 조직의 시트, 상기 시트에서 얻은 관상 구조체 및 상기 관상 구조체로 이루어진 인공 혈관 | |
RU2037317C1 (ru) | Тканевый трансплантат | |
Noishiki et al. | Development and evaluation of a pliable biological valved conduit. Part I: preparation, biochemical properties, and histological findings | |
Hess et al. | Evaluation of the patency rate of fibrous microvascular polyurethane prostheses after implantation in the rat aorta | |
JP2010221012A (ja) | 高張電解質溶液による生体組織の脱細胞化処理方法 | |
RU2633544C1 (ru) | Способ изготовления клапансодержащего кондуита из яремной вены крупного рогатого скота | |
Jarrell et al. | Perspectives in vascular surgery--biocompatible vascular surfaces: the past and future role of endothelial cells. | |
RU2797632C1 (ru) | Способ изготовления сосудистого трансплантата из вены пупочного канатика человека | |
US20040126404A1 (en) | Implant material | |
Sembiring et al. | Comparative Assessment of Various Concentration and Exposure Time of Sodium Dodecyl Sulfate as Decellularization Agents for Small-Vessels Vascular Tissue Engineering | |
JP2008517684A (ja) | 血管及び尿道の移植片を調製するためのヒアルロン酸誘導体を基礎としたチューブ構造 | |
Sembiring et al. | Comparative Assessment of Various Concentration and Exposure Time of Sodium Dodecyl Sulfate as Decellularization Agents for Small-Vessels Vascular Tissue Engineering. Open Access Maced J Med Sci. 2022 Jun 28; 10 (B): 1-9 | |
Popryadukhin et al. | Double layer tissue-engineered vascular graft of small diameter based on electrospun polylactide and fluoropolymer microfibers | |
Ilanloua et al. | https://pubmed. ncbi. nlm. nih. gov/30920157 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PPF | Opposition filed | ||
PUP | Patent expired |