US20050273119A1 - Double spiral patent foramen ovale closure clamp - Google Patents

Double spiral patent foramen ovale closure clamp Download PDF

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Publication number
US20050273119A1
US20050273119A1 US11008539 US853904A US2005273119A1 US 20050273119 A1 US20050273119 A1 US 20050273119A1 US 11008539 US11008539 US 11008539 US 853904 A US853904 A US 853904A US 2005273119 A1 US2005273119 A1 US 2005273119A1
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connecting member
device
wire
wires
pfo
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Abandoned
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US11008539
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David Widomski
Carol Devellian
Morris Simon
Morris (Mrs.)
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Gore W L and Associates Inc
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NMT Medical Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00526Methods of manufacturing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00579Barbed implements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00592Elastic or resilient implements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00606Implements H-shaped in cross-section, i.e. with occluders on both sides of the opening
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831Material properties
    • A61B2017/00867Material properties shape memory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A61B2017/0412Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors having anchoring barbs or pins extending outwardly from suture anchor body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A61B2017/0427Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors having anchoring barbs or pins extending outwardly from the anchor body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06166Sutures
    • A61B2017/06176Sutures with protrusions, e.g. barbs

Abstract

The present invention provides a device which is adapted to press together the septum primum and the septum secundum between the atrial chambers to close any tunnel in the septum. The device in its preferred form has two clamping members, one on each side of the septum and a central connector which connects the two clamping members and passes through the tunnel. The device is configured to conform to the anatomy such that the tunnel is not substantially deformed by the device. The central connector, in its preferred form has two wires that are spaced apart so that the wires are proximate the lateral sides of the tunnel. The spacing allows the device to be centered at an appropriate location.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • This application claims priority to provisional patent application 60/528,022 filed Dec. 9, 2003.
  • FIELD OF THE INVENTION
  • The present invention relates to devices and methods which are used to close septal openings. In particular, this invention is directed to devices and methods which are used to close a patent foramen ovale (PFO) in the septum between the left atrium and right atrium.
  • BACKGROUND OF THE INVENTION
  • A PFO, illustrated in FIGS. 1 and 2, is a persistent, one-way, usually flap-like opening in the wall between the right atrium and left atrium of the heart. Because left atrial (LA) pressure is normally higher than right atrial (RA) pressure, the flap usually stays closed. Under certain conditions, however, right atrial pressure can exceed left atrial pressure which creates the possibility that blood could pass from the right atrium to the left atrium and allow blood clots to enter the systemic circulation. It is desirable that this circumstance be reduced.
  • The foramen ovale serves a desired purpose when a fetus is gestating in utero. Since blood is oxygenated through the umbilical chord, and not through the developing lungs, the circulatory system of a heart in a fetus allows the blood to flow through the foramen ovale as a physiologic conduit for right-to-left shunting. After birth, with the establishment of pulmonary circulation, the increased left atrial blood flow and pressure results in functional closure of the foramen ovale. This functional closure is subsequently followed by anatomical closure of the two over-lapping layers of tissue the septum secundum 14 and septum primum 15. However, a PFO has been shown to persist in a number of adults.
  • The presence of a PFO is generally considered to have no therapeutic consequence in otherwise healthy adults. However, patients suffering a stroke or transient ischemic attack (TIA) in the presence of a PFO and without another cause of ischemic stroke paradoxical embolism via a PFO is considered in the diagnosis. While there is currently no proof for a cause-effect relationship, many studies have confirmed a strong association between the presence of a PFO and the risk for paradoxical embolism or stroke. In addition, there is good evidence that patients with PFO and paradoxical embolism are at increased risk for future, recurrent cerebrovascular events.
  • Accordingly, patients with an increased future risk are considered for prophylactic medical therapy to reduce the risk of a recurrent embolic event. These patients are commonly treated with oral anticoagulants, which have the potential for adverse side effects, such as hemorrhaging, hematoma, and interactions with a variety of other drugs. The use of these drugs can alter a person's recovery and necessitate adjustments in a person's daily living pattern.
  • In certain cases, such as when anticoagulation is contraindicated, surgery may be necessary or desirable to close the PFO. The surgery would typically include suturing a PFO closed by attaching the septum secundum to the septum primum. This sutured attachment can be accomplished with either an interrupted or a continuous stitch and is a common way a surgeon shuts a PFO under direct visualization.
  • Umbrella devices and a variety of other similar mechanical closure designs, developed initially for percutaneous closure of atrial septal defects (ASDs), have been used in some instances to close PFOs. These devices have the potential to allow patients to avoid the potential side effects often associated with anticoagulation therapies and the risks of invasive surgery. However, umbrella devices and the like which are designed for ASDs are not optimally suited for use as a PFO closure device.
  • Currently available designs of septal closure devices present drawbacks, including that the implantation procedure is technically complex. Additionally, there are not insignificant complication rates due to thrombus, fractures of the components, conduction system disturbances, perforations of heart tissue, and residual leaks. Many devices have high septal profile and may include large masses of foreign material which may lead to unfavorable body adaptation of a device. Since ASD devices are designed to occlude a hole, many lack anatomic conformability to the PFO flap-like anatomy. That is, when inserting an ASD into the heart to close a PFO, the narrow opening and the thin flap may form impediments to proper deployment. Even if an occlusive seal is formed, the device may be deployed in the heart on an angle which could leave some components not securely seated against the septum. Finally, some septal closure devices are complex to manufacture, which may result in lack of consistency in product performance.
  • Nitinol (an alloy of nickel and titanium) is known to be used in medical devices because of its biocompatablity and, especially, its unique properties. Nitinol is a member of a class of materials which exhibit shape memory characteristics. Specifically, nitinol has the ability to “remember” a shape and, after being deformed, will return to that shape once a certain temperature is reached. Hence, nitinol has been used to create medical devices that have a desired configuration in the body, e.g., a vena cava filter. The device is deformed into a delivery configuration (generally a reduced profile for delivery through a catheter). Once the device is delivered to the desired site, the nitinol changes configuration into the desired shape upon achieving a certain temperature. This is generally considered thermal responsive shape memory. Nitinol, and other materials, also exhibit superelastic shape memory. In this case, the nitinol can be restrained in a delivery configuration and then will return to the desired configuration as the device leaves the delivery catheter. Of course, some devices can be a combination of thermally induced shape memory and superelastic shape memory.
  • The present invention is designed to address these and other deficiencies of the prior art septal closure devices.
  • SUMMARY OF THE INVENTION
  • The present invention provides a device which is adapted to press together the septum primum and the septum secundum between the atrial chambers to close any tunnel in the septum. The device in its preferred form has two clamping members, one on each side of the septum and a central connector which connects the two clamping members and passes through the tunnel. The device is configured to conform to the anatomy such that the tunnel is not substantially deformed by the device. The central connector, in its preferred form has two wires that are spaced apart so that the wires are proximate the lateral sides of the tunnel. The spacing allows the device to be centered at an appropriate location.
  • In a preferred form of the device, the clamping members are spirals which are formed from nitinol. The spirals may be constructed of wire, or alternatively, may be constructed of nitinol sheets which have been cut or shaped to form the spirals. The spirals may circle around more or less than 360 degrees and may have the a helical form. In one preferred embodiment the connector may be attached to the inner end of the wire that forms the spiral, in another, the connector may be attached to the outer end of the wire that forms the spiral. Of course, depending on the desired configuration, the connector may be connected to the inner location on one side of the device and the outer location on the other side of the device.
  • The clamping member may be a spiral or some other structure or configuration which secures the septum together. For example, a plurality of wires may be used which could be spread out along the septum to provide the desired clamping force. Other shapes and orientations could be used which would spread the clamping force over a sufficient surface area to accomplish the desired effect.
  • The connecting member may be two or more wires which are configured to spread apart in the PFO tunnel. The spacing of the wires is sized to center the device in the desired clamping location in the septum. In one preferred embodiment, the wires are joined at ends and bow apart from each other to fit within the PFO tunnel. Alternatively, the wires may form an S-shaped curve to improve the centering location. Other shapes and configurations are possible.
  • In an alternate form the connecting member may be formed of thin wires that are wound into a helix (e.g., in the shape of a coil spring). The connecting member may have one or more helically wound wires that form the connecting member. The resultant connector may be shaped in the same manner as the other embodiments. In other embodiments, the connecting member may have an abrasive surface so that a healing response may be stimulated by the abrasive surface. Additionally, the abrasive surface may be directionally oriented. That is, if one were to feel the surface of the wire in one direction, the wire would feel smooth and in the other direction, the wire would feel abrasive or rough.
  • In still other embodiments, the connecting member may include a film which extends between the connecting wires. The film may be comprised of and/or impregnated with biological and/or bioresorbable material. In another embodiment a joint may be formed at a location along the length of the connecting member. The joint reduces the trauma of the closure device within the PFO. The device may also have a hook or some other piercing element to maintain the PFO closure device in the desired location. Of course, each of the configurations could be used in combination.
  • The device, in its preferred form, is adapted to be delivered through a catheter into the atria. The device is constrained into a delivery profile and introduced into a catheter for delivery to the heart. Once the catheter is located at the desired delivery site, the device is deployed into the site and changes shape into the desired configuration. The shape change could be a result of a thermally induced shape change or a change due to the superelastic character of the material. Once in the delivery location, the catheter is withdrawn.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a front elevational view from the left atrium of the atrial septum with patent foramen ovale (PFO);
  • FIG. 2 is a cross-sectional view of the atrial septum of FIG. 1;
  • FIG. 3 is a bottom plan view of the double spiral patent foramen ovale closure clamp of the present invention showing the connecting central loop;
  • FIG. 4 is a view in side elevation of the double spiral PFO closure clamp of FIG. 3;
  • FIG. 5A-5G show the steps for inserting the double spiral PFO closure clamp of FIGS. 3 and 4;
  • FIG. 6 is a front elevational view from the left atrium of the double spiral PFO closure clamp in place with the central loop in the PFO channel;
  • FIG. 7 is a cross-sectional view of the atrial septum and double spiral PFO closure clamp of FIG. 5;
  • FIG. 8 is a perspective view of a jig for forming the double spiral PFO closure clamp of the present invention; and
  • FIG. 9 is a top plan view of the jig of FIG. 7 with spiral sections of the double spiral PFO closure clamp of the present invention wound thereon.
  • FIG. 10 is a view in side elevation of a second embodiment of the double spiral PFO closure clamp of the present invention;
  • FIG. 11 is a front elevational view from the right atrium of the double spiral PFO closure clamp of FIG. 10;
  • FIG. 12 is a front elevational view from the left atrium of the double spiral PFO closure clamp of FIG. 10;
  • FIG. 13 is a view in front elevation of a second embodiment of a central connector for a PFO closure clamp of FIG. 10;
  • FIGS. 14A and 14B are a plan view and a view in side elevation, respectively of a jig for forming the double spiral PFO closure clamp of FIG. 10 with the central connector of FIG. 13;
  • FIGS. 15A and 15B are a plan are a plan view and a side elevation view, respectively, of the jig of FIGS. 14A and 14B with the left atrial spiral section of the double spiral PFO closure clamp of FIG. 10 and with one half of the central connector of FIG. 13 formed thereon;
  • FIGS. 16A and 16B are a plan view and a view in side elevation, respectively, of the jig of FIGS. 14A and 14B with the right atrial spiral section of the double spiral PFO closure clamp of FIG. 10 and with one half of the central connector of FIG. 13 formed thereon;
  • FIGS. 17A and 17B are a plan view and a side elevation view, respectively, of an expanded double spiral PFO closure clamp of FIG. 10 with one half of the central connector for FIG. 13;
  • FIGS. 18A and 18B are alternative embodiments of a center joint of the present invention using helically wound wire;
  • FIGS. 19A-19F are alternative embodiments of a center joint of the present invention using special surface preparations;
  • FIG. 20 is an alternative embodiment of a center joint of the present invention using a membrane;
  • FIGS. 21A and 21B are alternative embodiments of a center joint of the present invention using a flexible joint; and
  • FIGS. 22A and 22B are alternative embodiments of a center joint of the present invention in which piercing wires are used to secure the device at the desired location.
  • DESCRIPTION OF THE PREFERRED EMBODIMENT
  • With reference to FIGS. 1 and 2, the atrial septum 10 divides the left atrium and right atrium of the heart. The patent foramen ovale (PFO) channel 12 extends between the left and right atria and is closed by a flap 14 and 15. Due to the overlap of the septum primum over the septum secundum, the PFO channel or tunnel extends substantially parallel to the surface of the atrial septum. The anatomical structure presents a problem when attempts are made to use conventional septal occluders with opposed, spaced, parallel sections (possibly spiral) are joined by a straight wire or bridge which is substantially perpendicular to the planes of engagement between the sections and the atrial septum. The straight wire or bridge deforms the channel 12 and often prevents proper closure even when the septum primum and the septum secundum are biased toward one another by the spiral sections of the occluder.
  • Referring to FIGS. 3-7, the double spiral PFO closure clamp of the present invention indicated generally at 16 includes a left atrial spiral section 18 and an opposed right atrial spiral section 20 which are joined by an inclined central loop 22. The loops of each spiral extend progressively outward from the base loop in different planes, and the innermost loops 26 of the two spiral sections 18 and 20 are connected by the inclined central loop 22. The outermost free ends 28 of the base loops 24 are provided with protective balls 30.
  • With continued reference to FIGS. 3-7, in a preferred embodiment, the spirals that are disposed on each side of the septum and press against the septum with sufficient force to stabilize the device in the desired location. As illustrated, inner loops are connected and the outer loops are configured to compress against the septum. In an alternative configuration, not illustrated, the outer loops may be connected and the inner loops may be configured to press against the septum. In each embodiment, the center joint is configured to connect the loops and, according to several embodiments, the center joint is configured to center the device in the desired delivery location because the center joint is configured to spread out within the PFO tunnel and, as a result, become centered within the PFO tunnel.
  • The ball 30 of the right atrial spiral section 20 may be grasped and drawn into a protective sheath. As the free end 28 of the right atrial spiral section is drawn inwardly into the protective sheath, the coils of the spiral section straighten as they are drawn into the sheath until the inclined central loop 22 is reached. Then as the central loop enters the sheath, the sides of the central loop are compressed together, and as the central loop is enclosed by the sheath and moves inwardly, it draws the loops of the left atrial spiral section 18, beginning with the innermost loop 26, as a straight section into the sheath.
  • FIG. 5A shows the double spiral PFO closure clamp in straightened form enclosed by sheath 32. The tip of the sheath may be curved to assist the recovery of the curved loops of the double spiral PFO closure clamp. Here, the sheath is inserted through the PFO channel 12 from the right atrium into the left atrium, and the left atrium, and in FIG. 5B, a wire 34 connected within the sheath to the free end 28 of spiral section 20 forces the spiral section 18 out of the sheath so that it is deployed in the left atrium. Subsequently, as shown in FIG. 5C, the sheath and wire 34 are withdrawn toward the right atrium to draw the spiral section 18 against the atrial septum 10.
  • In FIG. 5D, after the inclined central loop 22 has been positioned within the sheath 32 in the PFO channel 12, the sheath is withdrawn to deploy and seat the inclined central loop in the PFO channel. Then, as shown in FIG. 5E, the wire 34 ejects the spiral section 20 into the right atrium against the atrial septum. In FIG. 5F, the wire 34 is released from the free end of the spiral section 20, and in FIG. 5G, the sheath 32 and wire 34 are withdrawn.
  • The spiral sections 18 and 20 are formed to be urged toward one another. Also, since the loops of each opposed spiral section 18 and 20 are in different planes and since the inclined central loop 22 joins the innermost loops 26 of each spiral section, the spiral section 18 will draw the spiral section 20 against the atrial septum once it is deployed from sheath 32.
  • FIGS. 6 and 7 show the double spiral PFO closure clamp 16 in place with the inclined central loop 22 seated in the PFO channel. The spiral sections 18 and 20 are not aligned but are offset so that the inclined central loop follows the PFO channel and does not deform the channel 12. However, enough of the two spiral sections overlap so that the septum primum and the septum secundum are engaged thereby and biased to a closed position.
  • Since the inclined central loop 22 which joins the spiral sections 18 and 20 is seated in the PFO channel, it prevents shift or rotation of the spiral sections which might occur if a straight non-looped joined piece was used between the spiral sections.
  • FIGS. 8 and 9 disclose a jig 36 used to manufacture the double spiral PFO closure clamp 16. The jig includes two stepped cone shaped sections 38 and 40 which are each used to form one of the spiral sections 18 or 20 and one half of the inclined central loop 22. Each stepped cone shaped section includes a plurality of arcuate sections 42, 44, 46, and 48 of progressively decreasing size which terminate at a small, circular projection 50. The front faces 52, 54, 56, and 58 of each of the arcuate sections is flat and supports an inclined mandrel 60 having an arcuate side 62. The arcuate side 62 faces left on the cone shaped section 38 and right on the cone shaped section 40. The front faces 52 and 58 support projecting pins 64 and 66 respectively positioned above and below the arcuate side of the mandrel 60.
  • To form the double spiral PFO closure clamp 16, an elongate length of wire is formed upon each of the cone shaped sections 38 and 40 as shown in FIG. 9. Each of these lengths of wire 68 and 70 are preferably formed of shape memory material such as nitinol and are annealed after being wound in place on the stepped, cone shaped sections 38 and 40. The wire is wound clockwise on the cone shaped section 38 and counter-clockwise on the cone shaped section 40. Each length of wire begins at starting pin 72 and extends around the projecting pin 64 and the arcuate side 62 to the projecting pin 66. The wire extends behind the projecting pin 66 and around the circular projection 50. At the flat face 58, the wire drops and extends around the arcuate section 48 to the flat face 56 where the wire drops again to extend around the arcuate section 44, and at the flat face 52, the wire drops to extend around the arcuate section 42 to a terminal post 74. Thus the two spiral sections 18 and 20 of FIG. 4 are formed. Once the two wire sections are processed on the jig 36, they are removed from the core shaped sections 38 and 40 and one is inverted and rotated relative to the other so that the inclined, arcuate wire sections formed on the mandrels 60 may be welded together to form the inclined central loop 22. Now the free ends of each wire section which were held by the terminal pins 74 are provided with the protective balls 30.
  • With reference to FIGS. 10-12, a second embodiment of the double spiral PFO closure clamp of the present invention is indicated generally at 76. The double spiral PFO closure clamp 76 includes a right atrial spiral section 78 to contact the right side of the septum and an opposed left atrial spiral section 80 to contact the left side of the septum. These two spiral sections are joined by an inclined central loop 82 which rests in the PFO channel 12. Unlike the offset atrial spiral sections 18 and 20 of the PFO closure clamp 16, the atrial spiral sections 78 and 80 of the PFO closure clamp 76 are directly opposed in substantial alignment when they are deployed against the atrial septum. This is facilitated by connecting the large, outermost loop of each atrial spiral section to the inclined central loop 82.
  • As shown by FIG. 11, the outermost loop 84 of the right atrial spiral section 78 is connected to the bottom of the central loop 82 at 86, and curves upwardly over the septum and then inwardly to form the smaller inner loops of the right atrial spiral section. These inner loops terminate at an innermost free end 88 provided with a protective ball 30.
  • To form the left atrial spiral section 80 in opposed alignment with the right atrial spiral section, the outermost loop 90 is connected to the top of the central loop 82 at 92 as shown by FIG. 12. The outermost loop 90 then curves downwardly over the septum and then inwardly to form the inner loops of the left atrial spiral section. These inner loops terminate at an innermost free end 94 provided with a protective ball 30.
  • The outermost loops 84 and 90 are configured to position the left atrial spiral section and right atrial spiral section in aligned, opposed relationship.
  • Instead of connecting the two spiral sections 78 and 80 with a central loop which rests in the PFO channel, the central loop can be replaced with the double “S” shaped connector 96 of FIG. 13. This connector has rounded side surfaces 98 and 100 which engage the sides of the PFO channel, but the connections 86 and 92 with the outer loops 84 and 90 of the spiral sections 78 and 80 are oriented in opposite directions by the configuration of the connector. Thus forces on the connector from the spirals which would tend to cause shifting of a round central loop are offset to oppose shifting of the connector.
  • FIGS. 14A and 14B, 15A and 15B, 16A and 15B, and 17A and 17B show the manner in which the double spiral PFO closure clamp 76 with the double “S” shaped connector 96 is formed. A split jig 102 is used to form both the right atrial spiral section 78 and the left atrial spiral section 80. The jig includes two spaced stepped sections 104 and 106 having opposed arcuate steps which progressively decrease in size. Between the stepped sections are formed to form the double “S” shaped connector 96. These forms include a pin 108 which projects adjacent to a round form 110. This round form 110 contacts a second round form 112 which is adjacent to a second projection pin 114. Spaced from but adjacent to the round forms 110 and 112 are two spaced arcuate forms 116 and 118. Centered between the arcuate forms 116 and 118 is a round form 120. Wire end retaining screws 122, 124, and 126 are positioned outwardly from the stepped sections 104 and 106.
  • With reference to FIGS. 15A and 15B, the left atrial spiral section 80 and one half of the double “S” shaped connector 96 are formed by winding wire in a clockwise direction on the stepped sections 104 and 106. Beginning at the wire end retaining screw 124, the wire is passed around the pin 108 and across the round forms 110 and 112 and then around the form 112 and back to the round form 120. The wire is then brought around the round form 120 and then around the arcuate form 116 to the pin 114 to form one half of the double “S” shaped connector 96. From the pin 114, the wire is wound in a clockwise direction from the bottom to the top of the stepped sections 104 and 106 and is then secured to the wire end retaining screw 126. When the wire is thermal shape memory wire, it is annealed in place before the left atrial spiral section is removed from the jig 102.
  • As shown in FIGS. 16A and 16B, the right atrial spiral section 78 is formed in the reverse manner and is wound counter clockwise on the stepped sections 104 and 106. Beginning at the wire end retaining screw 124, the wire is passed around the pin 114, the round forms 112 and 110, the round form 120 and an arcuate form 118 to the pin 108 to form the remaining half of the double “S” shaped connector 96. The wire is then wound in a counter clockwise direction from the bottom to the top of the stepped sections 104 and 106 and is then passed to the wire end retaining screw 126.
  • FIGS. 17A and 17B show the manner in which the two atrial spiral sections 78 and 80 are joined to form the double spiral PFO closure clamp 76. The two atrial spiral sections are oriented back to back to form the double “S” shaped connector 96, and are secured together at 128 and 130.
  • The double spiral PFO closure clamp 76 can be straightened with a tubular delivery device for delivery and may be delivered across the PFO by catheter using a pusher wire. The left atrial spiral section 80 is delivered first into the left atrium and flattened against the septum. The central double “S” shaped connector 96 is then unsheathed in the PFO channel, and finally the right atrial spiral section 78 is released against the septum in the right atrium.
  • FIGS. 18A and 18B illustrate another embodiment of the center joint of the present invention. In this embodiment, the center joint is constructed of wire which has been wound to form a spiral 200 that connects ends 210 and 220. The spiral wound wire is flexible enough to accommodate a variety of anatomical configurations for the PFO tunnel. In this manner the spiral wound wire will conform to the PFO tunnel and will bend as necessary to allow the ends 210 and 220 to conform to the wall of the septum (not shown in this embodiment). The spirals are illustrate in an exaggerated and open manner. Preferably the wire will be tightly close together and have a small overall diameter. Alternatively, the wire may have a thin wire strand 225 disposed in the helical wire to ensure that the spiral does not expand beyond the length of the wire strand. The wire 225 allows the center joint to be flexible and conform to the PFO tunnel without expanding beyond the longitudinal distance of the wire strand. The ends 210 and 220 are illustrated as the wire elements of the CardioSeal device more specifically described in U.S. Pat. No. 5,629,766 which is incorporated by reference into this specification.
  • FIG. 18B illustrates another embodiment of the center joint with a pair of helically wound wires 230, 240 that form the center joint. Ends 245, 247 of the device that contact the walls of the septum are illustrated as spirals. Of course, one skilled in the art would recognize the that the ends could be in a variety of configurations and dimensions, for example, spiral and CardioSeal configurations. The illustration exaggerates relative dimension of the center joint for clarity. In this embodiment, the center joint wires may also have wire strands 250, 252 disposed with the helically wound wire similar to the wire described in connection with FIG. 18A. In this embodiment, the strands 250, 252 may have a bent configuration, such as illustrated so that the center joint is disposed at the desired (e.g., centered) location.
  • FIGS. 19A-19F illustrate various configuration of the center joint which may be used with a PFO closure device. In these illustrations, the center joint is illustrated without the ends. That is, only the portion that would be disposed within and next to the PFO tunnel is illustrated. The ends (not illustrated) would be connected at the locations identified by reference numberal 26. In these embodiments, different treatments are provided to the wires which assist in the positioning device and healing of the septum once the device is delivered. FIG. 19A illustrates two wires 260, 262 which are configured in an oval shape and are provided with a surface treatment which roughens the surface of the wires. FIG. 19B illustrates a magnified view of the wire 262 and shows bumps or roughness 264 on the wire. A variety of surface treatments may cause the roughness, for example, the wire may be electro-coated with a material that has a rougher surface. Alternatively, a mechanical knurling process may be used to roughen the surface. Finally, for example, the extrusion process of the wire manufacture may be modified to create a rough surface instead of a smooth. The rough surface may be randomly rough, as illustrated, or the rough surface may have a pattern, as would be typically achieved by a knurling or extrusion process. A rough surface in the center joint may provide certain advantages, for example, the rough surface may assure the center joint stays in place. Additionally, the roughened wires may stimulate a healing response by “irritating” the PFO tunnel in a manner that stimulates the body to heal and close the PFO tunnel.
  • Other configurations for the wires of the center joint are possible. FIGS. 19C and 19D illustrate an alternative treatment of the wire. FIG. 19C shows the wires 270 and 272 which are adapted to be delivered into the PFO tunnel and the wires include a roughness that is different in one direction than the other. That is, if one were to run the wire between a thumb and an index finger in one direction, it would be relatively smooth and in the other direction, it would feel more rough. FIG. 19D illustrates the directional “quills” 275 which provide a smooth surface (downward as illustrated) and a rough surface (in the upward direction as illustrated). The direction of the quills may be configured to allow for convenient placement of the device within the PFO and for improved resistance to movement. The quills may be placed on the device in a variety of methods including a post extrusion process or directional knurling.
  • In another configuration, illustrated in FIGS. 19E and 19F, the quills are provided having opposed direction. In this embodiment, the wires 280 and 282 have quills 284 which are directed toward the center of the center joint. Similarly, the quills 285, on the other side of the center joint, are also directed toward the center of the center joint. This configuration may allow for improved stability within the PFO once delivered. In each of the embodiments, the healing response may be improved using roughened or quilled surfaces for the center joint.
  • FIG. 20 illustrates yet another configuration for the center joint that includes a fabric or mesh. The center joint is formed by wires 290 and 292, a mesh or fabric 294 is secured to the wires using a variety of known techniques. The mesh itself could be a biological material that stimulates a biological response. Alternatively, the mesh may be impregnated with a chemical or biological agent that may stimulate a biological healing response. Finally, the mesh could be the vehicle to deliver an agent to the PFO tunnel.
  • FIGS. 21A and 21B also illustrate alternative embodiments of the center joints which provide improved movement within the PFO tunnel for the center joint. Specifically, as illustrated in FIG. 21A, a “trailer hitch” design is used to improve the ability of the wires to conform within the PFO tunnel. Wires 300, 310 form a single wire center joint and are connected by a “trailer hitch” connection 320. The connection is configured to allow improved movement of the wires so that the ends (not illustrated) can conform to the septal walls without unnecessary stress. In a modification of the embodiment illustrated in FIG. 21A is shown in FIG. 21B. In the embodiment illustrated, the wires 330 and 332 are joined at end 26, which as in the other embodiments, will secure the end wire configuration that secures against septum. Similarly, the 334 and 336 are joined at the other side of the center joint. A pair of “trailer hitch” connections 338 and 340 are used to allow the movement of the wires in the center joint. The use of connection 338 and 340 may provide for sufficient flexibility to allow for thicker, more stable wires to be used as the center joint. The use of thicker, stiffer wires may allow for greater resistance from movement for the center joint.
  • In the embodiment of the invention illustrated in FIG. 22A the wires that form the oval connection provide a length of wire that could pierce into the septal tissue to secure the center joint in the desire location and, as a result, stabilize the PFO closure device. In the embodiment illustrated, wires 340 and 342 are joined to wires 344 and 346, respectively. The joints 348 and 350 may be welds or other joints that allow for the reduced profile that is desirable for delivery through a catheter. The ends 352, 354, 356 and 358 are designed to pierce the septum and allow for the improved stability described above.
  • In a slightly modified configuration, the wires may be provided that are in a configuration illustrated in FIG. 22B. In this embodiment, joints 360 and 362 provide for the connection between the wires 364-370. The wires, as illustrated, have a shape that provides the greatest longitudinal width at the joint. This has the benefit of being able to keep the center joint centered within the PFO. In each of the embodiments described in connection with FIGS. 22A and 22B, the closure device is secured by the piercing elements. The wires can be constructed of a metal or a polymer, and have a circular cross-section or some other form such as a rectangle or polygon.

Claims (35)

  1. 1. A device adapted to press together the septum primum and the septum secundum between the atrial chambers, the device comprising:
    two clamping members, one on each side of the septum and a central connector which connects the two clamping members and passes through the tunnel wherein the central connector includes two wires that are spaced apart at a portion of their length so that the wires are proximate the lateral sides of the tunnel so that the device may be centered in a passage between the atrial chambers.
  2. 2. The device of claim 1 wherein at least one of the clamping members include elongate wire members that are spiral shaped.
  3. 3. The device of claim 2, wherein the central connector is connected to at least one clamping member at an inner part of the spiral shape.
  4. 4. The device of claim 2, wherein the central connector is connected to at least one clamping member at the outer part of the spiral shape.
  5. 5. The device of claim 2, wherein the force applied to the septum primum and septum secundum is created by the spiral shape of the elongate member.
  6. 6. The device of claim 1 wherein the clamping members are formed from nitinol.
  7. 7. The device of claim 1, wherein the central connector is formed from nitinol.
  8. 8. The device of claim 1, wherein the central connector is adapted to center the device in the lateral direction along a longitudinal passageway.
  9. 9. The device of claim 2, wherein the claimping members are constructed of nitinol sheets which have been shaped to form the spirals.
  10. 10. The device of claim 2 wherein the spirals circle around more than 360 degrees.
  11. 11. The device of claim 10 wherein the spirals have a helical form.
  12. 12. The device of claim 1, wherein the clamping members are formed by a plurality of wires and the wires are adapted to spread out along the septum to provide a desired clamping force.
  13. 13. A connecting member for a PFO closure device configured to join two end pieces adapted to be disposed along a Patent Foramen Ovale tunnel, the connecting member comprising at least one wire that forms an S shaped curve wherein the outermost lateral sides of the S shaped curves are configured to be adjacent the lateral sides of the Patent Foramen Ovale tunnel.
  14. 14. The connecting member for a PFO closure device of claim 13 wherein the connecting member includes a wire that is helically wound to minimize trauma to the PFO tissue.
  15. 15. The connecting member for a PFO closure device of claim 14 wherein the connecting member includes a helically wound wire wrapped around a central wire that provides stability to the connecting member.
  16. 16. The connecting member for a PFO closure device of claim 13 wherein the connecting member includes whiskers to facilitate the implantation of the device at an implantation location.
  17. 17. The connecting member for a PFO closure device of claim 13 wherein the surface of the connecting member is roughened to facilitate implantation of the device at an implantation location.
  18. 18. The connecting member for a PFO closure device of claim 17 wherein the surface of the connecting member is roughened such that friction along the wire from movement in one direction is higher than movement along the wire in the opposite direction.
  19. 19. The connecting member for a PFO closure device of claim 13 wherein at least one of the wires includes at least two wire segments joined at a location such that the wires are able to move with respect to on another.
  20. 20. The connecting member for a PFO closure device of claim 19 werein the at least two wires are joined by a trailer hitch-type joint.
  21. 21. A connecting member configured to join two end pieces adapted to be disposed along a Patent Foramen Ovale tunnel, the connecting member comprising at least two wires that are joined at each end and spread apart between the ends, wherein wires are adapted to spread out a predetermined amount that is less than a predetermined distance between the lateral sides of a Patent Foramen Ovale tunnel.
  22. 22. The connecting member for a PFO closure device of claim 21 wherein the connecting member includes a wire that is helically wound to minimize trauma to the PFO tissue.
  23. 23. The connecting member for a PFO closure device of claim 22 wherein the connecting member includes a helically wound wire wrapped around a central wire that provides stability to the connecting member.
  24. 24. The connecting member for a PFO closure device of claim 21 wherein the connecting member includes whiskers to facilitate the implantation of the device at an implantation location.
  25. 25. The connecting member for a PFO closure device of claim 21 wherein the surface of the connecting member is roughened to facilitate implantation of the device at an implantation location.
  26. 26. The connecting member for a PFO closure device of claim 25 wherein the surface of the connecting member is roughened such that friction along the wire from movement in one direction is higher than movement along the wire in the opposite direction.
  27. 27. The connecting member for a PFO closure device of claim 21 wherein at least one of the wires includes at least two wire segments joined at a location such that the wires are able to move with respect to on another.
  28. 28. The connecting member for a PFO closure device of claim 27 wherein the at least two wires are joined by a trailer hitch-type joint.
  29. 29. The connecting member for a PFO closure device of claim 21 wherein the at least two wire are adapted to have a hook to pierce the tissue where the device is intended to be implanted.
  30. 30. The connecting member for a PFO closure device of claim 21 further comprising a membrane attached to the connecting member.
  31. 31. The connecting member for a PFO closure device of claim 21 wherein the connecting member includes a surface coating that promotes tissue growth.
  32. 32. The connecting member for a PFO closure device of claim 13 further comprising a membrane attached to the connecting member.
  33. 31. The connecting member for a PFO closure device of claim 13 wherein the connecting member includes a surface coating that promotes tissue growth.
  34. 33. The device of claim 1 further including a membrane attached to the connecting member.
  35. 34. The device of claim 1 wherein the connecting member includes a surface coating that promotes tissue growth.
US11008539 2003-12-09 2004-12-09 Double spiral patent foramen ovale closure clamp Abandoned US20050273119A1 (en)

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Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060200197A1 (en) * 2005-03-02 2006-09-07 St. Jude Medical, Inc. Remote body tissue engaging methods and apparatus
US20060217761A1 (en) * 2005-03-24 2006-09-28 Opolski Steven W Curved arm intracardiac occluder
US20080039743A1 (en) * 2006-08-09 2008-02-14 Coherex Medical, Inc. Methods for determining characteristics of an internal tissue opening
US20080065149A1 (en) * 2006-09-11 2008-03-13 Thielen Joseph M PFO clip
WO2008094706A2 (en) * 2007-02-01 2008-08-07 Cook Incorporated Closure device and method of closing a bodily opening
US7648532B2 (en) 2003-05-19 2010-01-19 Septrx, Inc. Tissue distention device and related methods for therapeutic intervention
US20100030246A1 (en) * 2007-02-01 2010-02-04 Dusan Pavcnik Closure Device and Method For Occluding a Bodily Passageway
US7678132B2 (en) 2001-09-06 2010-03-16 Ovalis, Inc. Systems and methods for treating septal defects
US7740640B2 (en) 2001-09-06 2010-06-22 Ovalis, Inc. Clip apparatus for closing septal defects and methods of use
US20100211046A1 (en) * 2009-02-18 2010-08-19 Aga Medical Corporation Medical device with stiffener wire for occluding vascular defects
US20100305591A1 (en) * 2009-05-28 2010-12-02 Wilson-Cook Medical Inc. Tacking device and methods of deployment
US7846179B2 (en) 2005-09-01 2010-12-07 Ovalis, Inc. Suture-based systems and methods for treating septal defects
US8070826B2 (en) 2001-09-07 2011-12-06 Ovalis, Inc. Needle apparatus for closing septal defects and methods for using such apparatus
WO2012006153A1 (en) * 2010-06-29 2012-01-12 Yale University Tissue retractor assembly
US8529597B2 (en) 2006-08-09 2013-09-10 Coherex Medical, Inc. Devices for reducing the size of an internal tissue opening
US8579936B2 (en) 2005-07-05 2013-11-12 ProMed, Inc. Centering of delivery devices with respect to a septal defect
US8617205B2 (en) 2007-02-01 2013-12-31 Cook Medical Technologies Llc Closure device
US20140142610A1 (en) * 2012-11-16 2014-05-22 W.L. Gore & Associates, Inc. Space Filling Devices
US20140257375A1 (en) * 2013-03-11 2014-09-11 St. Jude Medical Puerto Rico Llc Active securement detachable sealing tip for extra-vascular closure device and methods
US8852088B2 (en) 2011-06-28 2014-10-07 Novatract Surgical, Inc. Tissue retractor assembly
US8979941B2 (en) 2006-08-09 2015-03-17 Coherex Medical, Inc. Devices for reducing the size of an internal tissue opening
US9023074B2 (en) 2010-10-15 2015-05-05 Cook Medical Technologies Llc Multi-stage occlusion devices
EP2967802A4 (en) * 2013-03-12 2016-11-23 Pfm Medical Inc Vascular occlusion device configured for infants

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008124603A1 (en) 2007-04-05 2008-10-16 Nmt Medical, Inc. Septal closure device with centering mechanism
US9119607B2 (en) 2008-03-07 2015-09-01 Gore Enterprise Holdings, Inc. Heart occlusion devices
US20130165967A1 (en) 2008-03-07 2013-06-27 W.L. Gore & Associates, Inc. Heart occlusion devices
US9138213B2 (en) * 2008-03-07 2015-09-22 W.L. Gore & Associates, Inc. Heart occlusion devices
US9770232B2 (en) 2011-08-12 2017-09-26 W. L. Gore & Associates, Inc. Heart occlusion devices
US9808230B2 (en) 2014-06-06 2017-11-07 W. L. Gore & Associates, Inc. Sealing device and delivery system
US20160338706A1 (en) * 2015-05-20 2016-11-24 Edwards Lifesciences Corporation Atrial septal closure device for re-access
US9848906B1 (en) 2017-06-20 2017-12-26 Joe Michael Eskridge Stent retriever having an expandable fragment guard

Citations (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3874388A (en) * 1973-02-12 1975-04-01 Ochsner Med Found Alton Shunt defect closure system
US3875648A (en) * 1973-04-04 1975-04-08 Dennison Mfg Co Fastener attachment apparatus and method
US4006747A (en) * 1975-04-23 1977-02-08 Ethicon, Inc. Surgical method
US4007743A (en) * 1975-10-20 1977-02-15 American Hospital Supply Corporation Opening mechanism for umbrella-like intravascular shunt defect closure device
US4149327A (en) * 1976-07-21 1979-04-17 Jura Elektroapparate-Fabriken L. Henzirohs A.G. Steam iron
US4425908A (en) * 1981-10-22 1984-01-17 Beth Israel Hospital Blood clot filter
US4738666A (en) * 1985-06-11 1988-04-19 Genus Catheter Technologies, Inc. Variable diameter catheter
US4902508A (en) * 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US4915107A (en) * 1988-03-09 1990-04-10 Harley International Medical Ltd. Automatic instrument for purse-string sutures for surgical use
US4917089A (en) * 1988-08-29 1990-04-17 Sideris Eleftherios B Buttoned device for the transvenous occlusion of intracardiac defects
US5078736A (en) * 1990-05-04 1992-01-07 Interventional Thermodynamics, Inc. Method and apparatus for maintaining patency in the body passages
US5106913A (en) * 1986-07-16 1992-04-21 Sumitomo Chemical Company, Limited Rubber composition
US5108420A (en) * 1991-02-01 1992-04-28 Temple University Aperture occlusion device
US5176659A (en) * 1991-02-28 1993-01-05 Mario Mancini Expandable intravenous catheter and method of using
US5192301A (en) * 1989-01-17 1993-03-09 Nippon Zeon Co., Ltd. Closing plug of a defect for medical use and a closing plug device utilizing it
US5275826A (en) * 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5282827A (en) * 1991-11-08 1994-02-01 Kensey Nash Corporation Hemostatic puncture closure system and method of use
US5284488A (en) * 1992-12-23 1994-02-08 Sideris Eleftherios B Adjustable devices for the occlusion of cardiac defects
US5304184A (en) * 1992-10-19 1994-04-19 Indiana University Foundation Apparatus and method for positive closure of an internal tissue membrane opening
US5480424A (en) * 1993-11-01 1996-01-02 Cox; James L. Heart valve replacement using flexible tubes
US5480353A (en) * 1995-02-02 1996-01-02 Garza, Jr.; Ponciano Shaker crank for a harvester
US5486193A (en) * 1992-01-22 1996-01-23 C. R. Bard, Inc. System for the percutaneous transluminal front-end loading delivery of a prosthetic occluder
US5507811A (en) * 1993-11-26 1996-04-16 Nissho Corporation Prosthetic device for atrial septal defect repair
US5601571A (en) * 1994-05-17 1997-02-11 Moss; Gerald Surgical fastener implantation device
US5603703A (en) * 1995-04-28 1997-02-18 Medtronic, Inc. Selectively aspirating stylet
US5618311A (en) * 1994-09-28 1997-04-08 Gryskiewicz; Joseph M. Surgical subcuticular fastener system
US5709707A (en) * 1995-10-30 1998-01-20 Children's Medical Center Corporation Self-centering umbrella-type septal closure device
US5713864A (en) * 1995-04-11 1998-02-03 Sims Level 1, Inc. Integral conductive polymer resistance heated tubing
US5717259A (en) * 1996-01-11 1998-02-10 Schexnayder; J. Rodney Electromagnetic machine
US5720754A (en) * 1989-08-16 1998-02-24 Medtronic, Inc. Device or apparatus for manipulating matter
US5725552A (en) * 1994-07-08 1998-03-10 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
US5733337A (en) * 1995-04-07 1998-03-31 Organogenesis, Inc. Tissue repair fabric
US5733294A (en) * 1996-02-28 1998-03-31 B. Braun Medical, Inc. Self expanding cardiovascular occlusion device, method of using and method of making the same
US5855614A (en) * 1993-02-22 1999-01-05 Heartport, Inc. Method and apparatus for thoracoscopic intracardiac procedures
US5861003A (en) * 1996-10-23 1999-01-19 The Cleveland Clinic Foundation Apparatus and method for occluding a defect or aperture within body surface
US5865791A (en) * 1995-06-07 1999-02-02 E.P. Technologies Inc. Atrial appendage stasis reduction procedure and devices
US5879366A (en) * 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US6010517A (en) * 1996-04-10 2000-01-04 Baccaro; Jorge Alberto Device for occluding abnormal vessel communications
US6019753A (en) * 1997-12-02 2000-02-01 Smiths Industries Public Limited Company Catheter assemblies and inner cannulae
US6024756A (en) * 1996-03-22 2000-02-15 Scimed Life Systems, Inc. Method of reversibly closing a septal defect
US6027519A (en) * 1997-12-15 2000-02-22 Stanford; Ulf Harry Catheter with expandable multiband segment
US6027509A (en) * 1996-10-03 2000-02-22 Scimed Life Systems, Inc. Stent retrieval device
US6030007A (en) * 1997-07-07 2000-02-29 Hughes Electronics Corporation Continually adjustable nonreturn knot
US6168588B1 (en) * 1995-12-12 2001-01-02 Medi-Dyne Inc. Overlapping welds for catheter constructions
US6171329B1 (en) * 1994-12-19 2001-01-09 Gore Enterprise Holdings, Inc. Self-expanding defect closure device and method of making and using
US6174322B1 (en) * 1997-08-08 2001-01-16 Cardia, Inc. Occlusion device for the closure of a physical anomaly such as a vascular aperture or an aperture in a septum
US6174330B1 (en) * 1997-08-01 2001-01-16 Schneider (Usa) Inc Bioabsorbable marker having radiopaque constituents
US6183443B1 (en) * 1992-10-15 2001-02-06 Scimed Life Systems, Inc. Expandable introducer sheath
US6187039B1 (en) * 1996-12-10 2001-02-13 Purdue Research Foundation Tubular submucosal graft constructs
US6190353B1 (en) * 1995-10-13 2001-02-20 Transvascular, Inc. Methods and apparatus for bypassing arterial obstructions and/or performing other transvascular procedures
US6190357B1 (en) * 1998-04-21 2001-02-20 Cardiothoracic Systems, Inc. Expandable cannula for performing cardiopulmonary bypass and method for using same
US6197016B1 (en) * 1991-12-13 2001-03-06 Endovascular Technologies, Inc. Dual valve, flexible expandable sheath and method
US6199262B1 (en) * 1997-08-20 2001-03-13 Medtronic, Inc. Method of making a guiding catheter
US6206895B1 (en) * 1999-07-13 2001-03-27 Scion Cardio-Vascular, Inc. Suture with toggle and delivery system
US6206907B1 (en) * 1999-05-07 2001-03-27 Cardia, Inc. Occlusion device with stranded wire support arms
US6334872B1 (en) * 1994-02-18 2002-01-01 Organogenesis Inc. Method for treating diseased or damaged organs
US20020010481A1 (en) * 1999-12-23 2002-01-24 Swaminathan Jayaraman Occlusive coil manufacture and delivery
US6342064B1 (en) * 1998-12-22 2002-01-29 Nipro Corporation Closure device for transcatheter operation and catheter assembly therefor
US6344048B1 (en) * 1997-07-10 2002-02-05 Scimed Life Systems, Inc. Removable occlusion system for aneurysm neck
US6344049B1 (en) * 1999-08-17 2002-02-05 Scion Cardio-Vascular, Inc. Filter for embolic material mounted on expandable frame and associated deployment system
US6346074B1 (en) * 1993-02-22 2002-02-12 Heartport, Inc. Devices for less invasive intracardiac interventions
US20020019648A1 (en) * 2000-04-19 2002-02-14 Dan Akerfeldt Intra-arterial occluder
US6348041B1 (en) * 1999-03-29 2002-02-19 Cook Incorporated Guidewire
US20020022859A1 (en) * 1999-03-12 2002-02-21 Michael Hogendijk Catheter having radially expandable main body
US20020022860A1 (en) * 2000-08-18 2002-02-21 Borillo Thomas E. Expandable implant devices for filtering blood flow from atrial appendages
US20020026208A1 (en) * 2000-01-05 2002-02-28 Medical Technology Group, Inc. Apparatus and methods for delivering a closure device
US6352552B1 (en) * 2000-05-02 2002-03-05 Scion Cardio-Vascular, Inc. Stent
US20020029048A1 (en) * 2000-09-01 2002-03-07 Arnold Miller Endovascular fastener and grafting apparatus and method
US6355052B1 (en) * 1996-02-09 2002-03-12 Pfm Produkte Fur Die Medizin Aktiengesellschaft Device for closure of body defect openings
US6356782B1 (en) * 1998-12-24 2002-03-12 Vivant Medical, Inc. Subcutaneous cavity marking device and method
US20020032462A1 (en) * 1998-06-10 2002-03-14 Russell A. Houser Thermal securing anastomosis systems
US20020032459A1 (en) * 1990-06-20 2002-03-14 Danforth Biomedical, Inc. Radially-expandable tubular elements for use in the construction of medical devices
US6358238B1 (en) * 1999-09-02 2002-03-19 Scimed Life Systems, Inc. Expandable micro-catheter
US20020034259A1 (en) * 2000-09-21 2002-03-21 Katsuyuki Tada Transmitter for automatically changing transmission data type within specified band
US20020035374A1 (en) * 2000-09-21 2002-03-21 Borillo Thomas E. Apparatus for implanting devices in atrial appendages
US20030004533A1 (en) * 2001-05-04 2003-01-02 Concentric Medical Bioactive polymer vaso-occlusive device
US6508828B1 (en) * 2000-11-03 2003-01-21 Radi Medical Systems Ab Sealing device and wound closure device
US20030023266A1 (en) * 2001-07-19 2003-01-30 Borillo Thomas E. Individually customized atrial appendage implant device
US6514515B1 (en) * 1999-03-04 2003-02-04 Tepha, Inc. Bioabsorbable, biocompatible polymers for tissue engineering
US20030028213A1 (en) * 2001-08-01 2003-02-06 Microvena Corporation Tissue opening occluder
US20030045893A1 (en) * 2001-09-06 2003-03-06 Integrated Vascular Systems, Inc. Clip apparatus for closing septal defects and methods of use
US20030050665A1 (en) * 2001-09-07 2003-03-13 Integrated Vascular Systems, Inc. Needle apparatus for closing septal defects and methods for using such apparatus
US20030055455A1 (en) * 2001-09-20 2003-03-20 Scimed Life Systems, Inc. Method and apparatus for treating septal defects
US20030057156A1 (en) * 2001-03-08 2003-03-27 Dean Peterson Atrial filter implants
US20030059640A1 (en) * 1999-11-19 2003-03-27 Denes Marton High strength vacuum deposited nitinol alloy films and method of making same
US6689589B2 (en) * 1997-09-19 2004-02-10 Metabolix, Inc. Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids
US20040044361A1 (en) * 1998-11-06 2004-03-04 Frazier Andrew G.C. Detachable atrial appendage occlusion balloon
US6712804B2 (en) * 1999-09-20 2004-03-30 Ev3 Sunnyvale, Inc. Method of closing an opening in a wall of the heart
US6712836B1 (en) * 1999-05-13 2004-03-30 St. Jude Medical Atg, Inc. Apparatus and methods for closing septal defects and occluding blood flow
US6838493B2 (en) * 1999-03-25 2005-01-04 Metabolix, Inc. Medical devices and applications of polyhydroxyalkanoate polymers
US20050025809A1 (en) * 2003-07-08 2005-02-03 Tepha, Inc. Poly-4-hydroxybutyrate matrices for sustained drug delivery
US20050043759A1 (en) * 2003-07-14 2005-02-24 Nmt Medical, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
US6867248B1 (en) * 1997-05-12 2005-03-15 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6867249B2 (en) * 2000-08-18 2005-03-15 Kin Man Amazon Lee Lightweight and porous construction materials containing rubber
US20060052821A1 (en) * 2001-09-06 2006-03-09 Ovalis, Inc. Systems and methods for treating septal defects
US20070010851A1 (en) * 2003-07-14 2007-01-11 Chanduszko Andrzej J Tubular patent foramen ovale (PFO) closure device with catch system
US7186251B2 (en) * 2003-03-27 2007-03-06 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
US7192435B2 (en) * 2003-09-18 2007-03-20 Cardia, Inc. Self centering closure device for septal occlusion

Family Cites Families (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3824631A (en) 1973-05-11 1974-07-23 Sampson Corp Bone joint fusion prosthesis
US3924631A (en) 1973-12-06 1975-12-09 Altair Inc Magnetic clamp
JPH027669B2 (en) 1984-09-13 1990-02-20 Terumo Corp
US4696300A (en) 1985-04-11 1987-09-29 Dennison Manufacturing Company Fastener for joining materials
US4710181A (en) 1985-06-11 1987-12-01 Genus Catheter Technologies, Inc. Variable diameter catheter
US4626245A (en) 1985-08-30 1986-12-02 Cordis Corporation Hemostatis valve comprising an elastomeric partition having opposed intersecting slits
US4710192A (en) 1985-12-30 1987-12-01 Liotta Domingo S Diaphragm and method for occlusion of the descending thoracic aorta
US4693249A (en) 1986-01-10 1987-09-15 Schenck Robert R Anastomosis device and method
US5478353A (en) 1987-05-14 1995-12-26 Yoon; Inbae Suture tie device system and method for suturing anatomical tissue proximate an opening
US5250430A (en) 1987-06-29 1993-10-05 Massachusetts Institute Of Technology Polyhydroxyalkanoate polymerase
US5245023A (en) 1987-06-29 1993-09-14 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
US4836204A (en) 1987-07-06 1989-06-06 Landymore Roderick W Method for effecting closure of a perforation in the septum of the heart
US4921479A (en) 1987-10-02 1990-05-01 Joseph Grayzel Catheter sheath with longitudinal seam
US4840623A (en) 1988-02-01 1989-06-20 Fbk International Corporation Medical catheter with splined internal wall
US4956178A (en) 1988-07-11 1990-09-11 Purdue Research Foundation Tissue graft composition
US5245080A (en) 1989-02-20 1993-09-14 Jouveinal Sa (+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-N-propylamine, process for preparing it and its therapeutical use
US5620461A (en) 1989-05-29 1997-04-15 Muijs Van De Moer; Wouter M. Sealing device
US5049131A (en) 1989-05-31 1991-09-17 Ashridge Ag Balloon catheter
US5149327A (en) 1989-09-05 1992-09-22 Terumo Kabushiki Kaisha Medical valve, catheter with valve, and catheter assembly
US5163131A (en) 1989-09-08 1992-11-10 Auspex Systems, Inc. Parallel i/o network file server architecture
US5226879A (en) 1990-03-01 1993-07-13 William D. Ensminger Implantable access device
US5453099A (en) 1990-03-26 1995-09-26 Becton, Dickinson And Company Catheter tubing of controlled in vivo softening
CA2057018C (en) 1990-04-02 1997-12-09 Kanji Inoue Device for nonoperatively occluding a defect
US5021059A (en) 1990-05-07 1991-06-04 Kensey Nash Corporation Plug device with pulley for sealing punctures in tissue and methods of use
US5037433A (en) 1990-05-17 1991-08-06 Wilk Peter J Endoscopic suturing device and related method and suture
FR2663217B1 (en) 1990-06-15 1992-10-16 Antheor Filter device intended for the prevention of embolisms.
US5041129A (en) 1990-07-02 1991-08-20 Acufex Microsurgical, Inc. Slotted suture anchor and method of anchoring a suture
US5063640A (en) 1990-10-26 1991-11-12 Link Charles T Endless filament paper clip
JPH04170966A (en) 1990-11-01 1992-06-18 Nippon Sherwood Kk Valvular body for catheter introducer blood stop valve
US5257637A (en) 1991-03-22 1993-11-02 El Gazayerli Mohamed M Method for suture knot placement and tying
US5304131A (en) 1991-07-15 1994-04-19 Paskar Larry D Catheter
CA2078530A1 (en) 1991-09-23 1993-03-24 Jay Erlebacher Percutaneous arterial puncture seal device and insertion tool therefore
EP0545091B1 (en) 1991-11-05 1999-07-07 The Children's Medical Center Corporation Occluder for repair of cardiac and vascular defects
CA2082090C (en) 1991-11-05 2004-04-27 Jack Fagan Improved occluder for repair of cardiac and vascular defects
US5222974A (en) 1991-11-08 1993-06-29 Kensey Nash Corporation Hemostatic puncture closure system and method of use
JP3393383B2 (en) 1992-01-21 2003-04-07 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ Septal defect closure device
US5316262A (en) 1992-01-31 1994-05-31 Suprex Corporation Fluid restrictor apparatus and method for making the same
US5167363A (en) 1992-02-10 1992-12-01 Adkinson Steven S Collapsible storage pen
US5411481A (en) 1992-04-08 1995-05-02 American Cyanamid Co. Surgical purse string suturing instrument and method
US5236440A (en) 1992-04-14 1993-08-17 American Cyanamid Company Surgical fastener
US5540712A (en) 1992-05-01 1996-07-30 Nitinol Medical Technologies, Inc. Stent and method and apparatus for forming and delivering the same
US5354308A (en) 1992-05-01 1994-10-11 Beth Israel Hospital Association Metal wire stent
DE4215449C1 (en) 1992-05-11 1993-09-02 Ethicon Gmbh & Co Kg, 2000 Norderstedt, De
US5312341A (en) 1992-08-14 1994-05-17 Wayne State University Retaining apparatus and procedure for transseptal catheterization
US5382259A (en) * 1992-10-26 1995-01-17 Target Therapeutics, Inc. Vasoocclusion coil with attached tubular woven or braided fibrous covering
US5417699A (en) 1992-12-10 1995-05-23 Perclose Incorporated Device and method for the percutaneous suturing of a vascular puncture site
US5320611A (en) 1993-02-04 1994-06-14 Peter M. Bonutti Expandable cannula having longitudinal wire and method of use
US5312435A (en) 1993-05-17 1994-05-17 Kensey Nash Corporation Fail predictable, reinforced anchor for hemostatic puncture closure
US5350363A (en) 1993-06-14 1994-09-27 Cordis Corporation Enhanced sheath valve
DE4324218A1 (en) 1993-07-19 1995-01-26 Bavaria Med Tech cuff catheter
US5538510A (en) 1994-01-31 1996-07-23 Cordis Corporation Catheter having coextruded tubing
WO1995027448A1 (en) 1994-04-06 1995-10-19 William Cook Europe A/S A medical article for implantation into the vascular system of a patient
US5853420A (en) 1994-04-21 1998-12-29 B. Braun Celsa Assembly comprising a blood filter for temporary or definitive use and device for implanting it, corresponding filter and method of implanting such a filter
DE69527141T2 (en) 1994-04-29 2002-11-07 Scimed Life Systems Inc Stent with collagen
US5453095A (en) 1994-06-07 1995-09-26 Cordis Corporation One piece self-aligning, self-lubricating catheter valve
US5433727A (en) 1994-08-16 1995-07-18 Sideris; Eleftherios B. Centering buttoned device for the occlusion of large defects for occluding
DE9413645U1 (en) 1994-08-24 1994-10-27 Schneidt Bernhard Ing Grad An apparatus for sealing a duct, in particular of the ductus arteriosus
US5702421A (en) 1995-01-11 1997-12-30 Schneidt; Bernhard Closure device for closing a vascular opening, such as patent ductus arteriosus
US5577299A (en) 1994-08-26 1996-11-26 Thompson; Carl W. Quick-release mechanical knot apparatus
US5522788A (en) 1994-10-26 1996-06-04 Kuzmak; Lubomyr I. Finger-like laparoscopic blunt dissector device
US5634936A (en) 1995-02-06 1997-06-03 Scimed Life Systems, Inc. Device for closing a septal defect
US5649959A (en) 1995-02-10 1997-07-22 Sherwood Medical Company Assembly for sealing a puncture in a vessel
US5711969A (en) 1995-04-07 1998-01-27 Purdue Research Foundation Large area submucosal tissue graft constructs
US6322548B1 (en) 1995-05-10 2001-11-27 Eclipse Surgical Technologies Delivery catheter system for heart chamber
CA2197614C (en) 1996-02-20 2002-07-02 Charles S. Taylor Surgical instruments and procedures for stabilizing the beating heart during coronary artery bypass graft surgery
US5755791A (en) 1996-04-05 1998-05-26 Purdue Research Foundation Perforated submucosal tissue graft constructs
US6488706B1 (en) 1996-05-08 2002-12-03 Carag Ag Device for plugging an opening such as in a wall of a hollow or tubular organ
US6949116B2 (en) 1996-05-08 2005-09-27 Carag Ag Device for plugging an opening such as in a wall of a hollow or tubular organ including biodegradable elements
US5893856A (en) 1996-06-12 1999-04-13 Mitek Surgical Products, Inc. Apparatus and method for binding a first layer of material to a second layer of material
US6143037A (en) 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US5690674A (en) 1996-07-02 1997-11-25 Cordis Corporation Wound closure with plug
GB9614950D0 (en) * 1996-07-16 1996-09-04 Anson Medical Ltd A ductus stent and delivery catheter
US5800516A (en) 1996-08-08 1998-09-01 Cordis Corporation Deployable and retrievable shape memory stent/tube and method
US6482224B1 (en) 1996-08-22 2002-11-19 The Trustees Of Columbia University In The City Of New York Endovascular flexible stapling device
US5776183A (en) 1996-08-23 1998-07-07 Kanesaka; Nozomu Expandable stent
US5741297A (en) 1996-08-28 1998-04-21 Simon; Morris Daisy occluder and method for septal defect repair
US5810884A (en) 1996-09-09 1998-09-22 Beth Israel Deaconess Medical Center Apparatus and method for closing a vascular perforation after percutaneous puncture of a blood vessel in a living subject
US5944691A (en) 1996-11-04 1999-08-31 Cordis Corporation Catheter having an expandable shaft
EP0936930B1 (en) 1996-11-05 2004-07-28 Purdue Research Foundation Myocardial graft constructs
US6315791B1 (en) 1996-12-03 2001-11-13 Atrium Medical Corporation Self-expanding prothesis
US6475232B1 (en) 1996-12-10 2002-11-05 Purdue Research Foundation Stent with reduced thrombogenicity
DK1671604T3 (en) 1996-12-10 2009-11-09 Purdue Research Foundation Synthetic tissue valve of
CA2224366C (en) * 1996-12-11 2006-10-31 Ethicon, Inc. Meniscal repair device
US5776162A (en) 1997-01-03 1998-07-07 Nitinol Medical Technologies, Inc. Vessel implantable shape memory appliance with superelastic hinged joint
JP3134287B2 (en) 1997-01-30 2001-02-13 株式会社ニッショー Intracardiac suture surgery for catheter assembly
JP3134288B2 (en) 1997-01-30 2001-02-13 株式会社ニッショー Intracardiac suture surgical instruments
US5993844A (en) 1997-05-08 1999-11-30 Organogenesis, Inc. Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix
US6610764B1 (en) 1997-05-12 2003-08-26 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6828357B1 (en) 1997-07-31 2004-12-07 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6071292A (en) 1997-06-28 2000-06-06 Transvascular, Inc. Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures
US6077880A (en) 1997-08-08 2000-06-20 Cordis Corporation Highly radiopaque polyolefins and method for making the same
US5902319A (en) 1997-09-25 1999-05-11 Daley; Robert J. Bioabsorbable staples
US6042606A (en) 1997-09-29 2000-03-28 Cook Incorporated Radially expandable non-axially contracting surgical stent
US6106913A (en) 1997-10-10 2000-08-22 Quantum Group, Inc Fibrous structures containing nanofibrils and other textile fibers
US5989268A (en) 1997-10-28 1999-11-23 Boston Scientific Corporation Endoscopic hemostatic clipping device
US5976174A (en) 1997-12-15 1999-11-02 Ruiz; Carlos E. Medical hole closure device and methods of use
US5944738A (en) 1998-02-06 1999-08-31 Aga Medical Corporation Percutaneous catheter directed constricting occlusion device
JP3799810B2 (en) 1998-03-30 2006-07-19 ニプロ株式会社 Closure plugs and catheter assembly for transcatheter surgery
US5993475A (en) 1998-04-22 1999-11-30 Bristol-Myers Squibb Co. Tissue repair device
US6113609A (en) 1998-05-26 2000-09-05 Scimed Life Systems, Inc. Implantable tissue fastener and system for treating gastroesophageal reflux disease
US6265333B1 (en) 1998-06-02 2001-07-24 Board Of Regents, University Of Nebraska-Lincoln Delamination resistant composites prepared by small diameter fiber reinforcement at ply interfaces
US7452371B2 (en) 1999-06-02 2008-11-18 Cook Incorporated Implantable vascular device
US6328822B1 (en) 1998-06-26 2001-12-11 Kiyohito Ishida Functionally graded alloy, use thereof and method for producing same
US6165183A (en) 1998-07-15 2000-12-26 St. Jude Medical, Inc. Mitral and tricuspid valve repair
US5919200A (en) 1998-10-09 1999-07-06 Hearten Medical, Inc. Balloon catheter for abrading a patent foramen ovale and method of using the balloon catheter
US6183496B1 (en) 1998-11-02 2001-02-06 Datascope Investment Corp. Collapsible hemostatic plug
US7044134B2 (en) 1999-11-08 2006-05-16 Ev3 Sunnyvale, Inc Method of implanting a device in the left atrial appendage
US6152144A (en) 1998-11-06 2000-11-28 Appriva Medical, Inc. Method and device for left atrial appendage occlusion
US6280447B1 (en) 1998-12-23 2001-08-28 Nuvasive, Inc. Bony tissue resector
US6371904B1 (en) 1998-12-24 2002-04-16 Vivant Medical, Inc. Subcutaneous cavity marking device and method
US6228097B1 (en) 1999-01-22 2001-05-08 Scion International, Inc. Surgical instrument for clipping and cutting blood vessels and organic structures
US6217590B1 (en) 1999-01-22 2001-04-17 Scion International, Inc. Surgical instrument for applying multiple staples and cutting blood vessels and organic structures and method therefor
US6277139B1 (en) 1999-04-01 2001-08-21 Scion Cardio-Vascular, Inc. Vascular protection and embolic material retriever
US6375671B1 (en) 1999-04-19 2002-04-23 Nipro Corporation Closure device for transcatheter operations
US6656206B2 (en) 1999-05-13 2003-12-02 Cardia, Inc. Occlusion device with non-thrombogenic properties
US6379368B1 (en) 1999-05-13 2002-04-30 Cardia, Inc. Occlusion device with non-thrombogenic properties
US6426145B1 (en) 1999-05-20 2002-07-30 Scimed Life Systems, Inc. Radiopaque compositions for visualization of medical devices
US6488689B1 (en) 1999-05-20 2002-12-03 Aaron V. Kaplan Methods and apparatus for transpericardial left atrial appendage closure
US6165204A (en) 1999-06-11 2000-12-26 Scion International, Inc. Shaped suture clip, appliance and method therefor
US6494888B1 (en) 1999-06-22 2002-12-17 Ndo Surgical, Inc. Tissue reconfiguration
US20040249367A1 (en) 2003-01-15 2004-12-09 Usgi Medical Corp. Endoluminal tool deployment system
US6306424B1 (en) 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue
US6245080B1 (en) 1999-07-13 2001-06-12 Scion Cardio-Vascular, Inc. Suture with toggle and delivery system
US6398796B2 (en) 1999-07-13 2002-06-04 Scion Cardio-Vascular, Inc. Suture with toggle and delivery system
US7892246B2 (en) 1999-07-28 2011-02-22 Bioconnect Systems, Inc. Devices and methods for interconnecting conduits and closing openings in tissue
US20010041914A1 (en) 1999-11-22 2001-11-15 Frazier Andrew G.C. Tissue patch deployment catheter
US6551303B1 (en) 1999-10-27 2003-04-22 Atritech, Inc. Barrier device for ostium of left atrial appendage
US6387104B1 (en) 1999-11-12 2002-05-14 Scimed Life Systems, Inc. Method and apparatus for endoscopic repair of the lower esophageal sphincter
US6371971B1 (en) 1999-11-15 2002-04-16 Scimed Life Systems, Inc. Guidewire filter and methods of use
DE10000137A1 (en) 2000-01-04 2001-07-12 Pfm Prod Fuer Die Med Ag Implantate for closing defect apertures in human or animal bodies, bearing structure of which can be reversed from secondary to primary form by elastic force
US20010034567A1 (en) 2000-01-20 2001-10-25 Allen Marc L. Remote management of retail petroleum equipment
FR2804567B1 (en) 2000-01-31 2002-04-12 St Microelectronics Sa Preamplifier video
EP1263336B1 (en) 2000-03-10 2004-02-18 Radius Medical Technologies, Inc. Surgical snare apparatus
US6227139B1 (en) 2000-03-16 2001-05-08 The United States Of America As Represented By The Secretary Of The Navy Control tab assisted lift reducing system for underwater hydrofoil surface
US6328689B1 (en) 2000-03-23 2001-12-11 Spiration, Inc., Lung constriction apparatus and method
US7056294B2 (en) 2000-04-13 2006-06-06 Ev3 Sunnyvale, Inc Method and apparatus for accessing the left atrial appendage
US6551344B2 (en) 2000-04-26 2003-04-22 Ev3 Inc. Septal defect occluder
US6214029B1 (en) 2000-04-26 2001-04-10 Microvena Corporation Septal defect occluder
US6599448B1 (en) 2000-05-10 2003-07-29 Hydromer, Inc. Radio-opaque polymeric compositions
US6334864B1 (en) 2000-05-17 2002-01-01 Aga Medical Corp. Alignment member for delivering a non-symmetric device with a predefined orientation
US6494846B1 (en) 2000-06-20 2002-12-17 Wayne Margolis Family Partnership, Ltd. Dual-mode catheter
US20020164729A1 (en) 2000-07-21 2002-11-07 Skraly Frank A. Production of polyhydroxyalkanoates from polyols
US6440152B1 (en) 2000-07-28 2002-08-27 Microvena Corporation Defect occluder release assembly and method
US6364853B1 (en) 2000-09-11 2002-04-02 Scion International, Inc. Irrigation and suction valve and method therefor
US6699278B2 (en) 2000-09-22 2004-03-02 Cordis Corporation Stent with optimal strength and radiopacity characteristics
CA2423061A1 (en) 2000-09-25 2002-03-28 Cohesion Technologies, Inc. Resorbable anastomosis stents and plugs
US6666861B1 (en) 2000-10-05 2003-12-23 James R. Grabek Atrial appendage remodeling device and method
US6375625B1 (en) 2000-10-18 2002-04-23 Scion Valley, Inc. In-line specimen trap and method therefor
US6629901B2 (en) 2000-11-09 2003-10-07 Ben Huang Composite grip for golf clubs
US6746404B2 (en) 2000-12-18 2004-06-08 Biosense, Inc. Method for anchoring a medical device between tissue
US6585719B2 (en) 2001-01-04 2003-07-01 Scimed Life Systems, Inc. Low profile metal/polymer tubes
US6814718B2 (en) 2001-01-09 2004-11-09 Rex Medical, L.P Dialysis catheter
US20020128680A1 (en) 2001-01-25 2002-09-12 Pavlovic Jennifer L. Distal protection device with electrospun polymer fiber matrix
US6550480B2 (en) 2001-01-31 2003-04-22 Numed/Tech Llc Lumen occluders made from thermodynamic materials
US6450987B1 (en) 2001-02-01 2002-09-17 Innercool Therapies, Inc. Collapsible guidewire lumen
US20020107531A1 (en) 2001-02-06 2002-08-08 Schreck Stefan G. Method and system for tissue repair using dual catheters
US6623518B2 (en) 2001-02-26 2003-09-23 Ev3 Peripheral, Inc. Implant delivery system with interlock
US6726696B1 (en) 2001-04-24 2004-04-27 Advanced Catheter Engineering, Inc. Patches and collars for medical applications and methods of use
US6921410B2 (en) 2001-05-29 2005-07-26 Scimed Life Systems, Inc. Injection molded vaso-occlusive elements
US6537300B2 (en) 2001-05-30 2003-03-25 Scimed Life Systems, Inc. Implantable obstruction device for septal defects
US7338514B2 (en) 2001-06-01 2008-03-04 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods and tools, and related methods of use
US6941169B2 (en) 2001-06-04 2005-09-06 Albert Einstein Healthcare Network Cardiac stimulating apparatus having a blood clot filter and atrial pacer
US6623506B2 (en) 2001-06-18 2003-09-23 Rex Medical, L.P Vein filter
US6585755B2 (en) 2001-06-29 2003-07-01 Advanced Cardiovascular Polymeric stent suitable for imaging by MRI and fluoroscopy
EP1467661A4 (en) 2001-12-19 2008-11-05 Nmt Medical Inc Septal occluder and associated methods
US7318833B2 (en) 2001-12-19 2008-01-15 Nmt Medical, Inc. PFO closure device with flexible thrombogenic joint and improved dislodgement resistance
US20030139819A1 (en) 2002-01-18 2003-07-24 Beer Nicholas De Method and apparatus for closing septal defects
CA2488337A1 (en) 2002-06-05 2003-12-18 Nmt Medical, Inc. Patent foramen ovale (pfo) closure device with radial and circumferential support
US6783491B2 (en) 2002-06-13 2004-08-31 Vahid Saadat Shape lockable apparatus and method for advancing an instrument through unsupported anatomy
US7766820B2 (en) 2002-10-25 2010-08-03 Nmt Medical, Inc. Expandable sheath tubing
JP4197965B2 (en) 2003-01-31 2008-12-17 オリンパス株式会社 High-frequency snare and medical equipment
CA2429314A1 (en) 2003-05-22 2004-11-22 Richard A. Dawson Collapsible shield for smoking animal lure
CA2536368A1 (en) 2003-08-19 2005-03-03 Nmt Medical, Inc. Expandable sheath tubing
US20050113868A1 (en) 2003-11-20 2005-05-26 Devellian Carol A. Device, with electrospun fabric, for a percutaneous transluminal procedure, and methods thereof
CN100413472C (en) 2004-02-04 2008-08-27 卡拉格股份公司 Implant for blocking body passage
US7871419B2 (en) 2004-03-03 2011-01-18 Nmt Medical, Inc. Delivery/recovery system for septal occluder
US7842053B2 (en) * 2004-05-06 2010-11-30 Nmt Medical, Inc. Double coil occluder
US7704268B2 (en) 2004-05-07 2010-04-27 Nmt Medical, Inc. Closure device with hinges
CA2563298A1 (en) 2004-05-07 2005-11-24 Nmt Medical, Inc. Catching mechanisms for tubular septal occluder
CA2581677C (en) 2004-09-24 2014-07-29 Nmt Medical, Inc. Occluder device double securement system for delivery/recovery of such occluder device
US8277480B2 (en) 2005-03-18 2012-10-02 W.L. Gore & Associates, Inc. Catch member for PFO occluder
US20060271089A1 (en) 2005-04-11 2006-11-30 Cierra, Inc. Methods and apparatus to achieve a closure of a layered tissue defect
US20070129755A1 (en) * 2005-12-05 2007-06-07 Ovalis, Inc. Clip-based systems and methods for treating septal defects
EP1962695A1 (en) 2005-12-22 2008-09-03 NMT Medical, Inc. Catch members for occluder devices

Patent Citations (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3874388A (en) * 1973-02-12 1975-04-01 Ochsner Med Found Alton Shunt defect closure system
US3875648A (en) * 1973-04-04 1975-04-08 Dennison Mfg Co Fastener attachment apparatus and method
US4006747A (en) * 1975-04-23 1977-02-08 Ethicon, Inc. Surgical method
US4007743A (en) * 1975-10-20 1977-02-15 American Hospital Supply Corporation Opening mechanism for umbrella-like intravascular shunt defect closure device
US4149327A (en) * 1976-07-21 1979-04-17 Jura Elektroapparate-Fabriken L. Henzirohs A.G. Steam iron
US4425908A (en) * 1981-10-22 1984-01-17 Beth Israel Hospital Blood clot filter
US4738666A (en) * 1985-06-11 1988-04-19 Genus Catheter Technologies, Inc. Variable diameter catheter
US5106913A (en) * 1986-07-16 1992-04-21 Sumitomo Chemical Company, Limited Rubber composition
US4915107A (en) * 1988-03-09 1990-04-10 Harley International Medical Ltd. Automatic instrument for purse-string sutures for surgical use
US4902508A (en) * 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US4917089A (en) * 1988-08-29 1990-04-17 Sideris Eleftherios B Buttoned device for the transvenous occlusion of intracardiac defects
US5192301A (en) * 1989-01-17 1993-03-09 Nippon Zeon Co., Ltd. Closing plug of a defect for medical use and a closing plug device utilizing it
US5720754A (en) * 1989-08-16 1998-02-24 Medtronic, Inc. Device or apparatus for manipulating matter
US5078736A (en) * 1990-05-04 1992-01-07 Interventional Thermodynamics, Inc. Method and apparatus for maintaining patency in the body passages
US20020032459A1 (en) * 1990-06-20 2002-03-14 Danforth Biomedical, Inc. Radially-expandable tubular elements for use in the construction of medical devices
US5108420A (en) * 1991-02-01 1992-04-28 Temple University Aperture occlusion device
US5176659A (en) * 1991-02-28 1993-01-05 Mario Mancini Expandable intravenous catheter and method of using
US5282827A (en) * 1991-11-08 1994-02-01 Kensey Nash Corporation Hemostatic puncture closure system and method of use
US6197016B1 (en) * 1991-12-13 2001-03-06 Endovascular Technologies, Inc. Dual valve, flexible expandable sheath and method
US5486193A (en) * 1992-01-22 1996-01-23 C. R. Bard, Inc. System for the percutaneous transluminal front-end loading delivery of a prosthetic occluder
US6183443B1 (en) * 1992-10-15 2001-02-06 Scimed Life Systems, Inc. Expandable introducer sheath
US5304184A (en) * 1992-10-19 1994-04-19 Indiana University Foundation Apparatus and method for positive closure of an internal tissue membrane opening
US5275826A (en) * 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5284488A (en) * 1992-12-23 1994-02-08 Sideris Eleftherios B Adjustable devices for the occlusion of cardiac defects
US6346074B1 (en) * 1993-02-22 2002-02-12 Heartport, Inc. Devices for less invasive intracardiac interventions
US5855614A (en) * 1993-02-22 1999-01-05 Heartport, Inc. Method and apparatus for thoracoscopic intracardiac procedures
US5480424A (en) * 1993-11-01 1996-01-02 Cox; James L. Heart valve replacement using flexible tubes
US5507811A (en) * 1993-11-26 1996-04-16 Nissho Corporation Prosthetic device for atrial septal defect repair
US6334872B1 (en) * 1994-02-18 2002-01-01 Organogenesis Inc. Method for treating diseased or damaged organs
US5601571A (en) * 1994-05-17 1997-02-11 Moss; Gerald Surgical fastener implantation device
US5725552A (en) * 1994-07-08 1998-03-10 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
US5618311A (en) * 1994-09-28 1997-04-08 Gryskiewicz; Joseph M. Surgical subcuticular fastener system
US6171329B1 (en) * 1994-12-19 2001-01-09 Gore Enterprise Holdings, Inc. Self-expanding defect closure device and method of making and using
US5480353A (en) * 1995-02-02 1996-01-02 Garza, Jr.; Ponciano Shaker crank for a harvester
US5733337A (en) * 1995-04-07 1998-03-31 Organogenesis, Inc. Tissue repair fabric
US5713864A (en) * 1995-04-11 1998-02-03 Sims Level 1, Inc. Integral conductive polymer resistance heated tubing
US5603703A (en) * 1995-04-28 1997-02-18 Medtronic, Inc. Selectively aspirating stylet
US5865791A (en) * 1995-06-07 1999-02-02 E.P. Technologies Inc. Atrial appendage stasis reduction procedure and devices
US6190353B1 (en) * 1995-10-13 2001-02-20 Transvascular, Inc. Methods and apparatus for bypassing arterial obstructions and/or performing other transvascular procedures
US5709707A (en) * 1995-10-30 1998-01-20 Children's Medical Center Corporation Self-centering umbrella-type septal closure device
US6168588B1 (en) * 1995-12-12 2001-01-02 Medi-Dyne Inc. Overlapping welds for catheter constructions
US5717259A (en) * 1996-01-11 1998-02-10 Schexnayder; J. Rodney Electromagnetic machine
US6355052B1 (en) * 1996-02-09 2002-03-12 Pfm Produkte Fur Die Medizin Aktiengesellschaft Device for closure of body defect openings
US5733294A (en) * 1996-02-28 1998-03-31 B. Braun Medical, Inc. Self expanding cardiovascular occlusion device, method of using and method of making the same
US6024756A (en) * 1996-03-22 2000-02-15 Scimed Life Systems, Inc. Method of reversibly closing a septal defect
US6010517A (en) * 1996-04-10 2000-01-04 Baccaro; Jorge Alberto Device for occluding abnormal vessel communications
US6027509A (en) * 1996-10-03 2000-02-22 Scimed Life Systems, Inc. Stent retrieval device
US5861003A (en) * 1996-10-23 1999-01-19 The Cleveland Clinic Foundation Apparatus and method for occluding a defect or aperture within body surface
US6187039B1 (en) * 1996-12-10 2001-02-13 Purdue Research Foundation Tubular submucosal graft constructs
US5879366A (en) * 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US6867248B1 (en) * 1997-05-12 2005-03-15 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6030007A (en) * 1997-07-07 2000-02-29 Hughes Electronics Corporation Continually adjustable nonreturn knot
US6344048B1 (en) * 1997-07-10 2002-02-05 Scimed Life Systems, Inc. Removable occlusion system for aneurysm neck
US6174330B1 (en) * 1997-08-01 2001-01-16 Schneider (Usa) Inc Bioabsorbable marker having radiopaque constituents
US6174322B1 (en) * 1997-08-08 2001-01-16 Cardia, Inc. Occlusion device for the closure of a physical anomaly such as a vascular aperture or an aperture in a septum
US6199262B1 (en) * 1997-08-20 2001-03-13 Medtronic, Inc. Method of making a guiding catheter
US6689589B2 (en) * 1997-09-19 2004-02-10 Metabolix, Inc. Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids
US6019753A (en) * 1997-12-02 2000-02-01 Smiths Industries Public Limited Company Catheter assemblies and inner cannulae
US6027519A (en) * 1997-12-15 2000-02-22 Stanford; Ulf Harry Catheter with expandable multiband segment
US6190357B1 (en) * 1998-04-21 2001-02-20 Cardiothoracic Systems, Inc. Expandable cannula for performing cardiopulmonary bypass and method for using same
US20020032462A1 (en) * 1998-06-10 2002-03-14 Russell A. Houser Thermal securing anastomosis systems
US20040044361A1 (en) * 1998-11-06 2004-03-04 Frazier Andrew G.C. Detachable atrial appendage occlusion balloon
US6342064B1 (en) * 1998-12-22 2002-01-29 Nipro Corporation Closure device for transcatheter operation and catheter assembly therefor
US6356782B1 (en) * 1998-12-24 2002-03-12 Vivant Medical, Inc. Subcutaneous cavity marking device and method
US6514515B1 (en) * 1999-03-04 2003-02-04 Tepha, Inc. Bioabsorbable, biocompatible polymers for tissue engineering
US20020022859A1 (en) * 1999-03-12 2002-02-21 Michael Hogendijk Catheter having radially expandable main body
US6867247B2 (en) * 1999-03-25 2005-03-15 Metabolix, Inc. Medical devices and applications of polyhydroxyalkanoate polymers
US6838493B2 (en) * 1999-03-25 2005-01-04 Metabolix, Inc. Medical devices and applications of polyhydroxyalkanoate polymers
US6348041B1 (en) * 1999-03-29 2002-02-19 Cook Incorporated Guidewire
US6206907B1 (en) * 1999-05-07 2001-03-27 Cardia, Inc. Occlusion device with stranded wire support arms
US6712836B1 (en) * 1999-05-13 2004-03-30 St. Jude Medical Atg, Inc. Apparatus and methods for closing septal defects and occluding blood flow
US6206895B1 (en) * 1999-07-13 2001-03-27 Scion Cardio-Vascular, Inc. Suture with toggle and delivery system
US6344049B1 (en) * 1999-08-17 2002-02-05 Scion Cardio-Vascular, Inc. Filter for embolic material mounted on expandable frame and associated deployment system
US6358238B1 (en) * 1999-09-02 2002-03-19 Scimed Life Systems, Inc. Expandable micro-catheter
US6712804B2 (en) * 1999-09-20 2004-03-30 Ev3 Sunnyvale, Inc. Method of closing an opening in a wall of the heart
US20030059640A1 (en) * 1999-11-19 2003-03-27 Denes Marton High strength vacuum deposited nitinol alloy films and method of making same
US20020010481A1 (en) * 1999-12-23 2002-01-24 Swaminathan Jayaraman Occlusive coil manufacture and delivery
US20020026208A1 (en) * 2000-01-05 2002-02-28 Medical Technology Group, Inc. Apparatus and methods for delivering a closure device
US20020019648A1 (en) * 2000-04-19 2002-02-14 Dan Akerfeldt Intra-arterial occluder
US6352552B1 (en) * 2000-05-02 2002-03-05 Scion Cardio-Vascular, Inc. Stent
US6867249B2 (en) * 2000-08-18 2005-03-15 Kin Man Amazon Lee Lightweight and porous construction materials containing rubber
US20020022860A1 (en) * 2000-08-18 2002-02-21 Borillo Thomas E. Expandable implant devices for filtering blood flow from atrial appendages
US20020029048A1 (en) * 2000-09-01 2002-03-07 Arnold Miller Endovascular fastener and grafting apparatus and method
US20020034259A1 (en) * 2000-09-21 2002-03-21 Katsuyuki Tada Transmitter for automatically changing transmission data type within specified band
US20020035374A1 (en) * 2000-09-21 2002-03-21 Borillo Thomas E. Apparatus for implanting devices in atrial appendages
US6508828B1 (en) * 2000-11-03 2003-01-21 Radi Medical Systems Ab Sealing device and wound closure device
US20030057156A1 (en) * 2001-03-08 2003-03-27 Dean Peterson Atrial filter implants
US20030004533A1 (en) * 2001-05-04 2003-01-02 Concentric Medical Bioactive polymer vaso-occlusive device
US20030023266A1 (en) * 2001-07-19 2003-01-30 Borillo Thomas E. Individually customized atrial appendage implant device
US20030028213A1 (en) * 2001-08-01 2003-02-06 Microvena Corporation Tissue opening occluder
US20060052821A1 (en) * 2001-09-06 2006-03-09 Ovalis, Inc. Systems and methods for treating septal defects
US20030045893A1 (en) * 2001-09-06 2003-03-06 Integrated Vascular Systems, Inc. Clip apparatus for closing septal defects and methods of use
US20030050665A1 (en) * 2001-09-07 2003-03-13 Integrated Vascular Systems, Inc. Needle apparatus for closing septal defects and methods for using such apparatus
US20030055455A1 (en) * 2001-09-20 2003-03-20 Scimed Life Systems, Inc. Method and apparatus for treating septal defects
US7186251B2 (en) * 2003-03-27 2007-03-06 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
US20050025809A1 (en) * 2003-07-08 2005-02-03 Tepha, Inc. Poly-4-hydroxybutyrate matrices for sustained drug delivery
US20050043759A1 (en) * 2003-07-14 2005-02-24 Nmt Medical, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
US20070010851A1 (en) * 2003-07-14 2007-01-11 Chanduszko Andrzej J Tubular patent foramen ovale (PFO) closure device with catch system
US7192435B2 (en) * 2003-09-18 2007-03-20 Cardia, Inc. Self centering closure device for septal occlusion

Cited By (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7678132B2 (en) 2001-09-06 2010-03-16 Ovalis, Inc. Systems and methods for treating septal defects
US20110218567A1 (en) * 2001-09-06 2011-09-08 Ryan Abbott Systems and Methods for Treating Septal Defects
US8758401B2 (en) 2001-09-06 2014-06-24 ProMed, Inc. Systems and methods for treating septal defects
US7686828B2 (en) 2001-09-06 2010-03-30 Ovalis, Inc. Systems and methods for treating septal defects
US7740640B2 (en) 2001-09-06 2010-06-22 Ovalis, Inc. Clip apparatus for closing septal defects and methods of use
US8747483B2 (en) 2001-09-07 2014-06-10 ProMed, Inc. Needle apparatus for closing septal defects and methods for using such apparatus
US8070826B2 (en) 2001-09-07 2011-12-06 Ovalis, Inc. Needle apparatus for closing septal defects and methods for using such apparatus
US8758395B2 (en) 2003-05-19 2014-06-24 Septrx, Inc. Embolic filtering method and apparatus
US7648532B2 (en) 2003-05-19 2010-01-19 Septrx, Inc. Tissue distention device and related methods for therapeutic intervention
US8920434B2 (en) * 2005-03-02 2014-12-30 St. Jude Medical, Cardiology Division, Inc. Remote body tissue engaging methods and apparatus
US20060200197A1 (en) * 2005-03-02 2006-09-07 St. Jude Medical, Inc. Remote body tissue engaging methods and apparatus
US8372113B2 (en) * 2005-03-24 2013-02-12 W.L. Gore & Associates, Inc. Curved arm intracardiac occluder
US20060217761A1 (en) * 2005-03-24 2006-09-28 Opolski Steven W Curved arm intracardiac occluder
US8579936B2 (en) 2005-07-05 2013-11-12 ProMed, Inc. Centering of delivery devices with respect to a septal defect
US7846179B2 (en) 2005-09-01 2010-12-07 Ovalis, Inc. Suture-based systems and methods for treating septal defects
US9585644B2 (en) 2006-08-09 2017-03-07 Coherex Medical, Inc. Devices for reducing the size of an internal tissue opening
US8979941B2 (en) 2006-08-09 2015-03-17 Coherex Medical, Inc. Devices for reducing the size of an internal tissue opening
US9138208B2 (en) 2006-08-09 2015-09-22 Coherex Medical, Inc. Devices for reducing the size of an internal tissue opening
US8840655B2 (en) 2006-08-09 2014-09-23 Coherex Medical, Inc. Systems and devices for reducing the size of an internal tissue opening
US8529597B2 (en) 2006-08-09 2013-09-10 Coherex Medical, Inc. Devices for reducing the size of an internal tissue opening
US8167894B2 (en) 2006-08-09 2012-05-01 Coherex Medical, Inc. Methods, systems and devices for reducing the size of an internal tissue opening
US20080119891A1 (en) * 2006-08-09 2008-05-22 Coherex Medical, Inc. Methods, systems and devices for reducing the size of an internal tissue opening
US20080039743A1 (en) * 2006-08-09 2008-02-14 Coherex Medical, Inc. Methods for determining characteristics of an internal tissue opening
US20080039804A1 (en) * 2006-08-09 2008-02-14 Coherex Medical, Inc. Systems and devices for reducing the size of an internal tissue opening
US9220487B2 (en) 2006-08-09 2015-12-29 Coherex Medical, Inc. Devices for reducing the size of an internal tissue opening
US8894682B2 (en) 2006-09-11 2014-11-25 Boston Scientific Scimed, Inc. PFO clip
WO2008033309A1 (en) * 2006-09-11 2008-03-20 Boston Scientific Limited Pfo clip
US20080065149A1 (en) * 2006-09-11 2008-03-13 Thielen Joseph M PFO clip
US9554783B2 (en) 2007-02-01 2017-01-31 Cook Medical Technologies Llc Closure device and method of closing a bodily opening
US8480707B2 (en) 2007-02-01 2013-07-09 Cook Medical Technologies Llc Closure device and method for occluding a bodily passageway
US9332977B2 (en) 2007-02-01 2016-05-10 Cook Medical Technologies Llc Closure device
WO2008094706A3 (en) * 2007-02-01 2009-02-19 Cook Inc Closure device and method of closing a bodily opening
US8617205B2 (en) 2007-02-01 2013-12-31 Cook Medical Technologies Llc Closure device
WO2008094706A2 (en) * 2007-02-01 2008-08-07 Cook Incorporated Closure device and method of closing a bodily opening
US20100030246A1 (en) * 2007-02-01 2010-02-04 Dusan Pavcnik Closure Device and Method For Occluding a Bodily Passageway
US20100211046A1 (en) * 2009-02-18 2010-08-19 Aga Medical Corporation Medical device with stiffener wire for occluding vascular defects
US9345476B2 (en) * 2009-05-28 2016-05-24 Cook Medical Technologies Llc Tacking device and methods of deployment
US20100305591A1 (en) * 2009-05-28 2010-12-02 Wilson-Cook Medical Inc. Tacking device and methods of deployment
CN103037778A (en) * 2010-06-29 2013-04-10 耶鲁大学 Tissue retractor assembly
WO2012006153A1 (en) * 2010-06-29 2012-01-12 Yale University Tissue retractor assembly
US9023074B2 (en) 2010-10-15 2015-05-05 Cook Medical Technologies Llc Multi-stage occlusion devices
US9107648B2 (en) 2011-06-28 2015-08-18 Novatract Surgical, Inc. Tissue retractor assembly
US8852088B2 (en) 2011-06-28 2014-10-07 Novatract Surgical, Inc. Tissue retractor assembly
US9241698B2 (en) 2011-06-28 2016-01-26 Novatract Surgical, Inc. Tissue retractor assembly
US20140142610A1 (en) * 2012-11-16 2014-05-22 W.L. Gore & Associates, Inc. Space Filling Devices
US20140257375A1 (en) * 2013-03-11 2014-09-11 St. Jude Medical Puerto Rico Llc Active securement detachable sealing tip for extra-vascular closure device and methods
US9107646B2 (en) * 2013-03-11 2015-08-18 St. Jude Medical Puerto Rico Llc Active securement detachable sealing tip for extra-vascular closure device and methods
EP2967802A4 (en) * 2013-03-12 2016-11-23 Pfm Medical Inc Vascular occlusion device configured for infants

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