DK170473B1 - S(-)-pyridobenzoxazinforbindelser - Google Patents

S(-)-pyridobenzoxazinforbindelser Download PDF

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Publication number
DK170473B1
DK170473B1 DK285086A DK285086A DK170473B1 DK 170473 B1 DK170473 B1 DK 170473B1 DK 285086 A DK285086 A DK 285086A DK 285086 A DK285086 A DK 285086A DK 170473 B1 DK170473 B1 DK 170473B1
Authority
DK
Denmark
Prior art keywords
compound
dihydro
benzoxazine
added
methyl
Prior art date
Application number
DK285086A
Other languages
Danish (da)
English (en)
Other versions
DK285086A (da
DK285086D0 (da
Inventor
Isao Hayakawa
Shohgo Atarashi
Shuichi Yokohama
Masazumi Imamura
Katsuichi Sakano
Nobuyuki Higashihashi
Masayuki Ohshima
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27281433&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK170473(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP60226499A external-priority patent/JPH0720946B2/ja
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of DK285086D0 publication Critical patent/DK285086D0/da
Publication of DK285086A publication Critical patent/DK285086A/da
Priority to DK198806416A priority Critical patent/DK175312B1/da
Application granted granted Critical
Publication of DK170473B1 publication Critical patent/DK170473B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK285086A 1985-06-20 1986-06-18 S(-)-pyridobenzoxazinforbindelser DK170473B1 (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK198806416A DK175312B1 (da) 1985-06-20 1988-11-17 Optisk aktive benzoxazinderivater

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP13471285 1985-06-20
JP13471285 1985-06-20
JP60226499A JPH0720946B2 (ja) 1985-10-11 1985-10-11 光学活性３−メチルベンゾオキサジン誘導体およびその製法
JP22649985 1985-10-11
JP1649686 1986-01-28
JP1649686 1986-01-28

Publications (3)

Publication Number Publication Date
DK285086D0 DK285086D0 (da) 1986-06-18
DK285086A DK285086A (da) 1986-12-21
DK170473B1 true DK170473B1 (da) 1995-09-11

Family

ID=27281433

Family Applications (1)

Application Number Title Priority Date Filing Date
DK285086A DK170473B1 (da) 1985-06-20 1986-06-18 S(-)-pyridobenzoxazinforbindelser

Country Status (16)

Country Link
US (3) US5053407A (no)
EP (1) EP0206283B1 (no)
KR (2) KR920010048B1 (no)
AT (1) ATE85057T1 (no)
BG (1) BG60527B2 (no)
CA (1) CA1304080C (no)
DE (2) DE19875012I2 (no)
DK (1) DK170473B1 (no)
ES (1) ES8801251A1 (no)
FI (1) FI90241C (no)
GR (1) GR861625B (no)
HK (1) HK91793A (no)
IE (1) IE59463B1 (no)
NL (1) NL980016I2 (no)
NO (1) NO166131C (no)
YU (3) YU44918B (no)

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DE3750396T2 (de) * 1986-12-25 1995-01-05 Daiichi Seiyaku Co Optisch aktive 2,3-Dihydrobenzoxazinderivate und Verfahren zu deren Herstellung.
FI95567C (fi) * 1987-12-25 1996-02-26 Daiichi Seiyaku Co Propoksibentseenijohdannaisia ja menetelmä niiden valmistamiseksi
US5175160A (en) * 1988-08-09 1992-12-29 Daiichi Pharmaceutical Co., Ltd. Antimicrobial agent for animals
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AU4376589A (en) * 1988-11-07 1990-05-10 Gist-Brocades N.V. Optically active benzoxazines and benzothiazines
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
FR2655545B1 (fr) 1989-12-11 1994-06-10 Rhone Poulenc Sante Nouvelle application therapeutique des derives des fluoroquinolones.
TW208013B (no) * 1990-03-01 1993-06-21 Daiichi Co Ltd
NO179912C (no) * 1990-11-28 1997-01-08 Daiichi Seiyaku Co Analogifremgangsmåte for fremstilling av et terapeutisk virksomt optisk aktivt pyridobenzoksazinderivat
AU674542B2 (en) * 1992-10-07 1997-01-02 Derivados Del Etilo, S.A. Process for obtaining benzoxazines useful for the synthesis of ofloxacin, levofloxacin and derivatives thereof
ES2055656B1 (es) * 1992-10-07 1995-11-16 Etilo Derivados Procedimiento para la obtencion de benzoxazinas utiles para sintesis de ofloxacina, levofloxacina y derivados.
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
ZA946853B (en) * 1993-09-10 1995-04-24 Daiichi Seiyaku Co Crystals of antimicrobial compound.
US5686095A (en) * 1995-10-23 1997-11-11 Price, Jr.; Francis W. Method of treating canker sores
WO1998003167A1 (en) 1996-07-24 1998-01-29 Warner-Lambert Company Isobutylgaba and its derivatives for the treatment of pain
US6248343B1 (en) 1998-01-20 2001-06-19 Ethicon, Inc. Therapeutic antimicrobial compositions
US6022551A (en) * 1998-01-20 2000-02-08 Ethicon, Inc. Antimicrobial composition
US5997893A (en) * 1998-01-20 1999-12-07 Ethicon, Inc. Alcohol based anti-microbial compositions with cosmetic appearance
US5972358A (en) * 1998-01-20 1999-10-26 Ethicon, Inc. Low tack lotion, gels and creams
KR100309871B1 (ko) 1999-02-24 2001-10-29 윤종용 (-)피리도벤즈옥사진 카르복실산 유도체의 제조방법
AU757777B2 (en) 1998-12-04 2003-03-06 Influx, Inc. Inhibitors of multidrug transporters
KR100617952B1 (ko) * 1999-03-04 2006-08-30 보령제약 주식회사 광학활성 피리도 벤즈옥사진 유도체의 제조방법
AU6873700A (en) * 1999-09-08 2001-04-10 Daiichi Pharmaceutical Co., Ltd. Process for the preparation of benzoxazine derivatives and intermediates therefor
KR20010103346A (ko) * 2000-05-09 2001-11-23 이후근 패각 입자와 접착제 그리고 물감을 혼합하여 그림 밑칠용재료를 제조하는 방법
JP2004518677A (ja) * 2000-12-21 2004-06-24 ファルマシア・アンド・アップジョン・カンパニー 抗菌性キノロン誘導体および細菌感染を治療するためのその使用
EP1367132B1 (en) * 2001-03-07 2009-08-12 Daiichi Sankyo Company, Limited Process for preparation of optically active propoxyaniline derivatives
CN1201028C (zh) 2001-04-27 2005-05-11 浦项产业科学研究院 具有优越热加工性能的高锰二联不锈钢及其制造方法
US7425628B2 (en) 2001-10-03 2008-09-16 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
US7629458B2 (en) * 2001-10-03 2009-12-08 Teva Pharmaceutical Industries Ltd. Preparation of levofloxacin and hemihydrate thereof
KR100440192B1 (ko) * 2001-11-22 2004-07-12 이수화학 주식회사 광학 활성 퀴놀론카르복실산 유도체의 제조방법
AU2002365416A1 (en) * 2001-11-29 2003-06-10 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
BR0215413A (pt) * 2001-12-24 2004-12-14 Teva Pharma Formula dosada com um comprimido central de ingrediente ativo encapado em uma capa anular prensada de material em pó ou granulado e processo e conjunto de ferramentas para a sua produção
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
EP2266590A3 (en) 2002-02-22 2011-04-20 Shire LLC Active agent delivery sytems and methods for protecting and administering active agents
CA2495271A1 (en) * 2002-08-14 2004-08-19 Teva Pharmaceutical Industries Ltd Synthesis of gatifloxacin
US20040152701A1 (en) * 2002-12-02 2004-08-05 Dr. Reddy's Laboratories Limited Novel anhydrous crystalline form of Levofloxacin and process for preparation there of
FR2859471B1 (fr) 2003-09-09 2006-02-03 Solvay Procede pour la fabrication d'un compose enantiopur
CA2596993A1 (en) 2005-02-07 2006-08-10 Mitsubishi Pharma Corporation Optically active tetrahydronaphthalene derivative
US8524735B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US7838532B2 (en) * 2005-05-18 2010-11-23 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
CA2642264A1 (en) * 2006-02-13 2007-08-30 Trustees Of Boston University Reca inhibitors with antibiotic activity, compositions and methods of use
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
US20070197548A1 (en) 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
WO2008019292A2 (en) * 2006-08-04 2008-02-14 Trustees Of Boston University Compositions and methods for potentiating antibiotic activity
EP1939206A1 (en) * 2006-12-22 2008-07-02 Farmaprojects, S.A. Process for the preparation of an antibacterial quinolone compound
US20100029938A1 (en) * 2006-12-22 2010-02-04 Farmaprojects, S. A. Process for the preparation of an antibacterial quinolone compound
US7964723B2 (en) 2008-08-02 2011-06-21 Apeloa-Kangyu And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
PL2344129T3 (pl) 2008-10-07 2018-07-31 Horizon Orphan Llc Formulacje fluorochinolonu w aerozolu dla poprawy właściwości farmakokinetycznych
JP2012505222A (ja) 2008-10-07 2012-03-01 エムペックス・ファーマシューティカルズ・インコーポレーテッド 肺炎症を低減するためのレボフロキサシンの吸入
KR20120025519A (ko) 2009-05-15 2012-03-15 레드엑스 파마 리미티드 산화환원 약물 유도체
CN101659669B (zh) * 2009-09-04 2011-07-20 诚达药业股份有限公司 左旋氧氟沙星的制备方法
ES2739979T3 (es) 2009-09-04 2020-02-05 Horizon Orphan Llc Uso de levofloxacino en aerosol para el tratamiento de la fibrosis quística
CN102775424A (zh) * 2012-07-09 2012-11-14 浙江司太立制药股份有限公司 一种左氧氟沙星杂质的制备方法
US10226460B2 (en) * 2014-05-09 2019-03-12 Tecnimede Sociedade Tecnico-Medicinal S.A. Pharmaceutically acceptable salts of pirlindole enantiomers for use in medicine
CN105037388A (zh) * 2015-08-28 2015-11-11 安徽环球药业股份有限公司 一种安妥沙星的制备方法
CN105367585B (zh) * 2015-12-02 2017-11-17 山东齐都药业有限公司 左氧氟沙星杂质的制备方法
WO2021250482A1 (en) 2020-06-11 2021-12-16 Sentiss Pharma Private Limited Ophthalmic compositions comprising a combination of fluoroquinolone antibacterial agent and an anti-inflammatory agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
JPS5852290A (ja) * 1981-09-21 1983-03-28 Dai Ichi Seiyaku Co Ltd ピリドベンゾオキサジンカルボン酸誘導体
DE3543513A1 (de) * 1985-12-10 1987-06-11 Bayer Ag Enantiomerenreine 1,8-verbrueckte 4-chinolon-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel und ihre verwendung zur herstellung von arzneimitteln

Also Published As

Publication number Publication date
EP0206283A3 (en) 1988-08-10
GR861625B (en) 1986-10-21
KR940003757B1 (ko) 1994-04-30
ES556292A0 (es) 1988-01-01
US4985557A (en) 1991-01-15
ES8801251A1 (es) 1988-01-01
HK91793A (en) 1993-09-10
DE19875012I2 (de) 2006-06-29
FI862643A (fi) 1986-12-21
DK285086A (da) 1986-12-21
YU45524B (en) 1992-05-28
IE861631L (en) 1986-12-20
DE3687599D1 (de) 1993-03-11
NL980016I1 (nl) 1998-07-01
FI90241B (fi) 1993-09-30
YU107386A (en) 1988-02-29
EP0206283A2 (en) 1986-12-30
NO166131B (no) 1991-02-25
NO166131C (no) 1991-06-05
US5142046A (en) 1992-08-25
ATE85057T1 (de) 1993-02-15
IE59463B1 (en) 1994-02-23
FI862643A0 (fi) 1986-06-19
BG60527B2 (bg) 1995-07-28
YU209889A (en) 1990-04-30
KR920009279A (ko) 1992-05-28
NO862426D0 (no) 1986-06-18
NO862426L (no) 1986-12-22
CA1304080C (en) 1992-06-23
YU186788A (en) 1989-04-30
KR920010048B1 (ko) 1992-11-13
FI90241C (fi) 1994-01-10
YU44918B (en) 1991-04-30
US5053407A (en) 1991-10-01
DK285086D0 (da) 1986-06-18
EP0206283B1 (en) 1993-01-27
DE3687599T2 (de) 1993-05-19
KR870000340A (ko) 1987-02-17
YU45512B (en) 1992-05-28
NL980016I2 (nl) 1998-08-03

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 1998 00015, 980427