BG60527B2 - Оптично активни пиридобензоксазинови производни и тяхното антимикробно приложение - Google Patents
Оптично активни пиридобензоксазинови производни и тяхното антимикробно приложение Download PDFInfo
- Publication number
- BG60527B2 BG60527B2 BG098511A BG9851194A BG60527B2 BG 60527 B2 BG60527 B2 BG 60527B2 BG 098511 A BG098511 A BG 098511A BG 9851194 A BG9851194 A BG 9851194A BG 60527 B2 BG60527 B2 BG 60527B2
- Authority
- BG
- Bulgaria
- Prior art keywords
- compound
- dihydro
- methyl
- added
- benzoxazine
- Prior art date
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- 238000001556 precipitation Methods 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13471285 | 1985-06-20 | ||
JP60226499A JPH0720946B2 (ja) | 1985-10-11 | 1985-10-11 | 光学活性3−メチルベンゾオキサジン誘導体およびその製法 |
JP1649686 | 1986-01-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
BG60527B2 true BG60527B2 (bg) | 1995-07-28 |
Family
ID=27281433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG098511A BG60527B2 (bg) | 1985-06-20 | 1994-02-22 | Оптично активни пиридобензоксазинови производни и тяхното антимикробно приложение |
Country Status (16)
Country | Link |
---|---|
US (3) | US5053407A (no) |
EP (1) | EP0206283B1 (no) |
KR (2) | KR920010048B1 (no) |
AT (1) | ATE85057T1 (no) |
BG (1) | BG60527B2 (no) |
CA (1) | CA1304080C (no) |
DE (2) | DE3687599T2 (no) |
DK (1) | DK170473B1 (no) |
ES (1) | ES8801251A1 (no) |
FI (1) | FI90241C (no) |
GR (1) | GR861625B (no) |
HK (1) | HK91793A (no) |
IE (1) | IE59463B1 (no) |
NL (1) | NL980016I2 (no) |
NO (1) | NO166131C (no) |
YU (3) | YU44918B (no) |
Families Citing this family (58)
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EP0273399B1 (en) * | 1986-12-25 | 1994-08-17 | Daiichi Pharmaceutical Co., Ltd. | Optically active 2,3-dihydrobenzoaxine derivatives and process for preparing the same |
NO172846C (no) * | 1987-12-25 | 1993-09-15 | Daiichi Seiyaku Co | Fremgangsmaate for fremstilling av 7,8-dihalogen-3-metyl-2,3-dihydro-2m-benzoksazinderivater og propoksybenzenderivater for utoevelse av fremgangsmaaten. |
US5175160A (en) * | 1988-08-09 | 1992-12-29 | Daiichi Pharmaceutical Co., Ltd. | Antimicrobial agent for animals |
MY104139A (en) * | 1988-08-09 | 1994-02-28 | Daiichi Seiyaku Co | Antimicrobial agent for animals |
AU4376589A (en) * | 1988-11-07 | 1990-05-10 | Gist-Brocades N.V. | Optically active benzoxazines and benzothiazines |
FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
FR2655545B1 (fr) * | 1989-12-11 | 1994-06-10 | Rhone Poulenc Sante | Nouvelle application therapeutique des derives des fluoroquinolones. |
TW208013B (no) * | 1990-03-01 | 1993-06-21 | Daiichi Co Ltd | |
NO179912C (no) * | 1990-11-28 | 1997-01-08 | Daiichi Seiyaku Co | Analogifremgangsmåte for fremstilling av et terapeutisk virksomt optisk aktivt pyridobenzoksazinderivat |
ES2055656B1 (es) * | 1992-10-07 | 1995-11-16 | Etilo Derivados | Procedimiento para la obtencion de benzoxazinas utiles para sintesis de ofloxacina, levofloxacina y derivados. |
AU674542B2 (en) * | 1992-10-07 | 1997-01-02 | Derivados Del Etilo, S.A. | Process for obtaining benzoxazines useful for the synthesis of ofloxacin, levofloxacin and derivatives thereof |
US5532239A (en) * | 1993-08-02 | 1996-07-02 | Assistance Publique - Hopitaux De Paris | Therapeutic application of fluoroquinolone derivatives |
ZA946853B (en) * | 1993-09-10 | 1995-04-24 | Daiichi Seiyaku Co | Crystals of antimicrobial compound. |
US5686095A (en) * | 1995-10-23 | 1997-11-11 | Price, Jr.; Francis W. | Method of treating canker sores |
CN1094757C (zh) | 1996-07-24 | 2002-11-27 | 沃尼尔·朗伯公司 | 用于治疗疼痛的异丁基γ-氨基丁酸及其衍生物 |
US6248343B1 (en) | 1998-01-20 | 2001-06-19 | Ethicon, Inc. | Therapeutic antimicrobial compositions |
US6022551A (en) * | 1998-01-20 | 2000-02-08 | Ethicon, Inc. | Antimicrobial composition |
US5972358A (en) * | 1998-01-20 | 1999-10-26 | Ethicon, Inc. | Low tack lotion, gels and creams |
US5997893A (en) * | 1998-01-20 | 1999-12-07 | Ethicon, Inc. | Alcohol based anti-microbial compositions with cosmetic appearance |
KR100309871B1 (ko) | 1999-02-24 | 2001-10-29 | 윤종용 | (-)피리도벤즈옥사진 카르복실산 유도체의 제조방법 |
IL143535A0 (en) | 1998-12-04 | 2002-04-21 | Influx Inc | Inhibitors of multidrug transporters |
KR100617952B1 (ko) * | 1999-03-04 | 2006-08-30 | 보령제약 주식회사 | 광학활성 피리도 벤즈옥사진 유도체의 제조방법 |
CA2660917C (en) * | 1999-09-08 | 2012-01-03 | Daiichi Sankyo Company, Limited | Process for producing benzoxazine derivative and production intermediate thereof |
KR20010103346A (ko) * | 2000-05-09 | 2001-11-23 | 이후근 | 패각 입자와 접착제 그리고 물감을 혼합하여 그림 밑칠용재료를 제조하는 방법 |
WO2002059116A2 (en) | 2000-12-21 | 2002-08-01 | Pharmacia & Upjohn Company | Antimicrobial quinolone derivatives and use of the same to treat bacterial infections |
JP4169332B2 (ja) * | 2001-03-07 | 2008-10-22 | 第一三共株式会社 | 光学活性なプロポキシアニリン誘導体の製造方法 |
CN1201028C (zh) | 2001-04-27 | 2005-05-11 | 浦项产业科学研究院 | 具有优越热加工性能的高锰二联不锈钢及其制造方法 |
US7425628B2 (en) * | 2001-10-03 | 2008-09-16 | Teva Pharmaceutical Industries Ltd. | Methods for the purification of levofloxacin |
US7629458B2 (en) | 2001-10-03 | 2009-12-08 | Teva Pharmaceutical Industries Ltd. | Preparation of levofloxacin and hemihydrate thereof |
KR100440192B1 (ko) * | 2001-11-22 | 2004-07-12 | 이수화학 주식회사 | 광학 활성 퀴놀론카르복실산 유도체의 제조방법 |
WO2003045329A2 (en) * | 2001-11-29 | 2003-06-05 | Teva Pharmaceutical Industries Ltd. | Methods for the purification of levofloxacin |
US20040052843A1 (en) * | 2001-12-24 | 2004-03-18 | Lerner E. Itzhak | Controlled release dosage forms |
NZ534104A (en) * | 2001-12-24 | 2007-03-30 | Teva Pharma | Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material |
AU2003217676B2 (en) | 2002-02-22 | 2009-06-11 | Takeda Pharmaceutical Company Limited | Active agent delivery systems and methods for protecting and administering active agents |
AU2003262704A1 (en) * | 2002-08-14 | 2004-08-30 | Teva Pharmaceutical Industries Ltd. | Synthesis of gatifloxacin |
US20040152701A1 (en) * | 2002-12-02 | 2004-08-05 | Dr. Reddy's Laboratories Limited | Novel anhydrous crystalline form of Levofloxacin and process for preparation there of |
FR2859471B1 (fr) | 2003-09-09 | 2006-02-03 | Solvay | Procede pour la fabrication d'un compose enantiopur |
CN101119986B (zh) | 2005-02-07 | 2011-07-06 | 田边三菱制药株式会社 | 光学活性四氢萘衍生物 |
US7838532B2 (en) * | 2005-05-18 | 2010-11-23 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
US8524734B2 (en) | 2005-05-18 | 2013-09-03 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
US20090264342A1 (en) * | 2006-02-13 | 2009-10-22 | Trustees Of Boston University | Compositions and methods for antibiotic potentiation and drug discovery |
US20070197548A1 (en) | 2006-02-17 | 2007-08-23 | Murthy Yerramilli V S | Fluoroquinolone compositions |
US7973022B2 (en) | 2006-02-17 | 2011-07-05 | Idexx Laboratories, Inc. | Fluoroquinolone carboxylic acid salt compositions |
US20100234348A1 (en) * | 2006-08-04 | 2010-09-16 | Trustees Of Boston University | Compositions and methods for potentiating antibiotic activity |
EP1939206A1 (en) * | 2006-12-22 | 2008-07-02 | Farmaprojects, S.A. | Process for the preparation of an antibacterial quinolone compound |
US20100029938A1 (en) * | 2006-12-22 | 2010-02-04 | Farmaprojects, S. A. | Process for the preparation of an antibacterial quinolone compound |
US7964723B2 (en) | 2008-08-02 | 2011-06-21 | Apeloa-Kangyu | And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate |
EP2346509B1 (en) | 2008-10-07 | 2020-05-13 | Horizon Orphan LLC | Inhalation of levofloxacin for reducing lung inflammation |
PL2344129T3 (pl) | 2008-10-07 | 2018-07-31 | Horizon Orphan Llc | Formulacje fluorochinolonu w aerozolu dla poprawy właściwości farmakokinetycznych |
CN102459169B (zh) | 2009-05-15 | 2014-12-31 | 莱德克斯制药有限公司 | 氧化还原药物衍生物 |
AU2010289326B2 (en) | 2009-09-04 | 2015-09-24 | Horizon Therapeutics U.S. Holding Llc | Use of aerosolized levofloxacin for treating cystic fibrosis |
CN101659669B (zh) * | 2009-09-04 | 2011-07-20 | 诚达药业股份有限公司 | 左旋氧氟沙星的制备方法 |
CN102775424A (zh) * | 2012-07-09 | 2012-11-14 | 浙江司太立制药股份有限公司 | 一种左氧氟沙星杂质的制备方法 |
BR112015023044A8 (pt) | 2013-03-15 | 2021-09-28 | Melinta Subsidiary Corp | Métodos para tratar infecções em pacientes acima do peso e obesos com o uso de antibióticos |
TN2016000495A1 (en) * | 2014-05-09 | 2018-04-04 | Tecnimede Sociedade Tecnico Medicinal S | Pharmaceutically acceptable salts of pirlindole enantiomers for use in medicine. |
CN105037388A (zh) * | 2015-08-28 | 2015-11-11 | 安徽环球药业股份有限公司 | 一种安妥沙星的制备方法 |
CN105367585B (zh) * | 2015-12-02 | 2017-11-17 | 山东齐都药业有限公司 | 左氧氟沙星杂质的制备方法 |
EP4149427A1 (en) | 2020-06-11 | 2023-03-22 | Sentiss Pharma Private Limited | Ophthalmic compositions comprising a combination of fluoroquinolone antibacterial agent and an anti-inflammatory agent |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5746986A (en) * | 1980-09-02 | 1982-03-17 | Dai Ichi Seiyaku Co Ltd | Pyrido(1,2,3-de)(1,4)benzoxazine derivative |
JPS5852290A (ja) * | 1981-09-21 | 1983-03-28 | Dai Ichi Seiyaku Co Ltd | ピリドベンゾオキサジンカルボン酸誘導体 |
DE3543513A1 (de) * | 1985-12-10 | 1987-06-11 | Bayer Ag | Enantiomerenreine 1,8-verbrueckte 4-chinolon-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel und ihre verwendung zur herstellung von arzneimitteln |
-
1986
- 1986-06-18 DK DK285086A patent/DK170473B1/da active Protection Beyond IP Right Term
- 1986-06-18 NO NO862426A patent/NO166131C/no not_active IP Right Cessation
- 1986-06-19 FI FI862643A patent/FI90241C/fi not_active IP Right Cessation
- 1986-06-19 ES ES556292A patent/ES8801251A1/es not_active Expired
- 1986-06-19 IE IE163186A patent/IE59463B1/en not_active IP Right Cessation
- 1986-06-19 YU YU1073/86A patent/YU44918B/xx unknown
- 1986-06-19 CA CA000512000A patent/CA1304080C/en not_active Expired - Lifetime
- 1986-06-20 EP EP86108442A patent/EP0206283B1/en not_active Expired - Lifetime
- 1986-06-20 DE DE8686108442T patent/DE3687599T2/de not_active Expired - Lifetime
- 1986-06-20 GR GR861625A patent/GR861625B/el unknown
- 1986-06-20 KR KR1019860004934A patent/KR920010048B1/ko not_active IP Right Cessation
- 1986-06-20 DE DE19863687599 patent/DE19875012I2/de active Active
- 1986-06-20 AT AT86108442T patent/ATE85057T1/de active
- 1986-06-20 US US06/876,623 patent/US5053407A/en not_active Expired - Lifetime
-
1988
- 1988-10-05 YU YU1867/88A patent/YU45512B/xx unknown
-
1989
- 1989-03-23 US US07/327,653 patent/US4985557A/en not_active Expired - Lifetime
- 1989-10-30 YU YU2098/89A patent/YU45524B/xx unknown
-
1990
- 1990-10-31 KR KR1019900017517A patent/KR940003757B1/ko not_active IP Right Cessation
-
1991
- 1991-08-28 US US07/754,198 patent/US5142046A/en not_active Expired - Lifetime
-
1993
- 1993-09-02 HK HK917/93A patent/HK91793A/xx not_active IP Right Cessation
-
1994
- 1994-02-22 BG BG098511A patent/BG60527B2/bg unknown
-
1998
- 1998-04-22 NL NL980016C patent/NL980016I2/nl unknown
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