|
PA8474101A1
(es)
|
1998-06-19 |
2000-09-29 |
Pfizer Prod Inc |
Compuestos de pirrolo [2,3-d] pirimidina
|
|
EP1065207A1
(en)
*
|
1999-07-02 |
2001-01-03 |
Aventis Pharma Deutschland GmbH |
Naphthyridine derivatives, processes for their preparation, their use, and pharmaceutical compositions comprising them
|
|
WO2001025220A1
(en)
*
|
1999-10-07 |
2001-04-12 |
Amgen Inc. |
Triazine kinase inhibitors
|
|
DE19948417A1
(de)
*
|
1999-10-07 |
2001-04-19 |
Morphochem Ag |
Imidazol-Derivate und ihre Verwendung als Arzneimittel
|
|
DZ3248A1
(fr)
|
1999-12-10 |
2001-06-14 |
Pfizer Prod Inc |
Composés à base de pyrrolo[2,3-d]pyrimidine
|
|
ATE369844T1
(de)
*
|
2000-01-24 |
2007-09-15 |
Genzyme Corp |
Inhibitoren des jak/stat-weges und deren verwendung zur behandlung von allgemeiner primärer osteoarthritis
|
|
EP1782800B1
(en)
*
|
2000-01-24 |
2013-12-18 |
Genzyme Corporation |
Methods for detecting JAK3 inhibitors
|
|
MY137020A
(en)
*
|
2000-04-27 |
2008-12-31 |
Abbott Lab |
Diazabicyclic central nervous system active agents
|
|
ATE323704T1
(de)
*
|
2000-06-26 |
2006-05-15 |
Pfizer Prod Inc |
Pyrrolo¬2,3-däpyrimidin verbindungen als immunosuppressive wirkstoffe
|
|
US6864255B2
(en)
|
2001-04-11 |
2005-03-08 |
Amgen Inc. |
Substituted triazinyl amide derivatives and methods of use
|
|
US6881737B2
(en)
|
2001-04-11 |
2005-04-19 |
Amgen Inc. |
Substituted triazinyl acrylamide derivatives and methods of use
|
|
US7301023B2
(en)
*
|
2001-05-31 |
2007-11-27 |
Pfizer Inc. |
Chiral salt resolution
|
|
MXPA03011998A
(es)
*
|
2001-06-23 |
2005-07-01 |
Aventis Pharma Inc |
Pirrolopirimidinas como inhibidores de protein cinasa.
|
|
GB0115393D0
(en)
*
|
2001-06-23 |
2001-08-15 |
Aventis Pharma Ltd |
Chemical compounds
|
|
GB0119249D0
(en)
|
2001-08-07 |
2001-10-03 |
Novartis Ag |
Organic compounds
|
|
US7323469B2
(en)
|
2001-08-07 |
2008-01-29 |
Novartis Ag |
7H-pyrrolo[2,3-d]pyrimidine derivatives
|
|
GT200200234A
(es)
|
2001-12-06 |
2003-06-27 |
|
Compuestos cristalinos novedosos
|
|
US6642381B2
(en)
*
|
2001-12-27 |
2003-11-04 |
Hoffman-La Roche Inc. |
Pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors
|
|
DE60305446D1
(de)
|
2002-01-07 |
2006-06-29 |
Eisai Co Ltd |
Desazapurine und deren verwendung
|
|
GB0202679D0
(en)
*
|
2002-02-05 |
2002-03-20 |
Glaxo Group Ltd |
Novel compounds
|
|
EP1388541A1
(en)
*
|
2002-08-09 |
2004-02-11 |
Centre National De La Recherche Scientifique (Cnrs) |
Pyrrolopyrazines as kinase inhibitors
|
|
MXPA05005576A
(es)
|
2002-11-26 |
2005-07-27 |
Pfizer Prod Inc |
Procedimiento de tratamiento del rechazo a un trasplante.
|
|
US7253166B2
(en)
*
|
2003-04-22 |
2007-08-07 |
Irm Llc |
6-phenyl-7H-pyrrolo[2,3-d]pyrimidine compounds that induce neuronal differentiation in embryonic stem cells
|
|
EP1682564A1
(en)
*
|
2003-10-27 |
2006-07-26 |
Genelabs Technologies, Inc. |
METHODS FOR PREPARING 7-(2 -SUBSTITUTED-s-D-RIBOFURANO SYL)-4-(NR2R3)-5-(SUBSTITUTED ETHYN-1-YL)-PYRROLO 2,3-D|PYRIMIDINE DERIVATIVES
|
|
WO2005069865A2
(en)
*
|
2004-01-13 |
2005-08-04 |
Ambit Biosciences Corporation |
Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
|
|
GB0403606D0
(en)
|
2004-02-18 |
2004-03-24 |
Novartis Ag |
Organic compounds
|
|
AU2005249380C1
(en)
*
|
2004-04-23 |
2012-09-20 |
Exelixis, Inc. |
Kinase modulators and methods of use
|
|
EP2583678A3
(en)
|
2004-06-24 |
2013-11-13 |
Novartis Vaccines and Diagnostics, Inc. |
Small molecule immunopotentiators and assays for their detection
|
|
CA2572314A1
(en)
|
2004-06-29 |
2006-01-12 |
Christopher N. Farthing |
Pyrrolo[2,3-d]pyrimidines that modulate ack1 and lck activity
|
|
TW200615268A
(en)
|
2004-08-02 |
2006-05-16 |
Osi Pharm Inc |
Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds
|
|
MY179032A
(en)
|
2004-10-25 |
2020-10-26 |
Cancer Research Tech Ltd |
Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
|
|
UY29177A1
(es)
|
2004-10-25 |
2006-05-31 |
Astex Therapeutics Ltd |
Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos
|
|
AR054416A1
(es)
|
2004-12-22 |
2007-06-27 |
Incyte Corp |
Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas.
|
|
FR2880626B1
(fr)
*
|
2005-01-13 |
2008-04-18 |
Aventis Pharma Sa |
Derives de la purine, compositions les contenant et utilisation
|
|
WO2006091450A1
(en)
*
|
2005-02-18 |
2006-08-31 |
Lexicon Genetics Incorporated |
4-piperidin-1-yl-7h-pyrrolo[2,3-d]pyrimidine compounds
|
|
CN101175753B
(zh)
|
2005-05-13 |
2011-03-23 |
Irm责任有限公司 |
作为蛋白激酶抑制剂的化合物和组合物
|
|
US8163767B2
(en)
|
2005-07-14 |
2012-04-24 |
Astellas Pharma Inc. |
Heterocyclic Janus Kinase 3 inhibitors
|
|
EP2251341A1
(en)
|
2005-07-14 |
2010-11-17 |
Astellas Pharma Inc. |
Heterocyclic Janus kinase 3 inhibitors
|
|
EP1926735A1
(en)
|
2005-09-22 |
2008-06-04 |
Incyte Corporation |
Tetracyclic inhibitors of janus kinases
|
|
US8580802B2
(en)
*
|
2005-09-30 |
2013-11-12 |
Vertex Pharmaceuticals Incorporated |
Pyrrolo[2,3-D]pyrimidines as inhibitors of Janus kinases
|
|
DK1966202T3
(da)
*
|
2005-12-13 |
2012-01-16 |
Incyte Corp |
Heteroarylsubstituerede pyrrolo[2,3-b]pyridiner og pyrrolo[2,3-d]pyrimidiner som Januskinaseinhibitorer
|
|
AU2015201850B2
(en)
*
|
2005-12-13 |
2017-03-02 |
Incyte Holdings Corporation |
Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
|
|
EP2007767B1
(en)
*
|
2006-03-11 |
2011-11-02 |
Vernalis (R&D) Ltd |
Pyrrolopyrimidine derivatives used as hsp90 inhibitors
|
|
SG170828A1
(en)
*
|
2006-04-05 |
2011-05-30 |
Vertex Pharmaceuticals Inc Us |
Deazapurines useful as inhibitors of janus kinases
|
|
GB0608176D0
(en)
*
|
2006-04-25 |
2006-06-07 |
Astex Therapeutics Ltd |
Pharmaceutical Compounds
|
|
WO2007125321A2
(en)
*
|
2006-04-25 |
2007-11-08 |
Astex Therapeutics Limited |
Purine and deazapurine derivatives as pharmaceutical compounds
|
|
WO2008012635A2
(en)
*
|
2006-07-26 |
2008-01-31 |
Pfizer Products Inc. |
Amine derivatives useful as anticancer agents
|
|
EP2061772A4
(en)
*
|
2006-09-11 |
2011-06-29 |
Curis Inc |
MULTIFUNCTIONAL SMALL MOLECULES AS PROLIFERATION-ACTIVE ACTIVE SUBSTANCES
|
|
US20080161320A1
(en)
*
|
2006-09-11 |
2008-07-03 |
Xiong Cai |
Fused bicyclic pyrimidines as ptk inhibitors containing a zinc binding moiety
|
|
WO2008075007A1
(en)
*
|
2006-12-21 |
2008-06-26 |
Cancer Research Technology Limited |
Morpholino-substituted bicycloheteroaryl compounds and their use as anti cancer agents
|
|
AR064416A1
(es)
*
|
2006-12-21 |
2009-04-01 |
Cancer Rec Tech Ltd |
Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas.
|
|
US8513270B2
(en)
|
2006-12-22 |
2013-08-20 |
Incyte Corporation |
Substituted heterocycles as Janus kinase inhibitors
|
|
MX2009007426A
(es)
|
2007-01-12 |
2009-07-17 |
Astellas Pharma Inc |
Compuesto de piridina condensado.
|
|
CA2682646A1
(en)
*
|
2007-04-02 |
2008-10-09 |
Palau Pharma, S.A. |
Pyrrolopyrimidine derivatives as jak3 inhibitors
|
|
UA99284C2
(ru)
|
2007-05-11 |
2012-08-10 |
Елі Ліллі Енд Компані |
ИНГИБИТОРЫ р70 S6-КИНАЗЫ
|
|
CL2008001709A1
(es)
|
2007-06-13 |
2008-11-03 |
Incyte Corp |
Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
|
|
DK3070090T3
(en)
|
2007-06-13 |
2019-03-18 |
Incyte Holdings Corp |
USE OF SALTS OF THE JANUS-KINASE INHIBITOR (R) -3- (4- (7H-PYRROLO [2,3-D] PYRIMIDIN-4-YL) -1H-PYRAZOL-1-YL) -3- CYCLOPENTYL PROPANNITRIL
|
|
GB0713602D0
(en)
*
|
2007-07-12 |
2007-08-22 |
Syngenta Participations Ag |
Chemical compounds
|
|
AU2008281849B2
(en)
*
|
2007-07-27 |
2013-11-28 |
Janssen Pharmaceutica Nv |
Pyrrolopyrimidines
|
|
WO2009021169A2
(en)
*
|
2007-08-08 |
2009-02-12 |
Lexicon Pharmaceuticals, Inc. |
(7h-pyrr0l0 [2, 3-d] pyrimidin-4-yl) -piperazines as kinase inhibitors for the treatment of cancer and inflammation
|
|
WO2009030871A1
(en)
*
|
2007-09-07 |
2009-03-12 |
Vernalis R & D Ltd |
Pyrrolopyrimidine derivatives having hsp90 inhibitory activity
|
|
WO2009047563A1
(en)
|
2007-10-11 |
2009-04-16 |
Astrazeneca Ab |
Pyrrolo [2, 3 -d] pyrimidin derivatives as protein kinase b inhibitors
|
|
CA2704599C
(en)
|
2007-11-16 |
2015-05-12 |
Incyte Corporation |
4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors
|
|
CN102026999B
(zh)
|
2008-03-11 |
2014-03-05 |
因塞特公司 |
作为jak抑制剂的氮杂环丁烷和环丁烷衍生物
|
|
KR20160129909A
(ko)
|
2008-04-21 |
2016-11-09 |
렉시컨 파마슈티컬스 인코퍼레이티드 |
Limk2 억제제, 그를 포함하는 조성물 및 그의 사용 방법
|
|
JP2011518836A
(ja)
|
2008-04-24 |
2011-06-30 |
インサイト・コーポレイション |
大環状化合物およびそれらのキナーゼ阻害剤としての使用
|
|
WO2010020905A1
(en)
|
2008-08-20 |
2010-02-25 |
Pfizer Inc. |
Pyrrolo[2,3-d]pyrimidine compounds
|
|
US8385364B2
(en)
*
|
2008-09-24 |
2013-02-26 |
Nec Laboratories America, Inc. |
Distributed message-passing based resource allocation in wireless systems
|
|
CL2009001884A1
(es)
*
|
2008-10-02 |
2010-05-14 |
Incyte Holdings Corp |
Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
|
|
JOP20190231A1
(ar)
|
2009-01-15 |
2017-06-16 |
Incyte Corp |
طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
|
|
DE102009005193A1
(de)
*
|
2009-01-20 |
2010-07-22 |
Merck Patent Gmbh |
Neue heterocyclische Verbindungen als MetAP-2 Inhibitoren
|
|
WO2010085597A1
(en)
|
2009-01-23 |
2010-07-29 |
Incyte Corporation |
Macrocyclic compounds and their use as kinase inhibitors
|
|
CA2752150A1
(en)
|
2009-02-11 |
2010-08-19 |
Reaction Biology Corp. |
Selective kinase inhibitors
|
|
ES2552805T3
(es)
|
2009-04-20 |
2015-12-02 |
Auspex Pharmaceuticals, Llc |
Inhibidores piperidínicos de la cinasa Janus 3
|
|
WO2010135650A1
(en)
*
|
2009-05-22 |
2010-11-25 |
Incyte Corporation |
N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS
|
|
AU2010249443B2
(en)
*
|
2009-05-22 |
2015-08-13 |
Incyte Holdings Corporation |
3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]octane- or heptane-nitrile as JAK inhibitors
|
|
US9346809B2
(en)
|
2009-07-08 |
2016-05-24 |
Leo Pharma A/S |
Heterocyclic compounds as JAK receptor and protein tyrosine kinase inhibitors
|
|
TWI466885B
(zh)
*
|
2009-07-31 |
2015-01-01 |
Japan Tobacco Inc |
含氮螺環化合物及其醫藥用途
|
|
TW201111385A
(en)
*
|
2009-08-27 |
2011-04-01 |
Biocryst Pharm Inc |
Heterocyclic compounds as janus kinase inhibitors
|
|
WO2011028685A1
(en)
|
2009-09-01 |
2011-03-10 |
Incyte Corporation |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
CN102711473B
(zh)
|
2009-09-04 |
2016-11-09 |
比奥根Ma公司 |
布鲁顿酪氨酸激酶抑制剂
|
|
AU2010289321A1
(en)
*
|
2009-09-04 |
2012-04-05 |
The Regents Of The University Of Michigan |
Compositions and methods for treatment of leukemia
|
|
CA2777114C
(en)
|
2009-10-09 |
2018-10-23 |
Incyte Corporation |
Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
|
|
PH12012500583A1
(en)
|
2009-10-15 |
2012-10-22 |
Pfizer |
Pyrrolo[2,3-d] pyrimidine compounds
|
|
US9074143B2
(en)
*
|
2009-12-11 |
2015-07-07 |
Uop Llc |
Process for producing hydrocarbon fuel
|
|
CA2782720A1
(en)
|
2009-12-18 |
2011-06-23 |
Pfizer Inc. |
Pyrrolo[2,3-d]pyrimidine compounds
|
|
MX2012009074A
(es)
|
2010-02-05 |
2012-08-23 |
Pfizer |
Compuestos de urea pirrolo [2, 3-d] pirimidina como inhibidores de janus quinasa.
|
|
JP5858434B2
(ja)
*
|
2010-02-18 |
2016-02-10 |
インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation |
Janusキナーゼ阻害薬としてのシクロブタンおよびメチルシクロブタン誘導体
|
|
TWI694826B
(zh)
|
2010-03-10 |
2020-06-01 |
美商英塞特公司 |
作為jak1抑制劑之哌啶-4-基三亞甲亞胺衍生物
|
|
MY161078A
(en)
|
2010-05-21 |
2017-04-14 |
Incyte Holdings Corp |
Topical formulation for a jak inhibitor
|
|
CN102985425A
(zh)
*
|
2010-07-09 |
2013-03-20 |
利奥制药有限公司 |
作为蛋白酪氨酸激酶抑制剂的新的高哌嗪衍生物及其医药用途
|
|
US9346810B2
(en)
*
|
2010-08-20 |
2016-05-24 |
Hutchison Medipharma Limited |
Pyrrolopyrimidine compounds and uses thereof
|
|
CN102372717B
(zh)
*
|
2010-08-20 |
2014-06-18 |
和记黄埔医药(上海)有限公司 |
吡咯并嘧啶类化合物及其用途
|
|
WO2012022045A1
(en)
*
|
2010-08-20 |
2012-02-23 |
Hutchison Medipharma Limited |
Pyrrolopyrimidine compounds and uses thereof
|
|
TWI401258B
(zh)
*
|
2010-09-08 |
2013-07-11 |
Hutchison Medipharma Ltd |
吡咯並嘧啶類化合物及其用途
|
|
CA2818545C
(en)
|
2010-11-19 |
2019-04-16 |
Incyte Corporation |
Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
|
|
WO2012068450A1
(en)
|
2010-11-19 |
2012-05-24 |
Incyte Corporation |
Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
|
|
US9045485B2
(en)
|
2010-12-16 |
2015-06-02 |
Convergence Pharmaceuticals Limited |
ASK 1 inhibiting pyrrolopyrimidine derivatives
|
|
WO2012088682A1
(en)
*
|
2010-12-29 |
2012-07-05 |
Shanghai Fochon Pharmaceutical Co Ltd. |
2-(3-aminopiperidin-1-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7(3h,6h)-dione derivates as dipeptidyl peptidase iv(dpp-iv) inhibitors
|
|
JP2014501772A
(ja)
*
|
2011-01-07 |
2014-01-23 |
レオ ファーマ アクティーゼルスカブ |
タンパク質チロシンキナーゼ阻害薬としての新規スルファミドピペラジン誘導体およびその医薬用途
|
|
DE102011008352A1
(de)
*
|
2011-01-12 |
2012-07-12 |
Merck Patent Gmbh |
5-([1,2,3]Triazol-4-yl)-7H-pyrrolo-[2,3-d]pyrimidinderivate
|
|
CA2826295C
(en)
|
2011-02-04 |
2020-10-20 |
Duquesne University Of The Holy Spirit |
Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient
|
|
JP5936628B2
(ja)
|
2011-02-18 |
2016-06-22 |
ノバルティス・ファルマ・アクチェンゲゼルシャフトNovartis Pharma AG |
mTOR/JAK阻害剤併用療法
|
|
CA2830882C
(en)
|
2011-03-22 |
2021-03-16 |
Dinesh Barawkar |
Substituted fused tricyclic compounds, compositions and medicinal applications thereof
|
|
LT2694056T
(lt)
|
2011-04-01 |
2019-12-10 |
Astrazeneca Ab |
Terapinis gydymas
|
|
AR086983A1
(es)
|
2011-06-20 |
2014-02-05 |
Incyte Corp |
Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak
|
|
WO2013003250A1
(en)
*
|
2011-06-29 |
2013-01-03 |
Merck Sharp & Dohme Corp. |
Process for preparing chiral dipeptidyl peptidase-iv inhibitors
|
|
CA2841111A1
(en)
|
2011-07-08 |
2013-01-17 |
Novartis Ag |
Novel pyrrolo pyrimidine derivatives
|
|
CA2844507A1
(en)
|
2011-08-10 |
2013-02-14 |
Novartis Pharma Ag |
Jak pi3k/mtor combination therapy
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為jak抑制劑之環己基氮雜環丁烷衍生物
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
SG11201401471PA
(en)
|
2011-11-30 |
2014-08-28 |
Astrazeneca Ab |
Combination treatment of cancer
|
|
EP3750544B1
(en)
|
2011-11-30 |
2025-03-05 |
Emory University |
Jak inhibitors for use in the prevention or treatment of a viral disease caused by a coronaviridae
|
|
WO2013085802A1
(en)
*
|
2011-12-06 |
2013-06-13 |
Merck Sharp & Dohme Corp. |
Pyrrolopyrimidines as janus kinase inhibitors
|
|
AU2013204533B2
(en)
|
2012-04-17 |
2017-02-02 |
Astrazeneca Ab |
Crystalline forms
|
|
US9193733B2
(en)
|
2012-05-18 |
2015-11-24 |
Incyte Holdings Corporation |
Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
|
|
AR091273A1
(es)
|
2012-06-08 |
2015-01-21 |
Biogen Idec Inc |
Inhibidores de pirimidinil tirosina quinasa
|
|
AP3902A
(en)
*
|
2012-06-29 |
2016-11-17 |
Pfizer |
Novel 4-(substituted-amino)-7H-pyrrolo[2,3-d]pyrimidines as LRRK2 inhibitors
|
|
ES2889757T3
(es)
|
2012-09-06 |
2022-01-13 |
Plexxikon Inc |
Compuestos y procedimientos para la modulación de quinasas e indicaciones para estos
|
|
JP2015529242A
(ja)
|
2012-09-21 |
2015-10-05 |
アドヴィヌス セラピューティクス リミテッドAdvinus Therapeutics Limited |
置換された縮合三環式化合物、組成物およびその医薬用途
|
|
CN104662024B
(zh)
*
|
2012-10-26 |
2016-12-07 |
弗·哈夫曼-拉罗切有限公司 |
酪氨酸激酶抑制剂
|
|
CN102936251A
(zh)
*
|
2012-11-05 |
2013-02-20 |
上海毕得医药科技有限公司 |
一种吡咯并[2,3-d]嘧啶衍生物的制备方法
|
|
IL297429A
(en)
|
2012-11-15 |
2022-12-01 |
Incyte Holdings Corp |
Sustained release dosage forms of roxolitinib
|
|
SI3290421T1
(sl)
|
2013-02-22 |
2019-03-29 |
Pfizer Inc. |
Kombinacija derivatov pirolo (2,3-D)pirimidina z enim ali več dodatnimi sredstvi za zaviranje z janusom povezane kinaze (JAK)
|
|
SI2964650T1
(sl)
|
2013-03-06 |
2019-05-31 |
Incyte Holdings Corporation |
Postopki in vmesne spojine za izdelavo inhibitorja JAK
|
|
EP2970119B1
(en)
|
2013-03-14 |
2021-11-03 |
Merck Sharp & Dohme Corp. |
Novel indole derivatives useful as anti-diabetic agents
|
|
HUE049345T2
(hu)
|
2013-08-07 |
2020-09-28 |
Incyte Corp |
Nyújtott hatóanyag-leadású dózisformák JAK1 inhibitorhoz
|
|
HUE035264T2
(hu)
*
|
2013-12-05 |
2018-05-02 |
Pfizer |
Pirrolo[2,3-d]pirimidinil-, pirrolo[2,3-b]pirazinil- és pirrolo[2,3-d]-piridinil- akrilamidok
|
|
WO2015092592A1
(en)
|
2013-12-17 |
2015-06-25 |
Pfizer Inc. |
Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
|
|
WO2015184305A1
(en)
|
2014-05-30 |
2015-12-03 |
Incyte Corporation |
TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
|
|
EP3180344B1
(en)
|
2014-08-12 |
2019-09-18 |
Pfizer Inc |
Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase
|
|
USRE49687E1
(en)
|
2014-09-09 |
2023-10-10 |
The Regents Of The University Of Michigan |
Thienopyrimidine and thienopyridine compounds and methods of use thereof
|
|
CN105524067A
(zh)
*
|
2014-09-28 |
2016-04-27 |
江苏柯菲平医药股份有限公司 |
4-取代吡咯并[2,3-d]嘧啶化合物及其用途
|
|
WO2016178110A1
(en)
|
2015-05-01 |
2016-11-10 |
Pfizer Inc. |
Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof
|
|
AR104020A1
(es)
|
2015-06-04 |
2017-06-21 |
Kura Oncology Inc |
Métodos y composiciones para inhibir la interacción de menina con proteínas mill
|
|
WO2016197027A1
(en)
|
2015-06-04 |
2016-12-08 |
Kura Oncology, Inc. |
Methods and compositions for inhibiting the interaction of menin with mll proteins
|
|
EP3330271B1
(en)
*
|
2015-07-31 |
2022-09-07 |
Taiho Pharmaceutical Co., Ltd. |
PYRROLO[2,3-d]PYRIMIDINE COMPOUND OR SALT THEREOF
|
|
KR101771219B1
(ko)
*
|
2015-08-21 |
2017-09-05 |
양지화학 주식회사 |
야누스 키나제 1 선택적 억제제 및 그 의약 용도
|
|
RU2722149C1
(ru)
|
2015-09-14 |
2020-05-27 |
Пфайзер Инк. |
Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2
|
|
CN108472298B
(zh)
|
2015-11-24 |
2021-04-20 |
深圳阿拉丁医疗科技有限公司 |
选择性激酶抑制剂
|
|
CN107098908B
(zh)
*
|
2016-02-23 |
2021-01-08 |
欣凯医药科技(上海)有限公司 |
一种吡咯并嘧啶类化合物的制备方法和应用
|
|
PL3429591T3
(pl)
|
2016-03-16 |
2023-07-17 |
Kura Oncology, Inc. |
Podstawione pochodne tieno[2,3-d]pirymidyny jako inhibitory meniny-mll i metody ich zastosowania
|
|
EP3429585B1
(en)
|
2016-03-16 |
2021-11-24 |
Kura Oncology, Inc. |
Bridged bicyclic inhibitors of menin-mll and methods of use
|
|
CN107513067A
(zh)
|
2016-06-16 |
2017-12-26 |
北京赛林泰医药技术有限公司 |
含有取代环戊基的吡咯并嘧啶化合物
|
|
CN107513069A
(zh)
|
2016-06-16 |
2017-12-26 |
正大天晴药业集团股份有限公司 |
手性吡咯并嘧啶化合物的制备方法
|
|
JP7214632B2
(ja)
|
2016-07-21 |
2023-01-30 |
バイオジェン エムエー インク. |
ブルトン型チロシンキナーゼ阻害剤のコハク酸塩形態および組成物
|
|
US10316038B2
(en)
|
2017-01-25 |
2019-06-11 |
Aclaris Therapeutics, Inc. |
Pyrrolopyrimidine ITK inhibitors for treating inflammation and cancer
|
|
WO2018141842A1
(en)
*
|
2017-02-03 |
2018-08-09 |
Leo Pharma A/S |
5-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-5-AZASPIRO[2.5]OCTANE-8-CARBOXYLIC ACID DERIVATIVES AS NOVEL JAK KINASE INHIBITORS
|
|
EP3601249A4
(en)
|
2017-03-24 |
2020-12-16 |
Kura Oncology, Inc. |
METHODS OF TREATMENT OF MALIGNANT HEMOPATHIES AND EWING'S SARCOMA
|
|
CN108794480A
(zh)
*
|
2017-04-28 |
2018-11-13 |
天津药物研究院有限公司 |
吡咯并嘧啶类化合物、其制备方法和用途
|
|
US11542248B2
(en)
|
2017-06-08 |
2023-01-03 |
Kura Oncology, Inc. |
Methods and compositions for inhibiting the interaction of menin with MLL proteins
|
|
TW201920170A
(zh)
|
2017-09-20 |
2019-06-01 |
美商庫拉腫瘤技術股份有限公司 |
經取代之menin-mll 抑制劑及使用方法
|
|
WO2019090158A1
(en)
|
2017-11-03 |
2019-05-09 |
Aclaris Therapeutics, Inc. |
Substituted pyrrolopyrimidine jak inhibitors and methods of making and using the same
|
|
US10800775B2
(en)
|
2017-11-03 |
2020-10-13 |
Aclaris Therapeutics, Inc. |
Pyrazolyl pyrrolo[2,3-b]pyrmidine-5-carboxylate analogs and methods of making the same
|
|
TW201924683A
(zh)
|
2017-12-08 |
2019-07-01 |
美商英塞特公司 |
用於治療骨髓增生性贅瘤的低劑量組合療法
|
|
RS63312B1
(sr)
|
2018-01-30 |
2022-07-29 |
Incyte Corp |
Procesi za pripremu (1-(3-fluoro-2-(trifluorometil)izonikotinil)piperidin-4-on)
|
|
MX2022012285A
(es)
|
2018-03-30 |
2023-08-15 |
Incyte Corp |
Tratamiento de la hidradenitis supurativa mediante el uso de inhibidores de actividad de la cinasa janus (jak).
|
|
KR102849047B1
(ko)
|
2018-08-10 |
2025-08-22 |
어클라리스 쎄라퓨틱스, 인코포레이티드 |
피롤로피리미딘 itk 억제제
|
|
GB201818750D0
(en)
*
|
2018-11-16 |
2019-01-02 |
Institute Of Cancer Res Royal Cancer Hospital |
Lox inhibitors
|
|
CN109394768B
(zh)
*
|
2018-12-10 |
2019-08-23 |
牡丹江医学院 |
一种治疗湿疹的药物及其制备方法
|
|
NL2022471B1
(en)
|
2019-01-29 |
2020-08-18 |
Vationpharma B V |
Solid state forms of oclacitinib
|
|
CN113993585B
(zh)
*
|
2019-03-27 |
2024-10-01 |
英矽智能科技知识产权有限公司 |
双环jak抑制剂及其用途
|
|
EP3962897A4
(en)
|
2019-05-02 |
2022-12-14 |
Aclaris Therapeutics, Inc. |
SUBSTITUTED PYRROLOPYRIDINES AS JAK INHIBITORS
|
|
KR102503349B1
(ko)
|
2019-05-14 |
2023-02-23 |
프로벤션 바이오, 인코포레이티드 |
제1형 당뇨병을 예방하기 위한 방법 및 조성물
|
|
PE20230251A1
(es)
|
2019-11-22 |
2023-02-07 |
Incyte Corp |
Terapia de combinacion que comprende un inhibidor de alk2 y un inhibidor de jak2
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
US12006366B2
(en)
|
2020-06-11 |
2024-06-11 |
Provention Bio, Inc. |
Methods and compositions for preventing type 1 diabetes
|
|
US20250051337A1
(en)
*
|
2021-09-28 |
2025-02-13 |
Sanford Burnham Prebys Medical Discovery Institute |
Inhibitors of serine/threonine protein kinase stk3 or stk4 and uses thereof
|