DE69928792D1 - Imidazo-pyridin verbindungen, die die sekretion von magensäure hemmen - Google Patents

Imidazo-pyridin verbindungen, die die sekretion von magensäure hemmen

Info

Publication number
DE69928792D1
DE69928792D1 DE69928792T DE69928792T DE69928792D1 DE 69928792 D1 DE69928792 D1 DE 69928792D1 DE 69928792 T DE69928792 T DE 69928792T DE 69928792 T DE69928792 T DE 69928792T DE 69928792 D1 DE69928792 D1 DE 69928792D1
Authority
DE
Germany
Prior art keywords
imidazo
secretion
prevent
pyridine compounds
magic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69928792T
Other languages
English (en)
Other versions
DE69928792T2 (de
Inventor
Kosrat Amin
Michael Dahlstroem
Peter Nordberg
Ingemar Starke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE69928792D1 publication Critical patent/DE69928792D1/de
Publication of DE69928792T2 publication Critical patent/DE69928792T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69928792T 1998-04-29 1999-04-23 Imidazo-pyridin verbindungen, die die sekretion von magensäure hemmen Expired - Lifetime DE69928792T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9801526A SE9801526D0 (sv) 1998-04-29 1998-04-29 New compounds
SE9801526 1998-04-29
PCT/SE1999/000663 WO1999055706A1 (en) 1998-04-29 1999-04-23 Imidazo pyridine derivatives which inhibit gastric acid secretion

Publications (2)

Publication Number Publication Date
DE69928792D1 true DE69928792D1 (de) 2006-01-12
DE69928792T2 DE69928792T2 (de) 2006-07-20

Family

ID=20411154

Family Applications (4)

Application Number Title Priority Date Filing Date
DE69937076T Expired - Lifetime DE69937076T2 (de) 1998-04-29 1999-04-23 Zwischenprodukte für die Herstellung von Imidazo-Pyridin-Derivate
DE69927803T Expired - Lifetime DE69927803T2 (de) 1998-04-29 1999-04-23 Imidazo-pyridin verbindungen, die die sekretion von magensäure hemmen.
DE69928792T Expired - Lifetime DE69928792T2 (de) 1998-04-29 1999-04-23 Imidazo-pyridin verbindungen, die die sekretion von magensäure hemmen
DE69937077T Expired - Lifetime DE69937077T2 (de) 1998-04-29 1999-04-23 Zwischenprodukte für die Herstellung von Imidazo-Pyridin-Derivate

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE69937076T Expired - Lifetime DE69937076T2 (de) 1998-04-29 1999-04-23 Zwischenprodukte für die Herstellung von Imidazo-Pyridin-Derivate
DE69927803T Expired - Lifetime DE69927803T2 (de) 1998-04-29 1999-04-23 Imidazo-pyridin verbindungen, die die sekretion von magensäure hemmen.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69937077T Expired - Lifetime DE69937077T2 (de) 1998-04-29 1999-04-23 Zwischenprodukte für die Herstellung von Imidazo-Pyridin-Derivate

Country Status (34)

Country Link
US (2) US6313137B1 (de)
EP (4) EP1073656B1 (de)
JP (2) JP3692034B2 (de)
KR (3) KR100595806B1 (de)
CN (2) CN1165535C (de)
AR (2) AR015769A1 (de)
AT (4) ATE372339T1 (de)
AU (2) AU769108B2 (de)
BR (2) BR9909995B1 (de)
CA (2) CA2329922C (de)
CZ (2) CZ292567B6 (de)
DE (4) DE69937076T2 (de)
DK (2) DK1073656T3 (de)
EE (2) EE04916B1 (de)
ES (2) ES2252975T3 (de)
HK (5) HK1033457A1 (de)
HU (2) HUP0102425A3 (de)
ID (2) ID27530A (de)
IL (4) IL139200A0 (de)
IS (2) IS5684A (de)
MY (2) MY121389A (de)
NO (2) NO318203B1 (de)
NZ (2) NZ507639A (de)
PL (2) PL195000B1 (de)
RU (2) RU2238271C2 (de)
SA (2) SA99200064B1 (de)
SE (1) SE9801526D0 (de)
SI (1) SI1073656T1 (de)
SK (2) SK285768B6 (de)
TR (4) TR200003149T2 (de)
TW (2) TWI250159B (de)
UA (2) UA67769C2 (de)
WO (2) WO1999055705A1 (de)
ZA (2) ZA200005796B (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
SE9802794D0 (sv) * 1998-08-21 1998-08-21 Astra Ab New compounds
SE0003186D0 (sv) * 2000-09-07 2000-09-07 Astrazeneca Ab New process
US6900324B2 (en) 2000-09-07 2005-05-31 Astrazeneca Ab Process for preparing a substituted imidazopyridine compound
UA80393C2 (uk) 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
SE0100296D0 (sv) * 2001-02-01 2001-02-01 Astrazeneca Ab New compounds
SE0100297D0 (sv) * 2001-02-01 2001-02-01 Astrazeneca Ab New compounds
SE0100295D0 (sv) * 2001-02-01 2001-02-01 Astrazeneca Ab New compounds
EP1361868A1 (de) * 2001-02-13 2003-11-19 AstraZeneca AB Neue zubereitung zur modifizierten freisetzung
JP2004520422A (ja) * 2001-03-08 2004-07-08 アストラゼネカ・アクチエボラーグ 新しい用途
SE0102808D0 (sv) * 2001-08-22 2001-08-22 Astrazeneca Ab New compounds
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
SE0201939D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New combination
SE0201940D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New combination II
DE60317529T2 (de) 2002-09-19 2008-09-25 Schering Corp. Imidazopyridine als hemmstoffe cyclin abhängiger kinasen
JP2006508142A (ja) 2002-11-19 2006-03-09 アルタナ　ファルマ　アクチエンゲゼルシャフト ８−置換イミダゾピリジン
AR043002A1 (es) * 2003-02-18 2005-07-13 Altana Pharma Ag Imidazopirazinas 6-substituidos
KR101106905B1 (ko) * 2003-02-26 2012-01-25 수젠, 인크. 단백질 키나아제 억제제로서의 아미노헤테로아릴 화합물
PT1606261E (pt) 2003-03-10 2010-01-11 Nycomed Gmbh Novo processo para a preparação de roflumilast
SE525349C2 (sv) * 2003-06-23 2005-02-08 Volvo Penta Ab Utombordsdrev för båtar
SE0301903D0 (sv) * 2003-06-26 2003-06-26 Astrazeneca Ab Novel imidazopyridine compound III with therapeutic effect
SE0301905D0 (sv) * 2003-06-26 2003-06-26 Astrazeneca Ab Novel imidazopyridine compound I with therapeutic effect
SE0301904D0 (sv) 2003-06-26 2003-06-26 Astrazeneca Ab Novel imidazopyridine compound II with therapeutic effect
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
EP1682133A1 (de) * 2003-11-03 2006-07-26 AstraZeneca AB Imidazo-1,2-a-pyridin-derivate zur behandlung von beschwerdefreiem gastroösophagealem reflux
SE0303451D0 (sv) * 2003-12-18 2003-12-18 Astrazeneca Ab New compounds
WO2005070927A2 (en) * 2004-01-26 2005-08-04 Altana Pharma Ag 1,2,4-triazolo[1,5-a] pyridines as gastric acid secretion inhibitors
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
EP1838309B1 (de) * 2004-12-17 2008-08-20 Pfizer, Inc. Chroman-derivate als säurepumpenantagonisten
EP1861074B1 (de) 2005-03-16 2013-04-24 Takeda GmbH Geschmacksmaskierte dosierform von roflumilast
AR056187A1 (es) * 2005-03-21 2007-09-26 S Bio Pte Ltd Derivados de imidazo[1,2-a)piridina: preparacion, composiciones farmaceuticas y uso para preparar medicamentos
US7666880B2 (en) 2005-03-21 2010-02-23 S*Bio Pte Ltd. Imidazo[1,2-A]pyridine derivatives: preparation and pharmaceutical applications
EP1861095A1 (de) * 2005-03-24 2007-12-05 Glaxo Group Limited Derivate von imidazo(1,2-a)pyridin als nützliche medikamente zur behandlung von magen-darm-erkrankungen
GB0513423D0 (en) * 2005-06-30 2005-08-03 Glaxo Group Ltd Novel compounds
CA2632283C (en) 2005-12-05 2011-06-21 Pfizer Products Inc. Polymorphs of a c-met/hgfr inhibitor
DE602006018354D1 (de) 2005-12-05 2010-12-30 Pfizer Prod Inc Verfahren zur behandlung von abnormalem zellwachstum
EP1996589A1 (de) * 2006-03-17 2008-12-03 RaQualia Pharma Inc Chromanderivate
US8728527B2 (en) 2006-07-24 2014-05-20 Luminus Biosciences, Inc. Solid nanoparticle formulation of water insoluble pharmaceutical substances with reduced ostwald ripening
WO2008059373A1 (en) * 2006-11-17 2008-05-22 Raqualia Pharma Inc. Imidazo [1, 2-a] pyrazine derivatives and their use as acid pump antagonists
EP1974729A1 (de) * 2007-03-28 2008-10-01 Santhera Pharmaceuticals (Schweiz) AG Substituierte Imidazopyridinderivate als Melanocortin-4-Rezeptorantagonisten
CN102066396B (zh) * 2008-03-31 2014-03-12 科学与工业研究委员会 用作抗胃液分泌或抗溃疡剂的药物组合物
AU2014201644B2 (en) * 2008-12-03 2015-05-21 Cinclus Pharma Holding AB (publ) Imidazopyridine derivatives which inhibit the secretion of gastric acid
FI20086158A0 (fi) * 2008-12-03 2008-12-03 Mikael Dahlstroem Imidatsopyridiinijohdannaiset
KR101605063B1 (ko) * 2009-07-09 2016-03-21 라퀄리아 파마 인코포레이티드 소화관 운동이상이 관여하는 질환의 치료용 산 펌프 길항제
WO2014209841A2 (en) * 2013-06-25 2014-12-31 F. Hoffmann-La Roche Ag Compounds for treating spinal muscular atrophy
CN106029660B (zh) 2013-12-16 2019-11-15 阿萨纳生物科技有限责任公司 P2x3和/或p2x2/3化合物和方法
BR112016021910A2 (pt) * 2014-03-24 2017-08-15 Arqule Inc Processo de preparação de 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3h-imidazo[4,5-b]piridin-2-il)piridin-2-amina
CN106279151A (zh) * 2015-06-26 2017-01-04 江苏太瑞生诺生物医药科技有限公司 5-(2-(8-((2,6-二甲基苄基)氨基)-2,3-二甲基咪唑并[1,2-a]吡啶-6-甲酰胺基)乙氧基)-5-氧代戊酸的固体形式及其制备方法
KR101777971B1 (ko) * 2016-07-05 2017-09-12 제일약품주식회사 이미다조[1,2-a]피리딘 유도체, 이의 제조방법 및 이의 용도
KR20190057569A (ko) * 2017-11-20 2019-05-29 제일약품주식회사 7-아미노-1h-인돌-5-카르복사미드 유도체 및 이의 용도
US11666888B2 (en) 2018-02-05 2023-06-06 Bio-Rad Laboratories, Inc. Chromatography resin having an anionic exchange-hydrophobic mixed mode ligand
CN112004795A (zh) * 2018-04-10 2020-11-27 拜耳公司 制备2,6-二烷基苯乙酸的方法
RU2732297C2 (ru) * 2018-11-14 2020-09-15 Общество с ограниченной ответственностью "Гурус БиоФарм" Производные нестероидных противовоспалительных средств
US20220362223A1 (en) 2019-11-04 2022-11-17 Cinclus Pharma Holding AB Oral formulation of x842
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KR102496869B1 (ko) * 2022-07-29 2023-02-07 제일약품주식회사 이미다조[1,2-a]피리딘 화합물의 신규 염, 이의 결정형 및 제조방법
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ZA81219B (en) * 1980-01-23 1982-01-27 Schering Corp Imidazo (1,2-a) pyridines ,process for their preparation and pharmaceutical compositions containing them
EP0068378B1 (de) 1981-06-26 1986-03-05 Schering Corporation Imidazo(1,2-a)pyridine und -pyrazine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
US4725601A (en) * 1985-06-04 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers
EP0228006A1 (de) 1985-12-16 1987-07-08 Fujisawa Pharmaceutical Co., Ltd. Imidazopyridinverbindungen und Verfahren zu ihrer Herstellung
GB8722488D0 (en) * 1987-09-24 1987-10-28 Fujisawa Pharmaceutical Co Imidazopyridine compound

Also Published As

Publication number Publication date
AU769108B2 (en) 2004-01-15
KR100650472B1 (ko) 2006-11-28
ID27530A (id) 2001-04-12
DK1073656T3 (da) 2006-01-16
TR200102612T2 (tr) 2002-06-21
KR20050121760A (ko) 2005-12-27
BR9909995B1 (pt) 2010-07-13
JP3692034B2 (ja) 2005-09-07
NZ507638A (en) 2003-10-31
EP1073657A1 (de) 2001-02-07
BR9909996A (pt) 2000-12-26
EE200000664A (et) 2002-04-15
EP1491542B1 (de) 2007-09-05
BR9909995A (pt) 2000-12-26
TR200003176T2 (tr) 2001-03-21
AR015769A1 (es) 2001-05-16
UA66846C2 (uk) 2004-06-15
CN1165535C (zh) 2004-09-08
CZ20003982A3 (cs) 2001-02-14
NO317262B1 (no) 2004-09-27
SA99200065B1 (ar) 2006-11-07
MY121379A (en) 2006-01-28
ATE372340T1 (de) 2007-09-15
CA2329922C (en) 2006-04-11
SK14922000A3 (sk) 2001-06-11
NO20005451D0 (no) 2000-10-27
NZ507639A (en) 2004-01-30
JP2002513024A (ja) 2002-05-08
ATE312101T1 (de) 2005-12-15
EE04916B1 (et) 2007-10-15
ZA200005797B (en) 2002-01-18
US6313137B1 (en) 2001-11-06
IL139297A0 (en) 2001-11-25
DE69928792T2 (de) 2006-07-20
CZ20003981A3 (cs) 2001-03-14
JP3883383B2 (ja) 2007-02-21
ZA200005796B (en) 2002-01-18
IL139297A (en) 2007-06-03
DE69937077T2 (de) 2008-05-29
DE69937077D1 (de) 2007-10-18
KR100595806B1 (ko) 2006-07-03
HUP0102425A3 (en) 2002-12-28
KR20010043133A (ko) 2001-05-25
PL195000B1 (pl) 2007-07-31
DE69937076T2 (de) 2008-05-29
HUP0102313A2 (hu) 2001-12-28
HK1036984A1 (en) 2002-01-25
AU4300699A (en) 1999-11-16
EP1491542A3 (de) 2005-01-05
EP1073657B1 (de) 2005-12-07
AU4300799A (en) 1999-11-16
HK1033317A1 (en) 2001-08-24
TR200102728T2 (tr) 2002-06-21
JP2002513025A (ja) 2002-05-08
EP1491543B1 (de) 2007-09-05
ATE307130T1 (de) 2005-11-15
WO1999055706A9 (en) 2000-03-16
CN1307577A (zh) 2001-08-08
HUP0102425A2 (hu) 2001-11-28
NO318203B1 (no) 2005-02-14
DE69937076D1 (de) 2007-10-18
BR9909996B1 (pt) 2010-08-24
KR20010043134A (ko) 2001-05-25
IS5683A (is) 2000-10-25
IL139200A0 (en) 2001-11-25
CA2329921A1 (en) 1999-11-04
AU769190B2 (en) 2004-01-22
TR200003149T2 (tr) 2001-03-21
NO20005450L (no) 2000-12-22
WO1999055705A1 (en) 1999-11-04
EE200000626A (et) 2002-04-15
SA99200065A (ar) 2005-12-03
HK1036981A1 (en) 2002-01-25
DK1073657T3 (da) 2006-03-13
ATE372339T1 (de) 2007-09-15
SI1073656T1 (sl) 2006-02-28
WO1999055706A1 (en) 1999-11-04
MY121389A (en) 2006-01-28
EP1491543A1 (de) 2004-12-29
CZ293977B6 (cs) 2004-09-15
PL343797A1 (en) 2001-09-10
UA67769C2 (uk) 2004-07-15
SA99200064B1 (ar) 2006-10-11
IL139200A (en) 2010-04-29
RU2238271C2 (ru) 2004-10-20
CA2329922A1 (en) 1999-11-04
EP1073656A1 (de) 2001-02-07
CN1306533A (zh) 2001-08-01
HK1033457A1 (en) 2001-08-31
PL343801A1 (en) 2001-09-10
DE69927803D1 (de) 2006-03-02
ES2249913T3 (es) 2006-04-01
HUP0102313A3 (en) 2002-10-28
NO20005451L (no) 2000-12-27
DE69927803T2 (de) 2006-07-06
KR100595805B1 (ko) 2006-07-03
EP1073656B1 (de) 2005-10-19
CN1174980C (zh) 2004-11-10
EE04676B1 (et) 2006-08-15
NO20005450D0 (no) 2000-10-27
TW490466B (en) 2002-06-11
US6313136B1 (en) 2001-11-06
SK285768B6 (sk) 2007-07-06
IS5684A (is) 2000-10-25
RU2235725C2 (ru) 2004-09-10
EP1491542A2 (de) 2004-12-29
ID26819A (id) 2001-02-15
ES2252975T3 (es) 2006-05-16
TWI250159B (en) 2006-03-01
HK1071139A1 (en) 2005-07-08
AR015768A1 (es) 2001-05-16
SK14912000A3 (sk) 2001-06-11
CZ292567B6 (cs) 2003-10-15
SE9801526D0 (sv) 1998-04-29

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